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Media Farmasi : Jurnal Ilmu Farmasi (Journal Of Pharmaceutical Science)
Published by Universitas Ahmad Dahlan
ISSN : 14127946     EISSN : 25035223     DOI : 10.12928
Core Subject : Health, Science,
Chemistry Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology
Media Farmasi is a scientific journal published by the University of Ahmad Dahlan worked closely with Ikatan Apoteker Indonesia (IAI). Media Farmasi published two times a year, namely in March and September since 2002 with ISSN 1412-7946 and e-ISSN 2503-5223. The article published in the Journal Media Farmasi selected by editors and reviewed by the reviewer. Articles published in Media Farmasi must not be published in other journals or have been previously published. Media Farmasi publishes a review article, original article, as well as short communication in all scopes of Pharmaceutical Science.
Arjuna Subject : -
Articles 455 Documents
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Antibacterial activity of ethyl acetate extracts of fungal endophytes isolated from leaf gambir leaves (Uncaria gambir (Hunter) Roxb) Efendi, M. Rifqi; Rusdi, Mesa Sukmadani; Dinda, Anita
Media Farmasi: Jurnal Ilmu Farmasi Vol. 19 No. 1: March 2022
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/mf.v19i1.20483

Abstract

Gambir (Uncaria gambir (Hunter) Roxb) is a Sumatran medicinal plant that has various bioactivities, including antibacterial. This study aims to isolate endophytic fungi from gambier leaves and test the antibacterial activity of ethyl acetate extracts of fungal endophytes from gambir leaves. The fungal endophytes were isolated by inoculating the fungus obtained from gambir leaves on potato dextrose agar (PDA) media. The fungal endophytes were identified microscopically and macroscopically. Furthermore, the fungal endophytes were cultivated using rice media : aquades (100 : 110). The cultivated fungus was macerated using ethyl acetate solvent and tested using a screening test. The antibacterial activity of the ethyl acetate extract of endophytic fungi was conducted using the agar diffusion method against Gram-positive bacteria (Bacillus subtilis ATCC 6633 and Staphylococcus aureus ATCC 25923) and Gram-negative bacteria (Escherichia coli ATCC 25922 and Pseudomonas aeruginosa ATCC 27853). This study has revealed five fungal isolates from gambir leaves and identified the isolates as Penicillium sp 1 (0.39 g), Penicillium sp 2 (0.26 g), Neopestalotiopsis sp (0.97 g), Colletotrichum capsici (0.46 g), and Aspergillus sp (0.25 g). The ethyl acetate extracts of each fungal endophyte show the presence of phenolic compounds and have inhibition against Gram-positive and Gram-negative bacteria. The highest antibacterial activity is shown by ethyl acetate extracts of the fungal endophytes of Neopestalotiopsis sp at a concentration of 7.5% on P. aeruginosa ATCC 27853 23±3.9 mm and S. aureus ATCC 25923 14±2.5 mm. Tests on B. subtilis ATCC 6633 and E. coli ATCC 25922 with the highest inhibition zones were indicated by the ethyl acetate extracts of the fungus Aspergillus sp of 15.3±4 mm and 14±1.9 mm, respectively.
A comparison study between single aspirin antiplatelet and single clopidogrel antiplatelet on average period of recurrent stroke dr. Sayidiman Magetan Raising, Rahmawati; Hermawatiningsih, Oktaviarika Dewi; Qibtiah, Devi Mariatul
Media Farmasi: Jurnal Ilmu Farmasi Vol. 19 No. 1: March 2022
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/mf.v19i1.20639

Abstract

Stroke is a common neurological disease that rapidly develops clinical signs of focal and global neurological deficits, lasts 24 hours or more, and leads to death. The danger that threatens stroke sufferers is recurrent strokes which can be fatal and result in a worse quality of life than the first attack. This condition indicates that the effect of antiplatelet drugs is not strong, or called antiplatelet resistance. Antiplatelet is a blood thinner used by stroke sufferers to prevent blood clots and treat the narrowing blood vessels in the legs, namely in peripheral artery disease. This research aims to compare single aspirin antiplatelet and single clopidogrel antiplatelet on the average period of recurrent stroke. This observational research employed a cross-sectional approach by processing the medical record data of stroke patients from 2018 to 2020 at dr. Sayidiman Magetan Regional Public Hospital. The obtained data were then analyzed and concluded. The results show that the mean duration of recurrent stroke on aspirin antiplatelet use is 357.88. Meanwhile, the mean duration of recurrent stroke in the antiplatelet clopidogrel is 138.59 days. Moreover, there is a significant difference between the use of a single aspirin antiplatelet and single clopidogrel antiplatelet on the duration of recurrent stroke with a p-value of 0.000.
Toxicity test of Kedayan root infusion (Aristolochia sp.) using brine shrimp lethality test method Syuhada, Syuhada; Rukaya, Benazir Evita; Setiawan, Budi
Media Farmasi: Jurnal Ilmu Farmasi Vol. 19 No. 2: September 2022
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/mf.v19i2.21045

