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INDONESIA
Journal of Medical Physics and Biophysics
Published by Himpunan Fisika Medis dan Biofisika Indonesia
ISSN : 23552727     EISSN : 23552719     DOI : -
Core Subject : Health, Science,
Medicine & Pharmacology Physics
Journal of Medical Physics and Biophysics is a gold open-access journal and serves as official publication media of the Indonesian Association of Physicists in Medicine, IAPM (Aliansi Fisikawan Medik Indonesia, AFISMI). JMPB publishes articles with the general concern on the application of physics in medicine and the biological system. The role of physics highlighted in the journal can be of theoretical, experimental, or clinical nature. Review and original articles in radiation oncology, diagnostic and interventional radiology, nuclear medicine, biomaterial, physical biology, physical modeling of biological system, and other related sciences are welcome. Any opinions stated on the articles published in JMPB are those of the author(s) and do not necessarily reflect the policy of IAPM/AFISMI unless otherwise stated.
Arjuna Subject : -
Articles 69 Documents
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Setup uncertainty of head and neck cancer (HNC) patients treated with Image Guided and Intensity Modulated Radiotherapy (IG-IMRT) Nada Alia M Zamri; Hafiz M Zin
Journal of Medical Physics and Biophysics Vol 4, No 1 (2017)
Publisher : Indonesian Association of Physicists in Medicine (AIPM/AFISMI)

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Abstract

Advances in radiotherapy technology has made it possible to deliver highly conformal beams such as Intensity Modulated Radiotherapy (IMRT). The treatment is often guided by on-board cone-beam CT (CBCT) imaging system known as Image Guided Radiotherapy (IGRT). This retrospective study investigates the reproducibility of treatment setup for 25 head-and-neck cancer (HNC) patients underwent IMRT treatment at a new centre using kiloVoltage CBCT based-IGRT. All patients were immobilised using the HeadSTEPTM iFRAME. The planning target volume (PTV) margin was set to 3 mm for all directions during treatment planning. The pre-treatment CBCT imaging was acquired after patient setup. The treatment setup was corrected using online correction protocol for any errors ≥ 3 mm. 231 pre-treatment CBCT scans were acquired and setup errors were recorded in left-right (LR), anterior-posterior (AP) and superior-inferior (SI) directions. The treatment setup error of ≥ 3 mm occurred in 2.2% of measurements in LR direction, 1.7% in AP direction and 6.5% in SI direction. A PTV margin of 2.96 mm, 2.55 mm and 3.30 mm in RL, AP and SI directions, respectively was calculated using Van Herk formula, when no online corrections were performed. After online correction protocol, there were no more setup errors ≥3 mm in all three directions. The PTV margin was reduced to 2.53 mm (LR), 2.39 mm (AP) and 2.81 mm (SI). Therefore, CBCT-based online correction improves the accuracy of IMRT for HNC and reduces irradiated margin by reducing both systematic and random errors.
Wedge Factor Dependence on Computer Controlled Wedge System in Siemens ONCOR Linear Accelerator. Nasir Ilyas; Salman Farrukh; Jawed Iqbal; Syed Abdul Haseeb Ahmad
Journal of Medical Physics and Biophysics Vol 3, No 1 (2016)
Publisher : Indonesian Association of Physicists in Medicine (AIPM/AFISMI)

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Abstract

Wedge factor is the measurements which shows how much dose reduces to the target after introducing wedge between the source and target. In this work we will obtain the wedge factors by using VW (Virtual wedge) and Physical Wedge (PW) for different field sizes ( 10 x 10 cm2 ,15 x 15 cm2 and 20 x 20 cm2) , wedge angles (15°, 30° ,45° and 60° ) and energies (6 MV and 15 MV). This work will be carried out on Siemen’s linear accelerator (LINAC) and Iba-blue water phantom is used for scanning purpose. CC 13 ionization chamber is used for PW and LDA 99 for VW. The source to surface distance and depth in our work remain 100cm and 10 cm respectively. These detectors will be connected through different electrometers and all the observation will be taken through Omnipro version 7, a dosimetric software. The wedge factors will be plotted against various field sizes for both energies and wedge angles. The mean wedge factor will be analyzed by using Statistics package for social sciences (SPSS, V15) as a function of field size, wedge angle, energy and type of wedge to obtain the significance of these factors .If Analysis of Variance (ANOVA) were performed on the mean wedge factor by using F-test. The observations shows that wedge factor increases with field size and energy in both these conditions this increment is not statically significant , Wedge factor (WF) decreases with wedge angle also not statistically significant. The wedge factor in VW is greater than PW, it is highly statistically significant. 
Perbandingan profil berkas wedge lapangan kecil foton 6 MV terhadap pengaruh jaw dan MLC sebagai pembentuk lapangan Riana Dian Pertiwi; Wahyu Edy Wibowo; Elsa Angelina; Supriyanto Ardjo Pawiro
Journal of Medical Physics and Biophysics Vol 5, No 1 (2018)
Publisher : Indonesian Association of Physicists in Medicine (AIPM/AFISMI)

