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Pharmaciana: Jurnal Kefarmasian

PHARMACIANA
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Published by Universitas Ahmad Dahlan

ISSN : 20884559 EISSN : 24770256 DOI : 10.12928

Core Subject : Health,

Medicine & Pharmacology

Pharmaciana is a scientific journal published by the University of Ahmad Dahlan worked closely with Ikatan Apoteker Indonesia (IAI). Pharmaciana published three times a year, namely March, July and November. with ISSN 2088-4559 and e-ISSN 2477-0256. The article published in the Journal Pharmaciana selected by editors and reviewed by the reviewer. Articles published in Pharmaciana must not be published in other journals or have been previously published. Pharmaciana is indexed in google scholar, ACI (Asean Citation Index), Dimension (Crossreff), Garuda, Sinta, Sherpa Romeo, Index Copernicus International, DOAJ, and BASE. Pharmaciana is accredited by DIKTI (DGHE) of Indonesia No. 105/E/KPT/2022 April 07, 2022

Arjuna Subject : Kimia(semua kategori) - Kimia (Lain-Lain)

Articles 808 Documents

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Free fatty acids regulating action of Capparis decidua fruit on dyslipidemia in rats Avijit Saha; Sangeeta Ghosh; Alok K. Hazra; Sandip Ghosh; Tapas Kumar Sur
Pharmaciana Vol 12, No 2 (2022): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Capparis decidua belongs to family Capparidaceae in wastelands of India. The study aim was to determine the role of C. decidua fruits on the free fatty acids (FFA) profile in fat-rich diet (FRD) dyslipidemic rats. The methanolic extract of edible fruit of C. decidua (CD) was given orally to obese dyslipidemic rats at the dose of 125 mg/kg and 250 mg/kg for consecutive 28 days. CD treatment in FRD rats significantly restricts the body weight gains. Blood lipid profile was altered dose dependently and significantly after 4-week treatment with CD to FRD. rats. It significantly (p<0.05) enhanced serum FFA especially, g-linolinate, a-linolinate, arachidonate, ecosapentaenoate, docosapentaenoate and docosahexaenoate. Moreover, w3-PUFA content was also enhanced (50.3% and 78.8%) in the serum of CD treated animals, whereas MUFA was lowered (31.1% and 40%). Therefore, Capparis decidua fruit has a promising role on dyslipidemia and obesity and has the capabilities to regulate beneficial free fatty acids.

The comparison between combination of candesartan-amlodipine and candesartan-furosemide on blood pressure in hypertensive patients with chronic kidney disease Fitri Rachmaini; Dian Ayu Juwita; Almahdy A; Rahmad Abdillah; Yolanda Mayestika Wati
Pharmaciana Vol 12, No 2 (2022): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Chronic renal disease is significantly increased by hypertension. Controlling blood pressure is critical in hypertensive individuals. Patients who have good blood pressure (BP) control can reduce morbidity and mortality. This study aimed to compare blood pressure reduction of candesartan-amlodipine with the candesartan-furosemide combination in hypertensive patients with chronic renal disease. The study was conducted by a cohort study design. Retrieval of medical record data was carried out prospectively during the period February-April 2019. The blood pressure reduction was assessed by changes in mean systolic and mean diastolic blood pressure and mean diastolic blood pressure and was analyzed statistically with the SPSS program. A total of 54 patients met the inclusion criteria, consisting of 27 patients receiving candesartan-amlodipine combination and 27 patients receiving candesartan-furosemide combination therapy. The results of the sociodemographic characteristics patients were male 30 patients (55.6%), age 56-65 years 24 patients (44.4%), senior high school education level 31 patients (57.4%). Candesartan-amlodipine and candesartan-furosemide combinations both decreased blood pressure in patients. However, the result of the statistical analysis revealed that there was no significant difference in blood pressure decline. (p> 0.05) between the two combinations.

