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Pharmaciana: Jurnal Kefarmasian

PHARMACIANA
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Published by Universitas Ahmad Dahlan

ISSN : 20884559 EISSN : 24770256 DOI : 10.12928

Core Subject : Health,

Medicine & Pharmacology

Pharmaciana is a scientific journal published by the University of Ahmad Dahlan worked closely with Ikatan Apoteker Indonesia (IAI). Pharmaciana published three times a year, namely March, July and November. with ISSN 2088-4559 and e-ISSN 2477-0256. The article published in the Journal Pharmaciana selected by editors and reviewed by the reviewer. Articles published in Pharmaciana must not be published in other journals or have been previously published. Pharmaciana is indexed in google scholar, ACI (Asean Citation Index), Dimension (Crossreff), Garuda, Sinta, Sherpa Romeo, Index Copernicus International, DOAJ, and BASE. Pharmaciana is accredited by DIKTI (DGHE) of Indonesia No. 105/E/KPT/2022 April 07, 2022

Arjuna Subject : Kimia(semua kategori) - Kimia (Lain-Lain)

Articles 808 Documents

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Effect of Sargassum polycystum extract on liver and kidney of diabetic rats Muhamad Firdaus; Anies Chamidah; Annafi Riski Nurcholis; Siti Yulaikah; Pangestuty Yeni Anggraeni; Widya Adi Suryanata; Denny Alghafihqi; Rendi Hardiansyah
Pharmaciana Vol 7, No 2 (2017): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Hyperglycemia has been known able to incuce the free radical formation. The reactivity of free radical can affect the dysfunction and structural adjustment on liver and kidney of the diabetic. Polyphenol is bioactive that able to ameliorate the reactivity of free radical. This substance is also contained in brown seaweed.One of brown seaweeds that found on the Indonesia waters is Sargassum polycystum. The objective of this study was to evaluate the S. polycystum extract (SPE) to reduce the damage of the function and structure of liver and kidney in diabetic rats. SPE was obtained by drying, milling, extraction by methanol, concentrating, degassing by nitrogen gas, and finally freeze-drying, respectively. The male of rat strain Wistar was induced to diabetic by streptozotocin. This study was divided into four groups, i.e., normal, diabetic, diabetic + gliclazide and diabetic + SPE, respectively. The treatments of this experiment were executed for 45 days. The polyphenol content, malondialdehyde level, SGPT and SGOT levels, and creatinine levels were measured by the spectrophotometer, the blood glucose level was quantified by glucometer, and the insulin content was determined by ELISA method. The altering of the tissue structure was analyzed by staining method of hematoxylin and eosin. The result showed that the treatment of SPE on diabetic rats able to reduce the blood glucose level, malondialdehyde level of liver, and kidney,Â SGPT and SGOT level of liver, creatinine level of blood, and increase of insulin level and improve the liver, and kidney tissue profiles, respectively. These results indicate that SPE can reduce the destruction of structure and function on liver and kidney of the diabetics.Â

POTENSI PERAN FARMASIS DALAM MENINGKATKAN KUALITAS HIDUP PASIEN LANJUT USIA: PERSPEKTIF RAWAT RUMAH Dyah Aryani Perwitasari; Arief Muttaqien
Pharmaciana Vol 2, No 1 (2012): Pharmaciana
Publisher : Universitas Ahmad Dahlan

The Home Health Care program is getting popular as well. One of the outcomemeasured in this program is patientâ€™s quality of life. Home Health Care program is amultidisciplin program, which need the pharmacist role. The aim of this study was tofind out the potencial pharmacist role in increasing elderly patientsâ€™quality of lifeparticipated in Home Health Care program. This study used descriptive design withprospective data sampling. (World Health Organization Quality of Life) We usedWHOQoL as the instrument. The study period was conducted for 13 week in 2009 byvisiting the patients at their homes. The patients were participated in Home HealthCare program of Dr Sardjito hospital, Yogyakarta. Data was descriptively analized.We're recruited seven subjects in this study. In average, their quality of life was low(46,1Â±4,4). All of the patients received polypharmacy and were found the patientsincompliance in taking the medicines. The role of pharmacist were important in HomeHealth Care program for elderly patients to increase their quality of life. Thepharmacists are supposed to do the drug used monitoring, especially to the elderlypatients with polypharmacy. The advance technique for communication, information,and education is suggested to the pharmacist in this program.

