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Pharmaciana: Jurnal Kefarmasian

PHARMACIANA
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Published by Universitas Ahmad Dahlan

ISSN : 20884559 EISSN : 24770256 DOI : 10.12928

Core Subject : Health,

Medicine & Pharmacology

Pharmaciana is a scientific journal published by the University of Ahmad Dahlan worked closely with Ikatan Apoteker Indonesia (IAI). Pharmaciana published three times a year, namely March, July and November. with ISSN 2088-4559 and e-ISSN 2477-0256. The article published in the Journal Pharmaciana selected by editors and reviewed by the reviewer. Articles published in Pharmaciana must not be published in other journals or have been previously published. Pharmaciana is indexed in google scholar, ACI (Asean Citation Index), Dimension (Crossreff), Garuda, Sinta, Sherpa Romeo, Index Copernicus International, DOAJ, and BASE. Pharmaciana is accredited by DIKTI (DGHE) of Indonesia No. 105/E/KPT/2022 April 07, 2022

Arjuna Subject : Kimia(semua kategori) - Kimia (Lain-Lain)

Articles 808 Documents

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Cost-effectiveness analysis of antiemetics therapy in breast cancer patients with moderate emetogenic chemotherapy in Prof. Dr. Margono Soekarjo Hospital, Indonesia Ida Dzikriyani; Didik Setiawan
Pharmaciana Vol 11, No 3 (2021): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Chemotherapy-induced nausea and vomiting (CINV) significantly reduce the life quality of cancer patients. A 5-HT3 receptor antagonist, corticosteroid, and H2-blocker have been used to control moderate nausea and vomit in cancer patients. The exploration of the cost-effectiveness of several antiemetic combinations in breast cancer patients in Prof. Dr. Margono Soekardjo Hospital, Purwokerto, Indonesia was the aim of this research. Seventy-four Breast cancer patients who have prescribed moderate-emetogenic chemotherapy during the year 2017-1019 were included in this research. There were fifteen patients treated with the combination of ondansetron and dexamethasone (OD). Fourteen patients were treated with the combination of ondansetron and ranitidine (OR). Thirty-five patients were treated using ondansetron, dexamethasone, and ranitidine (ODR) combination. The effectiveness was represented by the absence of acute nausea and vomiting after receiving chemotherapy. The ODR combinations showed the highest effectivity on diminishing nausea and vomiting among breast cancer patients (0.400), followed by the OD combination (0.267) and the OR combination (0.214). However, the ODR combination generates the highest cost (4.6 million rupiahs) compared to other antiemetics combinations. Compared to the combination of ondansetron and dexamethasone, the combination of ODR provides higher ICER (ICER of 13 Million Rupiahs per case prevented) than the combination of OR (ICER of 8.5 million Rupiahs per case prevented). In conclusion, the combination of ondansetron, dexamethasone, and ranitidine generates the highest cost. It also provides the highest effectiveness in preventing nausea and vomiting.

The effectiveness and cost of lansoprazole and pantoprazole for stress ulcer prophylaxis in intensive care unit Mega Octavia; Zullies Ikawati; Tri Murti Andayani
Pharmaciana Vol 11, No 3 (2021): Pharmaciana
Publisher : Universitas Ahmad Dahlan

