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Media Farmasi : Jurnal Ilmu Farmasi (Journal Of Pharmaceutical Science)
Published by Universitas Ahmad Dahlan
ISSN : 14127946     EISSN : 25035223     DOI : 10.12928
Core Subject : Health, Science,
Chemistry Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology
Media Farmasi is a scientific journal published by the University of Ahmad Dahlan worked closely with Ikatan Apoteker Indonesia (IAI). Media Farmasi published two times a year, namely in March and September since 2002 with ISSN 1412-7946 and e-ISSN 2503-5223. The article published in the Journal Media Farmasi selected by editors and reviewed by the reviewer. Articles published in Media Farmasi must not be published in other journals or have been previously published. Media Farmasi publishes a review article, original article, as well as short communication in all scopes of Pharmaceutical Science.
Arjuna Subject : -
Articles 455 Documents
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In Vitro Antibacterial Activity of Ethanolic Extract of Pasak Bumi (Eurycoma longifolia) root against Streptococcus Pyogenes Naulita Turnip, Oktaviani; Urdha, Adyatma; Teresa, Astrid; Nawan, Nawan; Arleny, Ina
Media Farmasi: Jurnal Ilmu Farmasi Vol. 23 No. 1 (2026): March 2026
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/mf.v23i1.31803

Abstract

Infectious diseases remain a major public health concern in Indonesia, particularly upper respiratory tract infections such as pharyngitis caused by Streptococcus pyogenes. The increasing incidence of antibiotic resistance highlights the need for alternative antimicrobial agents from natural sources. Eurycoma longifolia (pasak bumi) is a medicinal plant known to contain bioactive compounds with potential antibacterial properties. This study aimed to evaluate the in vitro antibacterial activity of Eurycoma longifolia root extract against Streptococcus pyogenes. This study used a true experimental design with a post-test only control group. Antibacterial activity was tested using the disc diffusion method on Mueller Hinton Agar (MHA). Seven groups were tested: five extract concentrations (5%, 10%, 15%, 25%, and 50%), a positive control (erythromycin), and a negative control (aquades). Data were analysed using one-way ANOVA (p < 0.05). The extraction yielded 2.67% extract. The results showed inhibition zone diameters of 0 mm (negative control) and 22.35 mm (positive control). The extract exhibited inhibition zones of 2.0 mm, 3.25 mm, 3.5 mm, 3.75 mm, and 5.42 mm at concentrations of 5%, 10%, 15%, 25%, and 50%, respectively. Statistical analysis indicated significant differences among treatment groups. In conclusion, Eurycoma longifolia root extract demonstrated concentration-dependent antibacterial activity against Streptococcus pyogenes, with effects classified as weak to moderate. These findings suggest its potential as a natural antibacterial agent, although further studies are needed to optimize its efficacy.
Bioinformatics Study of Virulence Factors of Gastrointestinal Pathogens Clostridioides Difficile, Salmonella Enterica, and Enterococcus Faecalis Targeted by Apigenin Alif, Muhammad; Sri Martani, Natalia; Ka Praja, Rian
Media Farmasi: Jurnal Ilmu Farmasi Vol. 23 No. 1 (2026): March 2026
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/mf.v23i1.31811

Abstract

Apigenin is a naturally occurring flavonoid widely reported to possess antioxidant and antibacterial activities. Recent studies suggest that apigenin may act as an anti-virulence agent by targeting bacterial proteins involved in pathogenicity rather than directly killing bacterial cells. However, molecular interactions between apigenin and virulence-associated proteins of gastrointestinal pathogens have not been comprehensively explored using bioinformatics-based approaches. This study aimed to analyze and identify virulence-related proteins of Clostridioides difficile 630, Salmonella enterica CT18, and Enterococcus faecalis V583 that are potentially targeted by apigenin through a bioinformatics approach. Protein–compound interaction networks were constructed using STITCH v5.0, followed by functional classification and virulence prediction using VICMPred and VirulentPred. Immunogenic properties of the identified proteins were evaluated through B-cell epitope prediction and major histocompatibility complex class I and II binding analyses, while subcellular localization was predicted using PSORTb v3.0. The results demonstrated that apigenin interacted with ten proteins in each bacterial species, predominantly involving ATP-binding cassette transporters, membrane biosynthesis enzymes such as FabZ, catalase, and regulatory proteins associated with bacterial survival and adaptation. Epitope analysis revealed that all identified virulence-associated proteins contained high-scoring immunogenic regions, while subcellular localization analysis indicated that most proteins were localized in the cytoplasmic membrane, suggesting accessibility to small-molecule targeting. These findings suggest that apigenin has the potential to interact with key virulence-associated proteins of major gastrointestinal pathogens through molecular interaction–based mechanisms. Nevertheless, further experimental validation is required to confirm the biological relevance and mechanistic actions of apigenin.
Computational Design of Multi-Epitope Vaccine Candidates Targeting Reelin-Mediated Brain Metastases in HER2-Positive Breast Cancer Setiawan, Tirta; Asagabaldan, Meezan Ardhanu; alvionita, Mika
Media Farmasi: Jurnal Ilmu Farmasi Vol. 23 No. 1 (2026): March 2026
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/mf.v23i1.31824

