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INDONESIA
Indonesian Journal of Pharmaceutical Science and Technology
Published by Universitas Padjadjaran
ISSN : 23561971     EISSN : 2406856X     DOI : -
Core Subject : Health, Science,
Computer Science & IT Medicine & Pharmacology
Jurnal Sains dan Teknologi Farmasi Indonesia (IJPST) adalah publikasi ilmiah pada seluruh aspek Sains dan Teknologi Farmasi. Jurnal ini diterbitkan 3 kali setahun untuk menyediakan forum bagi apoteker, dan profesional kesehatan lainnya untuk berbagi praktik terbaik, meningkatkan jaringan kerja dan pendekatan yang lebih kolaboratif dalam Sains dan Teknologi Farmasi.
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Articles 511 Documents
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Gastroprotective Effect of Galangal, Turmeric and Their Combination on Rats’ Gastric Ulcers Ekowati, Heny; Anwar, Amalia Meisya; Audina, Fuzilestari Nur; Utami, Esti Dyah
Indonesian Journal of Pharmaceutical Science and Technology Vol 12, No 3 (2025)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v12i3.49741

Abstract

Galangal (AG) and turmeric (CL) have potential gastroprotective activity. Both have been shown to prevent oxidation by scavenging free radicals and blocking oxidative enzymes. This study evaluated the gastroprotective effects of galangal, turmeric, and their combination extract against gastric mucosal lesions induced by ethanol-hydrochloric acid (HCl). The experimental design comprised 5 groups: group I was administered with Tween 80 (1%), and group II was administered ranitidine (50 mg/kgBW) orally. The other three groups were administered AG and CL, and their combination was administered (1:1) (100 mg/200 kg BW) orally for six days. On the 7th day, the rats were induced by ethanol-HCl (1: 1 v/v) 8 mL/KgBW. Six hours later, the rat was sacrificed and dissected for their gastric. Gross ulcer area, lesion length, histology, pH, and ulcer index were observed. There were improvements in pH, lesion score, ulcer index, and curative ratio. The histopathological profile showed ulcer repairment and lowering of neutrophil inflammatory cell infiltration. Statistical analysis showed the potential equivalence of the single and combination treatments in their gastroprotective effects. Galangal, turmeric, and its combination have gastroprotective activities by repair of ulcer and gastric pH, increasing the curative ratio, and decreasing the ulcer index in the rat model.
Formulation and Antibacterial Activity of Basil (Ocimum basilicum Linn.) Essential Oil Emulgel Nilmawati, Nilmawati; Novitasari, Putri Rachma; Nuraisyah, Fatma; Rusdi, Niswa Fadilah; Widiyastuti, Lina
Indonesian Journal of Pharmaceutical Science and Technology Vol 12, No 3 (2025)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v12i3.60016

Abstract

Basil (Ocimum basilicum Linn.) essential oil contains methyl chavicol, which exhibits antibacterial properties. Basil essential oil has volatile and hydrophobic properties, so it is necessary to have an emulgel preparation that can stabilize and enhance its topical activity. This study aims to formulate an emulgel of basil essential oil and investigate its antibacterial activity against Staphylococcus aureus. Basil essential oil was analyzed using the GC-MS. The formulas of Basil essential oil emulgel were created through concentration variations of 5%, 7.5%, and 10%, respectively. These formulas were then tested for organoleptic properties, viscosity, pH, spreadability, and adhesion time. Additionally, antibacterial activity tests were conducted using the well diffusion method. Basil essential oil analysis identified methyl chavicol at 81.34%. All formulas had the white semi-solid form and they had specific basil odours, viscosity 1013.83 ±714.29; 1644.68 ± 888.68; 1923.26 ± 1733.67 cps, pH 5.73; 6.02; 6.90, spreadability 19.61 ± 0.24; 18.28 ± 0.32; 17.57 ± 0.26 gram.cm/second and adhesion time 8.03 ± 1.85; 5.07 ± 0.43; 5.51 ± 0.14 second. Furthermore, all the formulas inhibited the growth of Staphylococcus aureus (p<0.05). The 7.5% basil essential oil emulgel’s formula provides optimal results in terms of physical stability and antibacterial activity.
Pengembangan Formula dan Karakterisasi Nanostructured Lipid Carriers Tretinoin Menggunakan Compritol dan Tegocare Jafar, Garnadi; Sofian, Ryan; Pratama, Reza; Putriyanti, Al-fira
Indonesian Journal of Pharmaceutical Science and Technology Vol 12, No 3 (2025)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v12i3.53058

