Garuda - Garba Rujukan Digital

Article Per Year (5 Year)

All

Pharmaciana: Jurnal Kefarmasian

PHARMACIANA
Website

Published by Universitas Ahmad Dahlan

ISSN : 20884559 EISSN : 24770256 DOI : 10.12928

Core Subject : Health,

Medicine & Pharmacology

Pharmaciana is a scientific journal published by the University of Ahmad Dahlan worked closely with Ikatan Apoteker Indonesia (IAI). Pharmaciana published three times a year, namely March, July and November. with ISSN 2088-4559 and e-ISSN 2477-0256. The article published in the Journal Pharmaciana selected by editors and reviewed by the reviewer. Articles published in Pharmaciana must not be published in other journals or have been previously published. Pharmaciana is indexed in google scholar, ACI (Asean Citation Index), Dimension (Crossreff), Garuda, Sinta, Sherpa Romeo, Index Copernicus International, DOAJ, and BASE. Pharmaciana is accredited by DIKTI (DGHE) of Indonesia No. 105/E/KPT/2022 April 07, 2022

Arjuna Subject : Kimia(semua kategori) - Kimia (Lain-Lain)

Articles 808 Documents

45 46 47 48 49

AKTIVITAS ANTIOKSIDAN EKSTRAK Andrographis paniculata (Burm.f.) Ness DENGAN DUA PERBEDAAN PENGUAPAN Ichwan Ridwan Rais
Pharmaciana Vol 6, No 1 (2016): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Andrographis paniculata (Burm.f.) Ness is one of the native tradisional medicine in Indonesia which contain active flavonoid. It has potential activity as antioxidant, antibacterial, and inflammation. Antioxidant sensitive to light and heat. Flavonoid antioxidant activity could be decline by heat and oxidation. We can find these caution while evaporate the liquid solvent with heating in conventional evaporation to get dry extract. One of the conventional evaporation instrument is Rotary Evaporator. Other evaporation system, lyophillization is alternative to evaporate solvent without heat. This system uses instrument called Freeze Dryer. Present study about antioxidant activity influenced by two different evaporation using IC50 determination in DPPH oxidation proved that evaporation difference could change antioxidant ability. The result shows freeze dryer evaporation result with 17.06% of extract yield and 585.730 Âµg/mL IC50 value better than rotary evaporator with 24.96% of extract yield and 792.196 Âµg/mL IC50 value in solvent evaporate ability and antioxidant activity.

VALIDASI METODE ANALISA PENETAPAN KADAR EPIGALOKATEKIN GALAT DENGAN KROMATOGRAFI CAIR KINERJA TINGGI Nining Sugihartini; Achmad Fudholi; Suwidjiyo Pramono; Sismindari Sismindari
Pharmaciana Vol 4, No 1 (2014): Pharmaciana
Publisher : Universitas Ahmad Dahlan

High Performance Liquid Chromatography (HPLC) was one of analytical methods commonlyto determine the concentration of epigallocatechin gallate (EGCG) on green tea extract. The methodmust be validated in order to fit to its purpose. The aim of this research was to prove that the usedmethod has selectifity, liniearity, precise, accurate and know limit of detection (LOD) and limit ofquantification (LOQ) is acceptable. The selectifity of analytical method was determined bycalculating the resolution value between two peak. Data from 10 ug/ml and 100 ug/ml with 5replicates would give precition and accuration. Precition was known from CV value and accurationwas known from recovery value in each concentration. Liniearity was known from regression linearbetween concentration and wide area of peak. From regresion linear could calculate LOD and LOQ.Research show that method of analyse have selectificity with Rs= 2,27>1,5; liniearity with r= 0,99;precision with CV 8,74% at concentration 200 Âµg/ml and 3,74% at concentration 500 Âµg/ml;accuration with recovery 99,76% at concentration 200 Âµg/ml and 100,52% at concentration 500 Âµg/mland the value of LOD is 33,28 ug/ml and LOQ is 110,93 ug/ml.

