cover
Article Per Year (5 Year)
All
Home Page
OAI Link
Editorial Team
Contact
Reviewer
Google Scholar
Contact Name
widyasari putranti
Contact Email
widyasari@pharm.uad.ac.id
Phone
-
Journal Mail Official
mediafarmasi@pharm.uad.ac.id
Editorial Address
-
Location
Kota yogyakarta,
Daerah istimewa yogyakarta
INDONESIA
Media Farmasi : Jurnal Ilmu Farmasi (Journal Of Pharmaceutical Science)
Published by Universitas Ahmad Dahlan
ISSN : 14127946     EISSN : 25035223     DOI : 10.12928
Core Subject : Health, Science,
Chemistry Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology
Media Farmasi is a scientific journal published by the University of Ahmad Dahlan worked closely with Ikatan Apoteker Indonesia (IAI). Media Farmasi published two times a year, namely in March and September since 2002 with ISSN 1412-7946 and e-ISSN 2503-5223. The article published in the Journal Media Farmasi selected by editors and reviewed by the reviewer. Articles published in Media Farmasi must not be published in other journals or have been previously published. Media Farmasi publishes a review article, original article, as well as short communication in all scopes of Pharmaceutical Science.
Arjuna Subject : -
Articles 445 Documents
 41   42   43   44   45 
Relationship between Appropriate Antibiotics Used based on 2019 ATS/IDSA Guideline and Clinical Improvement in Inpatient Community Pneumonia Patients Maju, Mensiana Ayu; Setiawan, Christianus Heru
Media Farmasi: Jurnal Ilmu Farmasi Vol. 20 No. 2: September 2023
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/mf.v20i2.24463

Abstract

Community pneumonia is a serious infection obtained from the community environment, and one of the causes is bacteria. This infection causes lung inflammation and leads to death if not treated properly. The appropriate of empirical antibiotics can increase the success of therapy and prevent the emergence of bacterial resistance to various kinds of antibiotics. This study aims to assess the appropriateness of empiric antibiotic selection in community pneumonia using the 2019 ATS/IDSA antibiotic guideline and analyze its relationship with the patient's clinical response. This study is a retrospective cohort design type. Medical record data obtained, namely antibiotics and clinical response, were analyzed using the Mann-Whitney statistical test. There were differences in the average clinical improvement, including body temperature, heart rate, and respiratory rate, in the group of community pneumonia patients who used empiric antibiotics according to the guideline and those who did not follow the guidelines 2019 (P<0.05). According to the result, empiric antibiotics based on the 2019 ATS/IDSA guideline can increase therapy outcomes in inpatient community pneumonia patients.
Antibacterial Activities Of Papaya Seed (Carica papaya L.) Ethanol Extract With MAE And UAE Extraction Methods Towards Staphylococcus aureus Hartanti, Fini; Hidayati, Devi Nisa
Media Farmasi: Jurnal Ilmu Farmasi Vol. 20 No. 2: September 2023
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/mf.v20i2.24704

Abstract

Ethanol extract of papaya seeds produced by the maceration method has been shown to have antibacterial activity against S. aureus, P. aeruginous, S. thypi, and E. coli. This study aims to compare the antibacterial activity of the ethanol extract of papaya seeds obtained using the Microwave Assisted Extraction (MAE) and Ultrasound-Assisted Extraction (UAE) extraction methods on the growth of Staphylococcus aureus bacteria.Papaya seed powder was extracted using MAE and UAE extraction methods using 70% ethanol as a solvent in concentrations of 20%, 40%, 60%, and 80%. DMSO was used as negative control and chloramphenicol 30 g/disk as a positive control. The antibacterial activity test method used the disk diffusion method. The parameter observed was DDH (Diameter of Inhibitory Area) which was statistically analyzed using Two Way Anova at a 95% confidence level.The results showed that the ethanol extract of papaya seeds produced from the MAE and UAE extraction methods had antibacterial activity against Staphylococcus aureus in all concentration series. The statistical test showed a significant difference (p<0.05) in antibacterial activity against Staphylococcus aureus extracts obtained from two extraction methods: MAE and UAE. UAE method is recommended use. 
The potential of Sumbawa Honey (Apis dorsata) As a Natural Antioxidant Yumni, Gharsina Ghaisani; Listiana, Fina; Sari, Septi Puspita; Nadhiroh, Siti; Sumantri, Sumantri
Media Farmasi: Jurnal Ilmu Farmasi Vol. 20 No. 2: September 2023
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/mf.v20i2.24705

