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The Journal of Pure and Applied Chemistry Research

jpacr
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Published by Universitas Brawijaya

ISSN : 23024690 EISSN : 25410733 DOI : http://dx.doi.org/10.21776/ub.jpacr

Core Subject : Health, Science, Engineering,

Chemical Engineering, Chemistry & Bioengineering Chemistry Materials Science & Nanotechnology Medicine & Pharmacology

The Journal of Pure and Applied Chemistry Research focuses in publishing research articles in the field of Chemistry and Applied Chemistry. The target is in exploring, investigating, and developing chemicals sources from local and/or Indonesian to increase the value. Scope of the journal is organic chemistry, analytical chemistry, inorganic chemistry, biochemistry, and physical chemistry. Included the topic also organic chemistry natural product, theoretical and computational chemistry.

Arjuna Subject : Kimia(semua kategori) - Kimia (Lain-Lain)

Articles 10 Documents

Search results for , issue "Vol 6, No 3 (2017): Edition of September - December 2017" : 10 Documents clear

Synthesis and Characterization of Polyaniline Nanoparticle by Inverse Micelle Microemulsion Method Nuraini Uswatun Chasana; Siti Mariyah Ulfa; Masruri MASRURI
The Journal of Pure and Applied Chemistry Research Vol 6, No 3 (2017): Edition of September - December 2017
Publisher : Chemistry Department, The University of Brawijaya

Polyaniline (PANI) is a conductive polymer and potential for application in the electronic device manufacturing. This paper discloses a recent strategy in synthesis polyaniline nanoparticle (NP-PANI) using inverse micelle (IM) microemulsion method, and also characterization of the provided products. The synthesis step was conducted by mixing of aniline as a polymer precursor with PEG 400, n-hexane, n-butanol, ammonium persulfate and hydrochloric acid in three different reaction times, i.e. for 2, 6, and 12 hours at 26 oC. NP-PANI was afforded as a brown powder in 2.87%, 1.97% and 2.30% yield for NP-PANI-IM-2, NP-PANI-IM-6 and NP-PANI-IM-12. The characteristic on ultra violet-visible and infrared spectra exhibited NP-PANI was formed as an emeraldine salt oligomer. Moreover, their morphology was observed through scanning electron microscopy (SEM) and showed a different range of nanoparticle size, i.e. 50-62, 68-72 and 58-62 nm for NP-PANI-IM-2, NP-PANI-IM-6 and NP-PANI-IM-12, respectively. These products open the potency application in material science.

A Simple Photometer and Chemometrics Analysis for Quality Control of Sambiloto (Andrographis paniculata) Raw Material Rudi Heryanto; Derry Permana; Aryo Tedjo; Eti Rohaeti; Mohamad Rafi; Latifah Kosim Darusman
The Journal of Pure and Applied Chemistry Research Vol 6, No 3 (2017): Edition of September - December 2017
Publisher : Chemistry Department, The University of Brawijaya

In this paper, we described the use of a light emitting diode (LED)-based photometer and chemometric analysis for quality control of king of bitter or sambiloto (Andrographis paniculata) raw material. The quality of medicinal plants is determined by their chemical composition. The quantities of chemical components in medicinal plants can be assessed using spectroscopic technique. We used an “in house” photometer to generate spectra of sambiloto. The spectra were analyzed by chemometric methods, i.e. principal component analysis (PCA) and partial least square discriminant analysis (PLS-DA), with the aim of herbal quality classification based on the harvesting time. From the results obtained, based on thin layer chromatography analysis, sambiloto with different collection times (1, 2, and 3 months) contained different amounts of active compounds. Evaluation of sambiloto, using its spectra and chemometric analysis has successfully differentiated its quality based on harvesting time. PCA with the first two PC’s (PC-1 = 60% and PC-2 = 35%) was able to differentiate according to the harvesting time of sambiloto. Three models were obtained by PLS-DA and could be used to predict unknown sample of sambiloto according to the harvesting time

