Garuda - Garba Rujukan Digital

Article Per Year (5 Year)

All

Pharmaciana: Jurnal Kefarmasian

PHARMACIANA
Website

Published by Universitas Ahmad Dahlan

ISSN : 20884559 EISSN : 24770256 DOI : 10.12928

Core Subject : Health,

Medicine & Pharmacology

Pharmaciana is a scientific journal published by the University of Ahmad Dahlan worked closely with Ikatan Apoteker Indonesia (IAI). Pharmaciana published three times a year, namely March, July and November. with ISSN 2088-4559 and e-ISSN 2477-0256. The article published in the Journal Pharmaciana selected by editors and reviewed by the reviewer. Articles published in Pharmaciana must not be published in other journals or have been previously published. Pharmaciana is indexed in google scholar, ACI (Asean Citation Index), Dimension (Crossreff), Garuda, Sinta, Sherpa Romeo, Index Copernicus International, DOAJ, and BASE. Pharmaciana is accredited by DIKTI (DGHE) of Indonesia No. 105/E/KPT/2022 April 07, 2022

Arjuna Subject : Kimia(semua kategori) - Kimia (Lain-Lain)

Articles 808 Documents

44 45 46 47 48

Effect of nitrogen fertilizer to the flavonoid content of red amaranth (Amaranthus gangeticus L.) Ambar Pratiwi
Pharmaciana Vol 7, No 1 (2017): Pharmaciana
Publisher : Universitas Ahmad Dahlan

ABSTRACT Red amaranth (Amaranthus gangeticus L.) is a vegetable that has been frequently consumed. The red color in red spinach leaves due to the anthocyanin that is included in the flavonoid compounds. Flavonoid compounds are very usefull to the health, such as antioxidant, anticancer and antibacterial. Biosynthesis of flavonoids in the plant is influenced by environmental factors, one of which is a nutrient that is nitrogen. This study aimed to determine the effect of nitrogen fertilizer on the content of flavonoids in Red amaranth leaves. The results of this study are expected to provide information to the public about the optimal nitrogen fertilizer to increase the levels of flavonoids in Red amaranth leaves. In this research, red amaranth seed planting with the addition of nitrogen fertilizers of different concentrations (0%, 2%, 4%, 6%, 8% and 10%) from week 1 through week 5. The leaves are harvested to extract and analyze the content of flavonoids. The parameters measured were the growth of a Red amaranth plant height, number of leaves and leaf width; and levels of flavonoids with aluminum chloride method. The results showed that nitrogen fertilizer application significantly increases the growth and flavonoids in Red amaranth.Keywords: red amaranth, nitrogen fertilizer, flavonoid.

EFEK ULCEROGENIC DISPERSI PADAT IBUPROFEN-POLIVINILPIROLIDON (PVP) PADA TIKUS PUTIH JANTAN Ririt Vita Febrianti; Iis Wahyuningsih
Pharmaciana Vol 3, No 2 (2013): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Ibuprofen is an anti inflammatory, analgesic, and antipyretic agent. It has low solubility and bioavailability.The administration of ibuprofen in a long time and high dose can increased of side effect at gastrointestinal (pepticulcer). This study was aimed to determine the influence its solid dispersions formation on ulcerogenic effect ofibuprofen buprofenis compared with ibuprofen alone and physical mixture. Solid dispersion of Ibuprofen-PVP(1:1) was prepared by solvent method. The ulcerogenic test was conducted by observing is white rat, dividedrandomly into 5 groups are healthy group (aquadest), suspending agent control (PVP 1%), drug (ibuprofen) at adose of 360 mg/kg body weight, group solid dispersion (ibuprofen-PVP) and group physical mixture(ibuprofen-PVP). Rats gastric was observed of formation ulcer and evaluated by scoring then followed thecalculation by the index ulcer. The results showed that the number of ulcer index of ibuprofen is 6,67. Number ofulcer index of solid dispersion was 4,00 and physical mixture was 3,34. The ulcerogenic effect of solid dispersionand physical mixture difference was significant (p<0,05) compared with ibuprofen alone. Ulcerogenic effectadministration of solid dispersion was smaller than ibuprofen alone and statistically no different (p>0,05)compared with physical mixture.

