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UJI AKTIVITAS TABIR SURYA FORMULA SEDIAAN LOSIO EKSTRAK METANOL DAUN MANGKOKAN (Nothophanax scutellarium Merr.) Suryani Suryani; Rini Hamsidi; Nurlena Ikawati; Ahmad Zaeni; Hasnawati Hasnawati
MEDULA JURNAL ILMIAH FAKULLTAS KEDOKTERAN UNIVERSITAS HALU OLEO Vol 2, No 1 (2014)
Publisher : Halu Oleo University

Leaves of mangkokan (Nothophanax scutellarium Merr.) contain a potent antioxidant and sunscreen compounds. This plant potential to be developed into cosmetic products. One of cosmetic product that can be developed using natural product is lotion. This research aims to formulate lotion from methanol extracts of leaves mangkokan and determining the sunscreen activity of lotion with various concentration of the extract 1%; 2.5%; 5%; 7.5%; and 10% using laboratory experimental design. Preparation of mangkokan leaf extracts using methanol solvent by maceration method. Further tests conducted to determine the activity of sunscreen. Methanol extract of the leaves mangkokan then formulated to be lotion. Sunscreen activity of lotion was tested by determaining SPF values. Lotion methanol extract of leaves mangkokan resulting the highest SPF value contained in the methanol extract of the leaves mangkokan concentration of 10%. Keywords: mangkokan leaves, lotion, extract, lotion, sunscreen

FAKTOR - FAKTOR RISIKO USIA, ASUPAN TABLET FE DAN STATUS GIZI YANG BERHUBUNGAN DENGAN KEJADIAN ANEMIA PADA IBU HAMIL Waode Sitti Asfiah Udu; Andi Yulia; Sitti Wahidatun Asryani
MEDULA JURNAL ILMIAH FAKULLTAS KEDOKTERAN UNIVERSITAS HALU OLEO Vol 2, No 1 (2014)
Publisher : Halu Oleo University

Gravidarum anemia can increase the risk of mortality in pregnancy . The prevalence of gravidarum anemia in world is high especially in developing country according to data of WHO. This study aimed to identify the gravidarum anemia risk factors such age, Fe tablet consumption and nutritional status in pregnant woman at Poasia’s society health center region of Kendari City. This study used an analytical study with case control design. The case groups in this study are 40 pregnant woman with gravidarum anemia who have Hb<11 gr/dL while pregnant woman with Hb ≥ 11 gr/dL are used as control. Risk factor is assessing by Odds ratio. This study founded that age have OR = 7.21 (1.48-35.06; 95%), Fe tablet consumption have OR = 27.0 (7.68-94.87; 95%) and nutritional status have OR = 1.92 (0.69-5.33; 95%). As conclusions, age and Fe tablet consumption are risk factors for gravidarum anemia while nutritional status is not a risk factor for gravidarum anemia. Key words: Gravidarum anemia, age, Fe tablet consumption, nutritional status.

Bioaktifitas Antibakteri Ekstrak Etanol Teripang Pasir (Holothuria scabra) terhadap Pertumbuhan Klebsiella pneumoniae Secara In Vitro Fifit Ervitha; Sulastrianah Sulastrianah; Indria Hafizah
MEDULA JURNAL ILMIAH FAKULLTAS KEDOKTERAN UNIVERSITAS HALU OLEO Vol 3, No 1 (2015)
Publisher : Halu Oleo University

Holothuria scabra is one of the biota that commonly found in Southeast Sulawesi waters and traditionally use as a source food and medicine by local tribe. They also harvesting this species for exported to several countrywith high demand. Even this species have commmercially beneficience, but there is lack of publication about the bioactivity, especially H. Scabra derived from southeast Sulawesi. This study aims to determine secunder metabolite that contain in the extractand to examine antibacterial bioactivity of H. scabra ethanol extract againstKlebsiellapneumoniae by defining the Minimum Inhibitory Consentration. The method using an experimental with post test onlycontrol group design. The extraction is using maseration method and the extract then diluted and divided intoten concentration 100%, 50%, 25%, 12,5%, 6,25%, 3,125%, 1,56%, 0,78%, 0,39%, and 0,19%. The secunder metabolite was determined by using TLC and the MIC was determined by using dilution method. All consentration.As the result, TLC test showing positif result for alcaloid and triterpenoid and the nutrient broth starting to show no turbidity in concetration 0,78%. The conclusion of this study is ethanol extract of H. Scabra contain alkaloid and triterpenoid as secunder metabolite and the MIC was in 0,78% concentration.Keywords: Holothuria scabra, Klebsiella pneumoniae, MIC, alkaloid, terpenoid

