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INDONESIA
Program Kreativitas Mahasiswa - Penelitian
Published by DITJEN DIKTI KEMDIKBUD RI
ISSN : -     EISSN : -     DOI : -
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Articles 105 Documents
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KRIM KULIT BUAH DURIAN (Durio zibethinus L.) SEBAGAI OBAT HERBAL PENGOBATAN INFEKSI JAMUR Candida albicans Setyowati, Hanny; Hanifah, Hananun Zharfa; Nugraheni, Rr Putri
Program Kreativitas Mahasiswa - Penelitian PKM-P 2013
Publisher : Ditlitabmas, Ditjen DIKTI, Kemdikbud RI

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Abstract

Durian rind (Durio zibethinus L.) is a part of plant that has antifungal activity. This research purposed for made extract rind of Durio zibethinus L. formula cream and tasted the physical characteristic toward Candida albicans fungi. The formulation of extract rind of Durio zibethinus L. is made with variety of extract concentration: 15%, 20%, and 25%. Cream that is produced by physically tested covers: organoleptis,homogeneity, adhesive power, dispersive power, and protection power. The result of this research showed that extract rind of Durio zibethinus L. formula cream had antifungal activities towards Candida albicans and fulfill the physically tested covers. Keywords: Durio zibethinus L, Candida albicans, cream
EKSTRAKSI DNA Collocalia fuchiphaga DENGAN METODE PHENOL CHLOROFORM EXTRACTION DARI BERBAGAI MATERIAL SUMBER GENETIK Hendra, Hendra; Suryaningtyas, Natalia Widya Yuda; Riyanto, Cellica; Heryanto, Aditya Fendy
Program Kreativitas Mahasiswa - Penelitian PKM-P 2013
Publisher : Ditlitabmas, Ditjen DIKTI, Kemdikbud RI

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Abstract

DNA extraction is the first important step in molecular study. The aim of this research was to compare DNA extraction protocols, PCE and extraction kit for each genetic material sources (blood and feathers). For PCE method, we used three different extraction buffer. This study suggested that PCE method was more efficient than the extraction kit method. Meanwhile, extraction buffer 2 was more efficient for extracting feather DNA, while extraction buffer 3 was more efficient for extracting blood DNA. Wing feather was a favorable sample as genetic source for DNA extraction. Keywords: DNA extraction, phenol-chloroform, Collocalia fuchiphaga
PROPOLIS SEBAGAI SUPLEMEN BAGI PENDERITA TUBERKULOSIS DEWASA Pranandaru, Herlambang; Sembodo, Adi; Choirina, Julia; Wijaya, Fahrizal Kusuma; Sewaka, Septian Wisnu
Program Kreativitas Mahasiswa - Penelitian PKM-P 2013
Publisher : Ditlitabmas, Ditjen DIKTI, Kemdikbud RI

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Abstract

One of current world health problems is tuberculosis. Propolis can inhibit M. tuberculosis growth and increase the mediator of macrophage activator. The aim to proof that propolis as a supplement to heal in tuberculosis.  Research design is control experimental group, using 15 samples patient of positive BTA, divided into 2 groups, control (standard anti-tuberculosis) and experiment (combination of standard anti-tuberculosis+propolis). All patients randomly, take the propolis or placebo with 4 drops dosage every day during 2 month and BTA will be checked. The examination result shows that experiment group has better recovery than control group (p=0,020). It concluded that propolis can be a good choice as a supplement of treating infections caused by M.tuberculosis.Keywords: Propolis, Supplement, Recovery, Adult patient of tuberculosis.
ASIATIDRI: POTENSI KOMBINASI DAUN ARA SUNGSANG (ASYSTASIA GANGETICA SSP. MICRANTHA) DAN SELEDRI (APIUM GRAVEOLENS L.) SEBAGAI ALTERNATIF TEH HERBAL ANTI DIABETES MELLITUS Putri, Ayu Nirarai; Sari, Aulia Murti Novita; Eldy, Wikke Febrya
Program Kreativitas Mahasiswa - Penelitian PKM-P 2013
Publisher : Ditlitabmas, Ditjen DIKTI, Kemdikbud RI