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Abstract

Kanker sinonasal memiliki karakteristik yang unik berkaitan dengan anatomi yang berdekatan dengan OAR, sehingga memerlukan gradien dosis yang tinggi untuk melakukan treatment yang dapat diamati dengan melihat FWHM dan penumbra yang dihasilkan pada profil berkas pada lapangan wedge yang dihasilkan dengan menggunakan jaw dan MLC. Wedge yang digunakan merupakan physical wedge [L1] dengan sudut 15o, 30o, 45o, dan 60o  yang dilakukan di kedalaman 1.5 cm, 5 cm dan 10 cm pada lapangan 1 × 1 cm2, 2 × 2 cm2, 3 × 3 cm2 dan 4 × 4 cm2  dengan menggunakan film Gafchromic EBT3. Hasil menunjukkan nilai penumbra dan FWHM terbesar diperoleh dengan MLC sebagai pembentukan lapangan dan nilai terkecil dengan MLC (edge) sebagai pembentukan lapangan. Perbedaan hasil tersebut dikarenakan adanya perbedaan faktor transmisi jaw dan faktor transmisi MLC, dan adanya pengaruh dari kebocoran interleaf dan transmisi pada bagian tepi dari MLC. Penggunaan wedge pada profil berkas dapat mempengaruhi nilai FWHM dan penumbra yang dihasilkan sebagai akibat adanya efek beam hardening yang muncul dengan penggunaan physical wedge. Hasil studi ini menunjukkan pembentukan lapangan dengan menggunakan MLC (edge) merupakan pembentukan lapangan secara optimal, sedangkan penggunaan wedgedapat mempengaruhi nilai FWHM yang dihasilkan. [L1]Hindari kata berulang 
Jejak kontribusi JMPB dalam membangun budaya ilmiah Fisika Medis nasional: Edisi Khusus PIT-FMB 2017 Supriyanto Ardjo Pawiro
Journal of Medical Physics and Biophysics Vol 5, No 2 (2018)
Publisher : Indonesian Association of Physicists in Medicine (AIPM/AFISMI)

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Abstract

Efek Paparan Radiasi Gamma dan Pemberian Ekstrak Temulawak (Curcuma xanthorrhiza) Terhadap Pelebaran Vena Centralis Hepar Mencit (Mus musculus) Septiana Kurnia Sari; C S Widodo; U P Juswono
Journal of Medical Physics and Biophysics Vol 5, No 2 (2018)
Publisher : Indonesian Association of Physicists in Medicine (AIPM/AFISMI)

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Abstract

Gamma radiation is ionizing radiation causes cells damage. It was caused by interaction of radiation with cells can produce free radical. The cell defense mechanisms againts free radical involves an antioxidant that can neutralize and catch it. The objectives of this research were to analyze effects of gamma radiation exposure and treated with Curcuma xanthorrhiza extract in central vein to the mice’s liver. Eighty mices were used in this research and divided into three groups, negative control (K-), radiation non extract (R-) and extract plus radiation (R+). The mice were treated with 1.4; 2.0; 2.6; 3.2 and 3.8 gr/kg body weight. The exposure of gamma radiation are given during 10, 20, 30, 40 and 50 minutes. The measuring of central vein area is done by observated microscopic picture mice’s liver. The results showed that free radical forms lipid peroxidation that causes necrosis to the liver cells, one of them is widening of central vein. The treatment with Curcuma xanthorrhiza extract can prevent the enlargement of central vein with increasing Curcuma xanthorrhiza extract dosage, from 129424 µm2 menjadi 12941 µm2. Curcuma xanthorrhiza extract contains curcumin that can inhibit forming free radical because of gamma radiation to liver.
Analisis spektral entropi dan kompleksitas sinyal EEG pada Alzheimer’s Disease Nita Handayani; Y Akbar; I Arif; S N Khotimah; F Haryanto; W P Taruno
Journal of Medical Physics and Biophysics Vol 5, No 2 (2018)
Publisher : Indonesian Association of Physicists in Medicine (AIPM/AFISMI)