UJI EFEK ANTIHIPERGLIKEMIK EKSTRAK ETANOL DAUN KACAPIRING (Gardenia augusta, Merr) PADA TIKUS PUTIH JANTAN GALUR WISTAR Farida Baroroh; Nurfina Aznam; Hari Susanti
Pharmaciana Vol 1, No 1 (2011): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Kaca piring leaf (Gardenia augusta Merr.) was often used in traditional drugs fortreatment diabetes mellitus. This research aim to know the antihiperglycemic effectethanolic extract of kacapiring leaf on white rats male strain of Wistar and how muchantihiperglycemic effect compared with glibenklamid. This study used oral glucosetolerance test method with loading glucose 4,5 g/kgW. Tested animal where 24 whitemale rats strain of Wistar age 2-3 months with weight 180-250 gram, devided into 4groups, each groups consist of 6 rats. Group I was as negative control group givenCMC-Na 1%, group II was as positive control group given glibenklamid dose 1,35mg/kgBB, group III and IV where given ethanolic extract of kacapiring leaf dose 500mg/kgBB and 250 mg/kgBB. Glibenklamid and exstract are given orally 60 minutesbefore glucose. Blood was taken from orbitalis sinus at minute (-90), (-60), 0, 30, 60,120, 180, 240, and 300. Blood glucose level was determined with GOD PAP enzymaticmethod, absorbance was observed using spectrophotometer at 500 nm. The result of the study was performed by giving ethanolic extract of kacapiring leaf dose 500 mg/kgW and 250 mg/kgW had antihiperglycemic effect. Ethanolic extract of kacapiring leaf dose500 mg/kgW and 250 mg/kgW could reduce blood glucoce level 58,97% and 80,60% compared with glibenklamid dose 1,35 mg/kgW could reduce blood glucoce level73,93%.

Antioxidant activity, determination of total phenolic and flavonoid content of Muntingia calabura L. Extracts Anita Dwi Puspitasari; Ririn Lispita Wulandari
Pharmaciana Vol 7, No 2 (2017): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Muntingia calabura L. leaves were contained alkaloids, saponins, phenolic, flavonoids, and tannin. Phenolic and flavonoids compound had antioxidant activity. The present study aims to determine the antioxidant activity, determination of total phenolic and flavonoid content of ethanol extract of Muntingia calabura L. leaves and its fractions. Muntingia calabura L. leaves were macerated with 96% ethanol and then evaporated until ethanol extract was obtained. The ethanol extract was dissolved into water and then partitioned with n hexane and ethyl acetate to obtain the n hexane fraction, ethyl acetate fraction and water fraction. Determination of antioxidant activity of extracts and fractions was performed by free radical capture measurement method by 1,1-diphenyl-2-picrylhydrazyl (DPPH) in vitro. Vitamin C was used as a positive control with IC50 value of Â Â Â Â Â Â Â 25.74 Âµg/mL. The total phenolic and flavonoid content were determined using the colorimetric method using standard gallic acid for total phenolics and standard quercetin for flavonoid content. The results showed that ethyl acetat fraction showed the highest antioxidant activity with IC50 79.37 Î¼g/mL value compared to n hexane fraction (101.36 Î¼g/mL), ethanol extract (126.47 Î¼g/mL), and water fraction (129.85 Î¼g/mL). The ethyl acetate fraction contains the highest total phenolic of 510.57 mg GAE/g extract compared to ethanol extract (311.10 mg GAE/g extract), water fraction (292.74 mg GAE/g) extract, and n hexane fraction (103.95 mg GAE/g extract). The ethyl acetate fraction contained the highest flavonoid content of 76.32 mg QE/g extract compared to ethanol extract (39.63 mg QE/g extract), water fraction (14.29 mg QE/g extract) and n hexane fraction (3.30 mg QE/g extract). Total phenolic and total flavonoid levels were positively correlated with antioxidant activity

OPTIMASI KOMPOSISI TWEEN 80 DAN SPAN 80 SEBAGAI EMULGATOR DALAM REPELAN MINYAK ATSIRI DAUN SERE (Cymbopogon citratus (DC) Stapf) TERHADAP NYAMUK Aedes aegypti BETINA PADA BASIS VANISHING CREAM DENGAN METODE SIMPLEX LATTICE DESIGN Endah Nurlaela; Nining Sugihartini; Azis Ikhsanudin
Pharmaciana Vol 2, No 1 (2012): Pharmaciana
Publisher : Universitas Ahmad Dahlan

