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Jurnal Biotek Medisiana Indonesia
Published by Badan Penelitian dan Pengembangan Kesehatan, Kementerian Kesehatan
ISSN : 23015810     EISSN : 23548800     DOI : -
Core Subject : Health,
Health Professions
Jurnal Biotek Medisiana Indonesia published 2 times a year. This journal is a medium of information and research results and development areas for non-communicable diseases and public health program managers, as well as a means of communication the researchers /enthusiasts in the field of non-communicable diseases and infectious.
Arjuna Subject : -
Articles 64 Documents
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Hipertensi dan Diabetes Mellitus pada Wanita Usia Subur (WUS) di Daerah Urban di Indonesia -, Delima; Isnawati, Ani; Raini2, Mariana
Jurnal Biotek Medisiana Indonesia Vol 1, No 1 (2012)
Publisher : Central Basic Biomedical and Health Technology

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Abstract

Maternal mortality in Indonesia is still high. Gestational hypertension and diabetes mellitus are among the causes. Hypertension and diabetes mellitus in reproductive age women impact the gestation and the delivery. The objectives of this analysis on Riskesdas (National Basic Health Research) 2007 data were getting the percentage of hypertension and diabetes mellitus in reproductive age women in Indonesian urban in 2007.Analysis was done descriptively and analytically using Riskesdas 2007 community and biomedical data, i.e. blood pressure and blood glucose level. Total samples were 99 649 community samples and 8 951 biomedical samples. The results showed there were 10.2 % pregnant women aged 15-49 years old in Indonesian urban had hypertension and 4.9 % had diabetes mellitus, while 23.6 % of unpregnant women had hypertension and 4.0 % had diabetes mellitus. Three provinces with highest percentage of hypertension in unpregnant women were in Gorontalo, North Sulawesi, and South Kalimantan and highest percentage of diabetes mellitus were NAD, North Maluku, and Bangka Belitung. Unpregnant reproductive age women with DM had 2.3 times higher risk to have hypertension (adjusted prevalence OR=2.3; 95 % CI 1.82 % -2.99 %).Key words: reproductive age women, hypertension, diabetes mellitus, National Basic Health Research (Riskesdas) AbstrakAngka kematian maternal di Indonesia masih tinggi. Salah satu penyebabnya adalah hipertensi dan diabetes melitus pada masa kehamilan. Hipertensi dan diabetes melitus pada wanita usia subur dapat memengaruhi kehamilan dan persalinan. Analisis lanjut data Riset Kesehatan Dasar (Riskesdas) 2007 ini bertujuan menghitung persentase hipertensi dan diabetes melitus pada wanita usia subur di daerah urban Indonesia pada tahun 2007. Data Riskesdas 2007 bagian kesehatan masyarakat dan biomedik (kadar gula darah) dianalisis secara deskriptif dan analitik. Total sampel data kesehatan masyarakat sebanyak 99649 dan data biomedik sebanyak 8.951. Hasil analisis menunjukkan persentase hipertensi dan diabetes melitus pada wanita hamil usia 15-49 tahun di daerah urban Indonesia sebesar 10,2 % dan 4,9 %, sedangkan pada wanita yang tidak hamil sebesar 23,6 % dan 4,0 %. Tiga provinsi dengan persentase hipertensi tertinggi pada wanita tidak hamil adalah Gorontalo, Sulawesi Utara, dan Kalimantan Selatan, sedangkan provinsi dengan proporsi diabetes melitus tertinggi adalah Nanggroe Aceh Darussalam, Maluku Utara, dan Bangka Belitung. Wanita usia subur tidak hamil dengan diabetes mellitus mempunyai risiko 2,3 kali lebih tinggi untuk mengalami hipertensi (OR suaian= 2,3; 95% CI 1,82-2,99).Kata kunci: wanita usia subur, hipertensi, diabetes mellitus, Riset Kesehatan Dasar (Riskesdas).
Perbedaan Warna Kontainer Berkaitan dengan Keberadaan Jentik Aedes aegypti di Sekolah Dasar Budiyanto, Anif
Jurnal Biotek Medisiana Indonesia Vol 1, No 2 (2012)
Publisher : Central Basic Biomedical and Health Technology

