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Contact Name
Rizky Abdulah
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r.abdulah@unpad.ac.id
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editorial@ijcp.or.id
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Location
Kota bandung,
Jawa barat
INDONESIA
Jurnal Farmasi Klinik Indonesia
ISSN : 23375701     EISSN : 2337 5701     DOI : -
Core Subject :
Indonesian Journal of Clinical Pharmacy (IJCP) is a scientific publication on all aspect of clinical pharmacy. It published 4 times a year by Clinical Pharmacy Master Program Universitas Padjadjaran to provide a forum for clinicians, pharmacists, and other healthcare professionals to share best practice, encouraging networking and a more collaborative approach in patient care. Indonesian Journal of Clinical Pharmacy is intended to feature quality research articles in clinical pharmacy to become scientific guide in fields related to clinical pharmacy. It is a peer-reviewed journal and publishes original research articles, review articles, case reports, commentaries, and brief research communications on all aspects of Clinical Pharmacy. It is also a media for publicizing meetings and news relating to advances in Clinical Pharmacy in the regions.
Arjuna Subject : -
Articles 540 Documents
Peresepan Obat-obat Off-Label pada Pasien Anak Usia 0 Hingga 2 Tahun di Apotek Kota Bandung Pratiwi, Ami A.; Khairinnisa, Miski A.; Alfian, Sofa D.; Priyadi, Akhmad; Pradipta, Ivan S.; Abdulah, Rizky
Indonesian Journal of Clinical Pharmacy Vol 2, No 2 (2013)
Publisher : Indonesian Journal of Clinical Pharmacy

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (305.032 KB)

Abstract

Obat off-label merupakan obat yang diresepkan tetapi tidak sesuai dengan informasi resmi obat seperti indikasi obat yang tidak sesuai dengan yang dinyatakan oleh izin edar serta dosis, umur pasien, dan rute pemberian yang tidak sesuai. Penelitian ini dilakukan untuk mengetahui persentase jumlah resep pasien dokter spesialis anak yang mengandung obat off-label pada pasien anak usia 0 hingga 2 tahun di Apotek Kota Bandung serta mengetahui pola penggunaannya melalui studi observasional dengan pengambilan data secara retrospektif. Identifikasi obat yang diresepkan termasuk kategori off-label atau tidak berdasarkan Pediatric Dosage Handbook 2007, Drug Information Handbook (DIH) 2012, British National Formulary (BNF) 2009, MIMS USA 2013, MIMS Indonesia 2013, dan ISO 2012–2013. Berdasarkan hasil penelitian diperoleh 542 lembar resep off-label (19,77%) dari 2741 total lembar resep, serta sebanyak 699 (7,89%) item obat off-label dari 8861 obat, dengan persentase kategori off-label usia 70,53%, off-label dosis 19,74% dan off-label kontraindikasi 9,73%. Penelitian ini menunjukkan bahwa potensi peresepan obat off-label di apotek di Kota Bandung pada tahun 2012 tinggi sehingga perlu pemilihan obat yang tepat serta pengawasan dalam penggunaan obat pada anak.Kata kunci: Obat off-label, pediatri, peresepan, Bandung The Prescription of Off-Label Drugs towards 0–2 Years Old Pediatric Patients in Community Pharmacy in Bandung CityOff-label drug is a drug which is not prescribed in accordance with official drug information, including patient age, drug indications didn’t match with the marketing authorization, dosage and route ofadministration are not appropriate. This study was conducted to determine the percentage of patients pediatrician who prescribed with containing drugs off-label in pediatric patients aged 0 to 2 years at pharmacy in Bandung and determine the pattern of use through an observational study with retrospective data collection. Identification of medications that are prescribed off-label category or not based on the Pediatric Dosage Handbook 2007, Drug Information Handbook (DIH) in 2012, the British NationalFormulary (BNF) in 2009, MIMS USA 2013, MIMS Indonesia in 2013, and ISO 2012–2013. Based on the results obtained 542 pieces of off-label prescriptions (19.77%) of the 2741 total pieces recipes, as well as 699 (7.89%) of off-label drug items from 8861 drug, the percentage of off-label age category 70.53%, off-label doses of 19.74% and off-label contraindication 9.73%. The results of this study indicate that the uses of off-label drugs for children is high at Pharmacy in Bandung. This study is expected to be basicconsideration in examining the efficacy and safety in off-label drug uses for children aged 0 to 2 years.Key words: Off-label drug, pediatric, prescription, Bandung
Pengukuran Tingkat Pengetahuan tentang Hipertensi pada Pasien Hipertensi di Kota Bandung: Sebuah Studi Pendahuluan Sinuraya, Rano K.; Siagian, Bryan J.; Taufik, Adit; Destiani, Dika P.; Puspitasari, Irma M.; Lestari, Keri; Diantini, Ajeng
Indonesian Journal of Clinical Pharmacy Vol 6, No 4 (2017)
Publisher : Indonesian Journal of Clinical Pharmacy