The disease of Dengue hemorrhagic fever (DHF) is caused by the bite of femaleAedes aegypti mosquito. Cream of repelan sere leaf essential oils can be used to preventmosquito bites. The cream of volatile oil sere (Cymbopogon citratus (DC) Stapf)required emulsifier to maintain the stability of cream. Tween 80 and Span 80 is a widelyused emulsifier in a cream formula. Aims of this study is to determine the optimumcomposition of Tween 80 and Span 80 as emulsifier in a cream repelan of sere leafessential oils in the basis Vanishing Cream with Simplex Lattice Design methode. ThreeFormula cream is designed based on the Simplex Lattice Design methode with a ratio ofTween 80: Span 80 as follows: FI (100%-0%), F II (50%-50%), F III (0%-100%).Cream was then tested repelan activity and physical properties that includespreadibility, adhesivity and irritation. Data of physical properties and repellantactivity was calculate to get the optimum formula. The validity of optimization methodswas evaluated by comparing experimental results with predicted results in optimumcream formula with t test at 95% level of confidence. The results of study showed that theoptimum composition of Tween 80: Span 80 was 60%:40%. Cream with optimumemulsifier composition was predicted has spreadibility 29.24 cm2; adhesivity 3.512seconds; irritation 0.608; power repelan 41.469 minutes. T test results showed nosignificant differences between the experimental results and predicted results (p<0.05).

Formulation and test activities of hair tonic with a combination of the aqueous extracts of aloe vera ( Aloe vera L.) and licorice (Glycyrrhiza glabra L.) Sulistiorini Indriaty; Teti Indrawati; Shelly Taurhesia
Pharmaciana Vol 8, No 1 (2018): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Aloe vera contains lignin, folic acid, vitamin A, and 20 types of amino acids, while Glycyrrhiza glabra L. contains glycyrrhizin, steroids, and beta-glycyrrhetinic acid that benefit for hair health. This research aimed to produce hair tonic with the best activity from the combination of aloe vera and licorice extract. The phytochemicals in the aqueous extract of licorice and Aloe vera were screened. The hair tonic was then prepared with 3 formulas using 7.5% Aloe vera extract and 2.5% licorice extract, as well as 96% ethanol with varying percentages, namely 5, 10, and 15%. Afterward, the formulas were tested for their activity as hair fertilizer on 4 white male rabbits for 28 days. The evaluation of hair tonic preparation included organoleptic observation, pH, specific weight, viscosity, and hedonic tests. It measured hair growth rate, the acceleration of hair growth, and hair weight. The results showed that hair tonic containing a mixture of 7.5% of Aloe vera extract, 2.5% of licorice extract, and 96% ethanol with different percentages (i.e., 5, 10, and 15%) created a good hair fertilizer. Hair tonic prepared with 15% of 96% ethanol exhibited an optimum activity. It was characterized by brown color, distinctive odor, homogeneity, a specific weight of 1.0577 g/mL, a viscosity of 2.8479 cP to distilled water, and pH 5.5. Its effectiveness as hair fertilizer was evidenced by a hair growth rate of 2.6617 cm in 28 days, a hair growth acceleration of 0.1635 cm/day, and a hair weight of 0.1854 gram in 28 days.

EVALUASI ADVERSE DRUG REACTION ANTIDIABETES BERDASARKAN ALGORITMA NARANJO DI BANGSAL RAWAT INAP RS PKU MUHAMMADIYAH YOGYAKARTA PERIODE DESEMBER 2011-JANUARI 2012 Fitriyani Fitriyani; Woro Supadmi
Pharmaciana Vol 2, No 2 (2012): Pharmaciana
Publisher : Universitas Ahmad Dahlan

This study is aimed to evaluated the antidiabetic adverse reaction using theNaranjo algorithm for diabetes mellitus patients in PKU Muhammadiyah HospitalYogyakarta for period December 2011-January 2012. This study used descriptivemethod. The data was collected from the medical record and interviews from patientswith diabetes mellitus who had used antidiabetic drugs after 3 days. The data wereanalyzed using the Naranjo algorithm. The results showed that during the periodDecember 2011-January 2012 there were 17 male patients and 14 female patients withdiabetes mellitus. The antidiabetic drugs that used to patients were metformin,metformin combined with glibenclamide, metformin combined with insulin, thecombination with insulin and insulin glimepirid. Then, the study showed that Naranjoalgorithm method was not suitable for evaluation the antidiabetic adverse reaction fordiabetes mellitus patients in PKU Muhammadiyah Hospital in Yogyakarta for periodDecember 2011-January 2012, because from 10 questions on the Naranjo algorithmthere were only 4 questions that could be answered. It's because there was not data toanswer questions. Research on the side effects cohort method should be done with theinterview and patient monitoring.

