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Jurnal Farmasi Klinik Indonesia

ijcp
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Published by Universitas Padjadjaran

ISSN : 23375701 EISSN : 2337 5701 DOI : -

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Indonesian Journal of Clinical Pharmacy (IJCP) is a scientific publication on all aspect of clinical pharmacy. It published 4 times a year by Clinical Pharmacy Master Program Universitas Padjadjaran to provide a forum for clinicians, pharmacists, and other healthcare professionals to share best practice, encouraging networking and a more collaborative approach in patient care. Indonesian Journal of Clinical Pharmacy is intended to feature quality research articles in clinical pharmacy to become scientific guide in fields related to clinical pharmacy. It is a peer-reviewed journal and publishes original research articles, review articles, case reports, commentaries, and brief research communications on all aspects of Clinical Pharmacy. It is also a media for publicizing meetings and news relating to advances in Clinical Pharmacy in the regions.

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Articles 536 Documents

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Peningkatan Peran Apoteker dan Outcome Pasien Tuberkulosis Melalui Uji Coba Model Training-Education-Monitoring-Adherence-Networking (TEMAN) Apoteker Yasin, Nanang M.; Wahyono, Djoko; Riyanto, Bambang S.; Sari, Ika P.
Indonesian Journal of Clinical Pharmacy Vol 6, No 4 (2017)
Publisher : Indonesian Journal of Clinical Pharmacy

Model Training-Education-Monitoring-Adherence-Networking (TEMAN) Apoteker memberikan ruang bagi apoteker yang telah mendapatkan pelatihan untuk melakukan intervensi melalui edukasi pasien tuberkulosis (TB), monitoring terapi, asesmen kepatuhan pasien dan kerjasama dengan tenaga kesehatan lain. Penelitian ini bertujuan untuk mengetahui dampak uji coba model TEMAN Apoteker terhadap peran apoteker dan outcome pasien TB. Penelitian terdiri atas 2 tahap yaitu pelatihan dan intervensi apoteker dengan jenis penelitian quasi experimental study dengan rancangan one group pretest-posttest design. Setelah mendapatkan pelatihan, apoteker melakukan intervensi pada saat kunjungan rutin pasien TB di puskesmas dan Rumah Sakit Khusus Paru Respira di DIY. Subjek penelitian yang dilibatkan meliputi petugas TB (apoteker dan programmer TB) dan pasien dengan diagnosis baru TB yang memenuhi kriteria inklusi, yaitu usia lebih dari 15 tahun, mendapatkan terapi obat anti tuberkulosis (OAT), bersedia mengisi kuesioner dan menandatangani informed consent. Kriteria eksklusinya adalah pasien multi drug resistance (MDR) TB; memiliki penyakit hepatik, psikiatrik (mental) dan disfungsi kognitif. Instrumen yang dikembangkan peneliti adalah kuesioner untuk mengukur tingkat pengetahuan petugas TB dan kuesioner untuk mengukur tingkat pengetahuan dan kepatuhan pasien TB. Analisis data menggunakan analisis deskriptif dan uji Wilcoxon sign rank. Adanya pelatihan efektif meningkatkan pengetahuan 37 petugas TB secara bermakna p=0,000 dari rerata 11,3Â±3,00 (kategori menengah) menjadi 16,3Â±2,31 (kategori tinggi). Sebanyak 40 (81,6%) pasien meningkat pengetahuannya secara bermakna (p=0,000) dan sebanyak 5 (10,2%) pasien meningkat kepatuhannya secara bermakna (p=0,034) setelah intervensi apoteker. Di sisi lain, dari total 49 pasien TB, sebanyak 29 (59,2%) pasien bertambah berat badannya, 100% konversi sputum, 33 (67,3%) kejadian adverse drug reactions (ADR), dan 8 (16,3%) potensi interaksi obat menjadi terdokumentasi melalui monitoring apoteker. Intervensi model TEMAN Apoteker meningkatkan peran apoteker dan outcome pasien TB.Kata kunci: Anti-tuberkulosis, apoteker, kepatuhan, edukasi, intervensiÂ Enhancing Pharmacistâs Role and Tuberculosis Patient Outcomes Through Training-Education-Monitoring-Adherence-Networking (TEMAN) Pharmacist Model InterventionTraining-Education-Monitoring-Adherence-Networking (TEMAN) Pharmacist model provides opportunities for trained pharmacist to intervene through education of tuberculosis (TB) patient, therapy monitoring, assessment of patientâs adherence, and collaboration with other health professionals. The study aimed to determine the impact of TEMAN Pharmacist model intervention against the role of pharmacist and TB patient outcomes. The study design was a quasi-experimental study with one group pretest-posttest consisted of two phases: training and pharmacist intervention. After training, pharmacists intervene during regular visits TB patients in primary health care and Special Hospital Lung Respira in Yogyakarta. The research subjects were TB officer (pharmacist and TB programmers) and patients with newly TB diagnostic who met the inclusion criteria, i.e. patients aged 15 years or older, receiving antituberculosis therapy, and willing to fill out given questionnaires and signing a letter of approval for the study (informed consent). Meanwhile, the exclusion criteria were patients with multi-drug resistance (MDR) TB; have hepatic disease, psychiatry (mental), and cognitive dysfunction. The instrument developed was a questionnaire to measure the level of knowledge of TB officers and questionnaires to measure the level of knowledge and adherence of TB patients. The data were analyzed descriptively and by using Wilcoxon test. The training effectively improved the knowledge of participants significantly (p=0,000) on average 11.3Â±3.00 (intermediate category) to 16.3Â±2.31 (high category). A total of 40 (81.6%) TB patients increased their knowledge significantly (p=0,000) and 5 (10.2%) increased their adherence significantly (p=0,034) after the pharmacistâs intervention. Additionally, out of 49 patients, 29 (59.2%) patients increased body weight, 100% sputum smear conversion, 33 (67.3%) incidence of ADR, and 8 (16.3%) potential drug interactions were documented by the pharmacist monitoring. Intervention of TEMAN Pharmacist model improves the role of the pharmacist and the outcome of TB patients.Keywords: Adherence, antituberculosis, education, pharmacists, intervention

