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Media Farmasi : Jurnal Ilmu Farmasi (Journal Of Pharmaceutical Science)
Published by Universitas Ahmad Dahlan
ISSN : 14127946     EISSN : 25035223     DOI : 10.12928
Core Subject : Health, Science,
Chemistry Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology
Media Farmasi is a scientific journal published by the University of Ahmad Dahlan worked closely with Ikatan Apoteker Indonesia (IAI). Media Farmasi published two times a year, namely in March and September since 2002 with ISSN 1412-7946 and e-ISSN 2503-5223. The article published in the Journal Media Farmasi selected by editors and reviewed by the reviewer. Articles published in Media Farmasi must not be published in other journals or have been previously published. Media Farmasi publishes a review article, original article, as well as short communication in all scopes of Pharmaceutical Science.
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Articles 445 Documents
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UJI AKTIVITAS ANTIOKSIDAN DAN SPF (Sun Protection Factor) LENDIR BEKICOT (Achatina fulica) MENGGUNAKAN SPEKTROFOTOMETER UV-VIS Suhesti, Iin; Setiyanto, Riyan; Islami, Nabila Nurhaliza; Anggia, Cinti
Media Farmasi: Jurnal Ilmu Farmasi Vol. 18 No. 2: September 2021
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/mf.v18i2.21849

Abstract

Hewan bekicot (Achatina fulica) banyak dimanfaatkan sebagai pengobatan tradisional dan kosmetik karena mengandung protein achasin, acharan sulfat, zat beta aglutinin, asam hialuronat, enzim glikoprotein, proteoglycan, glycosaminoglycan dan allantoin. Tujuan penelitian ini yaitu untuk mengetahui aktivitas antioksidan dan tabir surya pada lendir bekicot menggunakan spektrofotometer uv-vis. Metode penelitian ini adalah eksperimental, menggunakan sampel lendir bekicot dengan konsentrasi 5%, 10%, dan 15%. Hasil skrining fitokimia diperoleh bahwa lendir bekicot mengandung senyawa metabolit sekunder berupa alkaloid, fenol, saponin, dan tanin. Berdasarkan hasil penelitian, aktivitas antioksidan lendir bekicot pada konsentrasi 5%, 10%, dan 15% memiliki nilai IC50 berturut-turut yaitu 83,63 ± 0,57 ppm; 57,93 ± 0,82 ppm; dan 31,59 ± 0,59 ppm dengan kategori kuat (IC50 50-100 ppm) dan kategori sangat kuat (IC50 < 50 ppm). Nilai SPF diperoleh berturut-turut yaitu 14,77 ± 0,42; 21,67 ± 0,06 dan 27,67± 0,59 dengan tipe proteksi maksimal (SPF 8-15) dan tipe proteksi ultra (SPF > 15). Berdasarkan analisis SPSS menggunakan One Way Anova diketahui bahwa variasi konsentrasi lendir bekicot berpengaruh signifikan terhadap hasil aktivitas antioksidan dan tabir surya sehingga dapat disimpulkan bahwa lendir bekicot memiliki aktivitas antioksidan yang dapat mencegah terbentuknya senyawa radikal bebas pada kulit dari dalam dan aktivitas tabir surya yang dapat melindungi kulit dari luar akibat radiasi sinar UV yang dipaparkan pada kulit setiap hari.
Antibacterial activity of Sappan (Caesalpinia sappan L.) wood methanol extract against Staphylococcus epidermidis Atunnisa, Waro; Zamzani, Irfan; Nashihah, Siti
Media Farmasi: Jurnal Ilmu Farmasi Vol. 20 No. 1: March 2023
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/mf.v20i1.21900

Abstract

The entry and proliferation of microorganisms, such as bacteria, cause skin infections. One of the bacteria that causes skin infections is Staphylococcus epidermidis. Sappan (Caesalpinia sappan L.) wood has been known to have various pharmacology activities, one of which is antibacterial, so its activities need to be developed and improved. This study aimed to determine the activity of the methanol extract of Sappan (C. sappan L.) wood as an antibacterial against S. epidermidis. This research was conducted by extracting Sappan wood powder with 96% methanol as solvent using the Ultrasound-Assisted Extraction (UAE) method and testing for antibacterial activity with concentrations of 25%, 50%, 75% and 100% using the disc method. Results showed that the methanol extract of Sappan wood had an antibacterial activity; the highest inhibition zone at a concentration of 75% was 29.25 mm. Sappan wood was expected to be a promising alternative therapy for overcoming acne problems and can increase economic value for the wider community. 
Validity and reliability of the Indonesian Version of HIV-KQ-18 in assessing public knowledge about HIV/AIDS in the special region of Yogyakarta Kurniawan, Muh. Deni; Arifin, Bustanul; Rokhman, M. Rifqi; Perwitasari, Dyah Aryani
Media Farmasi: Jurnal Ilmu Farmasi Vol. 19 No. 2: September 2022
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/mf.v19i2.22107