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (628.091 KB) | DOI: 10.15416/ijcp.2017.6.4.290

Abstract

Hipertensi merupakan penyebab umum dalam peningkatan angka mortalitas dan mobiditas di masyarakat. Selain merupakan silent killer, prevalensi penyakit ini semakin meningkat di seluruh dunia. Prevalensi hipertensi di Indonesia 25,8% dan Jawa Barat berada di peringkat keempat dengan prevalensi 29,4%. Penelitian ini bertujuan untuk mengukur tingkat pengetahuan pasien hipertensi terkait penyakit yang dideritanya. Studi ini merupakan penelitian observasional menggunakan rancangan potong lintang dan dilakukan pada bulan Juni–Oktober 2017 di Apotek Pendidikan Universitas Padjadjaran, Kota Bandung. Sejumlah seratus lima puluh responden mengisi kuesioner yang telah divalidasi setelah menandatangani informed consent terlebih dahulu. Hasil penelitian menunjukkan bahwa sebanyak 56,7% dari responden memiliki tingkat pengetahuan baik, 40% dari responden memiliki tingkat pengetahuan cukup, dan 3,3% dari responden memiliki tingkat pengetahuan kurang. Data kemudian diolah secara statistik sehingga diperoleh hasil bahwa tidak terdapat perbedaan bermakna (p>0,05) antara setiap kelompok responden terhadap sosiodemografi dan karakteristik klinis pasien. Hanya sekitar 50% responden yang memiliki tingkat pengetahuan baik, pasien yang memiliki tingkat pengetahuan cukup dan kurang umumnya adalah pasien dengan tingkat pendidikan rendah dan menderita hipertensi kurang dari lima tahun.Kata kunci: Fasilitas kesehatan primer, hipertensi, tingkat pengetahuan Assessment of Knowledge on Hypertension among Hypertensive Patients in Bandung City: A Preliminary StudyHypertension is a common health problems that can increase the mortality and mobility rate in the community. As a silent killer, the prevalence of this disease is increasing worldwide. The prevalence of hypertension in Indonesia is 25.8% and West Java is ranked at top four with prevalence of 29.4%. This study aimed to measure the level of knowledge of hypertensive patients about their disease. This study was an observational study using cross-sectional design in June–October 2017 at Apotek Pendidikan Universitas Padjadjaran, Bandung City. A total of one hundred and fifty respondents completed a validated questionnaire after signing informed consent. The results showed that 56.7% of respondents have “good” level of knowledge, 40% of respondents have “moderate” level of knowledge, and 3.3% of respondents have “poor” level of knowledge. Data were analyzed statistically, the results showed that there was no significant difference (p>0.05) between each group of respondents to sociodemographic and clinical characteristics of the patients. Only fifty percent of respondents have “good” level of knowledge, patients who have “moderate” and “poor” level of knowledge generally are patients with low levels of education and suffer from hypertension less than five years.Keywords: Hypertension, level of knowledge, primary health care
Potensi Interaksi Obat-Obat pada Resep Polifarmasi: Studi Retrospektif pada Salah Satu Apotek di Kota Bandung Herdaningsih, Sulastri; Muhtadi, Ahmad; Annisa, Nurul
Indonesian Journal of Clinical Pharmacy Vol 5, No 4 (2016)
Publisher : Indonesian Journal of Clinical Pharmacy

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (439.424 KB) | DOI: 10.15416/ijcp.2016.5.4.288