The formulation of probiotic Lactobacillus acidophilus granule with acacia and sodium alginate as binding agents Ari Widayanti; Lusi Susanah; Priyo Wahyudi
Pharmaciana Vol 8, No 1 (2018): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Probiotics are living microorganisms that can have a positive impact on health when consumed in adequate amounts. This research aimed to determine the effect of different binders on the viability of Lactobacillus acidophilus, a member of Lactic Acid Bacteria (LAB). The probiotic granules were prepared with wet granulation method using mannitol as the filling ingredient. Formulas I-III used acacia as a binder (3%, 4%, and 5%), while Formulas IV-VI used sodium alginate (1%, 1.5%, and 2%). The probiotic granules produced from all formulas were evaluated for flow time, the angle of repose, compressibility, and LAB viability. The LAB viability test results showed that all of the six formulas met the probiotic requirements, i.e., at least 107 CFUs (Colony Forming Units) per gram. The viable LAB in Formulas I-VI were 3.94x107, 4.4x107, 2.7x107, 2.6x107, 3.5x107, and 2.3x107 CFU/g, respectively. The data were analyzed by comparing the average values of the One-Sample T-Test results, followed by Mann-Whitney test. The results revealed that each formula had different capacity in maintaining the viability of Lactobacillus acidophilus with different binders (i.e., acacia and sodium alginate) as a probiotic product. Formula II (4% of acacia) produced probiotic granules that met the requirements of compressibility and the angle of repose. However, its granular flow time exceeded the standard.

STUDI KELARUTAN PROPAGERMANIUM DENGAN METODE KROMATOGRAFI CAIR KINERJA TINGGI Widyasari Putranti; Suwaldi Martodihardjo; Endang Lukitaningsih
Pharmaciana Vol 4, No 2 (2014): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Propagermanium, a synthetic organic compound of germanium is known as Î²- or biscarboxyethylgermaniumsesquioxide or Ge-132. It is found in some plants such as shelf fungus,ginseng, garlic, and Aloe vera. Ge-132 plays an important role for the pharmacological effectsof the plants. The solubility of propagermanium at a certain pH is not exactly known yet. Untilnow, the analytical methods for the analysis of Ge-132 so far have the shortcoming and thepropagermanium as germanium metal in the sample, so that improvement for propagermaniumanalysis was necessary to be conducted, primarily to be used for solubility assay. This studyaims to determine the effects of pH on the propagermanium solubility using HPLC method foranalysis. The results showed that validation parameters for analysis by using HPLC method e.iaccuracy, precision, and linearity, have met to the quantitative analysis requirements. Increasingthe pH causes increasing the solubility of propagermanium in the pH range of 3.0-3.6. Thesolubility result was 9.8514; 10.4204; 12.5446 mg/mL on pH 3.0; 3.3; 3.6.

STABILITAS FISIKA DAN KIMIA REKRISTAL DAN DISPERSI PADAT PIROKSIKAM-PEG 6000 Annas Binarjo
Pharmaciana Vol 5, No 1 (2015): Pharmaciana
Publisher : Universitas Ahmad Dahlan

It is hoped that solid dispersion and recrystalization can solve the problem of low solubility of piroxicam.Â Metastable polymorph or amorph state can be formed in solid dispersion and recrystalization preparation, leading to a better dissolution. During storage, the metastable polymorph or amorph will be changed to stable crystal, so that the dissolution will be decreased (physical instability), beside that the increasing of solubility also trigger the higher rate of decomposition (chemical instability).Â This research was purposed to reveal these two instability. The research was began by preparing recrystal of piroxicam (R) and solid dispersion piroxicam-PEG 6000 (DP) by solvent method using aseton.Â These preparate were stored in room temperature (25oC). The dissolution was tested after 1, 2, 3, and 4 month of storage, using dissolution efficiency for 60 minutes (DE60) as parameter, and also the drug content in bulk preparate was determined. The result showed that recrystalization and solid dispersion preparation did not decreaseÂ the piroxicam content.Â During storage, the DE60 and piroxicam content in R and DP were not changed (p>0.05). It could be concluded that R and DP prepared had a stable dissolution and purity.