Liquid Chromatography for Analysis of Metformin in Myrmeleon sp. Afidatul Muadifah; Hermin Sulistyarti; Sasangka Prasetyawan
The Journal of Pure and Applied Chemistry Research Vol 6, No 3 (2017): Edition of September - December 2017
Publisher : Chemistry Department, The University of Brawijaya

Myrmeleon sp is a typical of insect larva which has been used in Indonesia for diabetes treatment. However, there is no sufficient scientific report explaining the bioactive compounds in this insect. Based on our preliminary research, this insect contained metformin, i.e. one of bioactive compounds for the treatment of type-2 diabetes. Therefore, this study is focused on the development of separation technique using high performance liquid chromatography (HPLC) on a reverse phase C-18 column with UV detection to identify and quantify metformin in methanol extract of Myrmeleon sp. Several parameters of HPLC method were optimized with respect to high resolution of separation and accurate determination of metformin. Satisfied separation was obtained under gradient elution mode using aqueous methanol mobile phase varied from 50-90 % of methanol with flow rate of 0.5 mL/min and detection wavelength of 233 nm. The method performed total separation for all compounds in less than 11 minutes. Spiking technique was chosen for metformin identification and quantitation. Metformin in extract Myrmeleon sp was eluted at retention time (tR) of 4.095 minutes, similarly with retention time of standard metformin of 4.092 minutes. The quantity of metformin in Myrmeleon sp can be simply determined by comparing the additional area of standard metformin with area of metformin from extract Myrmeleon sp. The results confirmed that methanol extract of Myrmeleon sp contained anti-diabetes compound of metformin of 0.58 mg/g Myrmeleon sp larvae with acceptable coefficient variation of 5.56 %.

Green Tea Extract (Camellia sinensis L.) Effects on Uric Acid Levels on Hyperuricemia Rats (Rattus norvegicus) Putranty Widha Nugraheni; Fitria Rahmawati; Chanif Mahdi; Sasangka Prasetyawan
The Journal of Pure and Applied Chemistry Research Vol 6, No 3 (2017): Edition of September - December 2017
Publisher : Chemistry Department, The University of Brawijaya

Uric acid is the end product of purine degradation. When uric acid levels exceed normal limits, it will build up and cause hyperuricemia. Allopurinol is one of the most effective and common medicine for hyperuricemia, but it brings serious side effects, therefore it is needed alternative therapy for hyperuricemia. One plant that may be expected to low uric acid levels is green tea (Camellia sinensis L.), that contains many antioxidants polyphenols, especially flavonoids. Flavonoid has strong antioxidant properties, act as free radical and metal scavengers, and also xanthine oxidase (XOD) inhibitors. This study investigates the potential of green tea using various doses of 150 mg/kg, 300 mg/kg, and 600 mg/kg of body weight in 24 white male rats (Rattus norvegicus) Wistar strain that has been received high purine diet in 60 consecutive days. This study used DHBSA methods to measure uric acid levels in blood serum and urine that excreted 8 hours before surgery. Green tea extract that contains polyphenol can inhibit XOD activities, therefore, it leads to decrease uric acid level in blood and increase the excretion through urine by modulating urate gene transporter. A therapy with 600 mg/kg body weight of GTE is the most effective dose to decrease uric acid levels in serum and to increase excretion of exceeding uric acid significantly (p < 0.01), from One Way ANOVA and Tukey analysis.

The Effect of Phosphatation and Granulation Zeolite in the Adsorption of Cr(VI) Sri Wardhani; Reno Sunarinda Endrayana; Danar Purwonugroho
The Journal of Pure and Applied Chemistry Research Vol 6, No 3 (2017): Edition of September - December 2017
Publisher : Chemistry Department, The University of Brawijaya