Abstract

  Resep polifarmasi sangat umum terjadi dalam peresepan pasien rawat jalan maupun rawat inap di setiap fasilitas kesehatan. Polifarmasi dapat meningkatkan risiko terjadinya interaksi obat-obat atau Drug-drug Interactions (DDI’s) yang sebagian besar akan menimbulkan dampak merugikan dalam terapi pasien. Tujuan dari studi ini yaitu untuk menilai potensi DDI’s pada resep rawat jalan di salah satu apotek di kota Bandung. Data diproses melalui www.drugs.com database atau Drug Interactions Checker. Studi ini memaparkan prevalensi dan mengklasifikasikan jenis interaksi potensial berdasarkan level interaksi yaitu mayor, moderat dan minor. Total resep rawat jalan periode Januari–Maret 2014 adalah sebanyak 352 lembar resep yang didalamnya terdapat sebanyak 1.111 R/. Dari total keseluruhan jumlah lembar resep, terdapat 197 (55,97%) lembar resep yang masuk dalam kriteria inklusi. Sebanyak 121 lembar resep terdapat DDI’s potensial sebesar 34,38%. Keseluruhan DDI’s potensial yang terjadi adalah sebanyak 194 interaksi. DDI’s potensial mayor sebanyak 25 (12,89%), moderat sebanyak 134 (69,07%) dan minor 35 (8,04%). DDI’s terbanyak terdapat dalam kategori mayor dan moderat yang membutuhkan perhatian lebih dan tindakan pencegahan terhadap DDI’s potensial yang mungkin terjadi oleh dokter dan apoteker untuk memaksimalkan efektivitas terapi pasien.Kata kunci: Interaksi obat-obat, pasien rawat jalan, resep polifarmasiPotential of Drug-Drug Interaction in Polypharmacy Prescription: Retrospective Study on a Drugstore in Bandung Abstract Polypharmacy prescription very commonly occurs on prescribing the outpatient and inpatient in every health facility. Polypharmacy may increase the risk of Drug-drug Interactions (DDI’s) which mostly causes harm impact in the patient’s therapy. The aim of this study was to measure the potential of DDI’s on the outpatient prescription in one of the drugstore in Bandung. The data was processed through www. drugs.com database or Drug Interactions Checker. This study described the prevalence and classification of potential interactions based on interaction level of major, moderate, and minor. The number of outpatient prescription on January–March 2014 was 352 sheets of prescriptions with 1.111 R/. From overall numbers of prescriptions, there were 197 (55.97%) sheets of prescriptions on inclusion criteria. In 121 prescriptions, there were 34.38% of DDI’s potential. All of DDI’s potential occurs was 194 interactions. The major DDI’s potential of 25 (12.89%), moderate of 134 (69.07%) and minor of 35 (8.04%). The most of DDI’s found in major and moderate level need more attention and prevention aid against DDI’s potential that may occur by doctors and pharmacists to maximize the effectiveness of patient’s therapy.Keywords: Drug-drug Interactions (DDI’s), outpatient, polypharmacy prescription
Monitoring Penggunaan Antibiotik dengan Metode ATC/DDD dan DU 90%: Studi Observasional di Seluruh Puskesmas Kabupaten Gorontalo Utara Pani, Sarini; Barliana, Melisa I.; Halimah, Eli; Pradipta, Ivan S.; Annisa, Nurul
Indonesian Journal of Clinical Pharmacy Vol 4, No 4 (2015)
Publisher : Indonesian Journal of Clinical Pharmacy

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (340.684 KB) | DOI: 10.15416/ijcp.2015.4.4.280

