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INDONESIA
Journal of Medical Physics and Biophysics
Published by Himpunan Fisika Medis dan Biofisika Indonesia
ISSN : 23552727     EISSN : 23552719     DOI : -
Core Subject : Health, Science,
Medicine & Pharmacology Physics
Journal of Medical Physics and Biophysics is a gold open-access journal and serves as official publication media of the Indonesian Association of Physicists in Medicine, IAPM (Aliansi Fisikawan Medik Indonesia, AFISMI). JMPB publishes articles with the general concern on the application of physics in medicine and the biological system. The role of physics highlighted in the journal can be of theoretical, experimental, or clinical nature. Review and original articles in radiation oncology, diagnostic and interventional radiology, nuclear medicine, biomaterial, physical biology, physical modeling of biological system, and other related sciences are welcome. Any opinions stated on the articles published in JMPB are those of the author(s) and do not necessarily reflect the policy of IAPM/AFISMI unless otherwise stated.
Arjuna Subject : -
Articles 69 Documents
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The Effect of Casein Addition in Carbonate Apatite Mineral Crystallization Nur Aisyah Nuzulia; Savitri Damayanti; Serin Imsa Arizuni; Yessie Widya Sari
Journal of Medical Physics and Biophysics Vol 6, No 1 (2019)
Publisher : Indonesian Association of Physicists in Medicine (AIPM/AFISMI)

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Abstract

Milk protein has been considered as one of the influenced factors in bone mineral crystallization. Bone mineral is mainly formed by carbonate apatite in which the crystallization process depends on the two main processes, nucleation and crystal growth. This study showed the formation of carbonate apatite by using precipitation method and observed the influence of casein, milk protein, in carbonate apatite nucleation through synthesis and crystal growth through immersion in SBF.  The result showed that carbonate apatite type B was formed by using precipitation method with chicken eggshells as calcium precursor. The addition of casein concentration could promote the apatite nucleation and crystal growth with low casein concentration ( ≤ 7.5 g.l-1) while high casein concentration addition plays role as an inhibitor.
Peranan litbang Fisika Medik dalam memperbaiki penerapan proteksi radiasi pasien di Radiologi Diagnostik, Kedokteran Nuklir dan Radioterapi Nur Rahmah Hidayati
Journal of Medical Physics and Biophysics Vol 6, No 1 (2019)
Publisher : Indonesian Association of Physicists in Medicine (AIPM/AFISMI)

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Abstract

Monitoring harian pesawat linac dengan EPID: studi pendahuluan Andrian Dede Handika; Sugiyantari Sugiyantari
Journal of Medical Physics and Biophysics Vol 6, No 1 (2019)
Publisher : Indonesian Association of Physicists in Medicine (AIPM/AFISMI)

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Abstract

Took place in Persahabatan Hospital, Department of Radiotherapy, a research has been held using Linac Elekta Precise equipped by EPID (Electronic Portal Imaging Device). The research is focused on daily measurement on Linac using EPID and Ionization Chamber which the results were compared in effort to use EPID as alternative detector for daily measurement on Linac. The Linac Elekta Precise used in this research was equipped with EPID iViewGT a-Si flat panel with energy consist of 6 MV and 10 MV, 160 cm SDD (Source to Detector Distance), MU variations between 95-105 MU with 1 MU interval, and measured on 10 cm x 10 cm for the field size. Linac’s daily consistent measurement was held with 100 MU exposure and similar Linac’s parameter every day. EPID’s image beam profile evaluation was held along inplane and crossplane axis. The result is EPID’s calibration show a linear relation between pixel value and MU for both of energy beam (6 MV and 10 MV). Specifically, for Linac’s daily consistent measurement with 100 MU, the result show 3% deviation rate in general for both of energy beam which similar with Ionization Chamber measurement result. Flatness and symmetry that acquired from EPID’s image profile show no more than 2% deviation rate which still in tolerance limit. In conclusion, EPID’s daily image profile evaluation which covered output consistency, flatness, and symmetry beam profile show that EPID could be used for alternative detector for daily beam profile monitoring.
Pengukuran MTF (Modulation Transfer Function) berdasarkan LSF (Line Spread Function) dan PSF (Point Spread Function) pada pesawat PET/CT dan SPECT/CT Sharah Nataz Shilfa; M. Roslan Abdul Gani; Intan Apriliani Syaridatul Mu’minah; Fery Ardiansyah; Lukmanda Evan Lubis; Djarwani Soeharso Soejoko
Journal of Medical Physics and Biophysics Vol 6, No 1 (2019)
Publisher : Indonesian Association of Physicists in Medicine (AIPM/AFISMI)