Abstract

An assessment of public knowledge about HIV/AIDS is necessary for the development of educational strategies and materials. A valid and reliable instrument is needed to obtain comparable assessment of public knowledge about HIV/AIDS from time to time. This research study aims to determine the validity and reliability of the Indonesian version of HIV-KQ-18 in assessing public knowledge about HIV/AIDS in the Special Region of Yogyakarta. This research study used a cross-sectional design with the inclusion criteria being people living in Yogyakarta who were at least 18 years old and the exclusion criteria being respondents who did not fill out the instrument completely and did not fill out duplicate forms from the same respondent. The instrument was analyzed using product-moment correlation and known-group validity, while its reliability was tested using Kuder-Richardson Formula 20 (KR20). The total number of respondents as the subjects in this research study was 305. The results of the validity test of the HIV-KQ-18 obtained an r-xy value from 0.177-.564, greater than r-table (0.112), and the HIV-KQ-18 instrument exhibited high reliability with a KR20 value of 0.763. The test of known-groups validity showed that there were significant differences in all groups tested, except for the group based on age. The HIV-KQ-18 is a valid and reliable instrument and it can be used to assess public knowledge about HIV/AIDS in the Special Region of Yogyakarta.
Formulation and anti-bacterial of liquid soap combination of Citronella (Cymbopogon nardus L. Rendle), Cinnamon (Cinnamomum burmanni Ness Ex Bi.), and Orange Lemon (Citrus lemon L.) Essential Oils on Staphylococcus epidermidis Nafisah, Umi; Suhesti, Iin; Albetia, Puput
Media Farmasi: Jurnal Ilmu Farmasi Vol. 19 No. 2: September 2022
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/mf.v19i2.22387

Abstract

The condition of our community in the midst of a pandemic makes us aware of the importance of cleanliness. One way to maintain cleanliness is to clean our self with soap. Cinnamon has antibacterial activity against Staphylococcus aureus and Staphylococcus epidermidis. Lemongrass has antibacterial activity against Staphylococcus aureus, while lemons are able to inhibit the growth of Staphylococcus epidermidis and Propionibacterium acnes bacteria. The aims of this study are to determine the formulation and physical stability of liquid soap with a combination of lemongrass, cinnamon, and lemon essential oils and to determine its antibacterial activity against Staphylococcus epidermidis. Physical evaluation of soap includes organoleptic, homogeneity, viscosity, pH, and specific gravity which is compared with SNI, and hedonic test is performed. Antibacterial test was performed against Staphylococcus epidermidis.The results of the study obtained homogeneous liquid soap preparations, thick liquid form, a yellow-orange color, distinctive smell of citronella. Specific gravity (g/ml) test results meet the requirements of SNI, which is between 1.01 – 1.10 at room temperature. The results of the pH test meet the requirements of SNI, which are between 8 – 11. The results of the viscosity (cPas) test show that there is an increase in viscosity from week 1 to week 6. The increase in viscosity is related to particle size during storage. The foam height (cm) test results obtained F1: 11.76 ± 0.67, F2: 11.67 ± 1.25, F3: 11.33 ± 1.02, F4: 11.60 ± 0.79, F5: 11.18 ± 0.84. The results of the hedonic test obtained that the average respondent liked the foam produced, the shape, color, comfort when used, and the smell. The lowest value of the hedonic test is the smell of the liquid soap that is produced. From the results of antibacterial test against S. Epidermidis, it is known that liquid soap has antibacterial activity with strong inhibitory power.
Quality of life of dengue patients in Panembahan Senopati regional general hospital Wigatiningtyas, Ariska; Perwitasari, Dyah Aryani; Faridah, Imaniar Noor; Dania, Haafizah; Supadmi, Woro
Media Farmasi: Jurnal Ilmu Farmasi Vol. 19 No. 2: September 2022
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/mf.v19i2.22509