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Abstract

Alzheimer's Disease (AD) is a neurodegenerative disease characterized by decreased memory function and cognitive ability. The disease is caused by damage to neurons due to the accumulation of amyloid beta plaque (Aβ) and neurofibrillary tangles (NFTs) within the neurons. This condition causes the transmission of electrical signals in the brain to be inhibited and there is a change in the level of irregularity and complexity of brain signals. The purpose of this study was to measure the degree of irregularity and complexity of EEG data in AD patients with spectral entropy and Largest Lyapunov Exponent (LLE) quantities. EEG data recording uses 14-channel Emotiv Epoc with a sampling frequency of 128 Hz. The test subjects consisted of 9 subjects with Alzheimer's Disease and 10 control subjects. The Mann-Whitney U test statistic was used to see if there were significantly differences in the values of spectral entropy and LLE between the AD group and the control group. Based on the calculation results obtained that the value of spectral entropy of AD patients lower than control subjects (p <0.05) on P8, F4 and AF4 electrodes. The chaotic level test with LLE showed significantly difference (p <0.05) on AF3, F7, FC5, P8, T8, F4, F8 and AF4 electrodes between AD group and control group. The study of EEG nonlinear dynamics can be used to determine the degree of irregularity and complexity of brain signals.
Kajian dari Proses Studi Kontrol Kualitas Gambar Magnetic Resonance Imaging (MRI) pada Simulasi Treatment Planning Gamma Knife Irhas Irhas; Freddy Haryanto; Elia Soediatmoko
Journal of Medical Physics and Biophysics Vol 5, No 2 (2018)
Publisher : Indonesian Association of Physicists in Medicine (AIPM/AFISMI)

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Abstract

Kajian dari Proses Studi Kontrol Kualitas Gambar Magnetic Resonance Imaging (MRI) pada Simulasi Treatment Planning Gamma Knife
Pengembangan Teknik Enhancement dan Segmentation untuk Mendeteksi Tumor Dini di Paru-paru Tumpal Pandiangan; Ika Bali
Journal of Medical Physics and Biophysics Vol 5, No 2 (2018)
Publisher : Indonesian Association of Physicists in Medicine (AIPM/AFISMI)

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Abstract

Pengembangan Teknik Enhancement dan Segmentation untuk Mendeteksi Tumor Dini di Paru-paru
Verifikasi distribusi dosis menggunakan detektor 2D-Array sebagai evaluasi hasil kalkulasi algoritma collapsed cone dan monte carlo pada TPS Monaco 5.11 Andi Hariyadi
Journal of Medical Physics and Biophysics Vol 5, No 2 (2018)
Publisher : Indonesian Association of Physicists in Medicine (AIPM/AFISMI)

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Abstract

Verifikasi distribusi dosis menggunakan detektor 2D-Array sebagai evaluasi hasil kalkulasi algoritma collapsed cone dan monte carlo pada TPS Monaco 5.11
Pengaruh Antiscatter grid Terhadap Dosis dan Kualitas Citra pada Prosedur Radiologi Intervensional Eka Aulia Ardyanti; M. Roslan Abdul Gani; Lukmanda Evan Lubis; Djarwani Soeharso Soejoko
Journal of Medical Physics and Biophysics Vol 6, No 1 (2019)
Publisher : Indonesian Association of Physicists in Medicine (AIPM/AFISMI)

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Abstract

The study discusses the threshold of thickness required for antiscatter grid use on Siemens Artis Zee at “Dharmais” National Cancer Center, Jakarta. The device has adjustable modes of low, medium, and high fluoroscopy. Patients are represented by Polymethyl Methacrylate (PMMA) phantom with a thickness variation of 7-22 cm of 1 cm interval. The dose metrics was measured as the entrance skin dose (ESD) and the transmission dose, while the image quality metric employed being signal to noise ratio (SNR), leading the result to FOM as squared SNR per dose. The FOM bridged dose and image quality to determine threshold of antiscatter grid usage on fluoroscopy based on fantom thickness. As a result, antiscatter grid are recommended to be used for objects 11 cm and thicker on the use of low fluoroscopy mode, and 16 cm and thicker objects on high fluoroscopy mode. In medium fluoroscopy mode, no threshold was yielded due to tube current being higher than other modes, hence it is recommended to remove the antiscatter grid during the use of the medium fluoroscopy mode

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