Korelasi Peningkatan Kadar Trigliserida Terhadap Pembentukan Small Dense LDL Pada Pasien Diabetes Melitus Tipe 2 Musyarrafah Musyarrafah; Christiana Lethe; Joko Widodo
MEDULA JURNAL ILMIAH FAKULLTAS KEDOKTERAN UNIVERSITAS HALU OLEO Vol 2, No 2 (2015)
Publisher : Halu Oleo University

Type 2 diabetes increases of triglyceride level due to change of Low Density Lipoprotein (LDL)concentrations, with regard to both numbers and sizes of LDL particles. Small, dense LDL particles are more atherogenic than larger, buoyant LDL and that Apo B is more accurate measure than LDL with regard to predicting cardiovascular disease in patient with type 2 diabetes. This study to determine the correlation between elevated of triglyceride concentration to small dense LDL production in patient with type 2 diabetes. This study was cross sectional design. The subject in this study was type 2 diabetes patient with age more than30 years old (n=33). Triglyceride was analyzed by enzymatic-colorimetric method. Small dense LDL production was calculated by ratio of LDL/Apo B <1.2. Data analysis was performed with Spearman test with significance level of 0.05. The result showed that elevated of triglyceride concentration with small dense LDL formation (ratio of LDL/Apo B <1.2) found on 11 (33.4%) patient, while patient with the elevated of triglyceride concentration and non formation of small dense LDL (ratio of LDL/Apo B≥1,2) found on 9 (23.3%) patient. There was significantly correlation (p=0.027, r= -0.385) between the elevated of triglyceride concentration to the small dense LDL production. In conclusion, the elevated of triglyceride concentration lead to formation of small dense LDL in type 2 diabetes patient. Furthermore, LDL/Apo B ratio could be used as standard parameter to predict cardiovascular disease.Keyword: Type 2 diabetes, triglyceride, Apoliprotein B, small dense LDL.

Hubungan Indeks Massa Tubuh dengan Kejadian Premenstrual Syndrome pada Mahasiswi Fakultas Kedokteran Universitas Halu Oleo Angkatan 2012-2013 Amiruddin Eso; Juminten Saimin; Luphyta Nimandana
MEDULA JURNAL ILMIAH FAKULLTAS KEDOKTERAN UNIVERSITAS HALU OLEO Vol 3, No 2 (2016)
Publisher : Halu Oleo University

Background: Premenstrual syndrome (PMS) refers to a set of physical, psychological and emotional sympstoms during a part of a woman’s menstrual cycle. About 80-95% productive woman has experience with premenstrual syndrome could effect several aspects in their life. Several factor could cause premenstrual syndrome is increase level of estrogen hormone. Basic material of esterogen is fat, especially peripheral fat. that could be predicted by measuring the body mass index. The aim of the study is to examine the relationship between body mass index (BMI) and Premenstrual syndrome at female medical faculty, 2012-2013 of Haluoleo University. This study was an analytic observasional with cross sectional design. Samples in this study were 133 respondents from the female of Medical Faculty, of Halu Oleo University. Samples were obtained by proportional stratified random sampling. This study using American Psikiatry Assosoation (APA) questionnaire to diagnose premenstrual syndrome. Data were analyzed with chi-square. In this study, 55.6% of respondents having a Premenstrual Syndrome, in which 96.15% incidence of premenstrual syndrome occurred in overweight group. There is a significant relationship between body mass index with the incidence of premenstrual syndrome with p value = 0,000 (p <α = 0.05) in which increasing a person's weight, the tendency to experience incidence of premenstrual syndrome will also increase. There is a relationship between body mass index with the incidence of premenstrual syndrome on the female of Medical Faculty, 2012-2013 of Halu Oleo University.Keywords : Body Mass Index, Female Medical Students, Premenstrual syndrome

Hubungan Pengetahuan dan Sikap dengan Pemanfaatan Sumberdaya Hayati Laut Untuk Kesehatan Masyarakat Pesisir Kecamatan Soropia I Putu Sudayasa; Ratih Harlyan Lawenga
MEDULA JURNAL ILMIAH FAKULLTAS KEDOKTERAN UNIVERSITAS HALU OLEO Vol 3, No 2 (2016)
Publisher : Halu Oleo University

