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Correlation of Climate Factors, Population Density, and Larva Free Rate (ABJ) on the Incidence of Dengue Hemorrhagic Fever (DHF) in Kendari City Period 2012-2021 Fifi Nirmala; Nur S Layaly; La Ode Liaumin Azim
MEDULA JURNAL ILMIAH FAKULLTAS KEDOKTERAN UNIVERSITAS HALU OLEO Vol 9, No 2 (2022)
Publisher : Halu Oleo University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46496/medula.v9i2.25471

Background: Dengue Hemorrhagic Fever (DHF) is an infectious disease that is endemic in most tropical areas in the world and around 3.5 billion people live in areas where dengue is endemic. A large number of individuals residing in a certain area will facilitate the spread of dengue disease and accelerate the transmission of dengue virus from vectors. Climate is very important for the survival of the Aedes Aegypti mosquito because mosquito breeding sites will increase along with climate change. ABJ shows the density of larvae in an area. Purpose(s): This study aimed to determine the correlation of climate factors, population density, and larva free rate (ABJ) to the incidence of Dengue Hemorrhagic Fever (DHF) in Kendari City in 2012–2021. Methods: This research method was a cross sectional design and Spearman rank correlation analysis using SPSS application. The data used are secondary data in the form of data on rainfall, humidity, temperature, population density, and the incidence of DHF in a period of 10 years (2012-2021) and ABJ in a period 2016 - 2020. Results: The results of this study indicated that the rainfall variable (p value = 0,000, r = 0,416) and the humidity variable (p value = 0,000, r = 0,446) have a sufficient and unidirectional correlation coefficient to the incidence of DHF in Kendari City in 2012-2021, ABJ variable (p value = 0,014, r = -0,949) has a very strong and non-unidirectional correlation coefficient on the incidence of DHF in Kendari City in 2016-2020, and there is no correlation between the temperature variable (p value = 0,087) and the variable population density (p value = 0,651) with the incidence of DHF in Kendari City in 2012-2021. Conclusion: There was a correlation between rainfall and humidity variables on the incidence of DHF in Kendari City in 2012-2021, there was a correlation between the ABJ variable and the incidence of DHF in Kendari City in 2016-2020, and there wasn’t a correlation between temperature variable and population density variable on the incidence of DHF in Kendari City in 2012-2021.

Characteristic Test and Antihyperuricemia Activity of Ethanol Extract Stem of Etlingera rubroloba A.D Poulsen In vitro Asriullah Jabbar; Idin Sahidin; Khansa Rafida Triaqilah; Mubarak Mubarak; Muhammad Ilyas Yusuf
MEDULA JURNAL ILMIAH FAKULLTAS KEDOKTERAN UNIVERSITAS HALU OLEO Vol 9, No 2 (2022)
Publisher : Halu Oleo University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46496/medula.v9i2.25290

Background: Etlingera rubroloba (E. rubroloba) A.D Poulsen is one of the endemic plants of Southeast Sulawesi, which has the largest species in the world. Local people widely use this plant as traditional medicine. Many of these plant species have been previously reported as antioxidants, antibacterials, and others. However, for E. rubroloba, there are still very few reports from a pharmacological aspect, especially anthiperuricemia. Objective: This study was conducted to determine the characteristics and activity of the ethanol extract of the stem of E. rubroloba A.D Poulsen in vitro. Methods: The stems of E. rubroloba A.D Poulsen were extracted with ethanol solvent by maceration, then the filtrate obtained was evaporated using an evaporator to get an ethanol extract. Furthermore, the extract characterization test was carried out, including water content, ash content, water-soluble extract content, and ethanol-soluble extract content. Then the antihyperuricemia activity test in vitro using the Xanthine Oxidase (XO) kit. Results: The results of the characteristic test showed that the ethanolic extract of E. rubroloba contained 5.15% water content, 5.485% ash content, 55.2% water-soluble extract content, and 56.52% ethanol-soluble extract content. Furthermore, the antihyperuricemic activity of the ethanol extract of E. rubroloba was IC50 48.59 ± 0.03 g/mL and Allopurinol 42.21 ± 0.02 g/mL as positive controls. Conclusion: E. rubroloba stem ethanol extract has characterization results according to the literature, has antihyperuricemia activity, and is a reference for the development of traditional drugs

Antioxidant Potential of Organic Fraction of Turi Leaf Extract (Sesbania grandiflora L.) Using DPPH Reagent Wa Ode Sitti Musnina; Randa Wulaisfan; Jumriana Akhyar; Yonelian Yuyun
MEDULA JURNAL ILMIAH FAKULLTAS KEDOKTERAN UNIVERSITAS HALU OLEO Vol 9, No 2 (2022)
Publisher : Halu Oleo University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46496/medula.v9i2.25291