The purpose of this research to study effect of contact time on adsorption of Cr(VI) ion using Granules Alumino Silico Phosphate (GASP) and the effect of Cr (VI) concentration on adsorption capacity at GASP. The GASF synthesis process is carried out in several main stages: 1) activation of zeolite with addition of HCl, 2) zeolite phosphatation with addition of NH4H2PO4 ratio Si/P = 1/6 at 235ᴼC for 5 hours, 3) how make GASP with addition of zeolite phosphate (Alumino Silicone Phosphate) and chitosan gel with a syringe pump speed of 50 mL/min. GASP is characterized using XRF, FT-IR and SAA. The contact time effect is tested using 0.1 g of GASF in K2CrO4 100 mg/L with a contact time variation of 0.5; 1.0; 1.5; 2.0 and 2.5 hours. The concentration effect on adsorption capacity is tested out using 0.1 g of GASP in K2CrO4 with concentration variation 25, 50, 75, 100 and 150 mg / L for 2 hours (optimum contact time). The adsorption capacity can be determined using the Langmuir equation. XRF characterization results showed a decrease in SiO2 levels of 18.10% and Al2O3 by 2.2% after phosphatation process. FTIR characterization results indicate the presence of O-H, N-H and C-H chitosan on absorption bands 1-3. The success of the phosphatation process was evidenced by the shift of wave numbers to the lower regions in the bands 7, 9 and 12 the absorption of tetrahedral silica and alumina shifted to bands 8, 10 and 13 tetrahedral phosphate uptake in accordance with Hooke's law. The result of the research showed that the optimum contact time occurred in the adsorption process for 2 hours. The concentration variation was directly proportional to the increase of the adsorbed Cr (VI) ion mass. The presence of phosphatation and chitosan addition process can increase the value of adsorption capacity by 48,077 mg / g.

Physical Properties and Characterization of Cassava Peel Waste Modified by Esterification Suci Susanti; Denis Al Karoma; Dian Mulyani; Masruri Masruri
The Journal of Pure and Applied Chemistry Research Vol 6, No 3 (2017): Edition of September - December 2017
Publisher : Chemistry Department, The University of Brawijaya

Cassava starch (Manihot esculenta) is polysaccharide compound which comprises of amylose and amylopectin. This paper demonstrated the characterization result of cassava peel waste modified by esterification with acetic acid and oleic acid. The products were analyzed by FT-IR, PSA, SEM, and XRD. FT-IR results represented carbonyl compound. DS value of acetic acid and oleic acid modification is 0.63 and 0.56, respectively. Characterization by PSA found the distribution frequency was 358.19 mm. SEM analysis was obtained rigid structure. From XRD result, the crystallinity of modified flour better than without modification.

Metabolite Variation of Peanut Hulls (Arachis hypogaea L.) from Three Locations of Lombok Island on the Basis of GC-MS Analysis Surya Hadi; Dina Asnawati; Baiq Mariana; Hijriati Sholehah; Andhina Rizkya Satriani; Seto Priyambodo
The Journal of Pure and Applied Chemistry Research Vol 6, No 3 (2017): Edition of September - December 2017
Publisher : Chemistry Department, The University of Brawijaya

This article is a part of studies to investigate the potential of natural products from Lombok Island for antidiabetic agents. This study was directed to learn the metabolite variations of peanut hulls collected from three different locations in Lombok Island. The hull samples were extracted in methanol, followed by partition process into three fractions using three solvents with varied polarities (dichloromethane, hexane and acetone). The fractions were then separated and identified for their chemical composition by using GC-MS instrument. Metabolite variations of three extracts showed that the antidiabetic compounds stigmast-5-en-3-ol and oleic acid were found in all three locations with different percentages of abundance. Another antidiabetic compound, linoleic acid, was only identified in peanut hulls from the village of Pringga Jurang (PJ). Besides the antidiabetic compounds, there were other major compounds with known biological activities discussed to find other uses of the hulls.

Melastoma malabathricum Fruit Extract-Mediated Synthesis of Silver Nanoparticles with Sensing Ability for High Concentrations of Mercury (II) Nitrate SALPRIMA YUDHA S; Aswin Falahudin; Meka Saima Perdani; Irfan Gustian; Saiqa Ikram
The Journal of Pure and Applied Chemistry Research Vol 6, No 3 (2017): Edition of September - December 2017
Publisher : Chemistry Department, The University of Brawijaya