The incidence of bleeding is increased in high risk patients with critical conditions in Intensive Care Unit (ICU). Appropriate prophylaxis medicine is necessary to reduce the incidence of stress ulcer bleeding during hospitalization in ICU which further can minimize the cost of patient care in the ICU. Currently, lansoprazole and pantoprazole are used as a stress ulcers prophylaxis. Nevertheless, there has not been sufficient evidence proving their effectiveness. This study was aimed to compare the effectiveness and cost between iv lansoprazole and iv pantoprazole as a stress ulcer prophylaxis in ICU. In this retrospective observational study, the data were obtained from medical records of all patients admitted to ICU in a District Hospital in Yogyakarta from January 2014 until December 2016. Effectiveness of therapy were obtained from objective data in the medical record by looking at the incidence of major (clinically signiï¬cant) and minor (overt gastrointestinal) bleeding. Chi-square analysis was performed to analyze the difference of bleeding incidence. The average cost was presented as Expected Monetary Value (EMV), which consisted of the cost of prophylaxis and treatment of bleeding. The difference in average cost was analyzed using independent t-test. A total of 119 patients were included in this study. There were 62 patients in the lansoprazole group and 47 patients in the pantoprazole group. Forty eight patients (77,4%) from lansoprazole group and 35 patients (61,4%) from pantoprazole group did not experience any GI bleeding. There was no statistical difference in the incidence of GI bleeding between the two groups (CI 95%, P-value = 0.057). The EMV of lansoprazole group was higher than pantoprazole group IDR 645.122,57 and IDR 511.629,39 respectively. In conclusion, there was no significant difference regarding the effectiveness between iv lansoprazole and iv pantoprazole as stress ulcer prophylaxis. Costs for the prophylaxis of stress ulcers is lower on the use of pantoprazole compared to lansoprazole.

Accelerated stability test of snakehead fish and kelulut honey ointment with CMC-Na as a binder Wintari Taurina; Mohamad Andrie; Nur Firdiena Titian Ratu
Pharmaciana Vol 11, No 3 (2021): Pharmaciana
Publisher : Universitas Ahmad Dahlan

The extract of snakehead fish (Channa striata) and kelulut honey (Heterotrigona itama) ointment was proven to have activity in wound healing. However, previous studies showed instability in the ointment as indicated by the occurrence of phase separation. This study used CMC-Na (Carboxymethyl Cellulose Sodium) with a concentration of 3% (F1), 4.5% (F2), and 6% (F3) as a binder. The stabilizer was added to increase the stability of the ointment preparation by binding to the aqueous phase and preventing it from leaving the ointment base. The test was carried out with the accelerated stability method at a temperature of 40Â° Â± 2Â° C and a humidity of 75% Â± 5% for 28 days. The evaluation includes organoleptic tests, homogeneity, spreadability, adhesion, and protection power. The results showed that CMC-Na increased the stability of the ointment. The data obtained show that the higher the CMC-Na concentration used, the higher the consistency and adhesion were, but the lower the spreadability of the preparation. The results of the average spreadability and adhesion power for formulation 1 were 5.09 cm and 1797.33 seconds, formulation 2 were 4.42 cm and 1798.33 seconds, and formulation 3 were 3.69 cm and 1799 seconds. The results of the One-Way ANOVA showed that all formulations experienced a significant decrease in adhesion and increase in spreadability during 28 days of storage. The best ointment that meets the physical stability criteria is shown by the CMC-Na 3% (F1) formulation, with a soft texture, homogeneous, a good spreadability (5-7 cm), a good adhesion (more than 4 seconds), and a good protective power for 28 days of testing.

Antibacterial compound from Euchema spinosum originated from Tasikmalaya West Java against pathogen bacteria with TLC-bioautography Indra Topik Maulana; Rifa Safira; Inge Aprianti; Livia Syafnir; Reza Abdul Kodir
Pharmaciana Vol 11, No 3 (2021): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Streptococcus mutans (Gram-positive) and Shigella dysenteriae (Gram-negative) are two types of pathogen bacteria. The use of synthetic antibiotics against both bacteria is known to impact the bacteria's resistance. E. spinosum from Tasikmalaya is a potential macroalgae as a source of an antibacterial compound for both bacteria. The research aims to determine the antibacterial metabolite compound from E. spinosum originated from Tasikmalaya against S. mutans and S. dysenteriae. The research was conducted through several stages, starting from phytochemical screening, gradual maceration using hexane, ethyl acetate, and methanol, determination of antibacterial activity, and TLC-bioautography. Phytochemical screening showed that both raw material and extracts contained alkaloids, flavonoids, and steroids. The result showed that hexane, ethyl acetate, and methanol extract could inhibit the growth of S. dysenteriae starting from a concentration of 400 Âµg/mL. However, only ethyl acetate extract can inhibit the growth ofÂ S. mutans,Â starting from a concentration of 20 Âµg/mL. The chromatogram of the hexane extract showed the presence of 6 spots, ethyl acetate extract showed 5, and the methanol extract showed only 4, resulted from the elution system, respectively. The TLC-bioautography againstÂ S. dysenteriaeÂ showed that there was the presence of three clear zones on the ethyl acetate extract, detected as flavonoid, and three clear zones on the methanol extract. The TLC-bioautography againstÂ S. mutansÂ showed one clear zone on the chromatogram of ethyl acetate extract. According to the AlCl3 spray reagent confirmation test, the active compound was the flavonoid group.