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Abstract

Study on the potential combination of Asystasia gangetica ssp. micrantha and Apium graveolens L.  tea for anti diabetes mellitus and its effective dose has been conducted on male Mus musculus. Complete random design with 5 treatments: positive and negative controls, 31,43 mg/30 g body weight (bw), 54.60 mg/30 g bw, 62.86 g/30 g bw with 4 replications was applied. Data was analyzed using ANOVA and LSD at 5%. After seven days infusion treatments indicated that there was significantly decrease in blood glucose level. The highest dose of 62.86 mg/30 g   decreased mice’s blood glucose level closed to their normal level.Keywords: Asiatidri, diabetes mellitus, blood glucose level.
PENGEMBANGAN METODE HPTLC-SPEKTROFOTODENSITOMETRI UNTUK PEMISAHAN SENYAWA RIFAMPISIN, ISONIAZID, PIRAZINAMIDA, DAN ETAMBUTOL Prawiranata, I Putu Hengky; Sugiastana, Bagus Nyoman; Putra, I Putu Krisnantara Wijaya; Dharmapradnyawati, Ni Nyoman Putri; Widhiartini, Ida Ayu Alit; Wirasuta, I Made Agus Gelgel; Widjaja, I Nyoman Kadjeng
Program Kreativitas Mahasiswa - Penelitian PKM-P 2013
Publisher : Ditlitabmas, Ditjen DIKTI, Kemdikbud RI

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Abstract

A simple chromatography saparation method for rifampicin, isoniazid, pyrazinamide, and ethambutol by using an impregnated TLC plate with paraffin has been studied. The aim of this study was to develop as simultan separation method of rifampicin, isoniazid, pyrazinamide, and ethambutol. TLC silica gel GF254 was impregnated with paraffin in diethyl ether 10% (v/v). Plate was actived on 110°C, 30 minutes. Some variation of mobile phase was used based on a mixture of ethanol and water. The best chromatographic parameters resulting in use a mixture of ethanol:water (95:5 v/v) were added 5% of glacial acetic acid and 1% of diethylamine as mobile phase. Ethambutol can was derivatized by iodine vapor, but it not detected at a TLC-spektrofotodensitometer, so for a validation only rifampicin, isoniazid, and pyrazinamide. This mobile phase gave good separation with Rs>1 and α>1. The chromatography plates were scanned at 335 nm for rifampicin and at 275 nm for isoniazid and pyrazinamide using a TLC-spektrofotodensitometer. Method validation was includes determining the specificity, LOD, and precision of the method. The method was developed in this study had good validation. Specificity of method was determined by purity factor value, on this method was obtained of purity factor (r(s,m) dan r(m,e))<0,99. The results of this study indicate good precision by intraday and interday assay (RSD<20%) of the method validation. LOD for rifampicin, isoniazid, and pyrazinamide was 15,339  ng,  29,719 ng, and 26,892 ng respectively. The method was developed can be used as a reference for separation of rifampicin, isoniazid, pyrazinamide, and ethambutol in biologis or drug samples. Keywords:     Rifampicin, isoniazid, pyrazinamide, ethambutol, impregnation, derivatization
INOVASI PEMBELAJARAN BERBASIS MASALAH BERBANTUAN MEDIA TRANSVISI UNTUK MENINGKATKAN KETERAMPILAN PROSES SAINS Rahayu, Indah Puji; Yulianingsih, Utari; Septiani, Dwi; Wijaya, Angga Adistia
Program Kreativitas Mahasiswa - Penelitian PKM-P 2013
Publisher : Ditlitabmas, Ditjen DIKTI, Kemdikbud RI

