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Pharmaciana: Jurnal Kefarmasian

PHARMACIANA
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Published by Universitas Ahmad Dahlan

ISSN : 20884559 EISSN : 24770256 DOI : 10.12928

Core Subject : Health,

Medicine & Pharmacology

Pharmaciana is a scientific journal published by the University of Ahmad Dahlan worked closely with Ikatan Apoteker Indonesia (IAI). Pharmaciana published three times a year, namely March, July and November. with ISSN 2088-4559 and e-ISSN 2477-0256. The article published in the Journal Pharmaciana selected by editors and reviewed by the reviewer. Articles published in Pharmaciana must not be published in other journals or have been previously published. Pharmaciana is indexed in google scholar, ACI (Asean Citation Index), Dimension (Crossreff), Garuda, Sinta, Sherpa Romeo, Index Copernicus International, DOAJ, and BASE. Pharmaciana is accredited by DIKTI (DGHE) of Indonesia No. 105/E/KPT/2022 April 07, 2022

Arjuna Subject : Kimia(semua kategori) - Kimia (Lain-Lain)

Articles 808 Documents

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Extraction and characterization of pectin from the fruit peel of Benincasa hispida (Thunb.) cogn La Ode Akbar Rasydy; Nita Rusdiana; Mira Eria Anggraini
Pharmaciana Vol 12, No 3 (2022): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Pectin is a polysaccharide and a major component of most plant cell walls and the functions as an adsorbent, emulsifying agent, gelling agent, stabilizer, and gelling agent. one of which is by utilizing the skin of Bligo fruit (Benincasa hispida (Thunb.) Cogn). This study aims to determine the presence of pectin contained in the skin of Bligo fruit using a completely randomized design (CRD) using 4 variations. concentration of citric acid solvent (5%,7%,9% and 11%) with extraction time consisting of 4 levels (30, 60, 90 and 120 minutes). The characteristics of the pectin produced were determined including water content, ash content, equivalent weight, methoxyl content, galacturonic acid content, and degree of esterification. This type of research is experimental research in the laboratory. The results showed that the highest yield was obtained from 7% citric acid concentration with an extraction time of 60 minutes, the yield value was 9.8%. The characteristics of the pectin obtained included water content of 11.6% and 9.2%; ash content of 8.8% and 8.7%; equivalent weight of 797,448 mg and 761,035 mg; methoxyl content 2.561% and 2.466%; galacturonic acid content 117.088% and 112.281%; esterification degree of 12,417 and 12,469%. FTIR spectroscopy which was used to compare the results of the spectra of extracted pectin and standard pectin showed the similarity of each absorption functional group.

Antibacterial activity of methanol extract Rhizophora mucronata leaves toward Salmonella typhi: leading the typhoid fever Rinto Muhammad Nur; Resmila Dewi; Sutriani Kaliu
Pharmaciana Vol 12, No 3 (2022): Pharmaciana
Publisher : Universitas Ahmad Dahlan

The community has utilized Mangrove extensively, particularly as a component of traditional medicine. Rhizophora mucronata is one species that possess antibacterial, antiviral, antifungal, and insecticidal properties. According to reports, R. mucronata has antibacterial properties against the Salmonella typhi bacteria that cause typhoid fever. This research aims to obtain a methanol extract of R. mucronata leaves and assess its antibacterial potential as natural new medicine, particularly for treating typhoid fever. The extraction method is maceration with a 70 percent methanol solvent. Well, diffusion is utilized to determine antibacterial activity. Alkaloid, flavonoid, saponin, steroid, tannin, and triterpenoid are the chemical compounds identified in the methanol extract of R. mucronata leaves (MERmL). Ten percent concentration of MERmL exhibited moderate antibacterial activity (7.970.25 mm), whereas 30 percent concentration (11.380.29 mm) and 50 percent concentration (16.070.40 mm) exhibited intense antibacterial activity. Based on these findings, R. mucronata leaf methanol extracts with higher concentrations have more potent antibacterial activity against S. typhi in typhoid fever treatments.