Optimization transdermal patch of polymer combination of chitosan and HPMC-loaded ibuprofen using factorial designs Shaum Shiyan; Misirti Maulidia Anis Marketama; Galih Pratiwi
Pharmaciana Vol 11, No 3 (2021): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Ibuprofen is a non-steroidal anti-inflammatory drug that has a disadvantage in its oral use, such as gastrointestinal disorders, nausea, vomiting and gastric ulcers. Transdermal patch dosage forms are an alternative in overcoming this weakness. The transdermal patch is formulated using a special membrane that can control drug release in a matrix system. Therefore, this study optimizes chitosan and HPMC as polymers using a factorial design approach. The parameters tested included weight uniformity, patch thickness, swelling index, in vitro release rate, folding resistance, ibuprofen uniformity, surface pH, and moisture content. The interactions between the components were evaluated using Fourier transform infrared spectrophotometry-attenuated total reflectance (FTIR-ATR). The optimum concentration of chitosan was 0.5% and HPMC 6% with CV values for weight uniformity of 0.003 Â± 1.202%; humidity 0.543 Â± 5.595%; swelling index 4.611 Â± 23,657%; thickness 0.052 Â± 2.428%; surface pH 5; durability is less than 300 times and the uniformity of ibuprofen levels is 1.52 Â± 2.99%. The design approach using the FFD22 obtained an effective and efficient mathematical-statistical model to determine the optimal polymer combination in the formula. As an additional instrument in design evaluation, the chemometric approach is constructive in modeling and optimization.

A 5 year retrospective analysis of adverse drug reactions associated with antimicrobials in a teaching hospital of Andaman and Nicobar islands Mangesh Bankar; Priyanka Pravinbhai Hotha; Nimisha Elezebeth Zachariah
Pharmaciana Vol 11, No 3 (2021): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Antimicrobials are used widely especially in developing countries, due to the high prevalence of various infectious diseases. Inappropriate use of antimicrobials are associated with adverse drug reactions. The present study was done to analyze the patterns of Adverse Drug Reactions (ADR) due to antimicrobials reported to Adverse Drug Reaction Monitoring Centre (AMC) during the last five years.Â This was a 5 year retrospective and cross-sectional study. After collecting demographic details of patients, ADR forms, and ADR associated with the antimicrobial class of drugs, data were analyzed for further details. A total of 877 ADRs, 360 ADRs belonged to the antimicrobial group. When data was analyzed data, it revealed that the majority of ADRs (73.05%) were reported in the adult group, 75.27% of reactions belonged to A category, Ceftriaxone (17.2%) was the most common drug-associated with ADRs, majority of ADRs were related to skin (56.66%), rash (27.5%) was the most common ADR encountered with antimicrobial use, 73.61% reactions were non-serious, 69.44% of ADRs recovered, and 77.77% of ADRs were probable category. Ceftriaxone was responsible for the maximum number of ADRs. The study results provide information regarding the pattern of ADRs associated with antimicrobials, and this might be helpful for improving the awareness of healthcare providers about PvPI and subsequently increase the spontaneous reporting of ADRs.