PENGARUH UKURAN PARTIKEL BERAS HITAM (Oryza sativa L.) TERHADAP RENDEMEN EKSTRAK DAN KANDUNGAN TOTAL ANTOSIANIN Ria Maulida; Any Guntarti
Pharmaciana Vol 5, No 1 (2015): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Black rice has been tested for its high anthocyanin content. Black rice can be one of the potential sources of anthocyanin. Particle size is one of factors which influences amount of isolated Â biocompound Â in maceration process. Decreasing particle size can increase the amount of isolated Â biocompound and extract yield value. The high value of extract yield shows effectiveness of maceration process. In this research, particle size variation has been done maceration process for investigating its influence on black rice extract yield and total anthocyanin content of maceration Â result. This study used black rice ( Oryza sativa L.) from Beringharjo market, Yogyakarta. Maceration Â with solvent of ethanol 96% add ed HCl 37% until pH 1,0(1:6) is done for 6 x 24 hours, with particle Â size variation: mesh 20/40, 40/60 and whole bran of black rice. Data of extract yield and total Â anthocyanin content are analyzed by using one-way ANOVA with confidence level 95%. The results Â revealed that extract yield and total anthocyanin content of black rice extract with particle size Â variation: mesh 20/40, 40/60 and whole bran of black rice intact 6%; 16%; 11,26%; and Â 30,76 mg/100 Â g; 1167,80 mg /100 g; 322,23 mg/100 g, respectively. There is significant difference Â between Â tested groups (P< 0,05). We concluded that particle size of black rice influences extract yield Â and total anthocyanin content of maceration result.

PENGEMBANGAN PREPARASI NANOPARTIKEL THYMOQUINONE-KITOSAN DENGAN METODE KOSOLVEN MENGGUNAKAN ISOPROPIL ALKOHOL Annas Binarjo; Tedjo Yuwono; Renny Priyanti
Pharmaciana Vol 5, No 2 (2015): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Thymoquinone, an active compound isolated from black cumin seeds (Nigella sativa L.), has pharmacological activity as anticancer, antiinflammatory, and immunomodulator. This compound has a volatile nature, easily oxidized, and low melting point, leading to difficulties in tablet formulation. Moreover, its low solubility in water leading to low bioavailability. Therefore, it is necessary to develop nanoparticle drug delivery systems to solve these problems. Chitosan-thymoquinone nanoparticles can be formed using sodium tripolyphosphate as cross linker by cosolven method. Chitosan solution in acetate buffer pH 4 was added to thymoquinone solution in 50%, 75%, 100% isopropyl alcohol, than sodium tripoliphosphate solution in water was added slowly in a gently stirrer.Â The nanoparticle produced was characterized in its loading capacity (LC), particle morphology, particle size, and zeta potential, as well as the loading efficiency (LE) of nanoparticle. Factorial Design Optimization resulted that the best condistion is achieved by 75% isopropyl alcohol using thymoquinone level of 10 mg/mL and chitosan level of 10 mg/mL. In this condition, the nanoparticle has LC of 8.71%, LE of 76.29%, 609.8 nm in diameter and zeta potential of 137.9 mV. It can be concluded that isopropyl alcohol can help the formation of nanoparticles thymoquinone. The particle size and zeta potential is too big, therefore it is craved to modify the process by variation in thymoquinone, chitosan, and sodium tripoliphosphat concentration.

Identifying active compounds of soursop ethanolic fraction as Î±-glucosidase inhibitor Eko Mugiyanto; Agung Nur Cahyanta; I Made Agus Sunadi Putra; Siswa Setyahadi; Partomuan Simanjuntak
Pharmaciana Vol 9, No 2 (2019): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Postprandial hyperglycemia is triggered by two enteric proteins (Î±-amylase and Î±-glucosidase) connected to the brush border of intestinal cells. In diabetic populations, Type 2 Diabetes Mellitus is more prevalent, and Î±-glucosidase inhibition is the suitable therapy for delaying glucose intake after meals. This study was designed to investigate chemical compounds for their potential inhibitory effects on Î±-glucosidase. It employed a spectrophotometric method with p-nitrophenyl-Î±-D-glucopyranose from Saccharomyces cerevisiae as an alpha-glucosidaseÂ substrate. The ethanolicÂ fraction was acquired from assay- or activity-guided fractionation. The findings showed that the ethanolic fraction of soursop leaves exhibited the most significant inhibitory activity with an IC50 of 0.17 Î¼g/ml. The data analysis and active compounds identification were carried out by LC-MS and FT-IR. Â The active compounds of the resulted mixture comprised of Muricatin C, cis-Reticulatacin-10-one, and 3-Methylquercetin 7-[galactosyl-(1->4)-glucoside].