A strategic approach was developed to synthesize silver nanoparticles from AgNO3 using Melastoma malabathricum seed extract. The reaction of silver ions with the organic compounds in the seed extract proceeded smoothly at room temperature without any additional capping agent. The appearance of an absorption peak around 427 nm provided evidence for the presence of silver nanoparticles in the reaction mixture. A diluted solution of the silver nanoparticles was treated with various concentrations of mercury (II) nitrate solutions and the resulting reaction was monitored using UV-Vis spectrophotometry

Studies of In Vitro and In Silico of Immobilized Xylanase on Zeolite Matrix Activated with Hydrochloric Acid Janatun Na’imah; Sasangka Prasetyawan; Arie Srihardyastutie
The Journal of Pure and Applied Chemistry Research Vol 6, No 3 (2017): Edition of September - December 2017
Publisher : Chemistry Department, The University of Brawijaya

Xylanase is a hydrolase enzyme that can hydrolyze hemicellulose into xilo-oligosaccharide and xylose. This research is aimed to investigate the in vitro and in silico xylanase (isolated from the fungus Trichoderma viride) immobilized on the zeolite matrix activated with HCl 0.4 M solution. The study was performed using in silico docking molecular methods to investigate the interaction between the xylanase primarily to its ligand. Xylanase activity was determined by reducing sugar produced (xylose) by 1 mL of enzyme per minute. The optimum conditions of immobilized xylanase were measured according to the time agitation and concentration of xylanase. The time variation agitation used were 1, 2, 3, 4, and 5 hours, while variations in the concentrations of a xylanase used were 11.500, 15.653, 20.444, 25.875, and 31.944 mg/mL. The optimum conditions of immobilized xylanase was obtained in the shaking time for 3 hours at a concentration of xylanase 15.653 mg/mL and immobilized xylanase activity generated at 46.755 μg.g-1.min-1. Immobilized xylanase activity was greater than the purified xylanase (15.976 μg.mL-1.min-1). These results were due to the cofactors Al (AlO4) and Si (SiO4) of zeolite was able to increase the kinetic energy caused the reaction rate between xylanase with the larger substrates. Cofactor also increased the kinetic energy and can enhance the rate of reaction between a xylanase with its substrate, in order to give greater activity. Immobilized xylanase was stable and its reusability as much as 6 times which afforded the activity 21.331 μg.g-1.min-1 and the efficiency of 56.77%.

Synthesis and Characterization of PVDF-LiBOB Electrolyte Membrane with ZrO2 as Additives Etty Wigayati; Rosyid Ridlo; Achmad Subhan; Ibrahim Purawiardi
The Journal of Pure and Applied Chemistry Research Vol 6, No 3 (2017): Edition of September - December 2017
Publisher : Chemistry Department, The University of Brawijaya

The electrolyte membrane serves as ions medium transport and as a separator between the anode and cathode in lithium ion battery. The polymer used for the electrolyte membrane must have sufficiently high mechanical strength to withstand the pressure between the anode and cathode, a thin size and has a chemical and thermal stability.Polymer electrolyte membrane of Lithium bisoxalate Borate(LiBOB) salt with PVdF as matrix polymer and the additive is ZrO2 has been fabricated. The method used is a doctor blade. The concentration of the additive is varied. The membranes were characterized using FT-IR, XRD, SEM and EIS. XRD analysis showed that the crystallinity index increases with the addition of ZrO2. The presence of functional groups bewteen Lithium salts and polymer interaction shown by FTIR analysis. The morphology of the membrane surface was shown by SEM analysis. SEM image and mapping show the morphology of the membrane have typical porous layer. The electrical conductivity increases with additions of ZrO2.

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Masruri

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Home Page

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Contact Name Masruri

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Editorial Address Departemen Kimia, Fakultas MIPA, Universitas Brawijaya, Jl. Veteran 65145 Malang

Location Kota malang, Jawa timur INDONESIA

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Contact Name
Masruri

Contact Email
masruri@ub.ac.id

Phone
+62341-575838

Journal Mail Official
jpacr@ub.ac.id

Editorial Address
Departemen Kimia, Fakultas MIPA, Universitas Brawijaya, Jl. Veteran 65145 Malang

Location
Kota malang,

Jawa timur

INDONESIA