DNA identification of kayu kuning (yellow-fruited moonseed) from East Kalimantan, Indonesia Riski Sulistiarini
Pharmaciana Vol 12, No 3 (2022): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Kalimantan is an island with an abundance of kayu Kuning (yellow-fruited moonseed). Kayu kuning is used for three different plant species, namely Arcangelisia flava (L.) Merr., Fibraurea tinctoria Lour., and Coscinium fenestratum (Gaertn.) Colebr. Therefore, it creates confusion and may cause improper use. It has properties such as anti-diabetic, antiplasmodial, antidiarrheal, hepatitis, and antidote. The study uses the DNA barcode technique to identify kayu kuning (yellow-fruited moonseed) from East Kalimantan, Indonesia. The genomic DNA of kayu kuning (yellow-fruited moonseed) was extracted, and ITS primers were used for identification using polymerase chain reaction (PCR). It was compared with Arcangelisia flava, Fibraurea tinctoria, and Coscinium fenestratum as a phylogenetic tree. DNA sequence alignment of ITS and phylogenetic reconstruction revealed that kayu kuning (yellow-fruited moonseed) from East Kalimantan was closely related to A. flava. The kayu kuning (yellow-fruited moonseed) had 94.16% of sequence similarity with A. flava according to the ITS1 barcode.

The effect of surfactant on the solubility of kencur rhizome ethanol extract in self-nanoemulsifying drug delivery system Beti Pudyastuti; Triyadi Hendra Wijaya
Pharmaciana Vol 12, No 3 (2022): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Kencur (Kaempferia galanga L.) rhizome ethanol extract contains a lipophilic compound of ethyl p-methoxycinnamate. Self-nanoemulsifying drug delivery system (SNEDDS) formulation can increase the solubility of the extract in water. The purpose of this study was to determine the effect of surfactant combination on the kencur rhizome extract in the SNEDDS system. The SNEDDS formulations were carried out by selecting the surfactant ratio of Tween 80:Span 80 and Tween 80:Chremophor RH 40, followed by selecting the ratio of surfactant mixtures to polyethylene glycol 400 as co-surfactant, and to virgin coconut oil as the oil phase. The clarity, transmittance, emulsification time, particle size, and polydispersity index were evaluated. The stability test was carried out in aquadest, artificial gastric fluid, and artificial intestinal fluid for 4 hours at 37°C. The results showed that the combination of Tween 80: Chremophor RH 40 produced better SNEDDS than Tween 80:Span 80. The combination of surfactant-cosurfactant of Tween 80:Chremophor RH 40:PEG 400 at ratio 3:1 and 1:1 could produce homogenous dispersed SNEDDS showing droplet size of 23,0 and 21,8 nm; transmittance of 95.63% and 93.83%, and SNEDDS preconcentrate emulsified less than 35 seconds. The single surfactant Tween 80:PEG 400 at the ratio 3:1 produce better dispersed SNEDDS than the combined surfactant with droplet size 16.3 nm, transmittance 97.85%, and SNEDDS preconcentrate emulsified less than 45 seconds. The SNEDDS system could produce a smaller droplet size than the extract in aquadest.

Comparative analysis of the stability features of human alpha-defensins as candidates for the future COVID-19 therapy through molecular dynamics Taufik Muhammad Fakih; Dwi Syah Fitra Ramadhan; Arfan Arfan
Pharmaciana Vol 12, No 3 (2022): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Coronavirus 19 (COVID-19) is still a global health issue to date, SARS-CoV-2 is a novel coronavirus that is responsible for this sickness. The receptor-binding domain of the SARS-CoV-2 virus associates with angiotensin-converting enzyme 2 (ACE-2) and allows the virus to enter human cells. Natural peptides such alpha-defensin are thought to attach to the SARS-CoV-2 RBD and prohibit it from engaging with ACE-2. Molecular dynamics simulations using a computational approach are utilized to understand the stability of six alpha-defensin macromolecules using the Gromacs 2016 software. The trajectories formed are then analyzed using VMD 1.9.4 and BIOVIA Discovery Studio 2020 software. Finally, the free energy is estimated using the MM/PBSA method. The alpha-defensins 2 macromolecules were found to have the best stability based on numerous study results (trajectory visualization, RMSD, RMSF, and free energy calculations). As a result, these macromolecules could be used to build new antiviral treatments for COVID-19 infectious disease candidates.

