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INDONESIA
Medical Journal of Indonesia
Published by Universitas Indonesia
ISSN : 08531773     EISSN : 22528083     DOI : 10.13181
Core Subject : Health,
Medicine & Pharmacology
This quarterly medical journal is an official scientific journal of the Faculty of Medicine Universitas Indonesia in collaboration with German-Indonesian Medical Association (DIGM) Indexed in: IMSEAR; CAB Abstracts; Global Health; HINARI; DOAJ; DRJI; Google Scholar; JournalTOCs; Ulrichsweb Global Serial Directory; WorldCat; New Jour; Electronic Journals Library; ISJD Accredited (2013-2018) by DIKTI Kemendikbud Republik Indonesia (No:58/DIKTI/Kep/2013)
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Articles 1,639 Documents
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Perianesthetic management in a teenager with focal cortical dysplasia who underwent an epilepsy surgery Yeap, Boon Tat; Koo, Thai Hau; Ang, Song Yee; Hassan, Mohamad Hasyizan
Medical Journal of Indonesia Vol. 34 No. 2 (2025): June
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13181/mji.cr.257555

Abstract

Medically resistant epilepsy (MRE) is defined as the failure of adequate trials of 2 tolerated and appropriately used antiepileptic drugs to achieve sustained seizure freedom, where epilepsy surgery (ES) is indicated in patients with MRE due to complex epileptic syndromes, such as Lennox-Gastaut and Sturge-Weber syndromes, and focal cortical dysplasia (FCD), to disconnect the epileptogenic foci from other cerebral structures. ES demands excruciating perianesthetic considerations due to its complexity and various pharmacological interactions. Our patient is a 15-year-old male with MRE secondary to FCD. He successfully underwent ES in our neurosurgical center. We describe our perianesthetic challenges in addition to a brief overview of MRE and FCD.
Predictors of syphilis infection among HIV pre-exposure prophylaxis users Nguyen, Thanh Tran Ai; Vu-Tri, Thanh; Nguyen, Vu Hoang Anh; Nguyen-Thi, My-Tien; Luu-Thi, Huyen-Trang; Ly, Thanh-Thao; Phan, Yen Thi Hoai
Medical Journal of Indonesia Vol. 34 No. 1 (2025): March
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13181/mji.oa.257601

Abstract

BACKGROUND Pre-exposure prophylaxis (PrEP) has revolutionized HIV prevention worldwide. However, research has shown a contradictory trend in which PrEP helps reduce HIV incidence, but increases sexually transmitted infections (STIs), especially in high-risk groups like men who have sex with men and female sex workers. This study aimed to examine the association between sex, age, occupational status, hepatitis B virus (HBV) infection, and hepatitis C virus (HCV) infection with syphilis infection among PrEP users. METHODS The cross-sectional survey was conducted over 1 year, with 864 participants in Thu Duc City Hospital, Vietnam. The chi-square test was utilized for descriptive analysis. Binary logistic regression models estimated the association between sex, age, occupational status, HBV infection, and HCV infection with syphilis infection. Odds ratio (OR) and 95% confidence intervals (CIs) were calculated. RESULTS Of 864 participants, 147 (18.2%) men and 68 (23.7%) employed individuals were tested positive for syphilis. The findings indicated that men (OR = 13.805; 95% CI = 1.886−101.024), employed individuals (OR = 1.838; 95% CI = 1.191−2.834), and HBV infection (OR = 2.076; 95% CI = 1.108−3.891) were significantly associated with an increased risk of syphilis infection. CONCLUSIONS Men, employed individuals, and individuals infected with HBV face a higher risk of syphilis infection among PrEP users.
Expression of DUSP1, LINC02202, and LINC01554 as a biomarker panel in the diagnosis and prognosis of breast cancer Khoshnazar, Seyedeh Mahdieh; Kazemi, Mandana; Jahanbani, Parnian; Abed, Mohammad Reza Moghare; Afshoon, Shamim
Medical Journal of Indonesia Vol. 34 No. 1 (2025): March
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13181/mji.oa.257624