The level of biodiversity in Indonesia as a tropical country is very high, the potential of marine biological resource makes the sea of Indonesia called as Marine Mega-Biodiversity region in the world. Therefore it was expected especially in coastal communities can take and utilizing of marine biological resource optimally, especially for conventional and traditional for health. However basical knowledge and attitude of coastal communities about coastal and marine resources primarily for its management is still lack. The lack of the basical knowledge can affect the inability of society to engage in the use of coastal and marine resources, especially the utilization of marine biological resources in health. The aim of this research was to determine the relationship between knowledge and attitude to the utilization of marine biological resource for health on coastal communities area of Soropia wich one of coastal areas in Southeast Sulawesi with high potential of marine biological resorces. The research method used observational design with cross sectional approach. The subjects of the research were coastal communities in Soropia located in three villages, namely Tapulaga, Leppe and Bajoe. This research was conducted for January 2016, with 292 respondents of population. The sample were selected by using stratified random sampling technique that obtained 167 respondents. Bivariate analysis was performed by Chi square and Fisher test.The result of bivariate analysis showed that there was significant relationship between knowledge (p=0,000) and the utilization of marine biological resource for health and there was significant relationship between attitude (p=0,014) and the utilization of marine biological resource for health. This research concluded that there were significant relationship between knowledge and attitude to the utilization of marine biological resource for health in the coastal community area of Soropia. The present research suggested that there would be further research that investigated the efficacy of Enhalus acoroides root as the alternative treatment to resolve Diabetes disease, Semele cordiformis as the alternative medication to cure Hepatitis disease and Siganus sp. bile as the alternative analgesic medication to wounds caused by fish bone.Keywords: marine biological resource,health, knowledge, attitude, coastal community

Uji Efek Antipiretik dan Antiinflamasi Ekstrak Etanol Buah Pare (Momordica charantia L.) terhadap Mencit Jantan Parawansah Parawansah; Wahyuni Wahyuni; Zakiyatul Mahmudah
MEDULA JURNAL ILMIAH FAKULLTAS KEDOKTERAN UNIVERSITAS HALU OLEO Vol 4, No 1 (2016)
Publisher : Halu Oleo University

This research was carried out to determine the content of secondary metabolites contained in the ethanol extract of bitter melon (Momordica charantia L.) and antipyretic and antiinflammatory effects on mice. Bitter melon extract obtained by maceration method using ethanol 96%. Bitter melo ethanol extract was made in three variations of dose 50 mg / KgBW, 150 mg / KgBW, and 250 mg / KgBW. The content of secondary metabolites determined phytochemical Skrining by TLC (thin layer chromatography) with specific reagent. Antipyretic effect performed by vaccine DPT (Diphtheria Pertussis Tetanus) as inducers of fever and Parasetamol 500 mg as a positive control and antiinflammatory effect using the method of edema artificial on the soles of the mice foot with carrageenan 2% as an aphrodisiac edema and Diclofenac Sodium 50 mg as a positive control. Subjects used is a white male mice were given intraperitoneally (i.p). Analysis of the data using ANOVA statistical analysis and continued with LSD Post Hoc test. Phytochemical screening results showed that ethanol extract of bitter melon contains alkaloids, tannins, flavonoids, saponins, and triterpenoids. The results indicated that ethanol extract of bitter melon at dose of 150 mg/KgBW has antipyretic effect with total temperature decrease 1,1oC and anti-inflammatory effects with the largest of inflammation inhibition percent by 68.57%. One way ANOVA analysis signify a probability value (p) < 0.05 with 95 % of confidence level that indicate a significant influence of ethanol extract of bitter melon to its antipyretic and antiinflammatory effects on male mice.Keywords : Antipyretic, Anti-inflammatory, Momordica charantia, Bitter melon

Hubungan Infeksi Torch Pada Kehamilan Dengan Kejadian Kelainan Kongenital Pada Bayi Baru Lahir Zida Maulina Aini; Juminten Saimin
MEDULA JURNAL ILMIAH FAKULLTAS KEDOKTERAN UNIVERSITAS HALU OLEO Vol 4, No 2 (2017)
Publisher : Halu Oleo University