Abstract

Honey is a natural ingredient that Indonesian people widely use to maintain a healthy body. One of the benefits of honey is as an antioxidant. This antioxidant activity is influenced by the producing bee, the source plant, and the producing area. This study aims to determine the antioxidant activity of Sumbawa honey originating from NTT. Honey samples were collected and dried using the freeze-drying method and then macerated with 70% ethanol. The viscous extract obtained was then fractionated using a liquid-liquid extraction method using n-hexane, ethyl acetate and ethanol-water as solvents so that the n-hexane (NF), ethyl acetate (EF) and water (WF) fractions were obtained. Each sample was tested for its antioxidant activity using the ABTS method with Trolox as a comparison. The results obtained were ethanol extract, NF, EF and AF had IC50 values respectively 96.054; 106,953; 70,206; and 101,649 g/ml. That indicates that the ethyl acetate fraction has a higher antioxidant activity than other solvents. 
Mapping rheumatoid arthritis susceptibility through integrative bioinformatics and genomics Medi Sushanti, Nining; Adikusuma, Wirawan; Afief, Arief Rahman; La’ah, Anita Silas; Firdayani, Firdayani; Chong, Rockie; Zakaria, Zainul Amiruddin; Purwanto, Barkah Djaka; Satria, Rahmat Dani; Khair, Riat; Septama, Abdi Wira; Irham, Lalu Muhammad
Media Farmasi: Jurnal Ilmu Farmasi Vol. 20 No. 1: March 2023
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/mf.v20i1.24912

Abstract

Rheumatoid arthritis (RA) is an autoimmune disease that influences several organs and tissues, especially the synovial joints, and is associated with multiple genetic and environmental factors. Numerous databases provide information on the relationship between a specific gene and the disease pathogenesis. However, it is important to further prioritize biological risk genes for downstream development and validation.  This study aims to map RA-association genetic variation using genome-wide association study (GWAS) databases and prioritize influential genes in RA pathogenesis based on functional annotations. These functional annotations include missense/nonsense mutations, cis-expression quantitative trait locus (cis-eQTL), overlap knockout mouse phenotype (KMP), protein-protein interaction (PPI), molecular pathway analysis (MPA), and primary immunodeficiency (PID). 119 genetic variants mapped had a potential high risk for RA based on functional scoring. The top eight risk genes of RA are TYK2 and IFNGR2, followed by TNFRSF1A, IL12RB1 and CD40, C5, NCF2, and IL6R. These candidate genes are potential biomarkers for RA that can aid drug discovery and disease diagnosis.
Effect of Red Betel (Piper crocatum) Leaf Ethanol Extract On Increased Creatinine and Ureum Levels In White Rat Wistar Strain Induced Streptozotosin-Nikotinamid Navirius, Franz June; Pamudji, Gunawan; Herowati, Rina
Media Farmasi: Jurnal Ilmu Farmasi Vol. 20 No. 2: September 2023
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/mf.v20i2.25457