Background: White turi leaf (Sesbania grandiflora) is a plant from the Leguminosae family that isused as traditional medicine. Purpose(s): To determine the antioxidant potential of white turi leafextract (Sesbania grandiflora L) using DPPH reagent. Methods: White turi leaves (S. grandiflora)were extracted using maceration technique with ethanol the solvent. The ethanol extract wasfractionated using a liquid-liquid extraction using n-hexane, ethyl acetate, and ethanol. In addition,phytochemical screening was also carried out on secundary metabolite compounds contained in theethanol extract, it’s organic fractions. Results: Ethanol extract obtained as much as 160 g (16%).Fractionation of 10 grams of ethanol extract obtained n-hexane fraction 2.9 g (29%); ethyl acetatefraction 0.8 g (8%); and ethanol fraction 6.1 g (61%). Phytochemical screening showed that theethanol extract and ethyl acetate fraction contained flavonoids, saponins, and tannins; the ethanolfraction contains terpenoids, flavonoids, saponins, and tannins; while the n-hexane fraction containstannin compounds. The antioxidant activity of the ethanol extract, ethyl acetate fraction, and ethanolfraction were tested using the DPPH radical scavenging method. The antioxidant activity assayshowed that the SC50 values of the ethanol extract, ethyl acetate fraction, and ethanol fraction were234.7; 66,244, and 106.755 ppm, vitamin C as a positif control with SC50 3,006 ppm. Conclusion:white turi leaf extract (S. grandiflora) has antioxidant activity less than 22-78 times than controlpositif, so it is not potential as an antioxidant.

Hubungan Derajat Kelainan Radiologik dengan Derajat Nyeri pada Penderita Osteoartritis Sendi Lutut di Rumah Sakit Umum Daerah Kota Kendari Iis Ainu Rahma; Mario Polo Widjaya; Muhammad Rustam; Agussalim Ali
MEDULA JURNAL ILMIAH FAKULLTAS KEDOKTERAN UNIVERSITAS HALU OLEO Vol 6, No 3 (2019): Edisi Suplemen
Publisher : Halu Oleo University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46496/medula.v6i3.25496

Background: Osteoarthritic (OA) is a degenerative disease with slow progressive which has a characteristic pathological sign of joint deterioration as a result of biochemical, metabolic, physiological, and pathological changes. Pain is a complaint that is generally felt by people with osteoarthritis and has a different degree in each patient. Purpose: The purpose of this study determine the correlation between radiological abnormalities staging and pain level with osteoartritic of knee joint of Rumah Sakit Umum Daerah Kota Kendari. Method: This research is an observasional analytic study with cross-sectional approach. 37 sampels were acquired through total sampling. Data were analyzed using the Spearman correlation test (p value <0,05). Result: Result of the univariat analysis show that most patients have moderate radiological abnormality that were 12 (32.43%) and most of patient have severe pain level that were 19 (51.35%). Based on bivariat statistical test, a positive correlation was obtained between radiological abnormalities staging and pain level with osteoartritic of knee joint with p=0,000 and r=0,831. Conclusion: There was a significant correlation between radiological abnormalities staging and pain level with osteoartritic of knee joint of Rumah Sakit Umum Daerah Kota Kendari.Keywords: Osteoarthritic, Radiological abnormalities staging, Pain level

Aktivitas Antibakteri dan Skrining Fitokimia Ekstrak Etanol Daun Jambu Mete Anacardium occidentale L. Terhadap Pertumbuhan Escherichia coli Antibacterial Activity and Phytochemical Screening of Ethanol Extract of Cashew Leaves Anacardium occidentale L. Against Escherichia coli Eka Astuty
MEDULA (JURNAL ILMIAH FAKULTAS KEDOKTERAN UNIVERSITAS HALU OLEO) Vol 10, No 1 (2022)
Publisher : Halu Oleo University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46496/medula.v10i1.26112