Abstract

Penggunaan antibiotik yang tidak rasional dapat menyebabkan peningkatan morbiditas dan mortalitas. Monitoring penggunaan antibiotik diperlukan dalam mendukung program pemerintah khususnya Dinas Kesehatan yang menyatakan penggunaan antibiotik untuk penyakit ISPA non-pneumonia adalah kurang dari 20%. Evaluasi penggunaan antibiotik ini menggunakan metode ATC/DDD dan DU 90%. Antibiotik yang digunakan untuk ISPA non-pneumonia adalah sebanyak 9 jenis dan antibiotik yang masuk dalam DU90% sebanyak 3 jenis yaitu amoksisilin 500 mg (2,723 DDD/1000 pasien-hari), siprofloksasin (0,378 DDD/1000 pasien-hari) dan sefadroksil (0,202 DDD/1000 pasien-hari). Analisis data secara kuantitatif menggunakan ATC/DDD menunjukkan bahwa antibiotik yang banyak digunakan adalah amoksisilin (500 mg) 2723 DDD/1000 pasien-hari dan yang paling sedikit yaitu amoksisilin (125 mg/5 ml) 1,5 DDD/1000 pasien-hari. Efek peresepan penggunaan antibiotik jangka pendek pada pelayanan pengobatan dasar dapat meningkatkan kejadian resistensi. Diperlukan studi kualitatif untuk mengetahui pola ketidakrasionalan penggunaan antibiotik di pusat pelayanan kesehatan masyarakat tersebut dan mengembangkan model intervensinya.Kata kunci: ATC/DDD, DU 90%, ISPA non-pneumonia antibiotikMonitoring the Use of Antibiotics by the ATC/DDD Method and DU 90%: Observational Studies in Community Health Service Centers in North Gorontalo DistrictIrrational use of antibiotics may lead to increase morbidity and mortality. Monitoring of antibiotics was required to support government programs, especially The Department of Health stating the use of antibiotics for non-respiratory diseases pneumonia was less than 20%. The evaluation of antibiotics use in this research applied ATC / DDD methods and DU 90%. The antibiotic used for non-pneumonia ARI were 9 types and the antibiotics contained DU 90% were three types namely amoxicillin 500 mg (2,723 DDD/1000 patients-year), ciprofloxacin (0,378 DDD/1000 patients-day) and cefadroxil (0,202 DDD/1000 patients-day). Quantitative data analysis using the ATC / DDD indicated that the most used antibiotic was amoxicillin (500 mg) 2723 DDD / 1000 patients-day and the least was amoxicillin (125 mg / 5 ml) 1.5 DDD / 1000 patients-day. The effects of short-term use of antibiotic prescribing in primary medical care could increase the resistance. Qualitative studies were needed to determine the pattern of irrational antibiotic use in community health service center and to develop the intervention model.Keywords: ARI non-pneumonia antibiotics, ATC/DDD, DU 90%
Hubungan Pola Sensitivitas Bakteri pada Penggunaan Antibiotik Empirik terhadap Pencapaian Clinical Outcome Pasien Pneumonia Anak Gatera, Vesara A.; Muhtadi, Ahmad; Halimah, Eli; Prasetyo, Dwi
Indonesian Journal of Clinical Pharmacy Vol 3, No 4 (2014)
Publisher : Indonesian Journal of Clinical Pharmacy

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (259.583 KB) | DOI: 10.15416/ijcp.2014.3.4.127

Abstract

Pneumonia merupakan salah satu penyakit infeksi yang memerlukan upaya komprehensif dan efektif dalam penanganannya terutama dalam penggunaan antibiotik empiris. Penggunaan antibiotik empiris harus berdasarkan pola sensitivitas terhadap bakteri. Penelitian ini bertujuan untuk mengevaluasi penggunaan antibiotik berdasarkan pola sensitivitas dengan memperhatikan faktor clinical outcome pasien sebagai tujuan pengobatan. Penelitian ini dilaksanakan di RS Dr. Hasan Sadikin pada bulan Oktober–Desember 2013 dengan menerapkan desain potong lintang secara retrospektif. Data sekunder diperoleh dari rekam medis dalam kurun waktu Januari 2011–Desember 2012. Objek penelitian terdiri dari rekam medis 24 pasien berusia 1–5 tahun dengan hasil kultur positif dan menerima resep antibiotik. Hasil penelitian ini menunjukkan penggunaan sefotaksim-ampisilin sebesar 37,5%, sefotaksim 33,3%, ampisilin 20,8%, dan seftriakson 8,4%. Antibiotik yang paling memengaruhi pencapaian clinical outcome dengan taraf kepercayaan 95% adalah kombinasi sefotaksim-ampisilin (p=0,044) dengan tingkat sensitivitas 77,7%. Pola sensitivitas penggunaan antibiotik memengaruhi clinical outcome padapasien pneumonia anak.Kata kunci: Clinical outcome, pneumonia, sensitivitas antibiotikAssociation of Pattern of Bacteria Sensitivity During the Empirical Antibiotics Use to the Achievement of Clinical Outcome in Pediatric Patients with PneumoniaPneumonia is one of infectious diseases that require a comprehensive and effective effort in its treatment,including in the use of empirical antibiotics. The use of empirical antibiotics should be based on patterns of sensitivity toward bacteria. The aim of this study was to evaluate the use of antibiotics based on the sensitivity patterns by clinical outcomes as the goal of treatment. This study was conducted in Hasan Sadikin Hospital Bandung in October–December 2013 using a retrospective cross-sectional study design. Secondary data were obtained from medical records during January 2011–December 2012. This study consisted of 24 patients with positive culture test and received antibiotic prescription. The results showed the percentage of the use of cefotaxime-ampicillin (37.5%), cefotaxime (33.3%), ceftriaxone (20.8%), and ampicillin (8.4%). The most influential antibiotics for achieving clinical outcome using 95% confidence level is combination of cefotaxime-ampiciline (p=0.044) with 77.7% sensitivity level. This study suggested that the pattern of antibiotic sensitivity affected the clinical outcomes of pediatric patients with pneumonia.Key words: Clinical outcome, pneumonia, sensitivity of antibiotic
Uji Validitas dan Reliabilitas Kuesioner EORTC QLQ C-30 untuk Menilai Kualitas Hidup Pasien Kanker Ginekologi di RSUP Sanglah Denpasar Noviyani, Rini; Tunas, I Ketut; Indrayathi, Ayu; Budiana, Nyoman G.
Indonesian Journal of Clinical Pharmacy Vol 5, No 2 (2016)
Publisher : Indonesian Journal of Clinical Pharmacy