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Abstract

This study aims to know the value of MTF obtained by using two methods: LSF (Line Spread Function) and PSF (Point Spread Function) on PET/CT and SPECT/CT. Measurement done with LSF method performed by thin flood source 18F or 99mTc 12 mCi, while PSF using thin line source 18F atau 99mTc 2 mCi with diameter 0.5 mm. The MTF calculations are performed based on image profile, for PET/CT assisted by 3 filter types and 4 reconstruction algorithms while SPECT/CT based on collimator variation. MTF calculation method have done based on Tsujioka et al. (2014) by combining the ImageJ, MATLAB, and Origin spreadsheet. System performance is determined at 10% MTF. The measurement results on PET/CT showed MTF highest value obtained by the Butterworth filter and reconstruction algorithm Iterative, Iterative 3D, and Backprojection with identical MTF value (0.155 cycles/mm) for LSF method, while PSF method by using Butterworth filter and Backprojection reconstruction algorithm obtained value 0.15 cycles/mm. In SPECT/CT, the second detector with LEHR collimator give MTF value to the LSF method and PSF method sequently 0.104 cycles/mm and 0075 cycles/mm. Based on the advantages and disadvantages of both methods, generally the PSF method is recommended as a spatial resolution QC program for nuclear medicine modalities.
Estimasi entrance skin dose (ESD) pada simulasi pemeriksaan radiologi intervensional dengan perangkat lunak berbasis androidTM Icha Renisha Mulia; M. Roslan A. Gani; Lukmanda Evan Lubis; Djarwani Soeharso Soejoko
Journal of Medical Physics and Biophysics Vol 7, No 1 (2020)
Publisher : Indonesian Association of Physicists in Medicine (AIPM/AFISMI)

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Abstract

Pada pesawat angiografi modern, dosis maupun DAP selama pemeriksaan ditampilkan pada  panel kendali. Namun, dosis tersebut tidak secara langsung menunjukkan dosis entrans kulit, utamanya pada pusat lapangan radiasi. Dengan menggunakan perangkat lunak berbasis AndroidTM telah dilakukan estimasi dosis entrans kulit pasien berdasarkan hasil pengukuran dengan fantom polymethyl methacrylate (PMMA). Dosis entrans kulit pasien yang dikalkulasi dengan mengacu pada Kerma at Reference Point (Ka,r) dan Dose Area Product (DAP) dilakukan dengan memasukkan koreksi geometrik akibat kemiringan gantri, atenuasi meja pasien, koefisien konversi kerma udara menjadi dosis serap, dan faktor hamburan balik. Hasil kalkulasi ESD merupakan dosis titik pada pusat lapangan radiasi, bukanlah dosis maksimum yang diterima kulit pasien. Hasil kalkulasi dibandingkan dengan hasil pengukuran ESD pada simulasi dengan fantom PMMA. Penelitian dilakukan dengan pesawat angiografi Siemens Artis Zee dengan kondisi eksposi 69-87 kV dan filter tambahan 0,1 mmCu.  Pengukuran dengan thermo-luminescent dosemeters (TLD) dilakukan pada proyeksi penyinaran posterior-anterior (PA), left anterior oblique (LAO), right anterior oblique (RAO), cranial (CRA) dan caudal (CAU). Diskrepansi ESD hasil kalkulasi dan ESD pengukuran memiliki rata-rata 0,66-5,25%  untuk kalkulasi mengacu  DAP dan 0,52-5,17%. untuk kalkulasi mengacu Ka,r. 
Perbandingan perencanaan radioterapi IMRT kanker servik stadium IIB menggunakan fasilitas optimization beam angle dan teknik manual pada TPS Eclipse Septi Purwaningsih; Ahmad Mutohar; Wahyu Edy Wibowo; Spriyanto Ardjo Pawiro
Journal of Medical Physics and Biophysics Vol 7, No 1 (2020)
Publisher : Indonesian Association of Physicists in Medicine (AIPM/AFISMI)