ABSTRACT Introduction: TORCH infection in pregnancy in Indonesia shows a high prevalence, ranging from 5.5% to 84%. The results showed that from 100 samples of pregnant women who had an infection, one of TORCH was found to have 12% of children with congenital abnormalities, 70% had abortion and 18% had Intra Uterine Fetal Death (IUFD). TORCH infection has not received serious attention in pregnant women in Southeast Sulawesi. Methods: The design of this study used cross-sectional studies. The research was conducted in RS Ibu and Anak Permata Bunda and RS dr.Ismoyo Kendari from 2013-2016. Sample examination of TORCH infection include IgG Toxoplasma, IgG Rubella, and IgG Cytomegalovirus. The results of the examination are TORCH infection (IgG Toxo, IgG Rubella, IgG CMV) and observation of pregnant mother until newborn. Bivariate analysis was done to see the relationship between independent variable and dependent using statistical test odds ratio (OR) 2x2 contigency table with 95% confidence level (α = 0,05). Result: Subjects of this research were 33 people by total technique Sampling. Results examination of TORCH infection are obtained: IgG Toxoplasma (+), IgG Rubella (+), IgG CMV (+), IgG Toxoplasma (+) IgG Rubella (+), IgG Toxoplasma (+) IgG CMV (+), IgG Rubella (+) IgG CMV (+), and IgG Toxoplasma (+) IgG Rubella (+) IgG CMV (+). The most frequent result of TORCH infection was IgG Toxoplasma (+) IgG Rubella (+) IgG CMV (+) of 11 samples (33.3%). Based on the obeservation of pregnant women to childbirth, there were 12 samples (36,4%), Abortus 8 samples (24,2%), congenital abnormalities 7 samples (21,2%), Intra Uterine Fetal Death (IUFD) 4 samples (12.1%), and Blighted Ovum (BO) of 2 samples (12.1%). Based on result of data analysis with Chi-Square statistical test to correlation of TORCH infection with congenital incidence in newborn p value was 0,092 (p> 0,05). These results suggest that TORCH infection is not associated with the incidence of congenital abnormalities in newborns. Conclusion: Based on this research, it was found that there was no correlation between TORCH infection in pregnancy with incidence of congenital abnormality (P = 0,092, p> 0,05). Some of the high yields of TORCH IgG titers have a baby aterm output. While the value of IgG titer that is not too high have abortus output, IUFD and congenital abnormalities. Keyword: TORCH, IgG, Congenital Disorders

Uji Antioksidan Ekstrak Etanol Buah dan Biji Mengkudu (Morinda citrifolia L.) dengan Metode DPPH (1,1-diphenyl-2-picrylhydrazyl) Pranita Aritrina; Parawansah Parawansah; Nurul Ardani
MEDULA JURNAL ILMIAH FAKULLTAS KEDOKTERAN UNIVERSITAS HALU OLEO Vol 5, No 1 (2017)
Publisher : Halu Oleo University

ABSTRACT Background: Free radicals and antioxidant were widely discussed in world of health because most of the diseases were initiated by presence of oxidation reaction in the body. The process of free radical formation could be inhibited by the presence of antioxidant. Antioxidant was a compound that can protect the biological system in the body. Research Purpose: This research aimed to analyze the potential of fruits and seeds of Morinda citrifolia L. as antioxidant which could counteract free radicals using DPPH (1,1-diphenyl-2-picrylhydrazyl) method. Research Method:This research used experimental method with post test only control design. The research was located in Integrated Laboratory of Faculty of Medicine and Pharmacy Laboratory of Faculty of Pharmacy of Halu Oleo University. Samples of this research were fruit and seed ethanol extract of Morinda citrifolia L.which were taken in West Kendari, Kendari City. The independent variables from this research were fruit ethanol extract and seed ethanol extract of cheese fruit and dependent variable was antioxidant potential. Potential and antioxidant activity (IC50) were tested by measuring DPPH (1,1-diphenyl-2-picrylhydrazyl) uptake using a spectrophotometer. Antioxidant activity (IC50) was analyzed using a linear regression equation. Research Result:The result of this research showed that there was a color changing of DPPH from purple to yellow on fruits ethanol extract and seeds ethanol extract of Morinda citrifolia L. and had antioxidant activity about IC50 398,99 ppm and 401,37 ppm, respectively.Conclusion: Conclusion from this research revealed that fruit ethanol extract and seed ethanol extract of Morinda citrifolia L.has weak antioxidant activity.Keywords : Antioxidant activity, DPPH method, IC50, Morinda citrifolia L.