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (556.049 KB) | DOI: 10.15416/ijcp.2016.5.2.106

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Dampak dari penyakit dan pengobatan kanker dapat diukur dengan indikator kualitas hidup menggunakan kuesioner EORTC QLQ C-30. Penelitian cross-sectional dilakukan menggunakan 30 pasien. Data dikumpulkan melalui metode purposive sampling pada pasien yang memenuhi kriteria inklusi, yaitu wanita berusia 30–70 tahun yang didiagnosis kanker ginekologi, pernah menjalani kemoterapi di RSUP Sanglah Denpasar, dan bersedia menandatangani formulir persetujuan pasca penjelasan. Pasien yang tidak dapat berkomunikasi secara rasional menjadi bagian kelompok eksklusi. Validitas dan reliabilitas instrumen diuji menggunakan analisis faktor konfirmatori dengan program STATA® versi 12. Hasil analisis faktor konfirmatori menunjukkan seluruh item pertanyaan memiliki loading factor ( ) > 0,70 sehingga seluruh butir pertanyaan adalah valid. Uji reliabilitas item memberikan nilai >0,50 untuk seluruh item pertanyaan yang menunjukkan seluruh item pertanyaan adalah reliabel. Hasil perhitungan validitas konstrak menghasilkan nilai VE= 0,90 dan reliabilitas konstrak (RF) adalah 1 yang berarti kuesioner EORTC QLQ C-30 memenuhi validitas dan reliabilitas konstrak. Kuesioner EORTC QLQ C-30 sebagai alat ukur kualitas hidup pasien kanker ginekologi di RSUP Sanglah Denpasar adalah valid dan reliabel.Kata kunci: Analisis faktor konfirmatori, kanker ginekologi, kuesioner EORTC QLQ C-30, RSUP Sanglah Denpasar, uji validitas dan reliabilitas Validity and Reliability of EORTC QLQ C-30 Questionnaire in Assessing Quality of Life of Gynecological Cancer Patients in Sanglah Hospital Denpasar  The impacts of cancer and its treatment can be measured by indicators of quality of life using the EORTC QLQ C-30 questionnaire. A cross-sectional study was done on 30 patients in Sanglah Hospital Denpasar. Data were collected through purposive sampling of patients who fit the inclusion criteria: women who were 30–70 years old were diagnosed with gynecological cancer, had chemotherapy in Sanglah Hospital, and had agreed to be part of the research by signing the informed consent form. Patients who were unable to rationally communicate became part of the exclusion group in this research. Validity and reliability of the tools in this study were tested using confirmatory factor analysis with STATA ®version 12. Confirmatory factor analysis indicates that all items have a loading factor ( )> 0.70 so that it can be said that all the questions are valid. Reliability items have the value > 0.50 for all questions which shows all questions are reliable. Construct validity of the results of the calculation produce a value VE = 0.90 and the reliability construct (RF) of 1, which meet both validity and reliability constructs. Questionnaire EORTC QLQ C-30 as a measurement of the quality of life of gynecological cancer patients in Sanglah Hospital are valid and reliable.Key words: EORTC QLQ C-30 questionnaire, confirmatory factor analysis, gynecological cancer,Sanglah Hospital Denpasar, the validity and reliability 
The Renal Toxicity of Welding Fumes in Heavy Equipment Manufacturer Workers Mulyana, Mulyana; Adi, Nuri P.; Kurniawidjaja, Meily Kurniawidjaja; Pratami, Vani N.; Wijaya, Andi; Yusuf, Irawan
Indonesian Journal of Clinical Pharmacy Vol 4, No 3 (2015)
Publisher : Indonesian Journal of Clinical Pharmacy

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (241.437 KB) | DOI: 10.15416/ijcp.2015.4.3.199