Abstract

Kedayan roots are still used by the Lundayeh Dayak people as traditional medicine. This plant is one of the Aristolochia sp. species whose production and distribution as traditional medicine or food supplements are prohibited by the Food and Drug Supervisory Agency of the Republic of Indonesia because it has side effects that are harmful to the body. The purpose of this study was to determine the toxicity of kedayan root infusion using the Brine Shrimp Lethality Test (BSLT) method based on the LC50 value. Toxicity test was carried out by varying the concentration of Kedayan root infusion, namely 100, 500, and 1000 ppm, as an intervention against Artemia salina Leach with a negative control in the form of 2.8% saline solution for 24 hours with 3 replications, then observing the presence or absence of movement of Artemia salina L. Larvae. Test results data in the form of % mortality obtained, then analyzed using the probit regression analysis method to determine the LC50 value. The results of this study indicate that the kedayan root infusion has very high toxicity, the LC50 value is 101.9278 ppm.
The relationship level of community's knowledge and attitude toward the use of antibiotics in Gandaria, South Jakarta Teodhora, Teodhora; Maliawati, Eka Putri
Media Farmasi: Jurnal Ilmu Farmasi Vol. 20 No. 1: March 2023
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/mf.v20i1.21117

Abstract

Antibiotics will be beneficial and have the anticipated therapeutic effect if prescribed and administered as instructed. The purpose of this study was to evaluate community attitudes and knowledge levels regarding the use of antibiotics, as well as the relationship between these two variables. The sample size for this descriptive-analytic study was 95 respondents, and a cross-sectional design was used. The sampling technique utilized was purposeful sampling. Women made up the bulk of responses (65.3%), and their age range was 36 to 45 (44.2%). The latest educational levels indicated were high school (61.1%), antibiotic use in the past or present (100%), and housewife (38.1%). The respondent received scores of 62.1% for "excellent" knowledge, 3.5% for "adequate" learning, and 7.4% for "poor" expertise. In contrast, there were 0.0% of participants in a horrible disposition, 52.6% with an acceptable attitude, and 47.4% with an excellent attitude. The Chi-Square test findings showed a significant value of 0.097, or more significant than 0.05, between the variable amount of knowledge and attitudes against antibiotics. The p-value (> 0.05) indicates no correlation between the level of competence and perspectives regarding the use of antibiotics. Education, knowledge, and attitudes toward antibiotics were found to be correlated, with a p-value of (0.05). It was determined that the local population had a good and insightful understanding of antibiotics.   
EFEK ANTIINFLAMASI NANOPARTIKEL KITOSAN-EKSTRAK KERING TERIPANG (Stichopus variegatus) SECARA IN VITRO DAN IN VIVO Hermawati, Ema; Abdillah, Syamsudin; Rahmat, Deni
Media Farmasi: Jurnal Ilmu Farmasi Vol. 18 No. 2: September 2021
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/mf.v18i2.21448

Abstract

Ekstrak teripang mengandung glukosamin yang berpotensi dapat menekan peradangan (inflamasi) dan menyembuhkan osteoarthritis. Penelitian ini bertujuan untuk menguji  aktivitas antiinflamasi secara in vitro dan in vivo dari nanopartikel kitosan-ekstrak kering teripang (Stichopus variegatus). Aktivitas antiinflamasi secara in vitro dilakukan dengan metode denaturasi protein Bovine Serum Albumin (BSA). Aktivitas antiinflamasi secara in vivo dilakukan dengan metode induksi karagenan pada telapak kaki tikus dengan parameter pengukuran edema kaki. Penelitian ini menggunakan tikus putih jantan galur Sprague-Dawley dan dibagi menjadi 4 kelompok yaitu kelompok yang diberi nanopartikel kitosan-ekstrak teripang kering dosis 50 mg/KgBB dan 100 mg/Kg BB, kelompok kontrol negatif (aquadest) serta kelompok kontrol positif (natrium diklofenak). Hasilnya menunjukkan bahwa sampel nanopartikel memiliki aktivitas antiinflamasi secara in vitro dengan nilai IC50 sebesar 267,76 bpj. Nanopartikel kitosan-ekstrak teripang kering dosis 50 mg/Kg BB dan 100 mg/KgBB memiliki aktivitas antiinflamasi dengan nilai persentase penghambatan inflamasi secara berturut-turut sebesar 53,37%, dan 49,95 %. Adapun nilai ED50 yaitu sebesar 99,27 mg/KgBB.
AKTIVITAS ANTIBAKTERI DAN BIOAUTOGRAFI EKSTRAK DAUN RAMBUSA (Passiflora foetida L) TERHADAP Pseudomonas aeruginosa-Klebsiella pneumoniae Sari, Ghani Nurfiana Fadma; Puspitasari, Ismi
Media Farmasi: Jurnal Ilmu Farmasi Vol. 18 No. 2: September 2021
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/mf.v18i2.21537