Penggunaan antibiotik di dua apotek di Surabaya: identifikasi faktor-faktor yang mempengaruhi kepatuhan pasien wahyu dewi tamayanti; Windrianita D.M. Sari; Bernadette Dian Novita Dewi
Pharmaciana Vol 6, No 2 (2016): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Attention to factors that affects proper use of antibiotics need to be conducted to prevent community resistance. This study was aimed to identify factors that affect patientsâ€™ compliance of antibiotic use in two pharmacies in Surabaya, Bhumyamca (A) and Tiara 2 (B). Subject of this study was people who purchased antibiotics in the two pharmacies. Data were collected through questionnaires, analyzed using descriptive statistic, and underwent Hosmer and Lemeshowâ€™s multiple regression tests. Factors such as: age, gender, income, duration and pattern of antibiotics use, antibiotics information, complaint and action after antibiotics side effect were observed. There were 94 respondents mainly 26 - 31 of age met the inclusion criteria. Female respondents in A were 74% and 68% in B. Respondents income was 2 to 3 million rupiah, in A (83%) and B (54%). Respondents use antibiotics mainly for 3 to 5 days, in A (47%) and B (50%). Most respondents use antibiotics after meals in A (92%) and B (88%). Antibiotics information was obtained mainly from healthcare providers in A (92%) and B (85%). Respondents had no complaints after antibiotics use in A (87%) and B (73%). Respondents (44%) stop antibiotics when complaints were occurred both in A and B, whereas 56% visited clinician. Respondents in A (86%) and B (89%) were consumed antibiotics in accordance to usage instruction. Conclusively, no factor was associated to patientsâ€™ compliance, except pattern of administration in B (0.011).

IMPACT OF LIMITED ORAL ANTITUBERCULOSIS INFORMATION TO THE TUBERCULOSIS PATIENTS' COMPLIANCE AND THEIR QUALITY OF LIFE Dian Handayani; Diah Aryani Perwitasari
Pharmaciana Vol 3, No 1 (2013): Pharmaciana
Publisher : Universitas Ahmad Dahlan

The study about impact of limited oral antituberculosis information delivered bypharmacist to patient compliance and their quality of life in two public health centers inYogyakarta has been carried out. This study was performed using cohort eventmonitoring design, with 14 pulmonary TB patients and positive Acid Resistant Basilwere treated with oral antituberculosis (OAT) for at least 1 month and were older than15 years old. We observed the compliance of one group of patients using oralantituberculosis who were serviced with OAT information and the other group withoutOAT information service. The patientsâ€™ compliance was checked by counting theremaining OAT and by interviewing the patients, meanwhile patientâ€™s quality of lifewere measured by SF-36 instrument. The correlation between limited OAT informationservice and patient compliance were analysed using Chi Square and quality of patientâ€™slife were analysed using Independent t-Test with 95% confidence level. It was shownthat characteristics of patients such as age, gender, education, duration of illness, andDirectly Observed Treatment involvement did not influence patient compliance. Therewas no significant correlation between limited OAT information service to patientcompliance and patientsâ€™ quality of life (P>0.05). There is no impact of limited OATinformation service to the TB patientsâ€™ compliance and their quality of life. Wesuggested that the further and deeply information service delivered by pharmacists inthe public helath centers in Yogyakarta should be carried out.

Pengaruh metode penyarian terhadap kadar alkaloid total daun jembirit (Tabernaemontana sphaerocarpa. BL) dengan metode spektrofotometri visibel Nina Salamah; Miftahul Rozak; Muhti Al Abror
Pharmaciana Vol 7, No 1 (2017): Pharmaciana
Publisher : Universitas Ahmad Dahlan

One of the plants which contain the alkaloid is a plant jembirit (Tabernaemontana sphaerocarpa BL. ).Sap and leaves from this plants have been used to treat skin diseases and sprain. Alkaloid from jembirit plants showed potent cytotoxicity against various human cancer cell. The goal of this research is to find out the influence of the extraction method against the level of total alkaloid jembirit leaves.Jembirit leaves were extracted by maceration method and extraction with Soxhlet apparatus usedÂ ethanol 70 % as a solvent . Standardization of extracts conducted by test of ash content, test of drying shrinkage, and extract yield. Qualitative analysis conducted by alkaloid test. Determination of total alkaloid was analyzed with visible spectrophotometry method using Bromocresol green as complexing agent. The results showed that jembirit leaves contained alkaloid compounds. The determination resulted the levels of total alkaloid of maceration was 0.727% Â± 0.0032, levels of total alkaloid extraction with Soxhlet apparatus was 0.666% Â± 0.0022. The stastitical analysis showed significance differences of total alkaloid levels between maceration method and extraction with Soxhlet apparatus viewed from siginificancy value (0.001<0.005).