Abstract

Exposure to welding fumes in the workplace has been associated with decreasing renal function. We studied renal function parameters in men workers from heavy equipment manufacturer exposed to welding fumes. This study aimed to evaluate renal function status among worker exposed to welding fumes. A case-control design, random study, was conducted among welder (35 subjects) and nonwelder (35 subjects) with more than 1 years experience in the same job task in a heavy equipment manufacturer. All subjects were completed physical examination, informed consent, questionnaire and laboratory tests. Renal function was easured as creatinine serum using enzimatic method. Urinary heavy metals level was analyzed using inductively coupled plasma mass spectrometry. Comparisson analysis between group was performed to determined median level for each variable. Linear regressionmodel was developed to predict renal function function parameter status urinary heavy metals level as variable. This study showed there were higher creatinine serum, chromium, iron, manganese and nickel in welder than non welder(p<0.05). After multivariate analysis, urinary nickel is a predictor for renal function status among welder. Exposure to welding fumes was significantly correlated with renal function status in welder. Nickel is the predictive variable for renal function. Although statistically significant but in clinical field needs carefully interpreting data.Keyword: Nickel, renal function, welder, welding fumesToksisitas Renal Uap Las pada Pekerja Industri Alat BeratPajanan uap las di tempat kerja telah dihubungkan dengan penurunan fungsi ginjal. Dalam penelitian ini, kami menguji status fungsi ginjal pada pekerja pria yang terpajan uap las di industri alat berat. Penelitian ini mengevaluasi status fungsi ginjal pada pekerja terpajan uap las, dengan desain kontrol kasus, acak, dilakukan pada 35 subjek pengelas dan 35 bukan pengelas yang telah bekerja paling tidak 1 tahun dengan jenis pekerjaan yang sama di industri alat berat. Seluruh subjek telah melakukan pemeriksaan fisik,pengisian form kesediaan setelah penjelasan, kuesioner, dan pemeriksaan laboratorium. Pemeriksaan kadar kreatinin dilakukan dengan metode enzimatik. Pemeriksaan kadar logam berat dalam urin dengan inductively copled plasma mass spectrometry. Dilakukan analisis perbandingan untuk membedakan nilai median antar kelompok. Dilakukan juga analisis multivariat untuk menentukan variabel prediksi. Hasil penelitian memperlihatkan bahwa status fungsi ginjal pada pekerja las lebih rendah dibandingkan dengan bukan pengelas. Nikel urin merupakan variabel prediksi yang bermakna terhadap penurunan fungsi ginjal. Walaupun secara statistik diketahui bermakna, namun dalam penggunaan klinis harus dilakukan interpretasi dengan hati-hati.Kata kunci: Fungsi ginjal, nikel, pengelas, uap las
Evaluasi Nilai Blood Urea Nitrogen dan Serum Kreatinin pada Pemberian Kemoterapi Paklitaksel-Karboplatin pada Pasien Kanker Serviks Sel Skuamosa Stadium IIB-IIIB Noviyani, Rini; Suwiyoga, Ketut; Dewi, Anak A. A. W. P.; Niruri, Rasmaya; Tunas, I. K.; Budiana, I N. G.
Indonesian Journal of Clinical Pharmacy Vol 3, No 2 (2014)
Publisher : Indonesian Journal of Clinical Pharmacy