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Abstract

This study aims to design problem based learning with transvisi media. The learning was applied to improve science process skills at electrolyte-nonelectrolyte material and concepts redox. Quasi experiment design with pretest-posttest control group was used. The differences between pre and post test of Science Process Skill was assumed as effect of treatment. Research subjects were two classgroup of X class in SMA N 1 Randublatung.  One class was as control group and the other was as experiment group. They were determined through cluster random sampling. Science process skill was measured by multiple choice test-with reason. Data were analyzed by t-test. Results showed that the implementation of problem based learning at electrolyte-nonelectrolyte and redox can improve students’ science process skills, as well as students gave positive responce to learning implementation. Keywords: Science Process Skills; Transvisi Media; PBL Model.
POTENSI EKSTRAK METANOL DAUN KAPUR (Harmsiopanax aculeatus, Harms) SEBAGAI OBAT ANTIMALARIA Wijaya, Jefry; Salenussa, Jusuf; Marantika, Jacky
Program Kreativitas Mahasiswa - Penelitian PKM-P 2013
Publisher : Ditlitabmas, Ditjen DIKTI, Kemdikbud RI

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Abstract

Kapur plant (Harmsiopanax aculeatus Harms) is traditionally used by Mollucans to treat malaria disease. Squeezed of young leaves which is dropped on the eye of sufferer is the way of its treatment. This research is aimed to assay haem polymerization inhibition activity, cytotoxic activity toward vero cells and to analysis chemical secondary metabolit of compound content on methanol extract of the old kapur leaves. Dried powder of kapur leaves (1 kg) is extracted by maceration technique using methanol solvent obtained 95,85g (9,59%) of methanol extract. Those extract which assayed haem polymerization inhibition on activity by Bassilico et al. (1998) method is shown IC50 values of 9410,93 µg/mL. Cytotoxic test toward vero cells using MTT assay, Kasugai et al. (1983) is shown that IC50 values is 9402,81 µg/mL. Phytochemical analysis by spray and visible reagent shown of flavanoids, phenolic, saponin an antraquinones compound. Keyword: Harmsiopanax acuelatus Harms, haem polymerization inhibition activity, cytotoxic activity, vero cell, phytochemical.
KAJIAN PERBEDAAN KATALIS DAN MEMINIMALISIR WAKTU DALAM PEMANFAATAN LIMBAH CAIR KELAPA SAWIT MENJADI BIODIESEL Purnamasari, Juita; Anggraini, Widya; Herdiansah, Riko
Program Kreativitas Mahasiswa - Penelitian PKM-P 2013
Publisher : Ditlitabmas, Ditjen DIKTI, Kemdikbud RI

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Abstract

The purpose of this study is to assess the quantity and quality of the biodiesel produced using ultrasonic technology with an acid catalyst and modification time. The raw material in this study is the oil fraction from palm oil processing wastewater. In the esterification process used two variations of the addition of an acid catalyst. The results showed the use of ultrasonic techniques with 0.5% H2SO4 catalyst with a time of 25 minutes and the temperature of 600C can produce a higher yield compared to other treatments. So also was able to meet the quality of SNI 04-7182-2006 for quality parameters density, viscosity, cetane number, cloud point and the number odium. Keywords: methyl ester, fraction of palm oil from waste water, ultrasonic technology
EFESIENSI PENGGUNAAN TEKNIK BIOFLOKULASI DALAM PEMANENAN MIKROALGA SPESIES Spirullina sp. DAN Botryococcus braunii UNTUK OPTIMALISASI PRODUKSI BIODIESEL Badriyah, Lia; Putra, Abdul Rahman; Saputra, Deni; Faiqoh, Iqoh; Nugraha, Aditya Hikmat
Program Kreativitas Mahasiswa - Penelitian PKM-P 2013
Publisher : Ditlitabmas, Ditjen DIKTI, Kemdikbud RI