Profil Kompatibilitas Sediaan Obat Intravena dengan Pelarut pada Pasien Intensive Care Unit Dwijayanti, Sharly; Irawati, Sylvi; Setiawan, Eko
Indonesian Journal of Clinical Pharmacy Vol 5, No 2 (2016)
Publisher : Indonesian Journal of Clinical Pharmacy

Kompatibilitas merupakan salah satu faktor penentu kualitas sediaan intravena (IV) yang berdampak pada keberhasilan terapi pasien Intensive Care Unit (ICU). Tujuan penelitian ini adalah mengidentifikasi profil kompatibilitas dan inkompatibilitas sediaan obat IV yang diberikan kepada pasien ICU. Penelitian observasional ini dilakukan secara prospektif pada pasien di ICU sebuah rumah sakit swasta Surabaya selama periode OktoberâDesember 2014. Pada penelitian ini, data pencampuran obat IV dengan pelarutnya dibandingkan dengan menggunakan brosur sediaan dan Handbook on Injectable Drugs Edisi 17 (2013) sebagai acuan untuk menganalisis kompatibilitas sediaan IV. Campuran antara obat IV dan pelarutnya diklasifikasikan sebagai campuran yang kompatibel, inkompatibel, no information (NI), not applicable (NA), dan not clear (NC) dengan menggunakan kriteria tertentu. Hasil penelitian menunjukkan terdapat 1.186 pencampuran antara senyawa obat IV dengan pelarut dari total 39 pasien ICU yang diamati. Tidak ditemukan pencampuran antara senyawa obat dengan pelarut yang inkompatibel, baik pada pasien dewasa maupun anak. Sebagian besar senyawa obat dicampur dengan pelarut yang kompatibel (dewasa: 72,31%; anak: 69,84%). Akan tetapi, berdasarkan 3 pustaka rujukan untuk kasus kompatibilitas sediaan IV yang digunakan dalam penelitian ini, masih terdapat campuran antara senyawa obat dengan pelarut yang belum diketahui informasi kompatibilitasnya sehingga diklasifikasikan sebagai NI (dewasa: 19,68%; anak: 30,16%). Sebagian kecil dari pencampuran senyawa obat IV dengan pelarutnya, diklasifikasikan sebagai NA dan NC, yaitu sebesar 7,48% dan 0,53%, secara berturut-turut. Terbatasnya informasi terkait kompatibilitas dan stabilitas sediaan IV tersebut mendorong dilakukannya pemantauan kondisi pasien dan kadar obat secara berkesinambungan.Kata kunci: Campuran intravena, ICU, kompatibilitasÂ Profile of Intravenous Admixture Compatibility in The Intensive Care Unit (ICU) Patients Compatibility is one of the important factors determining the quality of intravenous (IV) admixtures which may directly impact to the outcome of treatment to the Intensive Care Unit (ICU) patients. The objective of this study was to identify the profile of compatibility and incompatibility among IV admixtures given to the ICU patients. This observational research was conducted prospectively to the patients admitted in the ICU at a private hospital in Surabaya from OctoberâDecember 2014. In this research, compatibility data of IV drug and its solution was compared with drug brochure and Handbook on Injectable Drugs 17th ed (2013) as references to analyze the compatibility of IV admixtures. The admixture between IV drug and its solvent was classified as compatible, incompatible, no information (NI), not applicable (NA), and not clear (NC), using a specific criteria. There were 1.186 IV drugâsolvent admixtures observed in 39 ICU patients. There were no IV drug-solvent admixtures classified as incompatible in both adult and child patients. Most of IV drugs were admixed with compatible solvents (adults: 72.31%; children: 69.84%). However, according to two of IV drugs compatibility references used in this research, there were some IV drug-solvent admixtures with unknown information about its compatibility that were classified as NI (adults: 19.68%; children: 30.16%). There were a few of IV drug-solvent admixtures classified as NA and NC, of 7.48% and 0.53%, respectively. The lack of information related to compatibility and stability of the IV admixtures emphasize the importance to continually monitor patientsâ condition and drug concentration.Key words: Compatibility, ICU, intravenous admixture