Abstract

Brain metastases represent a critical clinical challenge in HER2-positive breast cancer (HER2+ BC), accounting for a disproportionately high share of disease-related mortality. Emerging evidence implicates Reelin protein (RELN) overexpression in facilitating blood-brain barrier penetration and cerebral colonization by HER2+ tumor cells, positioning RELN as a mechanistically relevant vaccine target. However, no prior studies have explored RELN-derived epitopes as vaccine candidates for this indication. Using an integrated immunoinformatic approach combining the Kolaskar-Tongaonkar antigenicity algorithm, ElliPro conformational epitope prediction, and NetCTL 1.2 cytotoxic T lymphocyte (CTL) prediction. We systematically characterized the epitope landscape of the RELN RR5-6 domain (725 residues; GenBank ID: 291463430). We identified twenty linear B-cell epitopes, four conformational B-cell epitopes (highest PI score: 0.999), and eleven CTL epitopes with prediction scores exceeding 0.75. Molecular docking of all CTL epitopes against HLA-A*02:01 (MHC class I) via PatchDock and FireDock yielded global binding energies ranging from −17.16 to −54.19 kcal/mol; CTL-epitope1 (47EEDSAMVFV55) demonstrated the most favorable binding energy (−54.19 kcal/mol), with critical interactions mediated by MHC residues Q155 and T73. Seven epitopes overlapped between B-cell and CTL predictions, suggesting potential for multi-arm immune activation. These findings provide a computational framework to prioritize RELN-derived candidates for in vitro and in vivo experimental validation, with translational implications for prophylactic and therapeutic vaccination strategies in HER2+ breast cancer brain metastases.
Impact of Technical Requirements Shifts for Salicylic Acid on Cost Structure and Product Quality in Cosmetic Companies Hasryani, Waode; Aliza Putriana, Aliza Putriana; Amalia, Eri
Media Farmasi: Jurnal Ilmu Farmasi Vol. 23 No. 1 (2026): March 2026
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/mf.v23i1.31888

Abstract

The strengthening of technical requirements for cosmetic ingredients represents an important regulatory development affecting the cosmetics industry. Salicylic acid, a widely used active ingredient in skincare formulations, is increasingly subject to stricter specifications related to purity, heavy metal contamination, and microbiological quality. This study aims to analyze the impact of enhanced technical requirements for salicylic acid on production costs and product quality in cosmetic manufacturing. The study was conducted using a literature review combined with a regulatory impact analysis based on secondary data from scientific publications, regulatory documents, and comparative market reports related to salicylic acid specifications and pricing. Relevant literature was identified through database searches in Google Scholar, Scopus, and PubMed using keywords such as “salicylic acid,” “cosmetic regulation,” “ingredient specification,” and “cosmetic ingredient safety.” Publications from 2010 to 2024 were considered. Sources were selected based on their relevance to regulatory standards, ingredient quality specifications, and cost implications in cosmetic manufacturing. The analysis indicates that pharmaceutical-grade salicylic acid meeting contemporary specifications may increase raw material costs by approximately 15–35% compared with technical-grade materials. Additional operational costs arise from stricter testing requirements and supplier qualification processes. However, enhanced specifications also contribute to improved product quality, including reduced heavy metal contamination, better microbiological safety, and improved batch consistency. Overall, the regulatory transition creates both compliance challenges and opportunities for the cosmetics industry. While higher standards may increase production costs, improved ingredient quality can enhance product safety and support market differentiation in quality-oriented consumer segments.
Integrative PharmGKB and GTEx Analysis Identifies Candidate Pharmacogenomic Biomarkers of Toxicity in Thyroid Cancer Therapy Rahmawati, Desti; Muhammad Irham, Lalu; Adikusuma, Wirawan; Lolita, Lolita; Gustinanda, Rizky; Chong, Rockie; Ates, Ilker; Dewi Tamayanti, Wahyu; Dani Satria, Rahmat
Media Farmasi: Jurnal Ilmu Farmasi Vol. 23 No. 1 (2026): March 2026
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/mf.v23i1.31952

Abstract

Systemic therapies such as Lenvatinib and radioiodine in thyroid cancer (TC) show promising clinical efficacy, but often cause significant toxicity. Interindividual variability in response to this toxicity is largely influenced by genetic factors, requiring a pharmacogenomic approach to accurately identify predictive biomarkers. This study aims to integrate pharmacogenomic and bioinformatics strategies in identifying genetic variants associated with the risk of TC therapy toxicity. The research method involved a systematic search of the PharmGKB database using the keyword “Thyroid Cancer.” The selection results were filtered based on clinical pharmacogenomic relevance and ESMO therapy guidelines. Only gene-drug pairs with Level of Evidence (LOE) 1A to 3 were included. Furthermore, genetic variant data were analyzed bioinformatically based on tissue expression profiles and biological relevance. The results of the study of three main systemic therapies (lenvatinib, sorafenib, and radioiodine) identified two biomarkers with LOE level 3: the rs776746 (CYP3A5) variant associated with lenvatinib toxicity, and rs620815 (ATM) associated with gastrointestinal toxicity due to radioiodine. Tissue expression analysis showed CYP3A5 to be dominant in the liver and intestines, supporting its role in drug metabolism, while ATM was widely expressed and involved in DNA repair. Both genes have potential as predictive biomarkers of TC therapy toxicity. This study demonstrates that the integration of pharmacogenomic and bioinformatics approaches can identify potential genetic biomarkers contributing to the risk of TC therapy toxicity. These findings strengthen the basis for the application of genetic-based precision medicine in optimizing the safety and individualization of TC therapy.

Page 46 of 46 | Total Record : 455

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