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Abstract

Mikroalga merupakan tanaman thalus yang memiliki klorofil sehingga sangat efisien dalam menangkap dan memanfaatkan energi matahari dan CO2 untuk keperluan fotosintesis. Mikroalga berpotensi sebagai alternatif  penghasil sumber energi baru dan terbarukan. Kendala yang terjadi dalam memanfaatkan mikroalga sebagai bahan energi terbarukan adalah pemanenan. Selama ini pemanenan mikroalga masih membutuhkan energi yang besar dan kurang ekonomis. Oleh karena Bioflokulasi menawarkan pemanenan mikroalga yang ekonomis, hemat energi serta ramah lingkungan. Bioflokulasi merupakan teknik pemanenan mikroalga dengan menggunakan makhluk hidup. Bioflokulasi selama ini menggunakan bakteri atau fungi sebagai agen pengendap, namun dengan menggunakan mahluk hidup lain membutuhkan biaya tambahan berupa substrat untuk hidup. Bioflokulasi dalam pemanenan mikroalga menawarkan pengendapan dengan bantuan mikroalga spesies lain. Penelitian ini menggunakan mikroalga Tetraselmis suecica dan Chlorella sp. Spesies ini menggantikan spesies yang sebelumnya (Spirullina sp. & Botryococcus braunii) dikarenakan kedua spesies tersebut kurang efektif jika dilihat dari nilai OD dan Persentase recovery.  Hasil penelitian menunjukan bahwa setelah dilakukan kultivasi selama 20 hari diperoleh waktu panen. Waktu panen untuk Tetraselmis suecica pada hari ke-13 dan Chlorella sp. pada hari ke-12. Berdasarkan nilai OD dan persentase recovery diketahui bahwa Chlorella sp termasuk mikroalga non flokulan, dan Tetraselmis suecica termasuk mikroalga flokulan. Dalam hal ini Chlorella sp. akan dipanen dengan Tetraselmis suecica  dalam teknik bioflokulasi. Selanjutnya diketahui perbandingan 4:4 yang merupakan perbandingan yang paling efisien untuk selanjutnya dilakukan ekstraksi kadar lemak. Kadar lemak Chlorella sp sebesar 8.9909 % dari berat kering. Sedangkan pemanenan dengan bantuan Tetraselmis suecica  didapatkan kadar lemak Chlorella sp sebesar 11.7094. Sehingga terjadi peningkatan lemak sebesar 30,24 %. Pemanenan dengan penggunaan teknik bioflokulasi diharapkan bisa menjadi langkah dalam optimalisasi produksi biodiesel. Kata kunci: mikroalga, bioflokulasi, biodiesel, ekonomis, ramah lingkungan
MAHKOTA DEWA (PHALERIA MACROCARPA) SEBAGAI ANTINEFROTOKSISITAS “DEWA PENYELAMAT” DALAM PENURUNAN EFEK SAMPING CISPLATIN Zulharini S, Meirizky; L.R, Annishfia; Hidayah, Siti Nurul; Iman, Naisbitt
Program Kreativitas Mahasiswa - Penelitian PKM-P 2013
Publisher : Ditlitabmas, Ditjen DIKTI, Kemdikbud RI

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Abstract

Cisplatin is one of the most widely used chemotherapeutic agent in cancer treatment, however it possess series of harmful adverse effects, most notably, nephrotoxicity. Due to that reason, a natural chemopreventive agent is needed to minimize cisplatin’s toxicity, namely, Mahkota Dewa fruit (Phaleria marcocarpa) extract. This research aim to determine anti nephrotoxic effect of mahkota dewa fruit on Vero cells, model of renal cells. Cytotoxic assay of mahkota dewa’s extract and cisplatin both single and combination was determined using MTT assay on HeLa cells and Vero cells. The cytotoxic assay resulted that IC50 value of cisplatin and Mahkota Dewa to HeLa cells were 18µM (5,4 µg/mL) and 845 µg/mL, respectively, whereas the IC50 value of cisplatin and Mahkota Dewa to Vero were 80 µM (24 µg/mL) and 730 µg/mL, respectively. The results indicated that cisplatin was more cytotoxic to HeLa cell in comparison to Vero cell. Combination treatment of mahkota dewa’s extract at 183 µg/mL and cisplatin 284 µM showed increased viability of Vero cells. Therefore, combination treatment of cisplatin and mahkota dewa are able to decrease nephrotoxicity of cisplatin to renal cells.  Keyword: Mahkota dewa, cisplatin, flavonoid, nephrotoxicity, HeLa cell, Vero cell

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