Effect of Gabapentin and Baclofen on Histology Study in Neuropathic Pain Fajrin, Fifteen A.; Khotib, Junaidi; Susilo, Imam
Indonesian Journal of Clinical Pharmacy Vol 4, No 4 (2015)
Publisher : Indonesian Journal of Clinical Pharmacy

Neuropathic pain resulted from injury to nerves is often resistant to current treatments and can seriously cause chronic pain if no appropriate treatment is given. This study was designed to prove the effectiveness of gabapentin and baclofen in increasing latency time toward thermal stimulus and recovering the morphology of dorsal horn of spinal cord in neuropathic-induced chronic pain. Forty mice were divided into 8 groups i.e sham, negative control, gabapentin at three different doses (10, 30, 100 nmol) and baclofen at three different doses (1, 10, 30 nmol). Neuropathic condition was induced by ligation of sciatic nerve with Partial Sciatic Nerve Ligation (PSNL) method. Gabapentin and baclofen were administrated intrathecally once a day for seven days, a week after neuropathic induction. Latency time toward thermal stimulus was measured on days 0, 1, 3, 5, 7, 8, 10, 12 and 14 after induction. Histology of the dorsal horn of spinal cord tissue was examined by haematoxylline-eosin staining. The results showed that intrathecal injection of gabapentin and baclofen significantly increased latency time of mice toward thermal stimulus compared with negative control. Gabapentin and baclofen are effective as treatment for neuropathic pain. They can also help the recovery process of the histology in dorsal horn in neuropathic pain.Keywords: Baclofen, dorsal horn, gabapentin, neuropathic pain, PSNLEfek Gabapentin dan Baclofen terhadap Studi Histologi pada Nyeri NeuropatiNyeri neuropati berasal dari luka pada saraf yang umumnya sulit diterapi sehingga menyebabkan nyeri kronik bila tanpa managemen terapi yang tepat. Tujuan penelitian ini adalah membuktikan efektivitas gabapentin dan baclofen dalam meningkatkan waktu ketahanan terhadap panas dan memperbaiki morfologi dorsal horn dari spinal cord pada keadaan nyeri kronik yang disebabkan neuropati. Empat puluh mencit terbagi ke dalam delapan kelompok, yaitu sham, kontrol negatif, gabapentin (dosis 10, 30 dan 100 nmol) serta baclofen (dosis 1, 10 dan 30 nmol). Nyeri neuropati diinduksi menggunakan metode Partial Sciatic Nerve Ligation (PSNL). Gabapentin dan baclofen diberikan secara intratekal satu kali sehari selama tujuh hari pada satu minggu setelah induksi nyeri neuropati. Waktu ketahanan terhadap stimulus panas diamati pada hari ke-0, 1, 3, 5, 7, 8, 10, 12, dan 14 setelah induksi. Histologi dorsal horn dari spinal cord mencit diamati menggunakan pewarnaan haematoxylline-eosin. Injeksi intratekalgabapentin dan baclofen meningkatkan waktu ketahanan terhadap stimulus panas secara signifikan dibandingkan kontrol negatif. Gabapentin dan baclofen efektif sebagai terapi nyeri neuropati. Keduanya juga dapat memperbaiki histologi dorsal horn pada kondisi nyeri neuropati.Kata kunci: Baclofen, dorsal horn, gabapentin, nyeri neuropati, PSNL

Deteksi Gen Resistensi Ampisilin (bla) pada Escherichia coli Isolat Klinik dengan Metode Polymerase Chain Reaction Milanda, Tiana; Saragih, Bonar C.; Kusuma, Sri A. F.
Indonesian Journal of Clinical Pharmacy Vol 3, No 3 (2014)
Publisher : Indonesian Journal of Clinical Pharmacy