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Abstract

Sebaran dosis merupakan salah satu bagian terpenting dari suatu keberhasilan perencanaan radioterapi. Treatment Planning System (TPS) yang di dalamnya terdapat menu optimization beam angle secara computerize akan menentukan jumlah dan beam angle yang tepat untuk suatu Planning Target Volume (PTV). Penelitian ini dibuat dengan tujuan membandingkan capaian perencanaan radioterapi terkait sebaran dosis menggunakan teknik Intensity Modulated Radiation Therapy (IMRT) yang diperoleh dari planning menggunakan fasilitas optimization beam angle dan teknik manual pada TPS Eclipse. Setiap pasien Servik IIB diuji coba dengan 5 variasi gantry planning yaitu: primer5 (00, 750, 1450, 2250, 2850), manual300 (300, 600, 900, 1200, 1500, 1800, 2100, 2400, 2700, 3000, 3300), manual450 (450, 900, 1350, 1800, 2250, 2700, 3150), auto300 dan auto450, serta dibuat 2 kelompok: kelompok A menggunakan ring/margin 2cm dan kelompok B tidak menggunakan ring/margin pada PTV. Pada penelitian kelompok A diperoleh nilai Indeks Konformitas (IK) maksimum mendekati nilai 1 pada planning setup primer5 sebesar 60% dan nilai Indeks Homogenitas (IH) paling mendekati nilai 0 diperoleh pada setup manual300, sebesar 80%. Sedangkan hasil penelitian kelompok B diperoleh nilai IK maksimum mendekati nilai 1 pada setup manual300 sebesar 100% dan nilai IH paling mendekati nilai 0 diperoleh pada setup manual300, sebesar 100%. Analisa penelitian kelompok A, setup yang menghasilkan nilai IK dan IH paling optimal diperoleh pada setup auto300 sebesar 20% dan pada kelompok B paling optimal pada setup manual300 sebesar 100%. Keberhasilan perencanaan radioterapi paling optimal diperoleh dengan teknik manual yaitu setup gantry manual300dan tanpa ring/margin PTV.
Optimisasi dosis dan kualitas citra pada radiologi diagnostik: langkah-langkah, tips, dan panduan praktis Lukmanda Evan Lubis; Djarwani Soeharso Soejoko
Journal of Medical Physics and Biophysics Vol 7, No 1 (2020)
Publisher : Indonesian Association of Physicists in Medicine (AIPM/AFISMI)

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Abstract

Potensi risiko radiasi pada pasien radiologi diagnostik menjadi isu yang menjadi perhatian khusus dalam konteks proteksi radiasi. Sebagai salah satu dari tiga prinsip proteksi radiasi, optimisasi menjadi upaya yang dikedepankan dalam menjamin keselamatan pasien. Deskripsi teknis mengenai panduan dan langkah-langkah optimisasi sejauh ini tidak tersedia dalam panduan nasional. Makalah ini menyajikan panduan praktis berdasarkan pengalaman dalam pelaksanaan optimisasi di fasilitas pelayanan kesehatan, dimana metode dan alur pelaksanaan menjadi fokus pembahasan. Hasil pelaksanaan optimisasi dan tips dalam setiap langkahnya juga diberikan sebagai contoh sederhana yang dapat memudahkan tenaga kesehatan dalam upaya pelaksanaan optimisasi di lingkungan kerjanya.
Audit dosimetri treatment planning system berkas foton pada radioterapi eksternal : A Review Andrian Dede Handika; Sonak Tioria Tarigan; Petrananda Dea Karunia; Ahmad Syafi'i; Annisa Rahma Fauzia; Khaerul Mar'ie; Putri Amalia Pontoh; Supriyanto Ardjo Pawiro
Journal of Medical Physics and Biophysics Vol 7, No 1 (2020)
Publisher : Indonesian Association of Physicists in Medicine (AIPM/AFISMI)