Abstract

Tretinoin memiliki sifat fisiko kimianya yaitu memiliki bobot molekul sebesar 300.4 dengan titik lelehnya yaitu 181°C serta memiliki LogP yaitu 6,3 dan nilai Pka sebesar 4,76. NLC adalah generasi pembawa baru yang memiliki potensi besar untuk penghantaran topikal. Sediaan NLC memiliki beberapa keunggulan dibandingkan formulasi topikal tradisional seperti pelepasan obat yang berkepanjangan, mengurangi iritasi kulit, dan kontak yang sangat baik dengan lokasi kulit yang terkena karena jangkauan pengiriman obat dalam skala nano. Penelitian ini untuk mengembangkan formula dan mengkarakterisasi NLC tretinoin dengan formula compritol, myritol dan tegocare. Formulasi NLC tretinoin dilakukan dengan metode homogenisasi panas kemudian disonikasi menggunakan probe sonikator. Formula NLC dikarakterisasi dengan mengukur ukuran partikel, indeks polidispersitas, zeta potensial, efisiensi penjerapan dan morfologi. Hasil karakterisasi menunjukkan bahwa NLC tretinoin memiliki ukuran partikel semua formula memiliki ukuran partikel <350 nm dengan 2 kali pengukuran selama 30 hari, indeks polidispersitas semua formula memiliki nilai <0,5, nilai zeta potensial semua formula memiliki nilai dengan rentang nilai (+->20 mV), %EE semua formula memiliki nilai >80%. NLC tretinoin diuji morfologinya menggunakan TEM dengan hasil berbentuk bulat. Hasilnya menunjukkan bahwa NLC Tretinoin menunjukkan hasil yang baik.
Plasma Fractionation: Conditions and Challenges Rambia, Ikhsan; Insyirah, Ariani; Claudiana, Nur Shelly Ester; Fath, Zulfa Tavira Al; Permadi, Najla Eksakta; Sriwidodo, Sriwidodo; Rustan, Mas Rahman
Indonesian Journal of Pharmaceutical Science and Technology Vol 12, No 3 (2025)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v12i3.63343

Abstract

Plasma is a blood component that has a role in treating various diseases, such as haemophilia and blood-clotting disorders. Plasma used for treatment is referred to as plasma-derived drug products (PDMPs), which are obtained through the plasma fractionation process. This study aims to explore the conditions of plasma fractionation in various countries and highlight some of the challenges faced by the plasma fractionation industry. The methods used include searching for articles published over the past decade from trusted sources, such as Google Scholar, PubMed, and ScienceDirect, using specific keywords. The results of literature studies related to plasma fractionation were obtained from 20 countries spanning several continents. The conditions and challenges faced in plasma fractionation in those countries differ. Some of the challenges faced are related to technology, regulation, plasma sources, human resources, and the economy. Currently, Indonesia is working with South Korea to build the first plasma fractionation facility. Therefore, the conditions and challenges faced by various countries can serve as a reference for Indonesia in preparing the factors that influence plasma fractionation development, in accordance with the World Health Organization (WHO) recommendations.
Aktivitas Antioksidan dan Kandungan Fitokimia Ekstrak Etanol Daun Pucuk Merah (Syzigium myrtifolium.Walp) yang Berwarna Hijau dan Merah Lestari, Uce; Muhaimin, Muhaimin; Maimum, Maimum; Yuliana, Yuliana
Indonesian Journal of Pharmaceutical Science and Technology Vol 12 (2025): Vol. 12 Suppl. 2 (2025)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v12i0.58521