Abstract

Red betel (Piper crocatum) is a herbal plant that has various bioactivities including antioxidant activity. Red betel leaf can be used in the treatment of diabetes mellitus and has properties as an antioxidant. This study aims to find the activity of normal levels of creatinine and urea induced by Streptozotosin-Nicotinamide in diabetic rats. Red betel leaves are extracted by soaking in 96% ethanol solvent. Phytochemical screening is used to test the class of compounds in red betel leaf extract using the test tube method. Experimental animals in the study were placed in 6 treatment groups, namely no treatment (CMC 1%), negative control (STZ-NA), positive control (Glibenclamide), dose 1 (125 mg/kg BW), dose 2 (250 mg/kg BW), and dose 3 (500 mg/kg BW). A UV-Vis spectrophotometer was used to measure creatinine and urea on days 24, 31, and 39. One Way ANOVA and Post Hoc Test Multiple Comparisons-Tukey HSD were the data analyzers used. Flavonoids, tannins, saponins and alkaloids were shown from the phytochemical screening. Data analysis showed that the 500 mg/kg BW ethanol extract of red betel leaves was able to produce creatinine and urea better than the 125 mg/kg BW and 250 mg/kg BW ethanol extracts of red betel leaves. This situation is due to red betel leaf extract 500 mg/kg BW Data analysis showed that the 500 mg/kg BW ethanol extract of red betel leaves was able to produce creatinine and urea better than the 125 mg/kg BW and 250 mg/kg BW ethanol extracts of red betel leaves.
Relationship between knowledge and behavior levels of antibiotic usage among pharmacy patients in sub-districts puguh and tegorejo Kendal Sonia, Monica Lita Amay; Al Farizi, Gilang Rizki; Ovikariani, Ovikariani
Media Farmasi: Jurnal Ilmu Farmasi Vol. 20 No. 1: March 2023
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/mf.v20i1.25497

Abstract

Antibiotic resistance is a very serious condition for public health care around the world. This situation is due to improper use of antibiotics that can be affected by self-medication or improper consumption of antibiotics due to lack of knowledge and lack of public awareness of antibiotic use. This study is aimed to determine the relationship of the level of knowledge of the behavior of the use of antibiotics in Pharmacy patients in sub-districts of Puguh and Tegorejo Kendal. This study was an observational study with a cross sectional approach in the research period of May-June 2022. The data collection was carried out by purposive sampling with a total of 130 respondents. The instruments used in the study are structured. Spearman test results showed that there is a relationship with the level of knowledge of antibiotic use behavior (p = <0.05) ; r = 0.549. The conclusion of the study is that there is a relationship between the level of knowledge of antibiotic use behavior in pharmacy patients in sub-districts of Puguh and Tegorejo Kendal.  
In Silico Study of the Potency of Purple Yam Anthocyanin Compounds (Dioscorea alata L.) As MAO-B and COMT Inhibitors in Parkinson's Disease Ramadhan, Muhammad Marwan; Utami, Dwi; Yuliani, Sapto
Media Farmasi: Jurnal Ilmu Farmasi Vol. 21 No. 1: March 2024
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/mf.v21i1.26076

Abstract

The purple yam plant (Dioscorea alata L.) is an economically important staple food for millions of people in tropical and subtropical regions. Dioscorea spp. anthocyanin chemicals have been demonstrated to have antioxidant and neuroprotective properties. The purpose of this study was to explore the potency of anthocyanin compounds in purple yam as antiparkinsonian agents via the monoamine oxidase B (MAO-B) receptor (pdb: 2V5Z) and the catechol-O-methyltransferase (COMT) receptor (pdb: 6I3C) using a molecular docking technique. The study was divided into four stages: (1) pharmacokinetic and Lipinski Rule evaluation, (2) protein (receptor) and ligand preparation, (3) docking method validation, and (4) molecular docking for MAO-B and COMT proteins. Pharmacokinetic prediction and Lipinski rule evaluation revealed that cyanidin, delphinidin, and delphinidin-3-glucoside had an ADMED profile and met Lipinski’s rule. The docking results showed that the binding energy (G) of the compounds cyanidin, delphinidin, and delphinidin-3-glucoside to the MAO-B receptor was lower (-9.50 kcal/mol) than that of the natural ligands ((-4.79 kcal/mol). The Cys172, Leu 171, Ile198, Phe168, Pro104, Trp119 and the 'gatekeeper' residue Ile199 are the amino acids that are majoring involved in MAO-B inhibitors. At the COMT receptor, all the tested compounds had a higher binding energy than native ligands (> -4.79 kcal/mol) except for Cyanidin 3,5-diglucoside (-4.64 kcal/mol). The amino acids Trp143 and Pro174, ensure correct substrate orientation, Mg2+ ions, and cofactor SAM, as well as residues Lys144 and Glu199. In conclusion, this study showed that based on the molecular docking approach, the active compounds of purple yam namely cyanidin, delphinidin, and delphinidin-3-glucoside have the potential to be developed as anti-parkinsonian agents through MAO-B and COMT.
Evaluation of the use of Antibiotics Quantitatively and Qualitatively in Pharyngitis Patients at Banda Sakti Public Health Center Lhokseumawe Yuziani, Yuziani; Sofia, Rizka; Siregar, Fely Syah Imara
Media Farmasi: Jurnal Ilmu Farmasi Vol. 20 No. 2: September 2023
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/mf.v20i2.26122