Abstract

Daun rambusa (Passiflora foetida L.) mempunyai khasiat sebagai antioksidan, antidiabetes dan antikolesterol, akan tetapi masih belum banyak informasi ilmiah tentang potensi daun rambusa sebagai antibakteri. Penelitian ini bertujuan untuk mengetahui golongan senyawa aktif dan aktivitas antibakteri dari ekstrak daun rambusa secara difusi. Daun rambusa diekstraksi secara maserasi menggunakan etanol 96%. Ekstrak yang diperoleh kemudian diidentifikasi kandungan golongan senyawa aktif menggunakan KLT-Bioautografi dan diuji aktivitas antibakteri dengan konsentrasi 20%, 40% dan 60% menggunakan metode difusi agar. Kontrol positif yang digunakan adalah kloramfenikol 0,1% dan kontrol negatif menggunakan DMSO 5%. Hasil penelitian menunjukkan bahwa ekstrak etanol daun rambusa efektif menghambat aktivitas bakteri Klebsiella pneumonia dan Pseudomonas aeruginosa. Konsentrasi ekstrak yang paling besar zona hambatnya yaitu konsentrasi 60% yang dikategorikan kuat. Pengujian aktivitas antibakteri dilakukan dengan metode bioautografi kontak hasilnya menunjukkan terdapat bercak pada kromatogram KLT yang menghasilkan zona hambat. Karakterisasi bercak dilakukan dengan penampak bercak AlCl3 dan diduga bahwa bercak tersebut flavonoid. 
A study of hemodynamic medicine use in intensive cardiac care unit of dr. Soedarso regional public hospital, Pontianak Rizkifani, Shoma; Khairunnisa, Intan; Untari, Eka Kartika
Media Farmasi: Jurnal Ilmu Farmasi Vol. 19 No. 1: March 2022
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/mf.v19i1.21538

Abstract

Hemodynamic medicines are important to recover patients with a critical period in the ICCU. Hemodynamic medicines have a small range of dose so that it has a large effect on the therapy. Therefore, a study on the use of hemodynamic medicines and doses is necessarily conducted. This study aims to investigate the use and doses of hemodynamic medicines administered to patients in the ICCU of dr. Soedarso Hospital Pontianak. This study is observational research with a descriptive cross-sectional design. The research sample was 49 patients who had met the inclusion criteria. The data were analyzed descriptively to describe the frequency and percentage. The results show that a single hemodynamic medicine is administered to 65% of the patients and a combination of hemodynamic medicines is administered to 35% of the patients. The single medicine refers to dobutamine administered to 84.4% of the patients. Meanwhile, the combination of hemodynamic medicines consists of dobutamine and norepinephrine that are administered to 52.9% of the patients. The doses of hemodynamic medicines frequently administered to patients are 3-5 μg/kg/min dobutamine, 3-10 μg/kg/min dopamine, 0.01-2-2 μg/kg/min norepinephrine, and 1 mg/ml epinephrine. This study concludes that dobutamine (inotropic) is the most frequently used single hemodynamic medicine, and norepinephrine (vasopressor) is the most frequently used combined hemodynamic medicine for the ICCU patients at dr. Soedarso Regional Public Hospital, Pontianak.
Direct medical cost of metformin and metformin-glimepiride in type 2 diabetes mellitus patients Sulastri, Sulastri; Hadiq, Shabran; Supadmi, Woro; Perwitasari, Dyah Aryani
Media Farmasi: Jurnal Ilmu Farmasi Vol. 19 No. 2: September 2022
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/mf.v19i2.21588