Hubungan Karakteristik Kontainer dengan Keberadaan Jentik Nyamuk Aedes aegypti di Wilayah Kerja Puskesmas Poasia Kota Kendari La Ode Alifariki; Mubarak Mubarak
MEDULA JURNAL ILMIAH FAKULLTAS KEDOKTERAN UNIVERSITAS HALU OLEO Vol 5, No 1 (2017)
Publisher : Halu Oleo University

ABSTRACT Date of DHF patients in the working area of Poasia Health Center of Kendari City shows that in 2015 31 people, where in January 6 patients, February 10 patients, while in 2016 as many as 48 patients ie January 1 patients and February 2 patients. In the year 2017 ie in January there were no patients and in February as many as 7 patients and there is 1 patient died. From these data it can be concluded that almost every month in every year occur DHF incidence, because DHF is a contagious disease and endemic disease that quickly lead to death if not handled appropriately. This study aims to determine the relationship of kontainer characteristics with the presence of larvae Aedes aegypti mosquitoes in the working area of Poasia public health center of kendari city. The type of this research is observational research with cross sectional study approach.The population in this study is all the houses in the working area of Poasia Health Center of Kendari City. samples of 85 samples. the statistical test used is chi square and phi test. The results showed that there was a correlation of kontainer material (X2hit) = 4,504 and φ = 0,258), kontainer location (X2hit) = 4,032 and φ = 0,242), kontainer color (X2hit) = 4,210 and φ = 0,246), condition of kontainer cover (X2hit ) = 5,171 and φ = 0,279) with presence of Aedes aegypti mosquito larvae. The public is expected to raise awareness in considering the condition of kontainers such as the color of bright kontainers, the kontainers must always be closed, the kontainer is not made of soil and glass and improve the behavior of Mosquito Nest Eradication.Keywords: Aedes aegypti mosquito larvae, kontainer characteristicsABSTRACT Date of DHF patients in the working area of Poasia Health Center of Kendari City shows that in 2015 31 people, where in January 6 patients, February 10 patients, while in 2016 as many as 48 patients ie January 1 patients and February 2 patients. In the year 2017 ie in January there were no patients and in February as many as 7 patients and there is 1 patient died. From these data it can be concluded that almost every month in every year occur DHF incidence, because DHF is a contagious disease and endemic disease that quickly lead to death if not handled appropriately. This study aims to determine the relationship of kontainer characteristics with the presence of larvae Aedes aegypti mosquitoes in the working area of Poasia public health center of kendari city. The type of this research is observational research with cross sectional study approach.The population in this study is all the houses in the working area of Poasia Health Center of Kendari City. samples of 85 samples. the statistical test used is chi square and phi test. The results showed that there was a correlation of kontainer material (X2hit) = 4,504 and φ = 0,258), kontainer location (X2hit) = 4,032 and φ = 0,242), kontainer color (X2hit) = 4,210 and φ = 0,246), condition of kontainer cover (X2hit ) = 5,171 and φ = 0,279) with presence of Aedes aegypti mosquito larvae. The public is expected to raise awareness in considering the condition of kontainers such as the color of bright kontainers, the kontainers must always be closed, the kontainer is not made of soil and glass and improve the behavior of Mosquito Nest Eradication.Keywords: Aedes aegypti mosquito larvae, kontainer characteristics

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Sulastrianah

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sulastrianahmuhtadi@gmail.com

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+6285242541601

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sulastrianahmuhtadi@gmail.com

Editorial Address
Kampus Hijau Bumi Tridharma Anduonohu Kendari Universitas Halu Oleo Fakultas Kedokteran

Location
Kota kendari,

Sulawesi tenggara

INDONESIA

Abstract

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Abstract

Home Page

OAI Link

Editorial Team

Contact

Reviewer

Google Scholar

Contact Name Sulastrianah

Contact Email sulastrianahmuhtadi@gmail.com

Phone +6285242541601

Journal Mail Official sulastrianahmuhtadi@gmail.com

Editorial Address Kampus Hijau Bumi Tridharma Anduonohu Kendari Universitas Halu Oleo Fakultas Kedokteran

Location Kota kendari, Sulawesi tenggara INDONESIA

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Abstract

Contact Name
Sulastrianah

Contact Email
sulastrianahmuhtadi@gmail.com

Phone
+6285242541601

Journal Mail Official
sulastrianahmuhtadi@gmail.com

Editorial Address
Kampus Hijau Bumi Tridharma Anduonohu Kendari Universitas Halu Oleo Fakultas Kedokteran

Location
Kota kendari,

Sulawesi tenggara

INDONESIA