Abstract

Salah satu antioksidan alami berasal dari daun pucuk merah yang mampu melawan radikal bebas dan mengurangi kerusakan oksidatif pada sel kulit. Penelitian ini bertujuan untuk mengetahui aktivitas antioksidan dan kandungan fitokimia dari Ektrak Etanol Daun Pucuk Merah Warna Hijau (EEDPMH) dan Ekstrak Etanol Daun Pucuk Merah Warna Merah (EEDPMM). Sampel diekstraksi menggunakan etanol 70%. Kandungan kimia dari EEDPMH dan EEDPMM yang dihasilkan diidentifikasi menggunakan skrining fitokimia dan KLT. Aktivitas antioksidan EEDPMH dan EEDPMM dilakukan dengan metode DPPH menggunakan spektrofotometer UV-Visible. Hasil analisis skrining fitokimia EEDPMH menunjukkan mengandung kadar polifenol total sebesar 1,29%, kadar flavonoid total sebesar 2,80%  sedangkan EEDPMM mengandung kadar polifenol total sebesar 14,03%, kadar flavonoid total sebesar 2,35%. Pada metode KLT diperoleh noda yang berfluoresensi pada UV 366 nm yang dapat diidentifikasi sebagai senyawa flavonoid dengan nilai Rf EEDPMH dan EEDPMM sebesar 0,22. Uji aktivitas antioksidan EEDPMH memiliki IC50 sebesar 6,164 ppm sedangkan EEDPMM memiliki IC50 sebesar 8,572 ppm. Data IC50 menunjukkan bahwa EEDPMH dan EEDPMM memiliki aktivitas antioksidan yang sangat kuat karena mengandung senyawa flavonoid.
Efek Imunostimulan Ekstrak dan Fraksi dari Buah Limpasu (Baccaurea lanceolata) pada Mencit Jantan Miranti, Rizka Mulya; Mulyani, Tuty; Nashihah, Siti
Indonesian Journal of Pharmaceutical Science and Technology Vol 13, No 1 (2026)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v13i1.52721

Abstract

Limpasu merupakan tanaman khas Kalimantan yang ditemukan di pegunungan Meratus dan secara empiris digunakan untuk membantu mengobati COVID-19. Buah limpasu mengandung senyawa fenol dan flavonoid yang telah terbukti memiliki aktivitas antioksidan dan antibakteri, namun uji coba sebagai imunomodulator belum pernah dilaporkan. Penelitian ini bertujuan mengevaluasi aktivitas imunomodulator ekstrak etanol buah limpasu (EEBL) serta fraksi etil asetat (FEA) dan fraksi air (FA) pada dosis 250 dan 500 mg/kgBB pada hewan. Buah limpasu diekstraksi menggunakan pelarut etanol 70% dengan metode maserasi dan difraksinasi dengan pelarut n-heksana, etil asetat, dan air. Pengujian imunomodulator dilakukan menggunakan metode uji bersihan karbon untuk menggambarkan aktivitas respon imun non spesifik, uji titer antibodi untuk menggambarkan aktivitas respon imun spesifik dan uji hipersensitivitas tipe lambat untuk menggambarkan respon imun seluler. Hasil uji bersihan karbon pada kelompok EEBL dan FEA menunjukkan aktivitas imunostimulan kuat, sedangkan kelompok FA menunjukkan hasil imunostimulan ringan. Hasil uji titer antibodi primer menunjukkan kelompok yang diberi zat uji memiliki angka titer antibodi lebih tinggi dibandingkan kontrol, namun hanya kelompok EEBL yang mengalami peningkatan angka titer antibodi sekunder. Selanjutnya, EEBL, FEA dan FA menyebabkan peningkatan tebal kaki mencit. Secara keseluruhan, hanya EEBLyang menunjukkan aktivitas imunostimulan berdasarkan respon imun non spesifik, spesifik dan seluler.
Hypoxic MSCs Reduce UV-B Collagen Loss by Modulating CD68 and TNF-α Expression Ati, Sri Umi; Putra, Agung; Sumarawati, Titiek; Setiawan, Eko; Ibrahim, Sugeng; Taskworo, Dodik
Indonesian Journal of Pharmaceutical Science and Technology Vol 13, No 1 (2026)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v13i1.63650