Escherichia coli merupakan bakteri batang Gram negatif yang dapat menjadi patogen jika jumlahnya meningkat atau berada di luar saluran pencernaan. E. coli yang patogen akan menghasilkan enterotoksin yang menyebabkan diare atau infeksi pada saluran kemih. Ampisilin merupakan salah satu antibiotik pilihan untuk mengatasi penyakit infeksi tersebut. Akhir-akhir ini ampisilin tidak lagi digunakan sebagai obat pilihan karena banyaknya kasus resistensi E. coli terhadap antibiotik tersebut. Penelitian ini bertujuanuntuk mendeteksi keberadaan gen yang bertanggung jawab terhadap resistensi antibiotik ampisilin pada E. coli isolat klinik. Sampel yang digunakan adalah hasil isolasi urin midstream pasien dengan gejala sistitis di Rumah Sakit Hasan Sadikin (RSHS) Bandung. Uji resistensi antibiotik menggunakan metode Polymerase Chain Reaction (PCR), baik PCR-koloni maupun PCR-DNA. Berdasarkan hasil uji resistensi terhadap ampisilin, E. coli hasil isolasi telah resisten terhadap ampisilin. Elektroforesis hasil PCR-koloni dan PCR-DNA menunjukkan bahwa resistensi terhadap ampisilin disebabkan oleh gen bla berukuran 199 pb. Diperlukan pemilihan antibiotik yang selektif dan rasional untuk mencegah resistensi ampisilin pada pasien dengan gejala sistitis.Kata kunci: bla, Escherichia coli, gen resistensi ampisilin, polymerase chain reactionDetection of Ampicillin Resistance Genes (bla) in Clinical Isolates ofEscherichia coli with Polymerase Chain Reaction MethodEscherichia coli is a rod negative Gram which could be pathogenic, if its value increases or located in outer gastrointestinal tract. Pathogenic E. coli will produce enterotoxin which will cause diarrhea or infection in urine tract. Ampicilin was one of particular antibiotics to overcome infection. Ampicilinnowadays is no longer used as first choice medicine, because of its resistance case. The aim of this research was to detect the presence of gene which is responsible to ampicilin resistant E. coli. We used isolated midstream urine from cystitis object in Hasan Sadikin Hospital as samples. Polymerase Chain Reaction (PCR) method (colony-PCR and DNA-PCR) were performed to invenstigate the antibiotic resistency. Based on the result of antibiotic susceptibility testing to ampicillin, E. coli samples were resistant to ampicilin. Electropherogram products of colony-PCR and DNA-PCR showed that the resistance case of ampicilin caused by bla gene (199 bp). Our result suggested that bla gene may be use to detect the ampicilin resistance. Furthermore, selective and rational antibiotic treatment is required toprevent ampicillin resistance in patients with symptoms of cystitis.Key words: Ampicillin resistance gene, bla, Escherichia coli, polymerase chain reaction

Pencegahan Penyakit Kardiovaskular pada Pasien Diabetes Melitus Rawat Jalan: Fokus pada Penggunaan Antiplatelet, Statin dan Antihipertensi yang Belum Rasional Lie, Putri G. C. E.; Irawati, Sylvi; Presley, Bobby
Indonesian Journal of Clinical Pharmacy Vol 5, No 3 (2016)
Publisher : Indonesian Journal of Clinical Pharmacy