Abstract

Pharyngitis is inflammation that occurs in the pharynx and often spreads to surrounding tissues which is one of the causes is a bacterial infection. Antibiotics are the main drug of choice for bacterial infection. Evaluation of the use of antibiotics can be done quantitatively and qualitatively. The importance of evaluating the use of antibiotics in pharyngitis patients can reduce drug side effects and prevent resistance. This study's objective was to evaluate if giving antibiotics to pharyngitis patients at Banda Sakti Public Health Lhokseumawe was appropriate, quantitatively using the Defined Daily Dose (DDD) method and qualitatively using the Gyssens method. This research is descriptive. The sampling technique used purposive sampling with a time-limited sampling method. The result showed that the use of antibiotics quantitatively using the DDD method found the highest total DDD was amoxicillin of 10,35 DDD/1000 patients, while the qualitative evaluation using the gyssens method for amoxicillin was classified as category IIIB because the gift was too short, cefadroxil was classified as category IVB because other antibiotics were safer, ciprofloxacin was classified as category V because it is not indicated. This study concludes that the use of antibiotics quantitatively using the DDD method found the highest total DDD was amoxicillin, while the evaluation of the use of antibiotics qualitatively classified inappropriate.
Online Learning Evaluation of Drug Information Service Lectures in The Faculty of Pharmacy, Sanata Dharma University Christasani, Putu Dyana; Wijoyo, Yosef
Media Farmasi: Jurnal Ilmu Farmasi Vol. 20 No. 2: September 2023
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/mf.v20i2.26271

Abstract

The COVID-19 pandemic impacted the need for new adaptations in the learning process, namely by implementing an online learning system. This method remains a trend in the future, so it is necessary to conduct research to evaluate the online lectures. The evaluation process evaluates at the microlevel, namely the process, learning outcomes, and student perceptions of the Drug Information Services course.This research is evaluative and descriptive, with a cross-sectional design and quantitative and qualitative approaches. Research was conducted at the Faculty of Pharmacy, Sanata Dharma University. The respondents were 124 USD Pharmacy S-1 students who took the Drug Information Services course in the odd semester of 2020–2021. Student learning outcomes and perceptions were obtained using validated assessment rubrics and reflection questionnaires.The results showed that the implementation of Drug Information Services lectures went according to the semester learning plan; there were minor revisions to improve the dynamics of student discussions. Students learning outcomes are in the "very good" category, except for the OSCE examination, which is relatively sufficient. Student have a positive perception of this online lecture. In conclusion, this online lecture can be maintained for the future with a slight modification to the oral exam, which uses the offline method by implementing strict health protocols.
Formulation And Evaluation of Preparations Edible Film Combination Gingerol And Curcumin As An Antibacterial Streptococcus pyogenes Causes Of Inflammation Of The Throat Nurdianti, Lusi; Lestari, Tresna; Nurmalasari, Anisa; Wulandari, Winda Trisna; Cahyati, Keni Ida; Setiawan, Fajar; Firmansya, Ardianes
Media Farmasi: Jurnal Ilmu Farmasi Vol. 21 No. 1: March 2024
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/mf.v21i1.27616