Identification of SNP rs1799854 ABCC8 gene and blood glucose levels in patients with type 2 diabetes mellitus at Moewardi hospital Surakarta Solo Mardiana Puji Lestari; Imaniar Noor Faridah; Rita Maliza; Melinda Widianingrum; Dyah Aryani Perwitasari
Pharmaciana Vol 11, No 3 (2021): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Type 2 diabetes mellitus (T2DM) is a complex metabolic disease characterized by high blood glucose levels due to impaired insulin secretion or insulin resistance. Polymorphisms in the ABCC8 gene rs1799854 are widely found to have an association with T2DM, where the ABCC8 gene encodes the SUR1 protein from the K-ATP channel that plays a role in insulin secretion in cells Î² pancreas. Mutations in the ABCC8 gene can cause potassium channels and insulin secretions problems that possibly decrease the effectiveness of the drug. Polymorphisms in some populations have been reported, but similar research on Solo's population has never been conducted. The purpose of this study is to identify the genotype of the ABCC8 gene in rs1799854 and the therapeutic outcome of blood glucose levels in T2DM patients. This research is cross-sectional research conducted prospectively at Moewardi Hospital Surakarta, Solo. Blood samples were collected from 10 T2DM patients who received sulfonylurea monotherapy taken through veins for genotype examination by DNA isolation, PCR amplification, and sequencing. Parameters of fasting blood glucose (FBG), 2-hour postprandial blood glucose, and HbA1c are measured as therapeutic outcomes. We found the dominant results in a mutant homozygote (TT) 40%; while wild type (CC); and a mutant heterozygote (CT) was 30%. Single Nucleotide Polymorphisms (SNP) of ABCC8 gene rs1799854, found in T2DM patients at Moewardi Hospital Surakarta, Solo, who received sulfonylurea therapy.

The antioxidant activity of Zingiber officinale, Hibiscus sabdariffa, and Caesalpinia sappan combination Ari Hasna Widyapuspa; Elizabeth Betty Elok Kristiani; Yohanes Martono
Pharmaciana Vol 12, No 1 (2022): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Medicinal plants have been used in traditional treatment since a long time ago by local people in Indonesia. Nowadays, the trend in the consumption of medicinal plants, especially herbal drinks, is increasing. Zingiber officinale, Hibiscus sabdariffa, and Caesalpinia sappan are their main materials of medicinal plants. They were chosen because of their high antioxidant contents. Nevertheless, there is no scientific research on the antioxidant activity of the combination of the three extracts. Therefore, the purpose of this study was to determine the total flavonoid contents and antioxidant activity, as well as to compare the antioxidant enhancement pattern of the combination. Samples were extracted by successive maceration with hexane and ethyl acetate as solvents. Total flavonoids contents were determined through colorimetric analysis and antioxidant activity was determined based on the DPPH method with the IC50 value as a parameter. Total flavonoids of ethyl acetate extract from Z. officinale, H. sabdariffa, and C. sappan were 30.28Â±0.04; 24.81Â±0.03; and 24.01Â±0.04 mg QE/ gram extract, and the IC50 value were 51.36Â±0.05; 83.37Â±0.06; and 35Â±0.04 ppm. Total flavonoid contents of their combination were 22.48Â±0.05 (0:1:1); 23.88Â±0.05 (1:1:1); 23.68Â±0.05 (1:4:1); 22.81Â±0.05; 28.81Â±0.04 (4:1:1); 27.55Â±0.03 (1:1:0); 24.41Â±0.04 mg QE/ gram extract (1:0:1). Antioxidant activities obtained from the combination were 57.50Â±0.05 (0:1:1); 52.25Â±0.06 (1:1:1); 71.50Â±0.06 (1:4:1); 45.74Â±0.05 (1:1:4); 54.36Â±0.05 (4:1:1); 68.97Â±0.06 (1:1:0); 40.52Â±0.05 ppm (1:0:1). The strongest antioxidant activity was C. sappan.Â