Abstract

Yogyakarta is one of the top 10 cities with the highest number of dengue cases in Indonesia. One of the reasons for this is the lack of knowledge about the dengue virus in the community. To find out the quality of life of dengue patients in the Bantul Penembahan Senopati Public Hospital.This research uses the descriptive method with a cross-sectional design. The sampling technique utilized was the purposive sampling method. 18 research subjects were chosen as the sample with an inclusion criteria of patients undergoing inpatient treatment and aged > 4 years of age. This study used the EQ-5D-5L and EQ-5D-Y.The quality of life of 70% of the adult patients experienced pain of EQ-VAS 67 ± 17.191, while all child patients experienced pain of EQ-VAS 54.375 ± 11.783. The quality of life of dengue patients was measured with the EQ-5D-5L for adults and EQ-5D-Y for children and obtained a poor score due to a decrease in the dimension of pain felt and the usual activities done such as working, studying, and playing.
An overview of Covid-19 patients with and without comorbid Diabetes Mellitus at Surabaya Hajj general hospital Hasanah, Uswatun; Darmawan, Endang; Sugiyarto, Sugiyarto
Media Farmasi: Jurnal Ilmu Farmasi Vol. 19 No. 2: September 2022
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/mf.v19i2.23246

Abstract

Diabetes mellitus (DM) is one of the most common comorbidities found in patients infected with Covid-19 with severity and death. To obtain an overview of Covid-19 patients with and without comorbid DM. A retrospective cohort study, taking subjective data on Covid-19 patients with and without DM at Surabaya Hajj general hospital for the period of March 2020 to June 2021. Data analysis using the Chi-square test was to determine differences in both test variables. The death of Covid-19 patients with comorbid DM was found with the condition in which the average random blood glucose (RBG) increased by >150 mg/dl (286 mg/dl), as well as in recovered patients (197 mg/dl); meanwhile, patients without comorbid DM died with also an increase in the RBG value (166 mg/dl). Male patients were found to be more prone to get infected with Covid-19 than female patients. It can be concluded that there was no significant difference in the severity of cases in Covid-19 patients with comorbid DM and without comorbid DM. Deaths due to Covid-19 in patients with comorbid DM or without comorbid DM occurs due to the increasing blood glucose value by >150 mg/dl.
Integration of genomic databases and bioinformatic approach to identify genomic variants for sjogren’s syndrome on multiple continents Puspitaningrum, Anisa Nova; Perwitasari, Dyah Aryani; Adikusuma, Wirawan; Djalilah, Gina Noor; Dania, Haafizah; Maliza, Rita; Faridah, Imaniar Noor; Sarasmita, Made Ary; Rezadhini, Melodia; Cheung, Rocky; Irham, Lalu Muhammad
Media Farmasi: Jurnal Ilmu Farmasi Vol. 19 No. 2: September 2022
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/mf.v19i2.23706

Abstract

An autoimmune disorder is an abnormality that causes a disease. It is caused by a weakened immune system. One of the autoimmune diseases is Sjogren’s syndrome, which affects the salivary and lacrimal glands and causes dry mouth, dry eyes, and dry skin. Sjogren’s syndrome influences humans of every age, with the symptoms occurring at the age of 45–55 years and rarely in children. One of the factors causing Sjogren’s syndrome is genetic disorders. To identify genes that can influence Sjogren’s syndrome in this study, we used several databases, including GWAS Catalog, HaploReg Version 4.1, GTEX portal, and Ensembl, particularly to identify the gene expression profiles of TNIP1, TNFAIP3, and IRF5 and the quantitative properties of locus’ expression. This research showed that the missense variants and splice donor rs2233290, rs2230926, and rs2004640 influenced the susceptibility of autoimmune diseases, especially Sjogren’s syndrome, in the fibroblast tissue, sigmoid tissue, sigmoid colon, skin, esophagus, and adrenal glands. The allele frequency of each variant was then assessed in African, American, European, and Asian populations. Our data showed that TNIP1, TNFAIP3, and IRF5 genes in African and American populations had higher frequencies than in the Asian population. This implies that the last of the aforementioned populations might be relatively susceptible to the autoimmune disease Sjogren’s syndrome.
The level of community knowledge about the use of antibiotics Sugihantoro, Hajar; Munawaroh, Ismea; Inayatillah, Fidia Rizkiah; Indrawijaya, Yen Yen Ari
Media Farmasi: Jurnal Ilmu Farmasi Vol. 20 No. 1: March 2023
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/mf.v20i1.23917