In silico analysis of wild-type and mutant KRAS Frengki Frengki; Dedi Prima Putra; Fatma Sriwahyuni; Daan Khambri; Henni Vanda
Pharmaciana Vol 9, No 1 (2019): Pharmaciana
Publisher : Universitas Ahmad Dahlan

The mutations of the KRAS gene at codons 12, 13, and 61 have been widely reported with different prognosis. In silico is one approach to explain the characteristics of the mutant genes. This study aimed to reveal the potential energy and fluctuations of the binding site and active site of wild-type KRAS (KRAS Wt) and mutant KRAS (KRAS Mt) at codons 12, 13, and 61. The samples used in this study were the sequences of KRAS Wt and KRAS Mt genes, which were subjected to in-silico analysis that included molecular homology, docking, and dynamics using MOE, PyMOL, and online CABS servers. The results showed that fluctuations in the binding site of all KRAS Mt were lower than that of KRAS Wt. On the contrary, the active site (switch I and switch II) of KRAS Mt fluctuated more widely than KRAS Wt. The potential energy of KRAS Mt before forming a complex with GTP was higher (p<0.01) than KRAS Wt. After this formation, it remained higher at codons 12 and 61 but lower at codons 11 and 13 (p <0.001). Mt G12A did not show any changes. The higher fluctuations in the switch I and switch II regions and the post energy of KRAS-GTP complexes may explain why types of cancers with mutations at codons 11 and 13 have a better prognosis than those with mutations at codons 12 and 61.

GAMBARAN JUMLAH SKS MATA KULIAH PERGURUAN TINGGI FARMASI INDONESIA YANG MENDUKUNG PENGGUNAAN OBAT YANG RASIONAL Hendy Ristiono; Sri Suryawati; Sulanto Saleh Danu
Pharmaciana Vol 5, No 2 (2015): Pharmaciana
Publisher : Universitas Ahmad Dahlan

According to World Â Health Organization (WHO), there are two major steps as a commitment to make changes in the implementation of pharmacy practice that are national drug policy and learning system changes in pharmacy education. The aim of the research was to obtain the cummulative credit overview in college of pharmacy in Indonesia that supporting Rational Drug Use based on promotion rational drug use (PRDU) and International network Â rational use of drug (INRUD). This study used a analytic descriptive design. The study was located in some colleges of pharmacy in Indonesia. Data was collected through observation of the recent curriculum used in the Indonesian college of pharmacy. Research were conducted by giving a questionnaire on the rational drug use topic in the curriculum and in-depth interviews with the dean or faculties appointed by the dean. The number of credits developed by 21 colleges of pharmacy as respondents have in between 140-158 credits. Median number of credits developed by C accreditation level are more than A and B accreditation level. Three ofÂ A accreditation level of colleges have number of credits in between 66-171 credits and a college with B accreditation level as much as 36.9 credits. Whereas in total of credits semester that support the RDU in Community and Clinical Pharmacy (CCP) interests has more than the non-CCP interests.

Exercise and consumption of herbal remedies decrease the risk of strokes in hypertension and diabetes mellitus patients undergoing a standard therapy Akrom Akrom; Melisa Rizki
Pharmaciana Vol 9, No 2 (2019): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Stroke is a serious problem faced worldwide. It can result in death, physical disability, and mental disability. Hypertension and Diabetes Mellitus (DM) patients are high-risk populations. The study attempted to determine the factors associated with the incidence of stroke in DM or hypertension outpatients. This analytic observational study used a case-control design and nonrandom sampling technique with consecutive sampling approach. With a 1:2 ratio, the subjects consisted of 49 stroke patients in the case group and 98 non-stroke patients (hypertensive) for the control group. Subjects were patients undergoing treatments at PKU Muhammadiyah Hospital in Bantul. Patient's lifestyle data were collected through face-to-face interviews with patients, while demographic information, diagnosis, and patient history were obtained from medical records using data retrieval forms (case record forms). The variable age was matched with sex to improve the efficiency and accuracy of the study. Data analysis included univariate (descriptive) analysis and bivariate analysis using the Chi-Square test. Factors associated with stroke incidence were smoking habit (OR = 2.940, CI: 1.314 <OR <6.576; P = 0.007), exercise routine (OR = 0.026, CI: 0.008 <OR <0.079, P = 0.000), high-fat food dietary pattern (OR = 3.629, CI: 1.119 <OR <11.766; P = 0.024), and the habit of consuming herbal remedies (OR = 0.299, CI: 0.107 <OR <0.833; P = 0.016). Â For hypertension or DM patients who took standard therapy at PKU Muhammadiyah Hospital in Bantul, smoking and fatty food consumption increased the risk of stroke, whereas physical exercise and herbs consumption habits reduced it.