ABSTRACTBackground: All parts of the cashew tree Anacardium occidentale L. (especially the leaves and bark) have been widely used as traditional herbal medicines, and are used throughout the world. Thus, in recent decades, the traditional medicinal properties of the Anacardium plant, and its various biological effects are being studied extensively. Purpose(s): This study aims to conduct a preliminary study of the antibacterial properties and phytochemical screening of the ethanol extract of cashew leaves. Methods: The antibacterial test of was determined by the Kirby baeur disc paper diffusion method. Qualitative test of phytochemical content was carried out using chemical reagents. Results: The results indicated that the ethanol extract of cashew leaves has an inhibitory effect on the growth of Escherichia coli. The smallest inhibition zone was found in the extract with a concentration of 10% of 5.75 mm and the largest was found at a concentration of 100% with a diameter of 14 mm. The phytochemical screening revealed that extracts contained; alkaloids, flavonoids, steroids, terpenoids, phenolics, saponins, and tanins Conclusion: The ethanol extract of cashew leaves was able to inhibit the growth of Escherichia coli test bacteria at all concentration variations. Phytochemical screening also found that the ethanol extract of cashew leaves contains alkaloids, flavonoids, steroid terpenoids, phenolics, saponins, and tannins which are known to have antibacterial properties.Keywords: cashew, ethanol extract, antibacteria ABSTRAKLatar Belakang: Semua bagian pohon jambu mete Anacardium occidentale L. (terutama daun dan kulit batang) telah banyak digunakan sebagai obat herbal tradisional, dan digunakan di seluruh dunia. Dengan demikian, dalam beberapa dekade terakhir, sifat obat tradisional tanaman Anacardium, dan berbagai efek biologis sedang dipelajari secara ekstensif Tujuan: Penelitian ini bertujuan untuk melakukan studi pendahuluan sifat antibakteri dan skrining fitokimia dari ekstrak etanol daun jambu mete. Metode: Uji antibakteri ekstrak ditentukan dengan metode difusi kertas cakram Kirby baeur. Uji kualitatif kandungan fitokimia dalam ekstrak dilakukan dengan pereaksi kimia. Hasil: Ekstrak etanol daun jambu mete memiliki daya hambat terhadap pertumbuhan Escherichia coli. Zona hambat terkecil terdapat pada ekstrak dengan konsentrasi 10% sebesar 5,75 mm dan terbesar terdapat pada konsentrasi 100% dengan diameter 14 mm. Hasil skrining fitokimia menunjukkan bahwa ekstrak etanol daun jambu mete mengandung senyawa golongan alkaloid, flavonoid, steroid, terpenoid, fenolik, saponin, dan tanin Simpulan: Ekstrak etanol daun jambu mete mampu menghambat pertumbuhan bakteri uji Escherichia coli pada semua variasi konsentrasi. Skrining fitokimia juga menemukan bahwa dalam ekstrak etanol daun jambu mete mengandung alkaloid, flavonoid, steroid terpenoid, fenolik, saponin, dan tannin yang diketahui memiki kemampuan sebagai antibakteriKata Kunci: jambu mete, ekstrak etanol, antibakteri

Analisis Penggunaan Kondom Pada Wanita Pekerja Seks Sebagai Upaya Pencegahan HIV/AIDS di Kota Kendari: Cross Sectional Study Adius Kusnan; Nur Indah Purnamasari; Nisa Melynia Arman; La Ode Alifariki
MEDULA (JURNAL ILMIAH FAKULTAS KEDOKTERAN UNIVERSITAS HALU OLEO) Vol 10, No 1 (2022)
Publisher : Halu Oleo University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46496/medula.v10i1.26733

Latar Belakang: Salah satu populasi yang berisiko tinggi HIV/AIDS adalah Wanita Pekerja Seks (WPS) dikarenakan perilaku seks yang tidak aman yakni berganti-ganti pasangan. Penggunaan kondom merupakan salah satu inisiatif untuk mencegah penularan HIV/AIDS, dan penggunaannya dapat dipengaruhi oleh berbagai variabel. Tujuan: Menganalisis berbagai faktor yang berhubungan dengan penggunaan kondom pada WPS sebagai upaya pencegahan HIV/AIDS. Metode: Penelitian cross sectional ini merupakan penelitian observasional analitik yang dilakukan di Kota Kendari dengan jumlah sampel 65 orang sesuai kriteria inklusi dan eksklusi yang dipilih menggunakan purposive sampling, analisis data menggunakan uji chi-square Pearson dengan nilai p-value ≤ 0.05 dinyatakan bermakna. Hasil: Pengetahuan baik tentang HIV/AIDS dan kondom (58,5%), memiliki sikap tentang penggunaan kondom positif (66,2%), ada paparan informasi tentang kondom untuk mencegah HIV/AIDS (95,4%) serta selalu menggunakan kondom (55,4%). Terdapat hubungan antara pengetahuan (p-value=0,012) dan sikap (p-value=0,027) penggunaan kondom pada WPS. Tidak terdapat hubungan keterpaparan informasi (p-value=0,084) dengan penggunaan kondom pada WPS. Simpulan: WSP yang memiliki pengetahuan kurang dan sikap negative cenderung berimplikasi pada menurunnya penggunaan kondom