Abstract

Ultraviolet-B (UV-B) radiation-induced skin photoaging is marked by collagen degradation and chronic inflammation, with limited effective treatments currently available. Hypoxic-preconditioned mesenchymal stem cells (H-MSCs) offer a novel therapeutic approach due to their immunomodulatory capabilities. This study evaluated the effects of H-MSCs at two doses (2.5×105 and 5×105 cells) on UVB-induced collagen loss, focusing on CD68 expression and TNF-α levels in a rat model. Male Wistar rats were divided into five groups: healthy controls, UV-B-exposed negative controls (saline), positive controls (hyaluronic acid), and two H-MSC-treated groups. After UV-B exposure (160 mJ/cm², five times per week for two weeks), validated H-MSCs were administered subcutaneously. Collagen content was assessed histologically, while CD68 gene expression and TNF-α levels were measured by qRT-PCR and ELISA, respectively. UVB exposure led to significant reductions in collagen and increased levels of inflammatory markers. H-MSC treatment showed dose-dependent anti-inflammatory effects, with the higher dose (5×105 cells) optimally reducing CD68 expression and TNF-α levels, nearly matching healthy controls. These results suggest that H-MSCs, particularly at higher doses, may be a promising therapy for UVB-induced skin damage and collagen loss.
Geographical Characterization of West Java Clove by FTIR and Chemometrics PCA Analysis Rachmawati, Winasih; Khoirunnisa, Intan; Asnawi, Aiyi
Indonesian Journal of Pharmaceutical Science and Technology Vol 13, No 1 (2026)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v13i1.61029

Abstract

Clove is a plant native to West Java, Indonesia, and its composition has been scientifically proven to have antioxidant, antibacterial, antinociceptive, and cytotoxic effects. The quality of a plant is influenced by its growth location, harvest time, and genetic attributes. This study was designed to determine the characteristics of the cloves from West Java. This study aimed to develop a clove fingerprint profile using Fourier transform infrared (FTIR) spectroscopy and principal component analysis (PCA) chemometrics across five regions of West Java. Clove flowers were collected from Bandung, Bogor, Purwakarta, Cianjur, and Tasikmalaya, Indonesia. The cloves were then extracted by maceration with 96% ethanol for three 24-hour periods. The extract was analyzed by FTIR over 4000-650 cm-1 and then subjected to preprocessing steps, including smoothing, differentiation, and Standard Normal Variate. A cumulative PC value of 91% formed three clusters with similar qualities in the score plot: Group 1 (Purwakarta), Group 2 (Bandung, Cianjur, and Tasikmalaya), and Group 3 (Bogor). Chemometric analysis can be used to authenticate and classify cloves based on geographical distribution.
Formulasi dan Karakterisasi Liposom Koenzim Q10 dengan Variasi Kolesterol dan Lesitin sebagai Fosfolipid Rochman, M Fatchur; Yumni, Gharsina Ghaisani; Ramaesa, Anjani; Octafia, Putri Yolanda; Nuladani, Anggriya Syahvirga Masidqi
Indonesian Journal of Pharmaceutical Science and Technology Vol 13, No 1 (2026)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v13i1.56987