Â Â Komplikasi penyakit kardiovaskular merupakan penyebab utama morbiditas dan mortalitas pada pasien diabetes melitus (DM) sekaligus dapat menambah beban biaya bagi pasien maupun negara dalam era Jaminan Kesehatan Nasional (JKN). Sebagai salah satu upaya untuk mencegah dan mengurangi risiko tersebut, American Diabetes Associaton (ADA) merekomendasikan pemberian statin, antiplatelet, dan antihipertensi pada pasien DM. Penelitian ini bertujuan untuk melihat profil penggunaan obat untuk pencegahan penyakit kardiovaskular pada pasien DM rawat jalan. Penelitian ini bersifat non-eksperimental dan cross-sectional, dilakukan terhadap 100 pasien DM rawat jalan di sebuah rumah sakit di Surabaya selama periode NovemberâDesember 2014. Hasil penelitian menunjukkan dari 100 pasien yang memenuhi kriteria penggunaan statin, hanya 25 pasien DM yang menggunakan statin. Sebanyak 23 (30,67%) pasien mendapatkan antiplatelet dari total 75 pasien DM yang memenuhi kriteria penggunaan antiplatelet. Antihipertensi ditemukan digunakan pada 42 pasien (87,50%) dari total 48 pasien DM dengan hipertensi, namun tidak semua pasien menggunakan angiotensin-converting enzyme inhibitors (ACEIs) atau angiotensin-receptor blockers (ARBs) sebagai pilihan terapi seperti yang direkomendasikan oleh berbagai pedoman terapi. Dengan demikian, secara keseluruhan penggunaan obat pencegahan penyakit kardiovaskular pada pasien DM masih belum optimal. Penelitian lebih lanjut diperlukan untuk mengidentifikasi faktor-faktor yang membatasi penggunaan obat pencegahan primer maupun sekunder penyakit kardiovaskular pada pasien DM.Kata kunci: Antihipertensi, antiplatelet, diabetes melitus, pencegahan kardiovaskular, statinÂ Prevention of Cardiovascular Disease in Diabetes Mellitus Outpatient: Focusing on Antiplatelet, Statins and Irrational Antihypertensive Drug Use Cardiovascular disease complication is a major cause of morbidity and mortality in diabetes mellitus (DM) patients and all at once is an addition to economic burden to both the patient and government in the era of universal coverage (UC). As one of strategies to prevent and reduce the risk of cardiovascular disease complication, American Diabetes Associaton (ADA) recommends the use of statins, antiplatelet, dan antihipertensive agents in DM patients. This study aimed to describe the profile of cardiovascular disease preventive drugs used in DM outpatients. This was non-experimental and cross-sectional study included 100 DM outpatients during the period of NovemberâDecember 2014. This study found that only 25 out of 100 patients who met-statin criteria were on statins. Antiplatelet agents were only prescribed in 23 (30.67%) out of 75 DM patients who met criteria. Antihypertensive agents were used in 42 (87.50%) out of 48 DM patients who were hypertensive, however angiotensin-converting enzyme inhibitors (ACEIs) or angiotensin-converting blockers (ARBs) were not used as an agent of choice as recommended by various guidelines. Overall, the use of cardiovascular disease preventive drugs in DM patients has yet to be optimal. Further research was needed to identify factors which confine the use of cardiovascular disease primary and secondary preventive drugs in DM patients.Keywords: Antihypertensive, antiplatelet, cardiovascular prevention, diabetes mellitus, statins

Pengaruh Pelayanan Kefarmasian Residensial terhadap Ketaatan dan Luaran Klinis Pasien Hipertensi Larasanty, Luh P. F; Meilinayanti, Ni Made L.; Susanti, Ni Made P.; Wirasuta, I Made A.G.
Indonesian Journal of Clinical Pharmacy Vol 4, No 3 (2015)
Publisher : Indonesian Journal of Clinical Pharmacy

Pada era jaminan kesehatan nasional, salah satu target pelayanan kefarmasian residensial adalah pasien hipertensi yang masuk ke dalam kategori kelompok pasien rujuk balik. Penelitian ini bertujuan untuk mengetahui pengaruh pelayanan kefarmasian residensial yang dilakukan apoteker terhadap ketaatan dan luaran klinis pasien hipertensi tanpa penyakit penyerta yang menjalani rawat jalan di Rumah Sakit Umum Daerah Wangaya Kotamadya Denpasar Bali. Desain penelitian ini adalah eksperimental dengan one group pre-post test design. Sebanyak 13 pasien yang memenuhi kriteria inklusi diberikan pelayanan kefarmasian residensial selama 16 kali kunjungan dalam kurun waktu tiga bulan. Skor hasil pengukuran dianalisis menggunakan regresi linier dan Uji Wilcoxon. Pelayanan kefarmasian residensial mampumeningkatkan ketaatan pasien dalam penggunaan obat, pengaturan diet, dan aktivitas fisik dari tingkat baik menjadi tingkat ketaatan tinggi (p=0,001) serta dapat meningkatkan ketaatan pasien terhadap pembatasan konsumsi alkohol dan rokok dari tingkat baik menjadi sangat baik. Pelaksanaan pelayanan kefarmasian dapat memberikan pengaruh dalam perbaikan luaran klinis pasien berupa penurunan tekanan darah sistolik (p=0,000). Pelayanan kefarmasian residensial memiliki pengaruh terhadap peningkatan ketaatan pasien terhadap penggunaan obat, pelaksanaan diet, pelaksanaan aktivitas fisik, serta terhadap pembatasan rokok dan konsumsi alkohol sehingga dapat memperbaiki luaran klinis pasien hipertensi.Kata kunci: Hipertensi, ketaatan pasien, pelayanan kefarmasian residensial, tekanan darahImpact of Pharmaceutical Home Care on Compliances and Clinical Outcomes of Hypertensive PatientsIn the Indonesian health universal coverage system the hypertensive patients that grouped into the refer back patient treatment category, is one target of pharmaceutical home care. The aim of this study was to carried out the impact of pharmaceutical home care on patient compliances and clinical outcomes ofhypertension without compeling indication out-patient on Wangaya General Hospital in the municipality of Denpasar Bali. Design research is an experimental study with one group pre-post test design. The thirteen patients who met the inclusion criteria will be given pharmaceutical home care services for 16 visits over three months period. The complianced levels were scored and statistical analyzed using linear regression and wilcoxon test. The pharmaceutical home care visit could increase the patients adherence to antihypertensive drug administration, increasing diet compliance, and adherence of physical exercise from good adherence to excellent adherence (p value=0,001), Pharmaceutical home care visit could increase patient compliance to restrictions of smoking and alcohol consumption from good adherence to very good adherence. The decreasing of the patientâs systolic blood pressure correlated to the pharmacist home visit (p value=0,000). The pharmaceutical home care has influenced on health behavior of hypertensive patients and the patients concordance to take their medication and introduced better clinical outcome.Keywords: Blood pressure, hypertension, patient compliances, pharmaceutical home care