Abstract

BACKGROUND Breast cancer is a major global health challenge, with diverse and complex gene expression profiles. Long noncoding RNAs (lncRNAs) have emerged as key regulators of various cancers, including breast cancer. This study aimed to investigate the expression and prognostic value of dual specificity phosphatase 1 (DUSP1), LINC02202, and LINC01554 in breast cancer tissues and explore their association with clinical parameters. METHODS DUSP1, LINC02202, and LINC01554 expression in healthy and breast tumor tissues were compared using in vitro and in silico conditions. In silico conditions examined their association with patient survival and disease prognosis through Kaplan−Meier and receiver operating characteristic curves. In vitro conditions examined the association between their expression and clinical parameters, such as tumor size, disease stage, and disease prognosis. RESULTS Our study found that DUSP1, LINC02202, and LINC01554 were significantly downregulated in breast tumor tissues compared to healthy tissues, as shown by both in vitro and in silico analyses. Their expression levels are also significantly associated with the prognosis of breast cancer. Notably, only LINC02202 expression was significantly correlated with reduced patient survival and tumor size. CONCLUSIONS This study provides novel insights into the expression and function of DUSP1 mRNA, LINC02202, and LINC01554 lncRNAs in breast cancer and identifies potential biomarkers and therapeutic targets for this disease.
Hematologic profile of hemoglobin constant spring and its co-inheritance with hemoglobin C: a case report Adzahar, Sumaiyah; Rahman, Sharifah Sakinah Syed Abdul; Nordin, Mohammad Hudzaifah; Rameli, Nabilah
Medical Journal of Indonesia Vol. 34 No. 1 (2025): March
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13181/mji.cr.257664

Abstract

Hemoglobin constant spring (Hb CS) is an alpha-globin variant characterized by an elongated alpha chain due to a mutation that leads to unstable hemoglobin (Hb) levels. Hemoglobin C (Hb C) is a beta-globin variant associated with mild hemolytic anemia. The co-inheritance of Hb CS and Hb C is uncommon and presents distinct hematologic features. We report the case of a 7-year-old Malaysian male who developed acute polyarthritis due to streptococcal infection. Routine blood tests revealed microcytic hypochromic anemia, suggestive of a thalassemia trait. Hb analysis via high-performance liquid chromatography and capillary electrophoresis detected low hemoglobin A levels with an additional peak in the Hb C zone. DNA analysis confirmed compound heterozygosity for Hb CS and Hb C. Family screening revealed that the mother is an Hb C carrier, and the father is an Hb CS carrier. This case report examined the hematological profile of a patient with this genetic combination.
Urinary calcium and matrix Gla protein levels in the kidney stones: a case-control study Ali, Zulfikar; Selanno, Fradelino Esau; Gunawan, I Putu Gde Fredy; Sulchan, Mohammad; Birowo, Ponco; Winarni, Tri Indah
Medical Journal of Indonesia Vol. 34 No. 1 (2025): March
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13181/mji.oa.257748

Abstract

BACKGROUND Kidney stones are a global issue with varying prevalence. The most common metabolic risk factor is hypercalciuria, a condition where excess calcium in the urine promotes stone formation. Matrix Gla protein (MGP) inhibits stone formation by preventing crystal growth. This study aimed to analyze the correlation between urinary calcium and MGP levels in kidney stone formation. METHODS A case-control study at Kardinah Hospital, Indonesia, included 64 patients with kidney stone and 64 healthy controls. Exclusion criteria included renal failure, stroke, kidney tumor, heart failure, and hemodialysis. Urinary calcium and MGP were measured using the 5’-nitro-5’-methyl-BAPTA method and enzyme-linked immunosorbent assay. Cut-off values were determined via receiver operating characteristic analysis. RESULTS Among 128 participants (mean age: 51.6), the optimal cut-off for urinary MGP was 1,405 ng/l (p = 0.00024) with 62.5% sensitivity and 72% specificity. Urinary calcium cut-off was 72.5 mg/24 hours with 81.3% sensitivity and 62.5% specificity. Higher urinary calcium and MGP levels were linked to kidney stones (OR: 7.22; 95% CI: 3.23–16.18 and OR: 4.26; 95% CI: 2.03–8.96, respectively). A significant association was found between urinary calcium and MGP (OR: 5.11; 95% CI: 2.31–11.29, p = 0.00006) that hypercalciuria and increased MGP levels are predictors of kidney stone formation. CONCLUSIONS Urinary calcium and MGP levels are associated with kidney stones. Elevated urinary calcium (>1,405 ng/l) increases MGP levels more than 5-fold. Depending on their levels, urinary calcium and MGP act as both promoters and inhibitors of stone formation.
Artificial intelligence, the state-of-the-art in scientific editing Christian, John; As’syifa, Salsa Billa; Widjaja, Felix Firyanto; Hamid, Agus Rizal Ardy Hariandy
Medical Journal of Indonesia Vol. 34 No. 1 (2025): March
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13181/mji.ed.258137

Abstract

[No abstract available]
Front & Back Matter of Indonesia, Medical Journal
Medical Journal of Indonesia Vol. 34 No. 1 (2025): March
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Clinical profiles and treatment evaluation of tuberculous uveitis in tertiary eye hospital in Jakarta Mahayani, Ni Made Widya; Susiyanti, Made; Sjamsoe, Soedarman; Utami, Anna Nur
Medical Journal of Indonesia Vol. 34 No. 2 (2025): June
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13181/mji.oa.257609