Analysis of the utilization and cost of antibiotics at an intensive care unit in Surabaya Eko Setiawan; Hidayat Felix; Adji Prayitno Setiadi
Pharmaciana Vol 7, No 2 (2017): Pharmaciana
Publisher : Universitas Ahmad Dahlan

The appropriateness of antibiotic utilization including the compatibility when it was mixed with other pharmaceutical products are important factors determining the effectiveness and cost of antibiotics treatment among patients admitted to the intensive care unit (ICU). The aim of this research was to figure out the antibiotics utilization, appropriateness, cost, and compatibility profile given to the inpatients of the intensive care unit in one hospital in Surabaya during November-December 2015. This research was prospective observational study using medical records as source of information. All patientsâ€™ data receiving antibiotics that met the inclusion and exclusion criteria was collected and analyzed descriptively. There were 42 patients participated in this research. Analysis of antibiotic utilization profile revealed 46 usage (65.71%) of single antibiotics and 24 usage (34.29%) of combination antibiotics. The most frequently used of antibiotic in single usage was ceftriaxone (43.48%) while in combination were ceftazidime and levofloxacin (12.50%). There were 30 antibiotics treatment changes that 43.34% was classified as escalation process and there was no (0%) any switching from intravenous to oral therapy. Only 4 out of 15 patients with infection related diagnosis (26.67%) got appropriate antibiotic treatment. Moreover, result from compatibility analysis found that 13.96% admixtures between antibiotics and other intravenous pharmaceutical products did not have clear compatibility status. The average of antibiotic cost per-patient was Rp. 459.492 (min-max: Rp 15.852,- to Rp 8.314.914,-).

EVALUASI IMPLEMENTASI PELAYANAN INFORMASI OBAT PASIEN RAWAT JALAN DI INSTALASI FARMASI RUMAH SAKIT YOGYAKARTA Farida Baroroh
Pharmaciana Vol 1, No 2 (2011): Pharmaciana
Publisher : Universitas Ahmad Dahlan

To support high quality health service in hospital, Pharmacy Installation ofYogyakarta Hospital needs to evaluate implementation of drug information service foroutpatient. This study is aimed to identify the realization of drug information service ofoutpatient implementation of Pharmacy Installation of Yogyakarta Hospital comparedto the specified target. This study was carried out by descriptive design using secondarydata of Pharmacy Installation programs, interview with a pharmacist was assignedoutpatients serving as research subjects, as well as direct observation of druginformation service for outpatient. Gap analysis was used to identify the comparisonbetween the realization and specified target. The result of this study of evaluation indrug information service implementation of outpatient showed negative gaps as muchas -0.67%. The component information presented included the efficacy of drugs, how touse, the rules of use, duration of drug use, drug side effects, however the components ofdrug information that is unallowed in Pharmacy Installation of Yogyakarta Hospitalhow shcedule of drug use and signs toxicity.

The relationship between patient satisfaction and effectiveness of insulin-based therapy for type 2 diabetes mellitus at Ulin Regional Public Hospital, Banjarmasin Risya Mulyani; Dedi Hartanto
Pharmaciana Vol 8, No 1 (2018): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Diabetes Mellitus (DM) can cause significant problems to the quality of life as it may increase the risk of complications. Dissatisfaction with therapy also contributes to its low effectiveness. Therapeutic satisfaction has an essential role in DM management, i.e., to optimize the effectiveness of the treatment. It is also believed to affect the decision-making process regarding patientsâ€˜ healthrelated issues. A routine assessment of the satisfaction of DM patients is useful for health professionals in identifying the potential problems experienced by those who are in the middle of DM treatment. This study aimed to determine the relationship between patient satisfaction and effectiveness of insulin-based therapy for type 2 DM at Ulin Regional Public Hospital, Banjarmasin. This research is a nonexperimental study with a cross-sectional design. The data were collected prospectively with purposive sampling method from the type 2 DM patients at the Pharmacy Installation of Ulin Regional Public Hospital, Banjarmasin. While the therapeutic satisfaction data were obtained using the Patient Satisfaction with Insulin Therapy (PSIT) questionnaire, the effectiveness of the therapy was identified by examining the HbA1c values. Fifty-six (56) respondents participated and filled in the questionnaire, and the answers were processed with bivariate analysis, namely the chi-square test. The results showed that the respondentsâ€˜ satisfaction with the treatments was mostly on a medium level according to 33 patients (58.9%). However, only 3.6% respondents found the therapy effective (HbA1c <6.5%). The remaining 96.4% thought that it was less effective in controlling diabetes. Based on the statistical analysis results, there is a significantly positive relationship between patient satisfaction and HbA1c value ([r= 0.828]; [p= 0.000]). There is also a significant positive relationship between patient satisfaction and the effectiveness of therapy in patients with type 2 diabetes at the Pharmacy Installation of Ulin Regional Public Hospital, Banjarmasin.