Penggunaan Daftar Tilik (Checklist) sebagai Panduan Read-Back Mengurangi Potensi Risiko Medication Error Maharjana, Ida Bagus N.; Kuswardhani, Tuty; Purwaningsih, Cok I. I.
Indonesian Journal of Clinical Pharmacy Vol 3, No 2 (2014)
Publisher : Indonesian Journal of Clinical Pharmacy

Rumah sakit sebagai lini terakhir pelayanan kesehatan berkewajiban memberikan pelayanan berkualitas dan beorientasi pada keselamatan pasien, salah satunya tanggung jawab dalam mencegah medication error. Kolaborasi dan komunikasi yang efektif antar profesi dibutuhkan demi tercapainya keselamatan pasien. Read-back merupakan salah satu cara dalam melakukan komunikasi efektif. Before-after study dengan pendekatan TQM PDCA. Sampel adalah catatan obat pada rekam medik pasien rawat inap RSUP Sanglah pada minggu ke-3 bulan Mei (before) dan minggu ke-3 bulan Juli (after) 2013. Perlakuan dengan menggunakan checklist, meminta waktu 2 menit untuk read-back oleh dokter dan perawat seusaivisite bersama. Didapatkan 57 sampel (before) dan 64 sampel (after). Before 45,54% ketidaklengkapan pengisian catatan obat pada rekam medik pasien yang berpotensi risiko medication error menjadi 10,17% setelah perlakuan read-back dengan checklist selama 10 minggu, dengan pencapaian 77,78% berdasarkan pendekatan TQM PDCA. Panduan read-back menggunaan daftar tilik (checklist) sebagai komunikasi efektif dapat menurunkan ketidaklengkapan pengisian catatan obat pada rekam medik yang berpotensi risiko medication error, 45,54% menjadi 10,17%.Kata kunci: Checklist, medication error, read-backChecklist Usage as a Guidance on Read-Back Reducing the Potential Risk of Medication ErrorHospital as a last line of health services shall provide quality service and oriented on patient safety, one responsibility in preventing medication errors. Effective collaboration and communication between the profession needed to achieve patient safety. Read-back is one way of doing effective communication. Before-after study with PDCA TQM approach. The samples were on the medication chart patient medical records in the 3rd week of May (before) and the 3rd week in July (after) 2013. Treatment using the check list, asked for time 2 minutes to read-back by the doctors and nurses after the visit together. Obtained 57 samples (before) and 64 samples (after). Before charging 45.54% incomplete medication chart on patient medical records that have the potential risk of medication error to 10.17% after treatment with a read back check list for 10 weeks, with 77.78% based on the achievement of the PDCA TQM approach. Checklistusage as a guidance on Read-back as an effective communication can reduce charging incompletenessdrug records on medical records that have the potential risk of medication errors, 45.54% to 10.17%.Key words: Checklist, medication error, read-back

Monitoring Terapi Warfarin pada Pasien Pelayanan Jantung pada Rumah Sakit di Bandung Putri, Norisca A.; Lestari, Keri; Diantini, Ajeng; Rusdiana, Taofik
Indonesian Journal of Clinical Pharmacy Vol 1, No 3 (2012)
Publisher : Indonesian Journal of Clinical Pharmacy