Abstract

BACKGROUND Tuberculous uveitis (TU) is the second most common cause of intraocular inflammation in Indonesia. This study aimed to determine the clinical characteristics of patients with TU and the therapies used at Jakarta Eye Center (JEC) Eye Hospitals and Clinics. METHODS This retrospective descriptive study included 265 eyes of 189 patients diagnosed with TU at the JEC Eye Hospital and Clinics between January 2018 and June 2022. This study used secondary data collected by reviewing patient medical records, including clinical profiles and therapeutic characteristics recorded during treatment. Data were analyzed using SPSS software version 24 for Windows. RESULTS Most patients (68.3%) complained of blurry vision, and 99 (52.4%) underwent an interferon-gamma release assay. HIV infection was present in 8.5% of the patients, and 4.8% had diabetes mellitus. Among them, 27 (14.3%) had posterior uveitis, 34 (18.0%) had anterior uveitis, and 127 (67.2%) had panuveitis. The most common feature of inflammation was vitreous opacity. Visual acuity (VA) improved to 0.4 (1.11) after treatment. The most common complication was cataract formation (71 patients). In the group that received combination therapy with systemic steroids and anti-tuberculosis treatment (ATT), 58.7% had a better VA. CONCLUSIONS TU has several clinical manifestations. Treatment with systemic steroids, ATT, or a combination of both can improve VA.
Conservative surgery for stage IC2 mucinous borderline ovarian tumor: a five-year follow-up case report Utami, Tofan Widya; Nasution, Hiro Hidaya Danial; Oktalia, Arisda; Kusuma, Fitriyadi; Purwoto, Gatot
Medical Journal of Indonesia Vol. 34 No. 2 (2025): June
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13181/mji.cr.257637

Abstract

Mucinous borderline ovarian tumors (MBOTs) represent a significant portion of all borderline ovarian tumors, including variants such as microinvasion and intraepithelial carcinoma, which have a higher recurrence risk. Conservative surgery is recommended for patients with MBOTs seeking fertility preservation, despite remaining a debated option to reduce recurrency. This case highlighted successful MBOT management using conservative surgery with unilateral salpingo-oophorectomy, providing insights into optimal recurrence control. A 30-year-old woman presented with abdominal enlargement, with imaging revealed a large right ovarian mass suspected to be malignant. A left salpingo-oophorectomy was performed, with final histopathology confirming MBOTs with microinvasion and intraepithelial carcinoma. No malignancy was found in the peritoneal fluid, and no adjuvant therapy was given due to fertility preservation reasons. No recurrence after 5 years of follow-up. This report highlights the potential of conservative surgery as a fertility-preserving option for young patients with stage IC2 MBOTs.
Validation and adaptation of the Indonesian version of thyroid cancer quality of life questionnaire Pramono, Laurentius Aswin; Shatri, Hamzah; Subekti, Imam; Prihartono, Nurhayati Adnan; Hatma, Ratna Djuwita; Kurniawidjaja, Meily; Prasetyo, Sabarinah; Kurniawan, Felicia
Medical Journal of Indonesia Vol. 34 No. 2 (2025): June
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13181/mji.oa.257639

Abstract

BACKGROUND The rising incidence of thyroid cancer in Indonesia has become a public health concern. This study was aimed to evaluate the validity of the thyroid cancer-quality of life-Indonesian version (ThyCa-QoL-ID). METHODS This cross-sectional study involved translating the original ThyCa-QoL questionnaire from English to Indonesian (T1), which was then back-translated into English (T2). The T2 questionnaire was compared with the original ThyCa-QoL questionnaire to refine T1, resulting in T3. The T3 questionnaire underwent cognitive and transcultural validation through individual assessment and focus group discussions with 10 doctors and 10 nurses at Cipto Mangunkusumo Hospital and St. Carolus Hospital, and 5 patients with thyroid cancer from St. Carolus Hospital. This process ensured cultural, language, and literacy adaptation processes for patients across different age groups. RESULTS The ThyCa-QoL questionnaire demonstrated validity, with all questions showing correlation calculation (r) above the r table. Test-retest reliability was measured by calculating the intraclass correlation coefficient for each question on the ThyCa-QoL questionnaire. The reliability test can be seen in the value of Cronbach’s alpha (0.915), exceeding the standard Cronbach’s alpha value standard (0.6). CONCLUSIONS The ThyCa-QoL-ID was confirmed as a valid and reliable tool for assessing the QoL of patients with thyroid cancer in Indonesia.

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