Abstract

Knowledge and use of antibiotics play a large and important role in the success of treatment, so that they do not cause negative effects, such as the cause of antibiotic resistance. The purpose of this study was to determine the profile and level of knowledge of the community regarding the use of antibiotics in Banyior Village, Sepulu District, Bangkalan Regency, East Java, Indonesia. This research is a cross-sectional descriptive study. The measurement is a closed questionnaire. Data were analyzed using SPSS version 18. The survey was conducted from October 2021 to December 2022 on 325 residents of Banyior Village. The result is that the antibiotic most often used by respondents is amoxicillin with a percentage of 47%. The majority of respondents, 45 percent, get antibiotics from drugstores or stalls. The knowledge level of the general public shows a good level of knowledge of 6.82%, an average level of knowledge of 19.60% and a low level of knowledge of 73.57%. The most widely used antibiotic by respondents in this study was amoxicillin, where the most common way to obtain it was through drug stores/stalls and public knowledge of the use of antibiotics was still low.
Standardization of Paku Lindung extract (Pneumatopteris callosa (Blume)) Fauzi, Muh Fajar; Widyaningsih, Wahyu
Media Farmasi: Jurnal Ilmu Farmasi Vol. 21 No. 1: March 2024
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/mf.v21i1.23941

Abstract

The standardization of the paku lindung extract was carried out to obtain new data regarding the standardization of the hedgehog extract which had not previously been established. In addition, this determination is carried out to obtain quality preparations in the form of a guarantee process, that the extract obtained has certain parameter values that are constant after the data has been determined. Extract standardization test includes specific parameters including organoleptic, soluble compounds in certain solvents. Non-specific parameter tests include drying shrinkage, moisture content, ash content, heavy metal contamination, microbial contamination. Chemical content test includes chromatogram pattern, determination of total flavonoid content. The yield of the resulting extract was 13.88±3.19% g. The test results of non-specific parameters include drying shrinkage 0.47±0.01%, moisture content 8.28±0.16%, total ash content 18.97±3.53%, acid insoluble ash content 1.69± 0.02%, total plate number 7.8x104±12.91 colonies/gram, yeast mold number 1x102±0.24 colonies/gram, heavy metal contamination of Cd, Cr and Pb negative and Fe of 73.88 ppm. The results of the specific parameter test include 85.55±4.29% water soluble compounds, 31.27±5.06% ethanol soluble compounds. The results of the chemical content test included the total flavonoid content of 16.6±17.60 mgEQ/g, the Rf value of the extract was the same as the Rf of quercetin with 5 variations of the mobile phase. The test results were carried out to meet the predetermined determination and provide new data on the standardization of the paku lindung extract.
Formulation and Evaluation of Pulp Devitalization Paste Combination of Jatropha Curcas L. and Piper Crocatum Leaves Extract Damarwati, Vella Lailli; Wahid, Rahmat A Hi; Primasari, Dyani; Harimurti, Sabtanti; Labibah, Lana; Syahrani, Syahrani; Krisridwany, Annisa
Media Farmasi: Jurnal Ilmu Farmasi Vol. 19 No. 2: September 2022
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/mf.v19i2.24041

Abstract

Dental caries require operative techniques such as pulp devitalization, but pulp devitalization materials that are often used by dentists have serious adverse effects that need to be considered, such as gingival injury and alveolar bone necrosis. Hence, the aim of the present study was to develop natural ingredients as an alternative to pulp devitalization from a combination of Jatropha curcas (Jatropha curcas L.) and red betel leaf extract (Piper crocatum) in the form of a paste and then conducting physical evaluation tests, Cyclooxygenase-2 (COX-2) tests, and also histopathological picture tests to the sample. The formulation of the pasta sample was carried out by the trituration method.  Formulation I (FI) contained 25% of Jatropha resin, 0.25% red betel leaf extract, and 25% Jatropha resin, 0.5% red betel leaf extract for Formulation II (FII). The paste produced was then evaluated for physical properties which consisted of organoleptic, homogeneity, pH, spreadability, adhesion, and anti-inflammatory power using test animals with COX-2 expression number parameters. The FI and FII treatment groups had met the requirements as paste formula. In the COX-2 expression test, FI has a COX-2 expression percentage value of 0.38% and a COX-2 suppression percentage value of 0.62%, while FII has a COX-2 expression percentage value of 0.59% and a COX-2 expression percentage of 0.59% and suppression of COX-2 of 0.41%. The optimal concentration of the paste formulation is the paste with a combination of 25% jatropha latex and 0.25% red betel leaf extract had been shown to have potential as an alternative to pulp devitalization

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