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Penelitian ini bertujuan untuk mengetahui monitoring terapi warfarin untuk menjamin ketepatan dosis,keamanan terapi, dan mengetahui apakah dosis terapi warfarin yang digunakan telah memenuhi kriteriaÂ penggunaan obat warfarin yang rasional. Derajat antikogulasi setiap pasien diukur dengan parameter waktu protrombin yang dinyatakan dengan International Normalized Ratio (INR). Metode Penelitian meliputi monitoring terapi warfarin terhadap 80 pasien di pelayanan jantung melalui PT-INR, pendataanklinis pasien meliputi, usia, jenis kelamin, berat badan, tinggi badan, jenis penyakit, dosis yang digunakan dan obat lain yang dikonsumsi secara bersamaan. Hasil monitoring menunjukkan rata-rata INR pasien yaitu 1,38Â± 0,42 hasil ANAVA (Î± = 0,05) menunjukkan tidak ada pengaruh dosis terhadap INR(p=0,13) tetapi ada pengaruh pada umur (p =0,014), hasil uji beda (Î± = 0,05) menunjukkan tidak ada perbedaan terhadap rata-rata INR berdasarkan jenis kelamin (p =0,051), umur (p =0,397), dan variasi dosis (p = 0,057). Hasil tersebut menunjukkan bahwa dosis warfarin belum mencapai target terapi INR (2â3).Kata kunci: Warfarin, penyakit trombotik, PT-INRÂ Warfarin Therapy Monitoring of Cardiac Care Patients in Hospital in BandungAbstractThe aims of this study were to identify the rational warfarin monitoring therapy to guarantee the rightdose, therapy security, and whether the dose of warfarin therapy has completed the rational criteria ornot. Degree of antikoagulasi for each patient is measured with protombin time as International Normalized Ratio (INR). The methods consist of warfarin monitoring therapy towards 80 patients at the heart service through the PT-INR constant, medical data, such as age, gender, weight, height, type of the disease, dose usage and another medicine which is used together, and statistical test of the average of INR. The monitoring result shows that patientâs INR average is 1,38 Â±0,42, the result of ANAVA (Î±=0,05)shows that thereâs no impact of dose towards INR (p=0,13) but thereâs an INR average impact basedon gender (p=0,051), age (p=0,397) and dose variation (p=0,057). The results shown that warfarin dose which used is not bleeding risk.Key words: Warfarin, trombotic disease, PT-INR

Perbedaan Asupan Nutrisi Makanan dan Indeks Massa Tubuh (IMT) antara Perokok Aktif dan Non-perokok pada Usia Dewasa Suryadinata, Rivan V.; Lorensia, Amelia; Sari, Rika K.
Indonesian Journal of Clinical Pharmacy Vol 6, No 3 (2017)
Publisher : Indonesian Journal of Clinical Pharmacy

Rokok merupakan salah satu ancaman terbesar bagi kesehatan masyarakat di dunia, dan perokok cenderung memiliki indeks massa tubuh (IMT) lebih rendah dan penurunan status gizi yang dapat meningkatkan risiko malnutrisi yang makin memperburuk kondisi kesehatan perokok dibandingkan dengan non-perokok. Tujuan penelitian ini adalah mengetahui perbedaan asupan nutrisi makanan terkait kalori perhari dan indeks massa tubuh (IMT) antara perokok aktif dan non-perokok. Penelitian ini menggunakan metode cross-sectional dengan pengumpulan responden menggunakan purposive sampling. Variabel-variabel yang akan diukur dalam penelitian ini meliputi: asupan nutrisi makanan dengan metode recall 24 jam dan IMT. Sampel penelitian ini adalah perokok aktif dan non-perokok usia dewasa di Surabaya pada bulan November 2015 hingga Januari 2016. Penelitian ini melibatkan 110 responden yang terdiri dari 55 perokok aktif dan 55 non-perokok, dengan sebaran data usia dan jenis kelamin yang homogen di antara kedua kelompok. Hasil uji perbedaan menunjukkan bahwa tidak terdapat perbedaan antara asupan nutrisi perokok aktif dengan non-perokok dengan Sig. 0,972 (p>0,05), dan tidak terdapat perbedaan antara IMT perokok aktif dengan non-perokok asupan nutrisi dengan nilai Sig. 0,745 (p>0,05). Oleh karena itu, disimpulkan bahwa tidak ada perbedaan asupan nutrisi dan IMT antara perokok aktif dan non-perokok.Kata kunci: Asupan nutrisi, indeks massa tubuh (IMT), perokokÂ Differences in Nutrition Food Intake and Body Mass Index between Smoker and Non-smoker in AdultSmoking is one of the greatest threats to public health in the world, and smokers tend to have a lower body mass index (BMI) and the decline in nutritional status that can increase the risk of malnutrition which worsen the health condition of smokers compared to non-smokers. The purpose of this study was to determine differences in nutrition-related food calories per day and body mass index (BMI) between active smokers and non-smokers. This study used cross-sectional with a collection of respondents using purposive sampling. The variables measured in this study includes nutritional intake of food with a 24-hour recall method and IMT. Samples were active smokers and non-smokers adulthood in Surabaya from November 2015 until January 2016. Results of research on the use of 110 respondents consisting of 55 active smokers and 55 non-smokers, with a distribution of data for age and sex homogeneous between the two groups. The test results show that the difference there were no differences between the nutritional intake of active smokers and nonâsmokers with Sig. 0.972 (p>0.05), and there is no difference between BMI active smokers and nonâsmokers for nutrients intake by the Sig. 0.745 (p>0.05). It was therefore concluded that there is no nutritional intake and BMI between active smokers and non-smokers.Keywords: Body mass index (BMI), nutrition, smoker