PENGHAMBATAN AKTIVITAS XANTHINE OXIDASE OLEH EKSTRAK ETANOL AKAR SAMBILOTO (Andrographis paniculata, Ness) SECARA IN VITRO Ulfah Septianingsih; Hari Susanti; Wahyu Widyaningsih
Pharmaciana Vol 2, No 2 (2012): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Sambiloto root of which contained of flavonoids used by the people fortraditional medicine. In the previous publication, an effective xanthine oxidaseinhibitory activity of flavonoids was reported. In research, in vitro xanthine oxidaseinhibitory activity of etanolic root extract of Andrographis paniculata was determinedand Allopurinol was used as a control. The etanolic extract was succesively extractedin a Soxhlet with petroleum eter. Inhibition of xanthine oxidase by etanolic extract wasmeasured the decrease of uric acid production and monitored by spectrophotometer at295 nm with xanthine as substrat. The enzyme inhibitory activity was calculated, andthen IC50 was determined. The result of analyzed with Kruskal Wallis and MannWhitney at 95% confidental level . The flavonoids of etanolic extract were separated onusing by paper chromatography and the spot changing was determined using UV 366with and without amonia.The result of the research showed that the etanolic extract ofAndrographis paniculata inhibited xanthine oxidase activity with IC50 16,54 Âµg/mlwhile Allopurinol 4,29 Âµg/ml. The etanolic extract contained flavon or flavonol.

UJI AKTIVITAS PENGHAMBATAN POLIMERISASI HEME (1)-N-(2-NITROBENZIL)-1,10- FENANTROLINIUM IODIDA DAN (1)-N-(4-NITROBENZIL)-1,10- FENANTROLINIUM IODIDA SECARA IN VITRO Laela Hayu Nurani; Dwi Utami; Wahyu Widyaningsih; Iin Narwanti; Eti Nurwening; Jumina Jumina
Pharmaciana Vol 4, No 2 (2014): Pharmaciana
Publisher : Universitas Ahmad Dahlan

The inhibitory activity of heme polymerization of (1)-N-(2-nitrobenzyl)-1,10- phenantrolinium iodide and (1)-N-(4-nitrobenzyl)-1,10-phenantrolinium iodide have been done. This study aims to analyse the (1)-N-(2-nitrobenzyl)-1,10-phenantrolinium iodide and (1)-N-(4-nitrobenzyl)-1,10-phenantrolinium iodide as inhibitory of polimerization heme. Analysis of heme inhibtory polimerization activity used the experimental in vitro method. The activity showed by IC50 (the capable concentration of extract to inhibiting polymerization heme by 50% ). The IC50 value acquired by probit analysis. Assess IC50 of (1)-N-(2-nitrobenzyl)- 1,10-phenantrolinium iodide not to be identified, (1)-N-(4-nitrobenzyl)-1,10-phenantrolinium iodide and chloroquine by successively are 0,571Â±0,071; 25,498Â±1,876 mg/mL. The result showed the (1)-N-(4-nitrobenzyl)-1,10-phenantrolinium iodide had the highest value of the heme polymerization inhibitory activity than chloroquin, (1)-N-(2-nitrobenzyl)-1,10- phenantrolinium iodide hadnâ€™t the heme polymerization inhibitory activity.