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Abstract

Containers inside and outside the school building are breeding places for Dengue vector. Presence or absence of Ae aegypti mosquito larvae in a container could be affected by the type, location, color, material, condition and volume of container lid. The purpose of this study was to determine the condition of container that affect the presence of Ae aegypti mosquito larvae. A cross sectional survey was conducted to collect mosquito larvae in primary schools in the district of Ogan Komering Ulu, South Sumatera Province with a single larvae method. Mosquito larvae were found in 54% of surveyed-schools (54%), and mostly were Aedes aegypti larvae (91%). There was a significant correlation between dark and light color differences of the water container in the presence of mosquito larvae (P value = 0.017, CI 95% = 1.2 to 2.9). On the other hand, there was no significant correlation between different types of containers, location of containers, material of containers, the container lid and the volume of water in a container in the presence of larvae. There was a significant correlation between the difference in container’s color (light and dark) in the presence of Ae aegypti mosquito larvae. It is recommended to have regular cleaning of the containers in order to prevent dirt or mosses covered the containers which will impress of being dark color.Key words: dengue, Aedes aegypti, larvae, containers, school. AbstrakKontainer bagian dalam dan luar sekolah menjadi tempat perindukan vektor Dengue. Ada tidaknya larva Aedes aegypti didalam kontainer dapat dipengaruhi oleh tipe, lokasi, warna, material kondisi dan volume dari kontainer. Tujuan dari penelitian ini untuk menentukan kondisi kontainer yang dapat mempengaruhi adanya larva Aedes aegypti. Penelitian ini adalah survey Cross seksional yang dilakukan dengan mengumpulkan larva nyamuk di sekolah dasar di Kabupaten Ogan Komering Ulu di Sumatera Selatan dengan metode larva tunggal. Larva nyamuk ditemukan pada 54% sekolah yang di survey, dan terutama adalah larva Aedes aegypti (91%). Tedapat korelasi signifikan adanya larva nyamuk diantara kontainer yang berwarna gelap dan terang (P value = 0,017, CI 95% = 1,2-2,9). pada sisi lain ditemukan korelasi yang tidak signifikan antara tipe, lokasi, material, ukuran dan volume air dalam kontainer terhadap keberadaan larva .Terdapat korelasi yang signifikan antara kontainer yang berwarna gelap dan terang dan keberadaan larva nyamuk Aedes aegypti. Direkomendasikan untuk selalu membersihkan kontainer supaya kontainer tidak memberikan warna gelap.Kata kunci: dengue Aedes aegyti, larva, container, sekolah
Sebaran Serotipe Virus Dengue di Pontianak, Medan dan Jakarta Tahun 2008 Herman, Reni; Utami, Basundari Sri; Tuti, Sekar; Novriani, Harly
Jurnal Biotek Medisiana Indonesia Vol 1, No 2 (2012)
Publisher : Central Basic Biomedical and Health Technology