Incision wound healing test ethanolic extract gel from Ekor Naga (Rhaphidophora pinnata (L.f) Schott) leaves in white male rats Fathnur Sanik; Havizur Rahman; Ave Olivia Rahman; Agung Giri Samudra; Cassa de Floris; Muhaimin Muhaimin
Pharmaciana Vol 12, No 2 (2022): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Ekor naga (Rhaphidophora pinnata (L.f) Schott) leaves have been researched and tested. So, it was known that the chemical content of secondary metabolites effect wound healing. This study aimed to determine the gel effect of ekor naga leaves extracts as a wound healing medicine. The research method evaluated organoleptic, pH, spreadability, and adhesion of gel preparations which were measured every week for four weeks. The testing of gel effect on the wound healing medicine was being performed. In 5 treatment groups namely positive control: Bioplasenton, Formula 0: negative control, Formula 1: 10% extract concentration, Formula 2: 15% extract concentration, and Formula 3: 20% extract concentration. The result obtained were analyzed by one-way ANOVA and continued by the Duncan test with a level of 95% confidence. The research results showed that formula 3 has the best wound healing effect, followed by formulas 2 and 1. The statistical results have a significant difference (p<0,05), but the results of stability observations of the formula two preparation have a stable. Evaluation value for four weeks of observation with a care effect of 95.3%. So, formula 2 is the best formula for stability and testing wound healing effectiveness.

Standardization of Cassia spectabilis DC leaves and antimalarial activities of ethyl acetate extract Wiwied Ekasari; Heny Arwati; Nindya Tresiana Putri; Dewi Hariyani; Rosalia Friska Ananda; Eko Suhartono
Pharmaciana Vol 12, No 2 (2022): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Cassia spectabilis is one of the Indonesian medicinal plants traditionally used to treat different diseases, including malaria. Quality of a drug derived from plants is also influenced by the quality of its raw materials. Thus, in order to assure the quality of products made from plants, it is necessary to standardize the raw materials and following with the antimalarial activity test. The aim of this study was to standardize the quality of C. spectabilis leaves and to evaluate its antimalarial activities of ethyl acetate extract. The fresh material of C. spectabilis leaves were observed its specific and non-specific parameters. In vitro test was done by using Plasmodium falciparum 3D7. In vivo test was done using 4-day suppressive test method against mice infected with P. berghei for four consecutive days. Heme detoxification inhibitory activity test was carried out using the modified Basilico method. The leaves of C. spectabilis meet the quality requirement for raw material of traditional medicine. The ethyl acetate extract showed in vitro antiplasmodial activity against P. falciparum 3D7 and in vivo antimalarial activity against P. berghei infection with IC50 value of 27.28 Î¼g/mL and ED50 value of 1.74 mg/kg, respectively. The extract also showed heme detoxification inhibitory activity with IC50 value of 0.33Â±0.01 mg/mL. The leaves of C. spectabilis leaves meet the quality requirement and the ethyl acetate extract from standardized C. spectabilis leaves possessed a potential an antimalarial activity which deserves to be further developed.

The effectiveness of avocado (Persea americana M.) leaves infusion as urinary stones dissolving in rats Ni Made Dwi Sandhiutami; Rika Sari Dewi; Alya Fariha
Pharmaciana Vol 12, No 2 (2022): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Urolithiasis is a pathological condition marked by the formation of urinary stones (calculi) in the urinary tract. Avocado leaf (Persea americana M.) contains substances that play crucial roles in the solubility of calcium in urinary stones, such as flavonoids, alkaloids, saponins, and magnesium. Empirically, avocado leaves are used to make urinating easier and break stones in the urinary tract. This study aims to determine the effect of avocado leaf infusion to dissolve urinary stones in white male rats. According to the experiment, 24 male white rats were divided into four groups; the negative control group (not given infusion), the 1 g/kg BW dose group, the 2 g/kg BW dose group, and the 3 g/kg BW dose group of avocado leaves infusion. The infusion was administered orally for seven consecutive days after 28 days of planting black silk thread as the stone core in the urinary tract. Then, the stone formed is taken. The weight and volume are measured. The urinary stones were tested qualitatively in terms of calcium and oxalate. The results showed that there were significant differences among treatment groups in weight and volume of urinary stones. The effect of bladder stone dissolving was best in the 3 g/kg BW group. The qualitative test also shows that urinary stones contain the same calcium and oxalate as urinary stones that form in humans. Avocado leaves infusion can have a urinary stone dissolving effect on white male rats. Increasing the dose of avocado leaves infusion increases its effectiveness as a urinary stone dissolution.