Abstract

Koenzim Q10 mengandung antioksidan yang bersifat tidak stabil terhadap cahaya. Untuk mengatasi ketidakstabilan tersebut, diperlukan sistem penghantaran berupa liposom yang dapat meningkatkan stabilitas zat aktif. Penelitian ini bertujuan untuk mengetahui karakteristik liposom koenzim Q10 yang dihasilkan dengan variasi konsentrasi kolesterol. Koenzim Q10 dienkapsulasi dalam sistem penghantaran liposom dengan berbagai konsentrasi kolesterol, yaitu FI (300 mg), FII (600 mg), dan FIII (900 mg), menggunakan metode hidrasi lapis tipis dan sonikasi. Liposom dibuat dengan komponen penyusun berupa lesitin kedelai, kolesterol, dan kloroform, serta dikarakterisasi melalui uji organoleptik, pH, efisiensi penjeratan, ukuran partikel, indeks polidispersitas, dan morfologi. Hasil penelitian menunjukkan bahwa liposom koenzim Q10 dengan variasi konsentrasi kolesterol memiliki karakteristik organoleptik berupa tekstur cair, warna kuning, dan aroma khas kedelai. Nilai pH berkisar antara 5,75 hingga 5,86. Efisiensi penjeratan masing-masing formula adalah FI sebesar 95,56%, FII sebesar 96,95%, dan FIII sebesar 97,88%. Ukuran partikel berkisar antara 154,8 hingga 187,5 nm, dengan indeks polidispersitas antara 0,230 hingga 0,450. Hasil uji morfologi menunjukkan globul berbentuk bulat. Berdasarkan hasil tersebut, liposom koenzim Q10 menunjukkan karakteristik fisikokimia yang baik.
Rimpang Etlingera rubroloba A.D. Poulsen sebagai Kandidat Imunostimulator terhadap Fagositosis Makrofag dan Sel CD8 Ilyas Y., Muhammad; Reymon, Reymon; Rasak, Adriatman; Rubak, Bonni; Pascayantri, Asniar; Malik, Fadhliyah; Jabbar, Asriullah; Wahyuni, Wahyuni; Setiawan, La Ode Roni; Halik, Halik; Sahidin, Idin
Indonesian Journal of Pharmaceutical Science and Technology Vol 13, No 1 (2026)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v13i1.52621

Abstract

Etlingera rubroloba A.D. Poulsen merupakan tumbuhan yang digunakan secara tradisional oleh masyarakat Sulawesi Tenggara untuk menjaga kebugaran tubuh dan telah terbukti secara ilmiah mampu meningkatkan sistem imun bawaan melalui peningkatan ekspresi reseptor sel makrofag (CD14). Namun, pengaruhnya terhadap aktivitas fagositosis makrofag dan kadar sel limfosit T sitotoksik (CD8+) belum pernah dilaporkan. Penelitian ini bermaksud mengevaluasi ekstrak etanol rimpang E. rubroloba terhadap efek peningkatan fagositosis makrofag dan kadar CD8+ pada tikus putih (Rattus norvegicus) galur Wistar. Sebanyak 24 ekor tikus dibagi enam kelompok, yaitu kontrol normal, kontrol negatif, kontrol positif, serta kelompok ekstrak dosis 200, 300, dan 400 mg/kg BB. Ekstrak diberikan secara oral selama tujuh hari, kemudian pada hari kedelapan hewan uji diinfeksi Staphylococcus aureus secara intraperitoneal. Aktivitas fagositosis diamati secara mikroskopik, sedangkan kadar CD8+ diukur menggunakan metode ELISA. Dosis 300 mg/kg BB menghasilkan peningkatan aktivitas fagositosis tertinggi sebesar 77,25% dan kadar CD8+ tertinggi sebesar 650,71 ng/mL, dengan perbedaan bermakna dibandingkan kontrol negatif (p<0,05). Temuan ini mengindikasikan bahwa rimpang E. rubroloba berpotensi dikembangkan sebagai kandidat imunostimulator alami.

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