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Abstract

The severity of clinical manifestation of dengue infection depends on the 4 virus serotypes. The aim of the study is to explore the distribution of dengue virus serotypes in 3 cities (Pontianak, Medan and Jakarta) in 2008.The study was a cross-sectional designed; data were obtained from each 2 hospitals in Pontianak, Medan and Jakarta. Sera samples were collected from patients visiting internal and pediatric units in the hospital, which met the inclusion criteria, i.e. had fever for 2 – 7 days, with hemorrhagic manifestation, and/or thrombocyte level less than 100.00/mm3, haematocrit >20% , and had informed-consent signed. Sample sizes were 90 patients from each hospital. About 5 mL blood samples were collected, and serum were separated for RT-PCR testing to determine virus serotype. About 244 sera were collected, i.e. 95 sera from Pontianak, 86 sera from Medan, and 65 sera from Jakarta. Patients visiting hospital mostly had fever for 4 days. More than 60% of RT-PCR tested sera were dengue positive; with the serotype composition Den-3, Den-2 and 3, Den-3 and 1, respectively in Pontianak, Medan and Jakarta.Four dengue virus serotype circulated in Pontianak, Medan and Jakarta, with the majority of serotype 3 (Den-3) in Pontianak and Jakarta, and serotype 2 (Den-2) in Medan.Key words: DHF, dengue, serotype AbstrakDi Indonesia penyakit Demam Berdarah Dengue (DBD) sampai saat ini masih merupakan salah satu masalah kesehatan masyarakat, terutama di kota-kota besar. Tujuan dari penelitian ini adalah untuk mengetahui sebaran serotipe virus dengue tahun 2008 di kota Pontianak, Medan dan Jakarta. Desain penelitian potong lintang. Data yang dikumpulkan masing-masing dari 2 Rumah Sakit di Medan, Pontianak dan Jakarta. Sampel sera dikumpulkan dari penderita yang datang kebagian Penyakit Dalam dan bagian Anak, kriteria demam 2 sampai 7 hari, dengan manifestasi perdarahan dan atau trombosit < 100.000/mm3, Hematokrit> 20% nilai normal serta menandatangani informed concent. Jumlah sampel dari masing-masing Rumah Sakit 90 sampel. Darah penderita diambil maksimal 5 ml, serum dipisahkan dan dilakukan pemeriksaan RT-PCR untuk menentukan serotype virus. Sampel yang terkumpul pada penelitian ini 244, 95 sera dari Pontianak, 86 sera dari Medan dan 65 sera dari Jakarta. Penderita datang ke Rumah Sakit terbanyak setelah 4 hari demam. Dari Hasil pemeriksaan RT-PCR, lebih dari 60% positif, dengan komposisi serotipe terbanyak di Pontianak dengue 3, di Medan dengue 2, diikuti dengue 3 dan di Jakarta dengue 3 diikuti dengue 1.Dari hasil penelitian ini disimpulkan bahwa keempat serotipe virus dengue bersirkulasi di Pontianak, Medan dan Jakarta, dengan mayoritas virus dengue serotipe 3 di Pontianak dan Jakarta, serotipe 2 di Medan.Kata kunci:DBD, dengue, serotype
Infeksi Virus Dengue Tanpa Gejala pada Keluarga Penderita DBD di Provinsi Jawa Barat Santya, Roy NRE; Riandi, M. Umar
Jurnal Biotek Medisiana Indonesia Vol 1, No 2 (2012)
Publisher : Central Basic Biomedical and Health Technology

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Abstract

Dengue Hemorrhagic Fever (DHF) in Indonesia shows an increasing trend since it was first reported in 1968. Based on data from 2003 to 2007, all districts in West Java province had reported outbreak of DHF. Dengue virus transmission is kept up by the presence of virus in the infective host in human and/or mosquitoes. A cross-sectional research was conducted to obtain the incidence of asymptomatic dengue infections in family members of the individual infected. Data was extracted from respondents who were family members of patients that showed immunological response to dengue virus infection. Out of 979 family members of patients tested, 183 (18.7%) individual showed asymptomatic positive immunological response of dengue virus infection. Respondents who leave in a district have risk to be infected 1.35 fold greater than those who leave in a city (p= 0,043; 95% CI =1,004-1,805). There is no significant risk to be infected among gender (female and male respondent) and age groups (≤ 15 years and > 15 years).There is a latent potential problem of sustainable dengue virus transmission in West Java Province. This condition requires attention because the existence of positive individuals without symptoms and their mobility play a role as a reservoir of dengue virus.Key words: dengue virus infection, asymptomatic, immunological responses AbstrakDemam Berdarah Dengue di Indonesia menunjukkan tren meningkat sejak dilaporkan sejak tahun 1968. Berdasarkan data tahun 2003-2007 seluruh Kabupaten di Jawa Barat melaporkan adanya KLB DBD. Transmisi virus dengue terus ada karena ada penularan virus antar manusia melalui nyamuk. Penelitian ini adalah Cross seksional yang dilakukan untuk mengetahui adanya insidens dengue tanpa gejala diantara anggota keluarga dari orang yang terinfeksi. Data diperoleh dari responden yang merupakan keluarga dari responden yang menunjukkan adanya respon imun terhadap virus dengue. Dari 979 anggota keluarga yang di test sebanyak 183 (18,7%) menunjukkan adanya respon imun terhadap virus dengue. Responden yang tinggal di kabupaten yang mempunyai risiko terinfeksi sebesar 1,35 lebih tinggi dari pada yang tinggal di dalam kota (p= 0,043; 95% CI = 1,004-1,805). Tidak ada risiko terinfeksi antara gender, kelompok umur (<15 tahun dan >15 tahun) yang signifikan. Terdapat problem laten untuk transmisi virus dengue yang terus menerus di Jawa Barat. Kondisi ini membutuhkan perhatian karena keberadaan individu tanpa gejala dan mobilitasnya berperan sebagai resevoa virus dengue.Kata kunci: Infeksi virus dengie, asymptomatic, respon imun
Virus-Virus Saluran Pernapasan yang Paling Banyak Ditemukan pada Anak Balita Pasien SARI (Severe Acute Respiratory Infections) -, Widoretno; Saragih, Siti Mariani; Lokida, Dewi
Jurnal Biotek Medisiana Indonesia Vol 1, No 2 (2012)
Publisher : Central Basic Biomedical and Health Technology