Page 46 of 81 | Total Record : 808

44 45 46 47 48

Filter by Year

2011 2025

Filter By Issues

All Issue Vol. 15 No. 3 (2025): Pharmaciana Vol. 15 No. 2 (2025): Pharmaciana Vol. 15 No. 1 (2025): Pharmaciana Vol. 14 No. 3 (2024): Pharmaciana Vol. 14 No. 2 (2024): Pharmaciana Vol 14, No 1 (2024): Pharmaciana Vol. 14 No. 1 (2024): Pharmaciana Vol 13, No 3 (2023): Pharmaciana Vol. 13 No. 3 (2023): Pharmaciana Vol 13, No 2 (2023): Pharmaciana Vol 13, No 1 (2023): Pharmaciana Vol 12, No 3 (2022): Pharmaciana Vol 12, No 2 (2022): Pharmaciana Vol 12, No 1 (2022): Pharmaciana Vol 11, No 3 (2021): Pharmaciana Vol 11, No 2 (2021): Pharmaciana Vol 11, No 1 (2021): Pharmaciana Vol 10, No 3 (2020): Pharmaciana Vol 10, No 2 (2020): Pharmaciana Vol 10, No 1 (2020): Pharmaciana Vol 9, No 2 (2019): Pharmaciana Vol 9, No 1 (2019): Pharmaciana Vol 8, No 2 (2018): Pharmaciana Vol. 8 No. 2 (2018): Pharmaciana Vol 8, No 2 (2018): Pharmaciana Vol 8, No 1 (2018): Pharmaciana Vol 8, No 1 (2018): Pharmaciana Vol 7, No 2 (2017): Pharmaciana Vol 7, No 2 (2017): Pharmaciana Vol 7, No 1 (2017): Pharmaciana Vol 7, No 1 (2017): Pharmaciana Vol 6, No 2 (2016): Pharmaciana Vol 6, No 2 (2016): Pharmaciana Vol 6, No 1 (2016): Pharmaciana Vol 6, No 1 (2016): Pharmaciana Vol 5, No 1 (2015): Pharmaciana Vol 5 No 1, 2015 Vol 5, No 2 (2015): Pharmaciana Vol 5, No 2 (2015): Pharmaciana Vol 5, No 1 (2015): Pharmaciana Vol 5, No 1 (2015): Pharmaciana Vol 4, No 2 (2014): Pharmaciana Vol. 4 No. 2 (2014): Pharmaciana Vol 4, No 2 (2014): Pharmaciana Vol 4, No 1 (2014): Pharmaciana Vol 4, No 1 (2014): Pharmaciana Vol 3, No 2 (2013): Pharmaciana Vol 3, No 2 (2013): Pharmaciana Vol 3, No 1 (2013): Pharmaciana Vol 3, No 1 (2013): Pharmaciana Vol 3, No 1: Mei 2013 Vol 2, No 2 (2012): Pharmaciana Vol 2, No 2: November 2012 Vol 2, No 2 (2012): Pharmaciana Vol 2, No 1: Mei 2012 Vol 2, No 1 (2012): Pharmaciana Vol 2, No 1 (2012): Pharmaciana Vol 1, No 2: November 2011 Vol 1, No 2 (2011): Pharmaciana Vol 1, No 2 (2011): Pharmaciana Vol 1, No 1: Mei 2011 Vol 1, No 1 (2011): Pharmaciana Vol 1, No 1 (2011): Pharmaciana More Issue

Home Page

OAI Link

Editorial Team

Contact

Reviewer

Google Scholar

Contact Name
Muhammad Syahrir

Contact Email
m.syahrir7406@unm.ac.id

Phone
-

Journal Mail Official
nurkhasanah@pharm.uad.ac.id

Editorial Address
Jl. Prof. Dr. Soepomo, S.H., Janturan, Warungboto, Umbulharjo, Yogyakarta, Indonesia Kode pos 55164

Location
Kota yogyakarta,

Daerah istimewa yogyakarta

INDONESIA

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Home Page

OAI Link

Editorial Team

Contact

Reviewer

Google Scholar

Contact Name Muhammad Syahrir

Contact Email m.syahrir7406@unm.ac.id

Phone -

Journal Mail Official nurkhasanah@pharm.uad.ac.id

Editorial Address Jl. Prof. Dr. Soepomo, S.H., Janturan, Warungboto, Umbulharjo, Yogyakarta, Indonesia Kode pos 55164

Location Kota yogyakarta, Daerah istimewa yogyakarta INDONESIA

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Contact Name
Muhammad Syahrir

Contact Email
m.syahrir7406@unm.ac.id

Phone
-

Journal Mail Official
nurkhasanah@pharm.uad.ac.id

Editorial Address
Jl. Prof. Dr. Soepomo, S.H., Janturan, Warungboto, Umbulharjo, Yogyakarta, Indonesia Kode pos 55164

Location
Kota yogyakarta,

Daerah istimewa yogyakarta

INDONESIA