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Biology, Medicine, & Natural Product Chemistry
Published by Universitas Islam Negeri Sunan Kalijaga Yogyakarta
ISSN : -     EISSN : -     DOI : -
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Medicine & Pharmacology Public Health
BIOLOGY, MEDICINE, & NATURAL PRODUCT CHEMISTRY, this journal is published to attract and disseminate innovative and expert findings in the fields of plant, animal, and microorganism secondary metabolite, and also the effect of natural product on biological system as a reference source for researchers in these fields, and with the aim to set international standards in their methodology.
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Articles 51 Documents
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Search results for , issue "Vol 12, No 1 (2023)" : 51 Documents clear
High Performance Liquid Chromatography (HPLC) for Detection of Glucosamine and Chondroitin Sulfate Compounds Rakhmiyati, Rakhmiyati; Widiyani, Tetri; Budiharjo, Agung
Biology, Medicine, & Natural Product Chemistry Vol 12, No 1 (2023)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2023.121.5-8

Abstract

Glucosamine and chondroitin sulfate are compounds found in shark cartilage (Carcharhinus sorrah). The two compounds have many health benefits, that is wound healing and helping the process of angiogenesis. This study aims to determine the content of glucosamine and chondroitin sulfate compounds in shark cartilage (SC) extract. The method used was High Performance Liquid Chromatography (HPLC) with potassium phosphate buffer solution at pH 3. The results of this research were SC extract contained glucosamine and chondroitin sulfate compounds with a retention time of 1.914 minutes.
Cardiotoxicity Effects of Herbal Medicine, A Review Article Shahin Gavanji
Biology, Medicine, & Natural Product Chemistry Vol 12, No 1 (2023)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2023.121.89-96

Abstract

With the development of human's modern society more and more people tend to use complementary and alternative medicine (CAM). Toxicological studies indicated that many herbal medicines have direct toxic effects on the circulatory system or cardiovascular system and cause harmful effects on the body. Cardiotoxicity or heart damage is a serious issue defined as heart electrophysiology dysfunction, affecting the cardiac structure, and muscle damage that arises from the drug or chemical poisoning agents, that may lead to heart failure. The aim of this review article is to provide various information about the potential adverse effects of herbal medicine on the cardiovascular system and introduce herbs that induced cardiac toxicity. To provide this review, all reported cases of cardiac toxicity induced by herbal medicines and natural products were collected through research articles and documents, and the most relevant articles, and books in various authentic search engines including Scopus, PubMed, SID (scientific information database), Science Direct and Google Scholar, from 1984 to April 2022 were searched, and selected herbs with therapeutic properties which induce toxic effects on the cardiovascular system are introduced. In this review, scientific data regarding cardiotoxicity showed that 16 herbs from 11 families may increase cardiac toxicity. Therefore, it's important to use herbal medicines and natural products under the guidance of medical professionals.
Potential Inhibition of ACE2 Membrane Protein by Flavone Glycosides for Blocking Entrance of SARS- CoV-2 into the Cells; a Computational Study Ahsan Ibrahim; Ehtisham Ul Haq
Biology, Medicine, & Natural Product Chemistry Vol 12, No 1 (2023)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2023.121.97-108

Abstract

Severe acute respiratory syndrome coronavirus 2 (SARS- CoV-2), since its emergence in Wuhan city of China in late 2019, had been a dilemma for the global healthcare system. Humongous efforts have been put in ascertaining the effective treatments for attenuation of the spread of corona virus disease (COVID-19) pandemic. The aim of this research study is to probe the potential inhibition of angiotensin converting enzyme 2 (ACE2) membrane protein by well-known flavone glycosides, hence preventing the binding of spike proteins with ACE2 and subsequent prevention of entry of SARS- CoV-2 inside the cells. The molecular docking analysis, for total ten flavone glycosides was carried out, that laid out propitious results in terms of binding energies towards the active residues of ACE2 protein with a range of -9.3 to -7.1 kcal/mol. The molecular dynamics simulation also yielded promising outcomes. The in-silico toxicity analysis of all the potential drug candidates was carried out that revealed that all the compounds were non-toxic and safe. Studies may be required for optimum formulation development using these compounds as a part of drug discovery and development phenomenon. This study may play a vital part in exploration of natural compounds in pharmacotherapy of COVID-19.
Phytochemical, Antimicrobial and Cytotoxic Activities of Strophanthus sarmentosus DC Julius Leke Abiola; Olapeju Oluyemisi Aiyelaagbe
Biology, Medicine, & Natural Product Chemistry Vol 12, No 1 (2023)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2023.121.119-126

Abstract

Strophanthus sarmentosus DC is used traditionally in the management of snake-bite, arthritis, eye infection, rheumatism, emetic and venereal diseases. Freshly collected mature Strophanthus sarmentosus plant parts were air-dried at room temperature. Each of the plant parts (leaf, stem and roots) was successively extracted by cold extraction method using hexane, ethyl acetate and methanol respectively. The crude extracts were subjected to phytochemical, antimicrobial and cytotoxicity analysis by employing chemical tests, agar diffusion and brine shrimps methods.The phytochemical screening showed the presence of tannins, saponins, glycosides, flavonoids, phenols, steroids, terpenoids and carbohydrates in all the extracts. The extracts demonstrated broad spectrum activities against both gram- positive and gram-negative bacteria and the fungi tested. The MIC and MMC of ethyl acetate and methanol extracts of the S. sarmentosus (stem) is between 0.3 and 5.0 mg/mL. The cytotoxic activity (LC50) of the S. sarmentosus extracts (leaf, stem and root) ranged between 117 g/mL and 270 g/mL, showing that the extracts are within the medium toxic level according to Clarksons toxicity index.
In-Vivo Alpha-Amylase and Alpha-Glucosidase Inhibitory Activities of Solanum anomalum Leaf Extract and Fractions Jude Efiom Okokon; Idongesit Charles Etuk; John Akpan Udobang; Nwakaego Omonigho Ebong
Biology, Medicine, & Natural Product Chemistry Vol 12, No 1 (2023)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2023.121.127-132