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Abstract

In children, 50% respiratory infection was caused by viruses. This research was aimed to identify type of viruses causing respiratory infection among SARI patients under five years old in several regions in Indonesia.Study design of this reserach was prospective study using survey and laboratory analysis. Data was being collected from SARI surveillance. There were 215 throat specimens from 350 children under five years old patients. Specimens were collected from March 2008 to December 2008. To detect viruses in the respiratory tract, this research used Multiplex Bead Array Assay technique.Among 215 specimens tested, 91 specimens (40.12%) were positive respiratory viruses. In children under 1 year old, Coxsakie and Enterovirus (8.72%) were two viruses that mostly detected. In children aged 2 to 3 years old, the virus that mostly found was Respiratory Syncytial virus. And in children aged 4 to 5 years old, Entero and Rhinovirus were mostly found (14.29%). Based on the distribution of respiratory viruses in hospital, there were two peaks shown in the graphs. Firstly, Entero and Rhinovirus were high in Kupang and DKI Jakarta. Secondly, Respiratory Syncytial virus was found high in Kupang, Semarang, and DKI Jakarta.Respiratory Syncytial, Coxsakie, Enterovirus, and Entero Rhinovirus were mostly identified in SARI Patients under five years old.Key word: respiratory viruses, SARI, children under five years AbstrakPada anak-anak lima puluh persen penyebab infeksi saluran pernapasan adalah virus. Tujuan dari penelitian ini adalah unutk mengetahui jenis virus-virus pernapasan pada pasien balita rawat inap penderita SARI (Severe Acute Respiratory Infectiouns) di beberapa daerah di Indonesia. Desain penelitian prospektif dengan jenis studi survey dan studi laboratorium. Data berasal dari spesimen tersimpan surveilans SARI. Jumlah spesimen 215 usap tenggorok dari total 350 pasien balita. Spesimen dikumpulkan dari bulan Maret 2008-Desember 2008. Untuk mendeteksi virus-virus pada saluran pernapasan digunakan teknologi Multiplex Bead Array Assay. Diantara 215 spesimen, 91 spesimen (40,12 %) positif virus pernapasan. Pada anak dibawah 1 tahun, virus yang paling banyak ditemui adalah virus Coxsakie dan Entero Virus (8,72 %). Sedangkan pada anak usia 2-3 tahun virus yang paling banyak ditemukan adalah virus Respiratory Syncytial (17,24 %) dan pada anak usia 4-5 tahun virus yang paling banyak ditemukan adalah virus Entero dan Rhinovirus (14,29 %). Berdasarkan distribusi virus pernapasan di rumah sakit terlihat 2 puncak grafik yang menunjukkan tingginya virus Entero dan Rhino di Daerah Kupang dan DKI. Puncak grafik kedua yang menunjukkan tingginya virus Respiratory Syncytial di Daerah Kupang, Semarang dan DKI. Virus Respiratory Syncytial, Coxsakie dan entero virus serta Entero-Rhinovirus paling banyak ditemukan pada pasien balita SARI.Kata kunci: virus pernapasan, SARI, anak balita
Kadar Kolesterol Tinggi Dan Faktor-Faktor Yang Berpengaruh Terhadap Kadar Kolesterol Darah Soleha, Maratu
Jurnal Biotek Medisiana Indonesia Vol 1, No 2 (2012)
Publisher : Central Basic Biomedical and Health Technology