Antidiabetic and antihyperlipidemic activity of ethanol extract of Ekor Naga leaves (Rhaphidophora pinnata (L.f) Schott ) in alloxan-induced male white rats Fathnur Sani K; Yuliasati Yuliawati; Havizur Rahman; Agung Giri Samudra
Pharmaciana Vol 12, No 3 (2022): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Antidiabetic and antihyperlipidemic have a very close relationship for Mellitus Diabetics. In previous research, Ekor Naga leaves (Rhaphidophora pinnata (L.f) Schott) had an antihyperglycemic effect. The effect was obtained from the presence of secondary metabolites, namely alkaloids, flavonoids, tannins, saponins, and steroids. This research is expected to be a further test of the antidiabetic and antihyperlipidemic effects of alloxan-induced male white rats. This research used an experimental method. The treatment group was divided into four groups, namely negative control (Na CMC 0,5%), positive control (10 mg/kg BW of glibenclamide), group one (250 mg/kg BW of Ekor Naga leaves extract), and group two (500 mg/kg BW of Ekor Naga leaves extract). Data were taken from blood sugar levels on the days 0th, 7th, 10th, and 14th. Total cholesterol, triglyceride, LDL, and HDL levels were observed on the 14th day. Results were analyzed by one-way ANOVA test. The followed by Duncan’s test. The result of ethanol extract from Ekor Naga leaves showed antidiabetic and antihyperlipidemic activity in alloxan-induced rats, which had a statistically significant difference relative the negative control (p<0,05) decreased the levels of blood glucose, total cholesterol, HDL, LDL, triglycerides. Where the best group is two (500 mg/kg BW of Extract) and followed by group one (250 mg/kg BW of Extract). We concluded that Ekor Naga leaves extract provides activity in the treatment option for patients with diabetes and hyperlipidemia.

In vitro antimicrobial activity and formulation of herbal anti-acne gel containing Rhizophora stylosa fruits extract Azrifitria Azrifitria; Sri Purwaningsih; Annisa Rahma Fatmala
Pharmaciana Vol 12, No 3 (2022): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Mangrove fruits have a variety of bioactive metabolites that may control microbial growth. The present study was conducted to formulate and evaluate the antibacterial activities of Rhizophora stylosa fruit extract. The antibacterial activity of R. stylosa crude extract was investigated against Staphylococcus aureus, Staphylococcus epidermidis, and Propionibacterium acnes by disc diffusion method. The herbal gel formulations were developed using different concentrations of kappa carrageenan and Carbomer 940 as the gelling agent. The physicochemical characteristics and in vitro antibacterial activity of the gel were evaluated. The results revealed that the extract had a minimum inhibitory concentration value of 0.05 mg/ml against S. aureus and P. acne, and 0.1 mg/mL against S. epidermidis. All herbal gel formulations with 0.5% w/w of the extract showed a strong inhibitory activity against P. acnes. The herbal gel showed a good homogeneity, pH, viscosity, spreadability, and physical stability in an accelerated condition. Among all formulation studied, F1 was considered as the optimized formulation which contains 0.5% of the R. stylosa fruit extract with 0.25% kappa carrageenan and 0.5% Carbomer 940. It can be concluded that the developed gel formulation has potential against Acne vulgaris. Further research is needed to determine the safety and efficacy so R. stylosa can be developed as an alternative natural anti-acne agent.

The effect of zinc oxide and Curcuma heyneana Val. combination on stability and sun protection factor (SPF) of lotion Dian Eka Ermawati; Dita Yuli Budiasih
Pharmaciana Vol 12, No 3 (2022): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Indonesian people risk-averse effects of Ultraviolet (UV) exposure, so they need skin protection agents. Zinc Oxide (ZnO) is an effective UV reflection, but at a concentration of more than 10%, it can cause skin irritation. Combining ZnO with other UV protective agents is necessary, so its concentration can be reduced but still effective. The flavonoid in C. heyneana has potential as a sunscreen because chromophore groups can absorb UV B and UV A light. This study aims to examine the effect of the combination of ZnO and C. heyneana on the stability and SPF value of lotion. The lotion is made in five variations of the composition of ZnO and C. heyneana, F1 of 100: 0%; F2 of 0:100%; F3 of 50:50%; F4 of 25:75%; and F5 of 75:25% respectively. Test parameters include organoleptic, pH, spreadability, viscosity, and SPF. The test is recorded before and after the cycling test. Statistical analysis using Paired Sample T-Test. The combination of ZnO and C. heyneana affected organoleptic, viscosity, spreadability, and SPF value but did not affect pH. The higher concentration of ZnO will increase the viscosity, pH, and SPF but decrease the spreadability. The formula with a combination of ZnO and C. heyneana of 50%:50% is selected because it has an SPF value of 13.24 and; a viscosity of 48.67 d.Pas; pH of 7.1; and spreadability of 3.81 cm.