The Activity of Notika Leaves (Archboldiodendron calosericeum KOBUSKI) Against Tumors Necrosis Factor Alpha (TNF-) Levels in Rats Nuralifah Nuralifah; Parawansah Parawansah; Fadhliyah Malik; Nining Yulianti
MEDULA (JURNAL ILMIAH FAKULTAS KEDOKTERAN UNIVERSITAS HALU OLEO) Vol 10, No 1 (2022)
Publisher : Halu Oleo University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46496/medula.v10i1.23816

Inflammation is a response process to tissue injury and infection. The inflammatory response causes the release of pro-inflammatory mediators such as IL-1, IL-6 and TNF-α which are the main cytokines in the acute inflammatory response. Plants that have the potential to be anti-inflammatory are notika leaves (Archboldiodendron calosericeum KOBUSKI). This research was conducted to determine the anti-inflammatory activity of the ethanol extract of notika leaves against the levels of Tumor Necrosis Factor Alpha (TNF-a) in wistar mice. This study used a post test only control group design. Using 5 treatment groups, namely positive control (diclofenac sodium), negative control (NaCMC 0.5%), 100 mg/kgBW extract test group, 200 mg/kgBW extract group and 300 mg/kgBW extract group. In vivo tests were carried out by induction of inflammatory substances, administering preparations and measuring TNF-α levels using the ELISA method. Data were analyzed using the One Way ANOVA test. The results showed that the mean levels of TNF-α in the positive control group (0.475 ng/L), negative control (0.816 ng/L), extract dose 100 mg/kgBW (0.67 ng/L), extract dose 200 mg/kgBW (0.7285 ng/L) and extract dosage of 300 mg/kgBW (0.7785 ng/L). The conclusion obtained is that the ethanol extract of notika leaves has anti-inflammatory activity against the levels of Tumor Necrosis Factor Alpha (TNF-a) in Wistar rats based on the reduction in levels with negative control and the best dose was 100 mg/kgBW.

Hubungan Faktor Risiko dengan Kejadian Sindrom Dispepsia Fungsional pada Mahasiswa Fakultas Kedokteran Universitas Khairun Muhammad Sultan Firman Syah; Abdul A Manaf; Fera The
MEDULA (JURNAL ILMIAH FAKULTAS KEDOKTERAN UNIVERSITAS HALU OLEO) Vol 10, No 1 (2022)
Publisher : Halu Oleo University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46496/medula.v10i1.25877

Dispepsia merupakan kumpulan rasa tidak nyaman, nyeri epigastrium, kembung, mual muntah, sendawa dan rasa penuh. Stres, pola makan, makanan/minuman iritatif, obat anti inflamasi non-steroid (OAINS), Helicobacter pylori, alkohol dan merokok merupakan faktor risiko dispepsia. Meski berada di urutan ke-8 dari 10 penyakit spesifik di Maluku Utara, belum ada penelitian terkait hubungan faktor risiko dengan kejadian pada kelompok ini, khususnya pada kaum muda di Universitas Khairun. Tujuan: Mengetahui hubungan faktor risiko dengan kejadian sindrom dispepsia fungsional pada mahasiswa Fakultas Kedokteran Universitas Khairun. Metode: Penelitian observasional analitik cross sectional ini dilaksanakan mengunakan metode random sampling dari populasi mahasiswa Fakultas Kedokteran Universitas Khairun pada Januari 2022. Data diperoleh melalui kuesioner. Hasil: Dari 136 sampel, sebagian besar berusia 20-24 tahun (54,4%), 71,3% perempuan, 52,5% memiliki tingkat stres normal, 64,7% memiliki pola makan teratur, 56,6% mengonsumsi makanan/minuman iritatif, 23,5% mengonsumsi OAINS, 2,2% perokok, dan 6,6% mengonsumsi alkohol. Dispepsia fungsional dialami 55,9% mahasiswa. Dari seluruh variabel independen, jenis kelamin, tingkat stres, diet iritatif, OAINS, dan status perokok ditemukan berhubungan bermakna secara statistis dengan kejadian dispepsia fungsional (p<0,05). Simpulan: Pada mahasiswa Fakultas Kedokteran Universitas Khairun, jenis kelamin, tingkat stres, diet iritatif, OAINS, dan status perokok ditemukan berhubungan bermakna secara statistis dengan kejadian dispepsia fungsional.Kata Kunci: Dispepsia, faktor risiko, mahasiswa fakultas kedokteran