UJI AKTIVITAS KOMBINASI EKSTRAK AIR LIDAH BUAYA ( Aloe vera L.) DAN AKAR MANIS (Glycyrrhiza glabra L.) SEBAGAI PENYUBUR RAMBUT Sulistiorini Indriaty; Teti Indrawati; Shelly Taurhesia
Pharmaciana Vol 6, No 1 (2016): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Aloe vera (Aloe vera L.) contains amino acids, vitamins, folic acid, and liquorice (Glycyrrhiza glabra L) containing glisirizin, and flavonoids, which have properties as fertilizer hair. This study aims to obtain a combination of extracts with activity most optimal fertilizer hair, made 3 combination with a combination of 1 (the water extract of liquorice concentration of 2.5% and 7.5% aloe vera), a combination of 2 (the water extract of liquorice concentrations of 2, 5% and 2.5% aloe vera), and combinations of 3 (the water extract of liquorice concentration of 5% and 7.5% aloe vera). Testing the activity of hair growth is done by measuring the rate of hair growth, hair growth acceleration and weight of rabbit hair for 28 days. Rabbit hair growth results showed the combination 1 has an average length of the largest hair with hair growth rate value of 2.97 cm, accelerated hair growth amounted to 0.15 cm / day on day 7 and weighing 0.13 gram hair.

PERBANDINGAN EFEKTIVITAS MISOPROSTOL DOSIS 50 µg DAN 100 µg TERHADAP KEBERHASILAN KELAHIRAN INDUKSI DI RSU PKU MUHAMMADIYAH YOGYAKARTA Haafizah Dania; Djoko Wahyono; Sulistiari Retnowati
Pharmaciana Vol 4, No 1 (2014): Pharmaciana
Publisher : Universitas Ahmad Dahlan

In recent years, misoprostol that is a prostaglandin E1 analogue has been used in cervix ripeningat pregnancy and labor induction. However, until now misoprostol dosage and administration route forinduction are various. There is no fix guide on administration and dosage of misoprostol. This researchwas intended to identify profile of misoprostol usage and effectiveness of misoprostol administrationat dosage of 50 Âµg and 100 µg on labor process progress of patient hospitalized in Yogyakarta PKUMuhammadiyah Hospital based on induction success. This research was non experimental research with historical cohort design. Limitation of this method was not all desired data exist in medical recordand capability of physician was not same. Subject was pregnant mothers giving birth with misoprostolinduction process in delivery room in Yogyakarta PKU Muhammadiyah Hospital from 1 January 2009to 31 December 2010. Data was obtained from medical record, which was then analyzed descriptivelyanalytically to identify misoprostol usage profile and effectiveness of misoprostol tablet administrationat 50 µg and 100 µg dosage on labor process progress. Research subjects who meet the inclusioncriteria in this research was 109 mothers, where 69 women (63,30%) got 50 µg misoprostol and 40women (36,70%) got 100 µg misoprostol. The results of this study indicate that the success ofinduction at 50 ug misoprostol group decreased by 89% compared with 100 ug misoprostol group (RR= 0.11), where the success of 50 ug misoprostol induction for 56 people from 69 people (81.16%),while the success induction at 100 ug misoprostol group as many as 39 people from 40 people(97.50%). The difference was statistically significant with p = 0.014 (p <0.05).

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Editorial Address Jl. Prof. Dr. Soepomo, S.H., Janturan, Warungboto, Umbulharjo, Yogyakarta, Indonesia Kode pos 55164

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Muhammad Syahrir

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m.syahrir7406@unm.ac.id

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Jl. Prof. Dr. Soepomo, S.H., Janturan, Warungboto, Umbulharjo, Yogyakarta, Indonesia Kode pos 55164

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Daerah istimewa yogyakarta

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