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15416/ijcp.2014.3.2.55

Abstract

Kemoterapi paklitaksel-karboplatin merupakan salah satu terapi untuk kanker serviks. Toksisitas kemoterapi pada ginjal dapat dinilai menggunakan nilai Blood Urea Nitrogen (BUN) dan serum kreatinin. Pada penelitian potong lintang prospektif ini diperoleh 6 pasien kanker serviks yang memenuhi kriteria penelitian. Pemeriksaan kadar BUN dan serum kreatinin dilakukan sebelum kemoterapi pertama dan sesudah kemoterapi seri ketiga. Rentang waktu kemoterapi pertama ke kemoterapi ketiga adalah tiga minggu. Pengambilan sampel penelitian menggunakan consecutive sampling. Data penelitian dianalisis menggunakan paired test dengan interval kepercayaan 95% dengan SPSS 17.0. Hasil evaluasi nilai BUN dan serum kreatinin sebelum dan sesudah kemoterapi menunjukkan tidak terdapat perbedaan yang bermakna antara sebelum kemoterapi pertama dengan sesudah kemoterapi ketiga (p>0,05). Hasil penelitian ini dapat digunakan dokter sebagai pertimbangan untuk memberikan kemoterapi dengan regimen paklitaksel-karboplatin sesuai prosedur yang berlaku karena terbukti tidak menimbulkan penurunan fungsi ginjal pada pasien kanker serviks skuamosa.Kata kunci: BUN, kanker serviks, kemoterapi, paklitaksel-karboplatin, serum kreatininEvaluation of Blood Urea Nitrogen and Serum Creatinine in Squamous Cell Cervical Cancer Patients Stadium IIb-IIIb Who Receiving Paclitaxel- Carboplatin ChemotherapyPaclitaxel-carboplatin chemotherapy is one of cervical cancer therapy. Renal toxicity from chemotherapy can be assessed using the value of  Blood Urea Nitrogen (BUN) and serum creatinine. In a prospective cross sectional study was obtained 6 cervical cancer patients who met the research criterias. Examination of BUN and serum creatinine performed before first and after third chemotherapy with the interval time of 3 weeks. Sampling method using consecutive sampling. Data were analyzed using paired test with 95% confidence intervals using the SPSS 17.0. BUN and serum creatinine before and after chemotherapy values obtained p>0.05. BUN and serum creatinine values showed no significant difference between before the first chemotherapy to after third chemotherapy. The doctor may consider using this combination chemotherapy in accordance with the procedures in force due to chemotherapy using paclitaxel- carboplatin shown to be effective and not cause renal toxicity in squamous cervical cancer patients.Key words: BUN, cervical cancer, chemotherapy, paclitaxel-carboplatin, serum creatinine
Hubungan Obesitas dan Hipertrigliseridemia dengan Risiko Perlemakan Hati pada Pasien di Makassar Kasim, Syaharuddin; Arief, Mansur; Sulaeman, Agus; Widodo, Joko
Indonesian Journal of Clinical Pharmacy Vol 1, No 4 (2012)
Publisher : Indonesian Journal of Clinical Pharmacy

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Abstract

Perlemakan hati terjadi akibat lipolisis berlebihan dari jaringan lemak dan peningkatan suplai asam lemak bebas ke hati. Derajat keparahan perlemakan hati berkorelasi dengan peningkatan berat badan. Penelitian ini bertujuan untuk menemukan hubungan antara obesitas, trigliserida, obesitas dan hipertrigliseridemia terhadap risiko terjadinya perlemakan hati. Penelitian cross sectional menggunakan data retrospektif yang diambil dari pasien check up di Laboratorium Klinik Prodia Makassar selama tahun 2006. Diagnosis perlemakan hati melalui pemeriksaan ultrasonografi, obesitas ditentukan dari indeks massa tubuh, dan trigliserida diukur dengan metode enzimatik kolorimetri. Dari 204 pasien check up, 67 pasien (32,8%) mengalami perlemakan hati. Pada pasien dengan perlemakan hati sebanyak 95,5% mengalami obesitas, 67,2% hipertrigliseridemia, dan 32,8% trigliserida normal. Terdapat hubungan bermakna antara obesitas (risiko relatif (RR)=18,7; 95% C.I 5,6–62,4; p=0,001), obesitas disertai hipertrigliseridemia (RR=5,1; 95% C.I 2,7–9,5; p<0,001) dengan perlemakan hati. Didapatkan hubungan bermakna antara perlemakan hati dengan obesitas. Trigliserida tidak berhubungan langsung tetapi hipertrigliseridemia disertai obesitas berhubungan bermakna dengan kejadian perlemakan.Kata kunci: Obesitas, trigliserida, hipertrigliseridemia, perlemakan hati Relationship between Obesity and Hypertriglyceridemia on Fatty Liver in Patients at MakassarAbstractFatty liver is caused by a failure of normal hepatic fat metabolism due to a dysfunction of either within the hepatocytes. The degree of fatty liver is correlating to the increase of body weight. The aim of this study is to investigate any specific relationship between fatty liver and obesity as well as hypertriglyceridemia.This is a cross sectional study by using the retrospective data which is obtained from medical check up at Prodia clinical laboratory during 2006, fatty liver is diagnosed by using ultrasonography,obesity on body mass index (BMI), and triglyceride level by enzymatic colorimetric method.In 204 subjects of medical check up subjects were analyzed. Fatty liver has been found in 67 subjects (32.8%),95.5% of subjects with obesity, 32.8 subjects with normal triglyceride and 67.2% subjects with hypertriglyceridemia. There are significant relationship of obesity (relative risk(RR)=18.7; 95% C.I 5.6–62.4;p=0.001), obesity and hypertrigliseridemia (RR=5.1; 95% C.I 2.7–9.5; p<0.001) with fatty liver. Thereare a significant relationship of fatty liver and as well as obesity. Triglyceride is not contributing directlyto fatty liver but hypertriglyceridemia with obesity have significant relationship with fatty liver.Key words: Obesity, triglyceride, hypertriglyceridemia, fatty liver
Evaluasi Kualitas Hidup Responden Hipertensi Usia 40–75 Tahun Menggunakan Instrumen SF-36 di Kecamatan Kalasan, Sleman, DIY Melani, Fransisca; Hasrat, Kresensia T.; Widyasti, Bonifasia A. C.; Suhadi, Rita
Indonesian Journal of Clinical Pharmacy Vol 6, No 3 (2017)
Publisher : Indonesian Journal of Clinical Pharmacy