Risk Factors for Acute Respiratory Infection in Toddlers : A Case Control Study Elpira Asmin; Mira Juanita; Vebiyanti Tentua
MEDULA (JURNAL ILMIAH FAKULTAS KEDOKTERAN UNIVERSITAS HALU OLEO) Vol 10, No 1 (2022)
Publisher : Halu Oleo University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46496/medula.v10i1.26409

Background: Acute Respiratory Infection (ARI) is a disease that attacks the upper and lower respiratory tract caused by bacteria and viruses. ARI is one of the causes of high morbidity and mortality in under-fives. Purpose(s): This study aims to determine the relationship between toddler age, immunization status, smoking habits of family members, mother's knowledge, and residential density to the incidence of ARI in the working area of the Namlea Health Center in 2021 Methods: This study is a research study quantitative analysis using a case control research design. The sample in the case group was taken using the simple random sampling method and the control group was taken using the accidental sampling method. Results: the age of toddlers who were 36 months (55.2%), incomplete immunization status (46.9%), smoking habits of family members (68.8%), low maternal knowledge (30.2%), and density of bedroom occupancy (60.4%). The results of the chi-square test showed that the p-values for each variable were age (p = 0.035), immunization status (p = 0.017), room occupancy density (p = 0.022), mother's knowledge (p = 0.046), and smoking habits. family members (p = 0.036). Conclusion: There is a significant relationship between age, immunization status, room occupancy density, mother's knowledge, and smoking habits of family members with the incidence of ARI in children under five in the working area of the Namlea Health Center in 2021.

Correlation between Chest Radiograph and Lung Ultrasound with Clinical Appearance in Hyaline Membrane Disease Patients Wa Ode Zerbarani; Sri Asriani; Mirna Muis; Ema Alasir
MEDULA (JURNAL ILMIAH FAKULTAS KEDOKTERAN UNIVERSITAS HALU OLEO) Vol 10, No 1 (2022)
Publisher : Halu Oleo University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46496/medula.v10i1.28495

ABSTRACT Background: Hyaline membrane disease (HMD) is a respiratory distress disease in premature infants due to surfactant deficiency. The combination of clinical, laboratory and radiological features makes it easy to quickly, precisely & accurately establish HMD which is important for early therapy in preventing death. Purpose: Knowing the suitability between chest X-ray & Thorax ultrasound with the clinical picture in HMD patients. Methods: This study is an observational study with a cross sectional method conducted in the radiology & NICU section of Dr. Wahidin Sudirohusodo Makassar from August 2021 to January 2022. Sampling was done by consecutive sampling. The researcher performed a thorax ultrasound & assessed the chest x-ray. The results were verified by two pediatric radiology consultants. Results: The largest sample was in neonates at 34 weeks of gestation, 8 samples (21.1%), sex with 25 samples (65.8%), the highest birth weight between 1000-2000 grams 32 samples (84.2%) , the most preterm etiology was due to severe preeclampsia in 13 samples (34.2%), the most deliveries were by cesarean section 34 samples (89.4%), the highest APGAR Score was in moderate degree 25 samples (65.8%), the highest O2 saturation was between 90 -94%, namely 24 samples (63.2%), the most down scores were moderate degrees 15 samples (39.5%), HMD degrees based on chest radiographs were mostly grade II 25 samples (65.8%), HMD degrees based on thorax ultrasound the most in the moderate degree 19 samples (50%).Conclusion: Ultrasound is considered as the radiological modality of choice because it is safe, inexpensive, easy & sensitive to assess respiratory distress in neonates but is influenced by the operator's ability to apply it.Keywords: hyaline membrane disease, down score, chest radiograph, lung ultrasound

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Sulastrianah

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Kampus Hijau Bumi Tridharma Anduonohu Kendari Universitas Halu Oleo Fakultas Kedokteran

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Kota kendari,

Sulawesi tenggara

INDONESIA

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Home Page

OAI Link

Editorial Team

Contact

Reviewer

Google Scholar

Contact Name Sulastrianah

Contact Email sulastrianahmuhtadi@gmail.com

Phone +6285242541601

Journal Mail Official sulastrianahmuhtadi@gmail.com

Editorial Address Kampus Hijau Bumi Tridharma Anduonohu Kendari Universitas Halu Oleo Fakultas Kedokteran

Location Kota kendari, Sulawesi tenggara INDONESIA

Abstract

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Contact Name
Sulastrianah

Contact Email
sulastrianahmuhtadi@gmail.com

Phone
+6285242541601

Journal Mail Official
sulastrianahmuhtadi@gmail.com

Editorial Address
Kampus Hijau Bumi Tridharma Anduonohu Kendari Universitas Halu Oleo Fakultas Kedokteran

Location
Kota kendari,

Sulawesi tenggara

INDONESIA