Diffusion rate of quercetin from chitosan-TPP nanoparticles dispersion of onion (Allium cepa L.) ethanol extract in medium phosphate buffer pH 7.4 Anisa Amalia; Rahmah Elfiyani; Putri Ulan Sari
Pharmaciana Vol 12, No 1 (2022): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Onion extract contains quercetin, which has anti-inflammatory properties. The absorption of quercetin in the extract can be improved by using the ionic gelation method to composition the extract into a nanoparticle system. Chitosan is a polymer that is used to make nanoparticles that impact medicinal drug absorption. Although many studies of nanoparticle coatings with chitosan have been performed, the effect of the chitosan concentration used remains an intriguing research issue, especially as a natural compound carrier.Â The goal of this study was to examine how varying chitosan polymer concentrations affected the rate of quercetin diffusion from onion (Allium cepa L.) ethanol extract nanoparticles. With 0.1% tripolyphosphate (TPP) as a crosslinker, the concentrations of chitosan used were 0.1% (F1), 0.2% (F2), 0.3% (F3), and 0.4% (F4). Organoleptic test, particle size measurement, zeta potential, polydisperse index, entrapment efficiency, density, and determination of quercetin diffusion rate using a phosphate buffer medium pH 7.4 were all used to analyze each composition. Transparent yellow nanoparticles with particle sizes ranging from 199.89 nm to 514.97 nm, a zeta potential of 47.73 mV to 51.36 mV, a polydispersity index of 0.57, an entrapment efficiency of 54.78 % to 59.06 %, and a density of 1.012 g/mL to 1.042 g/mL are the result of this system. In each composition, the rate of diffusion follows the Higuchi reaction kinetics. Increased chitosan concentration decreases the diffusion rate of onion ethanol extract nanoparticles (Allium cepa L). The fastest diffusion rate value with requirements-meeting physical properties was obtained in nanoparticle systems containing a 0.1 % chitosan solution.Â

The cholesterol-lowering activity of Averrhoa bilimbi L. leaves ethyl acetate fraction in hypercholesterolemic model Rahmad Abdillah; Fitra Fauziah; Putri Indah Lestari; Fitri Rachmaini
Pharmaciana Vol 12, No 1 (2022): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Averrhoa bilimbi L. is used widely as spices and traditional medicine, which contained several chemical compounds such as alkaloid, flavonoid, saponin, and tannin. The aim of this study is to discover the best dose of ethyl acetate fraction from A.bilimbi leaves, which have pharmacology activity on total cholesterol and triglycerides in the hypercholesterolemic model. Thirty adult male white mice were divided into six groups; each group was containing five animals. Five groups were given high-fat diet foods and PTU induced the animals to obtain hypercholesterolemia with a frequency of 1 time a day orally for 14 days, while the normal group was given vehicle (Na CMC 5%) and standard feed. On the 15th day the normal group was given vehicle (Na CMC 5%), negative control group was given high-fat feed, positive control group was given atorvastatin dose 0.26 mg/kg BW, and another group was given ethyl acetate fraction of A.bilimbi leaves dose 200, 400, and 800 mg/kg BW orally. All animal were treated until the 28th day. On day 29, the bloods were taken to determine the total cholesterol and trygliceride levels using clinical photometer 5010 v5+. The data was statistically analyzed using a one-way ANOVA followed by the Duncan Multiple Range Test.. This study indicates that administration of ethyl acetate fraction from A.bilimbi leaves can affect the total cholesterol levels and triglycerides in hypercholesterolemic mice (P<0.05). Ethyl acetate fraction dose 200 mg/kg BW shows the best activity in decreasing total cholesterol levels and triglycerides on mice hypercholesterolemic model (P<0.05).

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Jl. Prof. Dr. Soepomo, S.H., Janturan, Warungboto, Umbulharjo, Yogyakarta, Indonesia Kode pos 55164

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Home Page

OAI Link

Editorial Team

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Reviewer

Google Scholar

Contact Name Muhammad Syahrir

Contact Email m.syahrir7406@unm.ac.id

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Journal Mail Official nurkhasanah@pharm.uad.ac.id

Editorial Address Jl. Prof. Dr. Soepomo, S.H., Janturan, Warungboto, Umbulharjo, Yogyakarta, Indonesia Kode pos 55164

Location Kota yogyakarta, Daerah istimewa yogyakarta INDONESIA

Abstract

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Abstract

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Abstract

Contact Name
Muhammad Syahrir

Contact Email
m.syahrir7406@unm.ac.id

Phone
-

Journal Mail Official
nurkhasanah@pharm.uad.ac.id

Editorial Address
Jl. Prof. Dr. Soepomo, S.H., Janturan, Warungboto, Umbulharjo, Yogyakarta, Indonesia Kode pos 55164

Location
Kota yogyakarta,

Daerah istimewa yogyakarta

INDONESIA