Formulation optimization and wound healing activity of Vitex trifolia L leaf extract loaded chitosan hydrogel film on hyperglycemic rats Made Dwi Pradipta Wahyudi S; Dewa Ayu Arimurni; Komang Angelita Safira; Erika Yuda Colatama; Putu Bisma Duta Valenrika
Pharmaciana Vol 12, No 3 (2022): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Decreased blood supply, high blood sugar level, and a possibility of bacterial infection in diabetic wounds pose risk for limb loss and mortality. Therefore, proper wound care is needed to improve the quality of life of diabetic patients. Vitex trifolia L (Legundi) extract is reported to have antibacterial and antioxidant activity that enhances cell proliferation and migration. The antimicrobial and hemostatic properties of chitosan film are viewed as an ideal material for enhancing wound healing. The film should retain its integrity and flexibility while used on the skin, therefore chitosan was combined with PVA and PVP K30 to improve its quality. The objectives of this study were to optimize the concentration of chitosan, PVP K30, and PVA towards the Legundi extract film properties, and to evaluate its wound healing activity on hyperglycemic mice using an incision wound model. In this study, the film’s compositions were optimized using a simplex lattice design, and the effects of its components on their characteristics, such as thickness, weight, folding endurance, swelling rate, and swelling index, were evaluated. BALB/c Mice were divided into three groups (Group I, Group II, Group III) which were treated with normal saline, placebo film, and Legundi film respectively once daily for 8 days. The result suggested that chitosan and PVA were responsible for affecting the film’s thickness, weight, and folding endurance, whilst PVP K30 was the dominant factor in increasing the swelling index and rate of the film. The optimum formula of Legundi extract films consists of 1.15 %(b/v) chitosan, 1.25 %(b/v) PVP K30, and 1.6 %(b/v) PVA. The animal treated with Legundi extract film have higher wound closure compared to the control and placebo group four days after wound incision (p<0.05). Thus, Legundi extract film was a potential dressing to treat a diabetic wound.

Phytochemicals and toxicity of ketapang fruit flesh (Terminalia catappa. Linn) using the BSLT method Senny Widyaningsih; Mochamad Chasani; Undri Rastuti; Umi Salamah
Pharmaciana Vol 12, No 3 (2022): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Ketapang is widely used in traditional medicine. Parts of ketapang plant, such as roots, leaves, and bark, are known to have biological activities such as antioxidant, antimicrobial, anti-inflammatory, and anticancer. However, no biological activity has been reported on the flesh of the ketapang fruit. This research was conducted to obtain phytochemicals and toxicity information of ketapang fruit flesh as an anticancer medicine. Toxicity indicates the potential for a chemical compound to cause damage to living organisms, while phytochemicals indicate a group of compounds that have biological activity. Extraction of ketapang fruit flesh was carried out using various solvents, both polar and non-polar solvents, methanol, n-hexane, and ethyl acetate. The toxicity test used the Brine Shrimp Lethality Test (BSLT) method, while phytochemicals tests used the thin layer chromatography (TLC), in which identification of bioactive compounds of ketapang pulp extract used UV-Visible and FTIR spectroscopy. The results showed that the ketapang fruit flesh extract was toxic to Artemia salina Leach shrimp larvae. The most toxic was ethyl acetate extract, with an LC50 value was 17,171 ppm. The phytochemicals screening showed that ethyl acetate extract of the ketapang fruit flesh contained flavonoid, alkaloid, phenolic, terpenoid, and saponin compounds. Tracing using UV-Vis shows the presence of conjugated double bonds which refer to flavonoid compounds, as well as the IR spectrum which indicates the presence of a typical functional group of flavonoid compounds.

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Home Page

OAI Link

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Contact Name Muhammad Syahrir

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Journal Mail Official nurkhasanah@pharm.uad.ac.id

Editorial Address Jl. Prof. Dr. Soepomo, S.H., Janturan, Warungboto, Umbulharjo, Yogyakarta, Indonesia Kode pos 55164

Location Kota yogyakarta, Daerah istimewa yogyakarta INDONESIA

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Contact Name
Muhammad Syahrir

Contact Email
m.syahrir7406@unm.ac.id

Phone
-

Journal Mail Official
nurkhasanah@pharm.uad.ac.id

Editorial Address
Jl. Prof. Dr. Soepomo, S.H., Janturan, Warungboto, Umbulharjo, Yogyakarta, Indonesia Kode pos 55164

Location
Kota yogyakarta,

Daerah istimewa yogyakarta

INDONESIA