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Abstract

The cholesterol level in blood has become one of the risk factors of heart disease. One of the risk factors of heart disease is high cholesterol level. This article analysis variables that influence high cholesterol level in blood. Data were obtained from national health research in 2007 . Data consist of 21.178 respondents was clean up become 4.566 clean data ready to be analyze. Study design was cross sectional then analyzed with stata v. 9 followed by backward stepwise selection.Bivariate analysis shows gender, body mass index, sistole and diastole blood pressure, smoke habits and the responden who lack of strenuous activities have a tendency to hypercholesteromia risk.Key words: Hiperkolesterolemia, Indeks Massa Tubuh (IMT), sistolik, diastolik. AbstrakKadar kolesterol dalam darah yang tinggi merupakan salah satu faktor risiko penyakit jantung. Artikel ini membahas berbagai variabel yang mempengaruhi tingginya kadar kolesterol di dalam darah. Data untuk analisis diperoleh dari riset kesehatan dasar tahun 2007. Data terdiri dari 21.178 responden yang dibersihkan sehingga menjadi 4.566 data yang siap untuk dianalisis. Studi desain crossectional. Data dianalis dengan stata v.9 dilanjutkan dengan backward stepwise selection. Analisis dua variabel menunjukkan jenis kelamin, Indeks massa tubuh, tekanan darah, kebiasaan merokok dan kurangnya latihan fisik memiliki risiko hypercholesteromia.Key words: Hiperkolesterolemia, sistolik, diastolik.
Produksi Parthenogenetik Blastosis Mencit Sebagai Sumber Stem Cell Rinendyaputri, Ratih; Nikmah, Uly Alfi
Jurnal Biotek Medisiana Indonesia Vol 2, No 1 (2013)
Publisher : Central Basic Biomedical and Health Technology

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Abstract

Embryonic Stem Cells (ESCs) is a one of source for pluripotent stem cell that capable to differentiate into various cell types. This has opened up opportunities utilization of embryos as a source of stem cells. However, the use of embryos as objects of research still has ethical constraints. Currently parthenogenetic embryo in the blastocyst stage is considered to be one of the alternative sources of ESC are "ethical" because its obtained not from the fertilization of the oocyte and sperm. Parthenogenetic embryo derived from oocyte that activation in vitro to obtain embryos in the blastocyst stage. This research aims to produce blastocysts parthenogenetic mice as a source of ESC. In this study super ovulation performed on Swiss Webster female mice to obtain oocytes. Activation of mouse oocytes done by culturing oocytes in medium with 10 mM strontium chloride (SrCl2) and 5 mg / ml cytokalasin B for 6 hours and cultured for 4-5 days to get the embryo parthenogenetic. The results showed that development of mice oocyte activated to be 2 pronucleus (2PN), cleavage, morula and blastocyst sequence was 65%, 97%, 90% and 23%. The conclusion of this study indicate that the parthenogenetic embryos as sources of stem cells can be produced in vitro.Key words: stem cells, embryonic stem cells (ESCs), blastocyst, parthenogenetic AbstrakEmbryonic Stem Cells (ESCs) merupakan salah satu satu sumber sel punca (stem cell) yang bersifat pluripoten karena kemampuannya berdiferensiasi menjadi berbagai tipe sel. Hal inilah yang membuka peluang pemanfaatan embrio sebagai sumber stem cell. Namun pemanfaatan embrio sebagai objek penelitian masih mempunyai kendala etik. Saat ini embrio partenogenetik tahap blastosis dianggap dapat menjadi salah satu alternatif sumber ESC yang “etis” karena diperoleh bukan dari hasil fertilisasi antara oosit dan sperma. Embrio parthenogenetik diperoleh dari aktivasi oosit secara in vitro untuk memperoleh embrio tahap blastosis. Penelitian ini bertujuan memproduksi blastosis partenogenetik mencit sebagai sumber ESC. Pada penelitian ini superovulasi dilakukan pada mencit betina Swis webster untuk mendapatkan oosit. Aktivasi oosit mencit dilakukan dengan mengkultur oosit dalam medium dengan 10mM strontium chloride (SrCl2) dan 5 μg/ml cytokalasin B selama 6 jam dan kultur selama 4-5 hari untuk mendapatkan embrio partenogenetik. Hasil penelitian menunjukkan bahwa perkembangan oosit mencit yang telah teraktivasi menjadi tahap 2 pronukleus (2PN), cleavage, morula dan blastosis secara berurutan adalah 65%, 97%, 90% dan 23%. Kesimpulan dari penelitian ini menunjukkan bahwa embrio partenogenetik sebagai sumber stem cell dapat diproduksi secara in vitro.Kata kunci: Sel punca (stem cell), sel punca embrionik (ESCs), blastosis, partenogenetik
Ulasan Sistematik: Marka Molekular Penanda Patogenitas dan Sebaran Inang Pada Virus Avian Influenza H5N1 Adam, Kindi; Wulandari, R.Aj. Sri
Jurnal Biotek Medisiana Indonesia Vol 2, No 1 (2013)
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Abstract