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Abstract

Abstrak: Treatment Planning System (TPS) merupakan modalitas penting yang menentukan hasil tindakan radioterapi. Akurasi perhitungan dosis pada TPS dipengaruhi oleh algoritma yang digunakan. Berdasarkan database internasional, TPS termasuk salah satu penyebab utama terjadinya kecelakaan radiasi pada radioterapi. Oleh karena itu, TPS perlu diaudit secara dosimetri untuk memastikan akurasi dosis yang diterima oleh target serta mengurangi kemungkinan terjadinya kecelakaan radiasi pada radioterapi. Penelitian tentang audit dosimetri TPS berkas foton telah banyak dilakukan oleh peneliti di berbagai negara, namun hingga saat ini belum ada review artikel mengenai hasil penelitian-penelitian tersebut. Review artikel ini membahas tentang berbagai hasil penelitian audit dosimetri TPS berkas foton dengan algoritma yang berbeda di beberapa center rumah sakit. Terdapat beberapa jenis algoritma TPS yang dibahas antara lain: Adaptive Convolution (AC), Anisotropic Analytical Algorithm (AAA), superposisi, dan konvolusi. Audit dosimetri TPS menggunakan fantom CIRS 002LFC yang sebelumnya telah dipindai dengan CT-Scanner. Pengukuran dosis sebagian besar menggunakan detektor bilik ionisasi. Metodologi audit dosimetri mengikuti protokol TECDOC IAEA 1583. Sebagian besar deviasi hasil audit dosimetri TPS berkas foton berada pada rentang toleransi yang dianjurkan dalam TECDOC IAEA 1583. Deviasi diluar rentang toleransi umumnya ditemukan pada material inhomogen. Secara keseluruhan, berdasarkan hasil analisis, TPS dengan algoritma AC memiliki nilai deviasi paling kecil, selanjutnya AAA, superposisi, dan konvolusi. Nilai deviasi meningkat sebanding dengan energi berkas foton yang dihasilkan oleh Linier accelerator (Linac). Review hasil audit dosimetri TPS dengan algoritma yang lain dapat dilakukan sebagai pembanding.Abstract: Treatment Planning System (TPS) is an important modality which determines the radiotherapy treatment result. The accuracy of the dose calculation in TPS is affected by the applied algorithm. Based on the international database, TPS is one of the main factors which cause radiation accidents in radiotherapy. Therefore TPS has to be audited dosimetrically to ensure the accuracy of the dose delivery to targets and moreover to reduce the possibility of radiation accidents in radiotherapy. Studies about dosimetry audit of radiotherapy TPS, especially for photon beam, have been done in many countries. Yet there has been no article review about those studies.  Because of that, authors attempt to review some studies relating with dosimetry audit of TPS with different applied algorithms in some radiotherapy centers. There are four different algorithms explaining in this article review, those are adaptive convolution (AC), anisotropic analytical algorithm (AAA), superposition, and convolution. Dosimetry audit of TPS used CIRS phantom 002LFC which had been scanned with CT scanner. Most of the dose measurement used ionization chamber detector. The procedure of this dosimetry audit followed TECDOC IAEA 1583. The deviation of most former studies results is on tolerance range. The deviation beyond tolerance range is found in heterogeneous materials. Based on the analytical result, TPS with AC algorithm has the smallest deviation, followed by AAA, superposition, and the last is convolution. The deviation increases with the beam energy. Review about dosimetry audit of TPS with others algorithms can be done for the next project. Kata kunci : Audit dosimetri, TPS, algoritma, deviasi Keywords: Dosimetry Audit, TPS, algorithm, deviation
Review singkat dosimetri internal di kedokteran nuklir menggunakan Physiologically-based Pharmacokinetic (PBPK) model dan topik penelitian paper JMPB volume 7, No. 1 (2020) Deni Hardiansyah
Journal of Medical Physics and Biophysics Vol 7, No 1 (2020)
Publisher : Indonesian Association of Physicists in Medicine (AIPM/AFISMI)

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Abstract

Radiobiological evaluation of radiation cells survival based on linear quadratic and multi-target model Raizulnasuha Binti Ab Rashid; Wan Nordiana Rahman
Journal of Medical Physics and Biophysics Vol 7, No 1 (2020)
Publisher : Indonesian Association of Physicists in Medicine (AIPM/AFISMI)

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Abstract

Radiobiological model such as linear quadratic is widely used in clinical radiotherapy to predict the biophysical response of the tumour cell to the radiation. This study investigates the radiation cell survival using Linear Quadratic and Multi-Target model and their radiobiological parameters. The experimental works were conducted in-vitro using HeLa cells that were irradiated using photon and electron beams of different energy. Cells irradiation were performed in full scatter condition and exposed to radiation doses ranges from 1 to 10 Gy. Clonogenic assay is used as an endpoint to obtain the cell survival curves which later be fitted with linear quadratic and multi-target model. The results demonstrate that Multi-target model produce the fitting curves that are closed to the experimental data compare to linear quadratic model especially at high doses. Parameter analysis from both models indicates more biological damage inflicted by high energy electron beam. Correlation between the experimental cell survival data and radiobiological model analysis suggesting that radiobiological model could be applied in analysing cells’ radiation survival and damage

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