Abstract

Jahe (Zingiber officinale) dan kunyit (Curcuma longa L) merupakan tanaman herbal yang terkenal karena manfaat terapeutiknya. Tumbuhan ini mengandung unsur bioaktif yang masing-masing disebut sebagai gingerol dan kurkumin, yang menunjukkan kualitas potensi antibakteri. Tujuan utama dari penelitian ini adalah untuk menguji atribut dan sifat antibakteri dari zat-zat tersebut. potensi Edible Film yang terdiri dari 5% ekstrak jahe gingerol dan kombinasi kurkumin terhadap bakteri Streptococcus pyogenes. Penelitian ini menggunakan metode pengecoran pelarut, evaluasi film yang dapat dimakan melalui analisis sensori, pengukuran ketebalan, penilaian keseragaman berat, penentuan pH, pengujian kerapuhan, pengukuran ketahanan lipat, analisis waktu hancur dan disolusi, penentuan kadar air, penilaian elongasi dan kekuatan tarik, stabilitas pemeriksaan, uji hedonik, evaluasi aktivitas antibakteri terhadap bakteri Streptococcus pyogenes, dan analisis gugus fungsi. Hasil penelitian menunjukkan bahwa Edible Film mempunyai karakteristik berbentuk persegi panjang berukuran 2x3 cm dengan warna berbeda tiap formula, bau yang khas, rasa manis dan pedas, ketebalan 0,11 mm - 0,12 mm, keseragaman berat 60,3 mg-68,87 mg, kerapuhan. 1,14%-2,95%, ketahanan lipat >500x, waktu hancur <30 detik, waktu larut <60 detik, kadar udara 8,58%-12,05%, kuat tarik 2,42 MPa – 16,18 MPa yang sesuai dengan Standar Industri Jepang (JIS) dan teori yang ada, tetapi penambahan persen memberikan hasil yang buruk. Sediaan Edible film baik formula tunggal maupun kombinasi mampu menghambat bakteri dengan diameter zona hambat F2, F3, dan F4 masing-masing 6,56 mm, 6,36 mm, dan 6,92 mm terhadap bakteri Streptococcus pyogenes dengan masing-masing kategori sedang.

Page 44 of 45 | Total Record : 445

 41   42   43   44   45 

Filter by Year

2013 2025


Reset
Filter By Issues
All Issue Vol. 22 No. 2 (2025): September 2025 Vol. 22 No. 1: March 2025 Vol. 21 No. 2: September 2024 Vol. 21 No. 1: March 2024 Vol 20, No 2: September 2023 Vol. 20 No. 2: September 2023 Vol 20, No 1: March 2023 Vol. 20 No. 1: March 2023 Vol 19, No 2: September 2022 Vol. 19 No. 2: September 2022 Vol. 19 No. 1: March 2022 Vol 19, No 1: March 2022 Vol. 18 No. 2: September 2021 Vol 18, No 2: September 2021 Vol 18, No 1: Maret 2021 Vol. 18 No. 1: Maret 2021 Vol 17, No 2: September 2020 Vol. 17 No. 2: September 2020 Vol 17, No 1: Maret 2020 Vol. 17 No. 1: Maret 2020 Vol. 16 No. 2: September 2019 Vol 16, No 2: September 2019 Vol 16, No 1: Maret 2019 Vol. 16 No. 1: Maret 2019 Vol. 15 No. 2: September 2018 Vol 15, No 2: September 2018 Vol 15, No 1: Maret 2018 Vol 15, No 1 (2018) Vol. 15 No. 1: Maret 2018 Vol 14, No 2 : September 2017 Vol 14, No 2 : September 2017 Vol 14, No 1: Maret 2017 Vol. 14 No. 1: Maret 2017 Vol 14, No 1: Maret 2017 Vol. 13 No. 2: September 2016 Vol 13, No 2: September 2016 Vol 13, No 2: September 2016 Vol. 13 No. 1: Maret 2016 Vol 13, No 1: Maret 2016 Vol 13, No 1: Maret 2016 Vol 12, No 2: September 2015 Vol 12, No 2: September 2015 Vol. 12 No. 2: September 2015 Vol 12, No 1: Maret 2015 Vol. 12 No. 1: Maret 2015 Vol 12, No 1: Maret 2015 Vol 11, No 2: September 2014 Vol 11, No 2: September 2014 Vol. 11 No. 2: September 2014 Vol 11, No 1: Maret 2014 Vol 11, No 1: Maret 2014 Vol. 11 No. 1: Maret 2014 Vol 10, No 2: September 2013 Vol. 10 No. 2: September 2013 Vol 10, No 2: September 2013 More Issue