The effect of partially pregelatinized cassava starch as disintegrant for paracetamol tablet Okta Nama Putra; Winni Nur Auli; Musa Musa; Derina Paramitasari; Gabriela Kasih Mawarni
Pharmaciana Vol 12, No 3 (2022): Pharmaciana
Publisher : Universitas Ahmad Dahlan

The use of partially pregelatinized starch in tablet formulations is entirely various; one of them is disintegrant. Present pregelatinized starch is imported from another country, which is relatively expensive. In contrast, many plants can be used as starch sources, including cassava which is relatively abundant in Indonesia. This study aimed to determine the effect of using partially pregelatinized starch from cassava as a disintegrant in paracetamol tablets. In this study, seven formulas were used with different disintegrants, three formulas using partially pregelatinized starch from cassava with concentrations of F1 5%, F2 10%, and F3 15%, three formulas using Starch 1500 with the same concentration as partially pregelatinized starch from cassava and one control formula without disintegrant. The tablet was made using the wet granulation method. The tablets produced were tested for physical properties (hardness, disintegration, and dissolution). In addition, compact ability of partially pregelatinized starch from cassava was compared with Avicel, Starch 1500, and cassava starch. Based on the results of the study showed that partially pregelatinized starch from cassava produced tablets that tended to be capping with less hardness than tablets with Starch 1500 and control tablets. The compact ability test results showed that the compact ability of partially pregelatinized starch from cassava was better than Starch 1500 and cassava starch. The disintegration test results showed that tablets with partially pregelatinized starch from cassava had faster disintegration than tablets with Starch 1500 and control tablets. The dissolution profile of tablets with partially pregelatinized starch from cassava is also better than other formulas.

Fractionation of a phenolic compound from water spinach (Ipomoea aquatica) herbs as anti-dandruff against Malassezia sp. Meta Damaharyuningtyas; Kintoko Kintoko; Endang Darmawan
Pharmaciana Vol 12, No 3 (2022): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Dandruff is a scalp disorder caused by a fungus (Malassezia sp.). Water spinach (Ipomoea aquatica) contains phenolic compounds which has antifungal activity. The purpose of this research is to know the active fraction of Ipomoea aquatica herb which has antidandruff activity to against Malassezia sp. The study used true experimental design to antidandruff activity test. Fractionation used column chromatography which stationary phase with silica gel 60 powder and mobile phase with chloroform/methanol/acetyl acetate (8/2/0,1 v/v/v). In vitro antidandruff activity based on minimum inhibitory consentration (MIC) and minimum antifungal consentration (MFC) against Malassezia sp. of human dandruff isolate. The average of MIC and MFC among groups compared used Friedman test test (pâ‰¤ 0,05). The fraction 7 of water spinach (Ipomoea aquatica) herb have antidandruff activity against Malassezia sp. (MIC 125 Âµg/mL and MFC 250 Âµg/mL). Based on the results, fraction of water spinach (Ipomoea aquatica) herb have antidandruff activity against Malassezia sp. identified as phenolic compound.

Analysis of plasmid profiles of Escherichia coli bacteria and their resistance to several antibiotics Aldise Indah Nurdevi; Mauritz Pandapotan Marpaung
Pharmaciana Vol 12, No 3 (2022): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Escherichia coli is a bacteria belonging to the family Enterobacteriaceae. Escherichia coli is a harmful gram bacterium living in the digestive tract. These bacteria also live in water and soil, commonly referred to as coliform. This research aims to analyze the plasmid profile of Escherichia coli bacteria and its resistance to some antibiotics. To explore the plasmid profiles of Escherichia coli in a recent research electrophoresis gel, the antibiotic used in its resistance tests is the Amoxicillin, Tetracycline antibiotic, Ciprofloxacin, Sulfamethoxazole, and Streptomycin antibiotic. The electrophoresis results in a difference in the number of plasmid profiles with 1 to 2 ribbons of plasmid DNA different sizes from ˜1500 bp to ˜2300 bp. Antibiotic resistance tests have occurred in Amoxicillin, Ciprofloxacin, and some resistance samples to the Streptomycin antibiotic