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (701.309 KB) | DOI: 10.15416/ijcp.2017.6.3.200

Abstract

Hipertensi merupakan kondisi peningkatan tekanan darah sistolik lebih dari 140 mmHg dan tekanan darah diastolik lebih dari 90 mmHg. Status kesehatan yang buruk menunjukkan kualitas hidup yang buruk. Faktor-faktor yang dapat memengaruhi kualitas hidup adalah umur, pendidikan, penghasilan, BMI dan jenis kelamin. Tujuan dari penelitian ini adalah mengevaluasi perbedaan faktor risiko kesehatan dan faktor sosioekonomi dari kualitas hidup responden hipertensi di Kecamatan Kalasan, Sleman. Jenis penelitian ini adalah penelitian observasional dengan pendekatan cross-sectional. Responden dalam penelitian ini adalah penduduk usia 40–75 tahun. Pengambilan sampel dilakukan di 4 dukuh di Kecamatan Kalasan, yaitu Padukuhan Jetis, Padukuhan Pundung, Padukuhan Grumbulgede, dan Padukuhan Dhuri. Analisis data dilakukan dengan uji normalitas Kolmogorov-Smirnov, dilanjutkan dengan uji-t tidak berpasangan untuk masing-masing delapan domain kualitas hidup SF-36 dengan faktor risiko kesehatan dan sosioekonomi. Hasil penelitian menunjukkan pada faktor risiko kesehatan yaitu perbedaan kelompok usia memengaruhi kualitas hidup pada komponen kesehatan fisik (p<0,05), aspek fungsi fisik (p<0,05) dan peran fisik (p<0,05). Variabel sosioekonomi dari aspek sosioekonomi memengaruhi kualitas hidup pada komponen kesehatan mental (p<0,05) terkait aspek peran emosi (p<0,05) dan komponen kesehatan fisik (p<0,05) terkait aspek fungsi fisik (p<0,05) serta aspek peran fisik (p<0,05).Kata kunci: Hipertensi, kualitas hidup, risiko kesehatan dan sosioekonomiQuality of Life Evaluation of Respondents with Hypertension Aged 40–75 Years Using SF-36 Instruments in Kalasan District, Sleman, Yogyakarta ProvinceHypertension is a condition of an increase of systolic blood pressure over 140 mmHg and diastolic blood pressure over 90 mmHg. Poor health status indicates poor quality of life. There are many factors that may affect the quality of life, such as age, education, income, Body Mass Index (BMI) and sex. The purpose of this study was to evaluate the differences of health risk factors and socioeconomic factors on the quality of life of respondents with hypertension in Kalasan District, Sleman. This type of research is an observational study with cross-sectional approach. Respondents in this study were the people aged 40–75 years. Sampling was conducted in four hamlets in Kalasan District, named Padukuhan Jetis, Padukuhan Pundung, Padukuhan Grumbulgede, and Padukuhan Dhuri. The data analysis was performed with Kolmogorov-Smirnov normality test, followed by t-independent test for each of the eight domains of quality of life with the SF-36 health and socioeconomic risk factors. The results from health risk factors showed that the difference of age affected quality of life on physical health component (p<0.05), physical function aspect (p<0.05) and physical role (p<0.05). Socioeconomic aspects of socioeconomic variables affected the quality of life on the mental health component (p<0.05), related to the role of emotions aspect (p<0.05) and physical health component (p<0.05) related to physical function aspect (p<0.05) also the physical role aspect (p<0.05).Keywords: Health and socioeconomic risk factors, hypertension, quality of life

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