The epidemic arising out of H5N1 virus infection causes death case and material loss. Mutation of H5N1 virus that signify the increase of pathogenicity and change of dispersal of host response can be used to reference for early warning system of epidemic caused of avian influenza virus. The objective of this research is to obtain information related to molecular markers of pathogenicity of avian influenza. Reference searching is use to collect information about molecular markers related to pathogenicity. The keywords used on this study are: Avian influenza, H5N1, mutation, Pathogenicity, HA, NA, PB, PA, and NS. Thirty three research papers, 4 reviews and 1 scientific seminar are used on this research. The HA, NA and NS genes was reported to be an important gene that have molecular marker related to increase ofpathogenicity. Whereas HA, PB1, PB2 and PA genes was related to the adaptive ability and the dispersal of host of avian influenza virus. There is 30 amino acid that sign as molecular markers of pathogenicity of avian influenza H5N1. Mutation on 30 molecular markers of HA, NA, PB and NS genes can be used as predictor to anticipate mutation orientation of avian influenza virus to become highly pathogenic and host alteration.Thereby, virus mutation to become highly pathogenic can be anticipated early.Keybwords : Highly pathogenic avian Influenza, Mutation, Molecular Marker, Pathogenicity. HA, NA, PB, NS AbstrakEpidemi akibat virus H5N1 telah menimbulkan banyak korban jiwa dan materi.Mutasi virus H5N1 yang menandakan peningkatan patogenitas dan perubaan sebaran inang dapat dijadikan acuan untuk sistem deteksi dini kewaspadaan epidemi akibat virus avian influenza. Penelitian ini bertujuan mendapatkan informasi terkait dengan marka molekular penanda patogenitas virus avian influenza H5N1. Ulasan sistematis ini dilakukan dengan penelusuran literatur menggunakan Google scholar dan PubMed. Kata pencarian yang digunakan adalah Avian influenza, H5N1, mutation, Pathogenicity, HA,NA,PB,PA,NS. Referensi yang digunakan adalah 33 jurnal, 4 ulasan penelitian dan 1 seminar ilmiah dari dalam dan luar negeri. Gen HA, NA dan NS merupakan gen penting yang memiliki penanda molekuler yang berkaitan dengan peningkatan patogenitas virus avian influenza. Sedangkan gen PB1, PB2 dan PA berhubungan dengan adaptasi dan perubahan rentang inang. Jumlah penanda patogenitas pada gen HA, NA, PB dan NS adalah 30 asam amino. Mutasi pada 30 marka genetik gen HA, NA, PB dan NSmerupakan penanda molekular yang dapat digunakan sebagai panduan awal untuk mengantisipasi arah mutasi virus avian influenza menuju pergeseran rentang inang dan peningkatan patogenitasnya. Dengan demikian, perubahan virus avian influenza menjadi bersifat higly pathogenic dapat diantisipasi lebih dini.Kata kunci : Highly pathogenicavian Influenza, Mutasi,Marka Molekular, Patogenitas., HA, NA, PB, NS.
The Surprising Complexity of Virus-Host Cell Interaction Revealed by the Powerful Systems Biology Approaches of Genomics and Proteomics Rustanti, Lina
Jurnal Biotek Medisiana Indonesia Vol 2, No 1 (2013)
Publisher : Central Basic Biomedical and Health Technology