Page 47 of 81 | Total Record : 808

45 46 47 48 49

Filter by Year

2011 2025

Filter By Issues

All Issue Vol. 15 No. 3 (2025): Pharmaciana Vol. 15 No. 2 (2025): Pharmaciana Vol. 15 No. 1 (2025): Pharmaciana Vol. 14 No. 3 (2024): Pharmaciana Vol. 14 No. 2 (2024): Pharmaciana Vol. 14 No. 1 (2024): Pharmaciana Vol 14, No 1 (2024): Pharmaciana Vol 13, No 3 (2023): Pharmaciana Vol. 13 No. 3 (2023): Pharmaciana Vol 13, No 2 (2023): Pharmaciana Vol 13, No 1 (2023): Pharmaciana Vol 12, No 3 (2022): Pharmaciana Vol 12, No 2 (2022): Pharmaciana Vol 12, No 1 (2022): Pharmaciana Vol 11, No 3 (2021): Pharmaciana Vol 11, No 2 (2021): Pharmaciana Vol 11, No 1 (2021): Pharmaciana Vol 10, No 3 (2020): Pharmaciana Vol 10, No 2 (2020): Pharmaciana Vol 10, No 1 (2020): Pharmaciana Vol 9, No 2 (2019): Pharmaciana Vol 9, No 1 (2019): Pharmaciana Vol 8, No 2 (2018): Pharmaciana Vol. 8 No. 2 (2018): Pharmaciana Vol 8, No 2 (2018): Pharmaciana Vol 8, No 1 (2018): Pharmaciana Vol 8, No 1 (2018): Pharmaciana Vol 7, No 2 (2017): Pharmaciana Vol 7, No 2 (2017): Pharmaciana Vol 7, No 1 (2017): Pharmaciana Vol 7, No 1 (2017): Pharmaciana Vol 6, No 2 (2016): Pharmaciana Vol 6, No 2 (2016): Pharmaciana Vol 6, No 1 (2016): Pharmaciana Vol 6, No 1 (2016): Pharmaciana Vol 5, No 1 (2015): Pharmaciana Vol 5 No 1, 2015 Vol 5, No 2 (2015): Pharmaciana Vol 5, No 2 (2015): Pharmaciana Vol 5, No 1 (2015): Pharmaciana Vol 5, No 1 (2015): Pharmaciana Vol 4, No 2 (2014): Pharmaciana Vol 4, No 2 (2014): Pharmaciana Vol. 4 No. 2 (2014): Pharmaciana Vol 4, No 1 (2014): Pharmaciana Vol 4, No 1 (2014): Pharmaciana Vol 3, No 2 (2013): Pharmaciana Vol 3, No 2 (2013): Pharmaciana Vol 3, No 1 (2013): Pharmaciana Vol 3, No 1: Mei 2013 Vol 3, No 1 (2013): Pharmaciana Vol 2, No 2 (2012): Pharmaciana Vol 2, No 2: November 2012 Vol 2, No 2 (2012): Pharmaciana Vol 2, No 1: Mei 2012 Vol 2, No 1 (2012): Pharmaciana Vol 2, No 1 (2012): Pharmaciana Vol 1, No 2: November 2011 Vol 1, No 2 (2011): Pharmaciana Vol 1, No 2 (2011): Pharmaciana Vol 1, No 1 (2011): Pharmaciana Vol 1, No 1 (2011): Pharmaciana Vol 1, No 1: Mei 2011 More Issue

Home Page

OAI Link

Editorial Team

Contact

Reviewer

Google Scholar

Contact Name
Muhammad Syahrir

Contact Email
m.syahrir7406@unm.ac.id

Phone
-

Journal Mail Official
nurkhasanah@pharm.uad.ac.id

Editorial Address
Jl. Prof. Dr. Soepomo, S.H., Janturan, Warungboto, Umbulharjo, Yogyakarta, Indonesia Kode pos 55164

Location
Kota yogyakarta,

Daerah istimewa yogyakarta

INDONESIA

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Home Page

OAI Link

Editorial Team

Contact

Reviewer

Google Scholar

Contact Name Muhammad Syahrir

Contact Email m.syahrir7406@unm.ac.id

Phone -

Journal Mail Official nurkhasanah@pharm.uad.ac.id

Editorial Address Jl. Prof. Dr. Soepomo, S.H., Janturan, Warungboto, Umbulharjo, Yogyakarta, Indonesia Kode pos 55164

Location Kota yogyakarta, Daerah istimewa yogyakarta INDONESIA

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Contact Name
Muhammad Syahrir

Contact Email
m.syahrir7406@unm.ac.id

Phone
-

Journal Mail Official
nurkhasanah@pharm.uad.ac.id

Editorial Address
Jl. Prof. Dr. Soepomo, S.H., Janturan, Warungboto, Umbulharjo, Yogyakarta, Indonesia Kode pos 55164

Location
Kota yogyakarta,

Daerah istimewa yogyakarta

INDONESIA