Formulation and evaluation of orally disintegrating film (ODF) containing piperine-succinic acid cocrystal Uswatul Hasanah; Lili Fitriani; Verlia Nisrina Putri; Erizal Zaini
Pharmaciana Vol 13, No 1 (2023): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Piperine is a type of alkaloid found in plants of the Piperaceae family, including Piper nigrum and Piper longum, which has numerous pharmacological properties and is being developed as a nutraceutical. However, its poor solubility makes delivering in effective doses for therapeutic purposes challenging. To overcome this limitation, the cocrystals of piperine and succinic acid was prepared, which are more soluble, and then formulated into orally disintegrating films (ODFs) for better delivery. The cocrystals were formed using the slurry method, while the ODFs were made using the solvent-casting method with different concentrations of hydroxypropyl methylcellulose (HPMC) and polyethylene glycol (PEG) 400. The resulting films were evaluated for various parameters, such as their organoleptic characteristics, weight and thickness uniformity, pH, moisture content, swelling properties, and disintegration time. The results showed that the ODF with 6% HPMC as a film-forming polymer and 0.6% PEG 400 as a plasticizer loaded with 10 mg of piperine in the form of piperine-succinic acid cocrystal was the best formula. This ODF formulation disintegrated in less than one minute and was found to be a good film with uniform content.

Proper practice Of unused medicine disposal: opinions of patients at puskesmas 1 Umbulharjo Yogyakarta Ana Hidayati; Ela Fadilah Pramsa; Woro Supadmi
Pharmaciana Vol 13, No 1 (2023): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Management of unused medicines needs to be done correctly otherwise it will pose negative impacts on health and environment. The purpose of the study is to find out the opinion of patients and whether there is a relationship between demographic characteristics and opinions about patient's disposal practices of unused drugs. This type of research is an analytical observational with cross sectional approach. The number of samples determined by the Lameshow formula obtained a total sample of 96 patients. The sampling technique was carried out by purposive sampling. The research sample was patients who visited Umbulharjo 1 public health center who met the inclusion criteria within the period of March-June 2022. The research instrument was data collection sheet, and data analysis was completed using the chi-square test. Regarding respondents’ opinions on unused medicine disposal practice, results show that most patients return unused drugs to health workers (46.9%). There is a significant relationship between gender and disposal practice methods namely keeping unused medicine at home (p=0.002) and giving it to the patients’ relatives (p=0.049). In addition, there is a significant relationship between educational history and the method of keeping unused medicine at home (p = 0.000). The conclusion of this study is that many patients return unused drugs to health workers for as many as 45 patients (46.9%). There is a relationship between gender demographic characteristics and educational history with opinions about the practice of unused drug disposal.

Page 63 of 81 | Total Record : 808

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Home Page

OAI Link

Editorial Team

Contact

Reviewer

Google Scholar

Contact Name Muhammad Syahrir

Contact Email m.syahrir7406@unm.ac.id

Phone -

Journal Mail Official nurkhasanah@pharm.uad.ac.id

Editorial Address Jl. Prof. Dr. Soepomo, S.H., Janturan, Warungboto, Umbulharjo, Yogyakarta, Indonesia Kode pos 55164

Location Kota yogyakarta, Daerah istimewa yogyakarta INDONESIA

Abstract

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Abstract

Contact Name
Muhammad Syahrir

Contact Email
m.syahrir7406@unm.ac.id

Phone
-

Journal Mail Official
nurkhasanah@pharm.uad.ac.id

Editorial Address
Jl. Prof. Dr. Soepomo, S.H., Janturan, Warungboto, Umbulharjo, Yogyakarta, Indonesia Kode pos 55164

Location
Kota yogyakarta,

Daerah istimewa yogyakarta

INDONESIA