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Abstract

Understanding interaction between viruses and host cells during infection process is the first step in discovering appropriate drugs and vaccines against viral diseases. Advance technologies based on genomics and proteomics approaches provide great tools to disclose the complexity of virus-host interaction. In this essay, the application of RNAi screens method and proteomics-based approaches on influenza virus will be elucidated as an example. Using those methods, the primary factors controlling viral replication pathway were discovered. These findings are useful for the development of potential strategies to overcome viral diseases.Keywords : virus, host, pathogen, interaction, genomic, proteomic. AbstrakMemahami interaksi antara virus dan pejamu dalam proses infeksi merupakan langkah awal dalam upaya penemuan obat dan vaksin yang tepat untuk melawan penyakit yang disebabkan oleh virus. Pendekatan teknologi berbasis genomik dan proteomik merupakan terobosan yang dapat menjawab kompleksitas interaksi virus-pejamu. Dalam kajian ini, akan dibahas penerapan teknologi screening RNAi dan teknologi berbasis proteomik pada virus influenza. Dengan menggunakan metode ini, faktor-faktor utama yang mengontrol tahap replikasi virus akan dapat ditemukan. Penemuan ini sangat bermanfaat dalam pengembangan strategi pengobatan yang potensial untuk mengatasi penyakit bersumber virus.Kata kunci: virus, pejamu, patogen, interaksi, genomik, proteomik.
Perilaku Bertelur Nyamuk Aedes aegypti pada Media Air Tercemar Wurisastuti, Tri
Jurnal Biotek Medisiana Indonesia Vol 2, No 1 (2013)
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Abstract

The theory is believed that the mosquito Aedes aegypti does not like laying in a pool of contaminated water. However, some studies indicate a change in behavior of these mosquitoes breed. Authors conducted follow-up analysis of a descriptive study to determine whether the mosquito Aedes aegypti willing to lay their eggs in different media polluted water and polluted water knows that most preferably Aedes aegypti mosquitoes to lay eggs. Advanced analysis of R & D performed in Loka P2B2 Baturaja with the type of non-intervention and observational studies using analysis of variance (ANOVA) and Duncan test. Software used SAS 9.1. Analysis of variance showed that different types of water media have a real influence on the preference of Aedes aegypti mosquitoes lay their eggs on the 5% significance level with p-value of <0.0001. Cow manure contaminated water is the most preferred medium of Aedes aegypti mosquitoes lay their eggs.Keywords: medium water, eggs, Aedes aegypty, analysis of variance AbstrakTeori yang ada meyakini bahwa nyamuk Aedes aegypti tidak suka bertelur di genangan air tercemar. Namun beberapa penelitian menunjukkan adanya perubahan perilaku berkembang biak nyamuk tersebut. Penulis melakukan analisis lanjutan dari penelitian deskriptif dengan untuk mengetahui apakah nyamuk Aedes aegypti mau bertelur di berbagai media air tercemar dan mengetahui air tercemar yang paling disukai nyamuk Aedes aegypti untuk bertelur. Analisis lanjut dilakukan di Loka Litbang P2B2 Baturaja dengan jenis penelitian observasi non intervensi dan menggunakan analysis of varians (ANOVA) serta uji lanjut Duncan. Software yang digunakan SAS 9.1. Analysis of varians menunjukkan bahwa berbagai jenis media air memiliki pengaruh yang nyata terhadap kesukaan bertelur nyamuk Aedes aegypti pada taraf nyata 5% dengan nilai-p sebesar < 0.0001. Air yang tercemar kotoran sapi merupakan media yang paling disukai nyamuk Aedes aegypti meletakkan telurnya.Kata Kunci: media air, telur, Aedes aegypty, analysis of varians

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