Hubungan Persepsi terhadap Perilaku Swamedikasi Antibiotik: Studi Observasional melalui Pendekatan Teori Health Belief Model Insany, Annisa N.; Destiani, Dika P.; Sani, Anwar; Pradipta, Ivan S.; Sabdaningtyas, Lilik
Indonesian Journal of Clinical Pharmacy Vol 4, No 2 (2015)
Publisher : Indonesian Journal of Clinical Pharmacy

Tingginya perilaku swamedikasi antibiotik dapat meningkatkan peluang penggunaan antibiotik yang tidak rasional sehingga berdampak pada peningkatan resistensi antibiotik. Perubahan perilaku swamedikasi antibiotik diperlukan untuk menurunkan penggunaan antibiotik yang irasional. Penelitian ini bertujuan untuk mengetahui hubungan persepsi masyarakat terhadap praktik swamedikasi antibiotik yang bermanfaat untuk mengembangkan model intervensi dalam rangka menurunkan praktik swamedikasi antibiotik (SMA). Studi observasional analitik dilakukan pada bulan NovemberâDesember 2014 kepada masyarakat yang berkunjung ke fasilitas kesehatan primer di Kota Bandung. Wawancara terstruktur dengan menggunakan kuesioner tervalidasi dilakukan untuk melihat variabel perilaku swamedikasi serta variabel persepsi ancaman, keuntungan, hambatan, dan kemamampuan bertindak berdasarkan teori perubahan perilaku health belief model (HBM). Wawancara dilakukan terhadap 506 responden dewasa yang diambil secara acak di 43 puskesmas dan 8 apotek. Data yang diperoleh dianalisis dengan menggunakan statistik deskriptif dan regresi logistik (CI 95%, Î±=5%).Validitas kuesioner dinyatakan dengan koefisien korelasi >0,3 dan nilai reabilitas alpha-cronbach sebesar 0,719. Terdapat 29,45% responden yang melakukan swamedikasi antibiotik selama 6 bulan terakhir. Tidak terdapat hubungan signifikan antara variabel HBM (persepsi ancaman, keuntungan, hambatan, dan kemampuan bertindak) dengan perilaku swamedikasi antibiotik (p>0,05). Persepsi ancaman, keuntungan, hambatan, dan kemauan bertindak berdasarkan teori HBM menunjukkan hubungan yang lemah terhadap perilaku swamedikasi antibiotik. Mudahnya akses dalam membeli antibiotik secara bebas diduga menjadi faktor dalam perilaku SMA sehingga regulasi yang ketat diperlukan sebagai dasar intervensi dalam menurunkan perilaku SMA.Kata kunci: Antibiotik, health belief model, swamedikasiAssociation between Perceived Value and Self-Medication with Antibiotics: An Observational Study Based on Health Belief Model TheoryHigh prevalence of self medication with antibiotics can increase the probability of irrational use of antibiotics which may lead antibiotics resistance. Thus, shifting of behavior is required to minimize the irrational use of antibiotics. This study was aimed to determine the association between public perceivedvalue and self-medication with antibiotics which can be used to develop an intervention model in order to reduce the practice of self-medication with antibiotics. An observational study was conducted during the period of NovemberâDecember 2014.The subjects were patients who visit primary health care facilities in Bandung. A structured-interview that has been validated was used to investigate the association between perceived value and self-medication behavior based on the Health Belief Model theory (perceived susceptibility, benefits, barrier, and cues to action). Approximately 506 respondents were drawn randomly from 43 community healthcare centers and 8 pharmacies. Data was analyzed by using descriptive statistics and logistic regression (CI 95%, Î± = 5%). Validity and reliability of the questionnaire were shown with a correlation coefficient of >0.3 and a cronbach-alpha value of 0.719, respectively. We found that 29.45% of respondents practiced self-medication with antibiotics over the last six months. Additionally, there was no significant association between the perceived susceptibility, benefits, barrier, and cues to action with self-medication behavior (p>0.05). Easiness to access antibiotics without prescription was presumed as a factor that contribute to self-medication with antibiotics, therefore strict regulation in antibiotics use is very needed as a basic intervention to decrease self-medication with antibiotic.Key words: Antibiotics, health belief model, self-medication

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