Abstract

Diabetes mellitus (DM) requires long-term therapy. Selection of the right therapy was very important to provide optimal results at an affordable cost. One of the main standards of oral antidiabetic therapy prescribed for type 2 DM (T2DM) is metformin, either alone or in combination therapy. The purpose of this study was to describe the direct medical costs in type 2 DM patients between metformin and metformin-glimepiride therapy. This research was an observational and descriptive. Demographic and clinical data were taken prospectively from the complete medical records of data patients with the main diagnosis of DM who fulfilled the inclusion criteria in the period January 2019–November 2020 at RSU Nene Mallomo Sidenreng Rappang, South Sulawesi and the two Public Health Centers namely Puskesmas Galur. II and Panjatan II Kulon Progo Yogyakarta. Cost data includes total medical costs from the hospital/ healthcare perspective (cost of drugs, doctor's services and checkups, fees for checking Fasting Blood Glucose/ Gula darah Puasa (GDP) and Blood Glucose Level While/ Gula Darah Sewaktu (GDS)) and total costs from the Badan Penyelenggara Jaminan Sosial (BPJS)/ payer perspective (INA-CBG's rates) were covered by insurance. The results showed that the average direct medical costs at the hospital and the two Public Health Centers respectively were metformin therapy in IDR (Indonesian Rupiah) namely IDR 120.736 and IDR 9.072,- and metformin-glimepiride therapy of IDR 126.298,- and IDR 18.634,-. It can be concluded that the average direct medical cost of metformin therapy is lower than metformin-glimepiride therapy.
Cost-effectiveness analysis of metformin and metformin-glimepiride in patients with type 2 diabetes at nene mallomo sidrap general hospital Hadiq, Shabran; Supadmi, Woro; Perwitasari, Dyah Aryani
Media Farmasi: Jurnal Ilmu Farmasi Vol. 19 No. 2: September 2022
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/mf.v19i2.21608

Abstract

Metformin and metformin-glimepiride are cost-effective therapy options and are most commonly prescribed to treat type 2 diabetes mellitus (DM). This study aims to determine the cost-effectiveness of using metformin and metformin-glimepiride in patients with type 2 DM at Nene Mallomo Sidenreng Rappang General Hospital. This analytical descriptive observational research employed a retrospective cohort design. The data of type 2 DM patients, new and old patients, were obtained from the medical record unit. The target population was data of outpatients for the period January-December 2019. The parameter of the therapeutic effectiveness is the random blood sugar levels of the patients after receiving treatment. The data on cost from the hospital perspective were obtained from the administration and finance unit. Cost-effectiveness analysis employed calculations of the average cost-effectiveness ratio (ACER) and the incremental cost-effectiveness ratio (ICER). Meanwhile, the risk ratio (RR) employed the analytical chi-squared method to determine the relationship between the two types of therapies and their effectiveness. This study has revealed that 30 patients met the inclusion criteria; 14 patients received metformin therapy and 16 patients received metformin-glimepiride therapy. Metformin therapy is more effective (64.29%) and more costly (IDR120,736). The metformin's ACER value is 1877.99, and its ICER value is -3107.26. The cost-effectiveness analysis has revealed that metformin therapy is more cost-effective than metformin-glimepiride therapy. Meanwhile, the chi-squared analysis has discovered no relationship between the two therapies and their effectiveness. The RR value of 1.080 concludes that metformin has 1.080 as much therapeutic effectiveness as the metformin-glimepiride.
Formulation of self-nano emulsifying drug delivery system (SNEDDS) Red Ginger extract (Zingiber Officinale var. rubrum) Erliyana, Mila; Widyaningsih, Wahyu; Wumu, Dea Anggrainy; Wulansari, Widyanari Febriyana
Media Farmasi: Jurnal Ilmu Farmasi Vol. 19 No. 2: September 2022
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/mf.v19i2.21655

Abstract

Red ginger extract is one of the new medicinal discoveries made from natural substances that has pharmacological benefits in the treatment of diabetes. Many gingerol components in red ginger can aid in the treatment of diabetes mellitus. However, the administration of red ginger extract is not so effective, a delivery system such as SNEDDS (Self-Nano Emulsifying Drug Delivery System) must be developed. When compared to standard formulations, SNEDDS can boost the oral bioavailability of lipophilic medicines by up to 2.4 times. The oil phase of SNEDDS red ginger extract was virgin coconut oil, with tween 80 as a surfactant and PEG 400 as a co-surfactant. The fourth formula of the SNEDSS preparation of red ginger rhizome extract satisfied the requirements for a good nanoemulsion particle size in this study, with a percent T value of 99.7% and PSA test data showing that this formulation met the requirements for a good nanoemulsion particle size

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