Abstract

Solanum anomalum Thonn. ex Schumach. (family Solanaceae), an edible shrub whose fruits and leaves are used medicinally to treat diseases including diabetes was evaluated for effect on alpha amylase and alpha glucosidase enzymes in vivo. The leaf extract (70-210 mg/kg) and fractions (hexane, dichloromethane, ethyl acetate, methanol, 140 mg/kg) of S. anomalum were evaluated in vivo for inhibitory effect on alpha amylase and alpha glucosidase enzymes using starch, sucrose and maltose as substrates. Acarbose was used as reference drug. The leaf extract especially middle dose (140 mg/kg) and fractions (ethyl acetate and hexane) caused significant (p<0.05) reduction in blood glucose levels of treated with the various substrates used. Ethyl acetate fraction exerted the highest inhibitory effect when starch and maltose were used as substrates followed by n-hexane and methanol. n-Hexane was the most active fraction followed by ethyl acetate when sucrose was used as substrate. The results suggest that the leaf extract and fractions of S. anomalum have the potentials to inhibit alpha amylase and glucosidase in rats.
Ethnobotanical Survey of Aromatic and Medicinal Plants Used in Traditional Medicine and Agri-Food in The Fez-Meknes Region Hamza El Finou; Nadia Salhi; Asma Halmoune; Lhoussaine El Rhaffari
Biology, Medicine, & Natural Product Chemistry Vol 12, No 1 (2023)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2023.121.133-141

Abstract

In order to identify the medicinal plants used in agri-food and traditional medicine by the population of Fez-Meknes region (Morocco), a floristic and ethnobotanical study was carried out in 4 provinces of this region (Fez, Meknes, Azrou, Taza). Questionnaire forms were used to survey the usual users of the plants and herbalists and to collect as much information as possible on the therapeutic and dietary use of aromatic and medicinal plants in the region. For plants used for food, our survey identified 29 species divided into 26 genera and 16 families, including herbaceous plants (70%), trees (16.60%), shrubs (10%) and bushes (3.30%). The study of the medicinal flora used in traditional medicine also allowed the inventory 81 species belonging to 47 families. Leaves are the most commonly used part and the majority of remedies were prepared in the form of infusion (47%) and decoction (26%). Among all the diseases treated, digestive diseases are the most cited (25%), followed by dermatological diseases (21%). The present study allowed us to evaluate some traditional practices used by the Fez-Meknes region population. In this context, it is essential to carry out similar investigations in other regions of the kingdom, in order to safeguard this precious natural heritage by means of a monograph that is as complete as possible and to validate the remedies and preparations identified using rigorous scientific protocols.
Phytochemical, Antioxidant Screening, Antinociceptive, and Anti-inflammatory Activities of Boswellia dalzielii Hutch (Burseraceae) Root Ethanol Extract Using Animal Model MacDonald Idu; Anthonia Omoregbee; Benjamin Ogunma Gabriel
Biology, Medicine, & Natural Product Chemistry Vol 12, No 1 (2023)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2023.121.143-150

Abstract

This study investigated the biological activities and phytochemical screening of Boswellia dalzielii root ethanol extract. Standard procures were used to evaluate the phytochemicals and antioxidant capacity, antipyretic activity in bakers yeast-induced pyrexia in mice, analgesic property (hotplate and acetic acid-induced in mice), acute antiinflammation (carrageenan-induce in rats) and chronic arthritis (formalininduced in rats) on Boswellia dalzielii root ethanol extract. The phytochemical results revealed the presence of phenol, ascorbic acid, flavonoids, alkaloids, cardiac glycoside, tannin, saponin. The extract had a significant reduction in the body temperature in graded doses and 100 mg/kg paracetamol at 60 minutes when compared with the control, but 400 mg/kg was more effective (p<0.01). Morphine and plant extract showed a slight significant analgesic property at 0 and 30 minute compared to the control. The extract at 100 mg/kg elicited a significant increase at 60 and 90 minutes compared with the control, and it is comparable to 5 mg/kg morphine. The plant extract (100, 200, and 400 mg/kg) and aspirin (100mg/kg) shows significant analgesic properties compared to control (p<0.01) but 200 mg/kg of extract revealed highest percentage inhibition. The extract produced no significant reduction on carrageenan induced inflammatory at all dose level compared to control (p>0.05). The plant extract (100, 200, 400 mg/kg) and Indomethacin (1 mg/kg) reduced paw volume across the doses from day 4 compared to the control (p<0.01). The Boswellia dalzielii root extract is a promising antiinflammatory agent, it also possesses antipyretics, and analgesics effect validating the folklore claim.
Antioxidant and Antibacterial Activity of Pomegranate Extract (Punica granatum L.) in Lip Balm Formulation Maria Grasela Kase; Aniek Prasetyaningsih; Dwi Aditiyarini
Biology, Medicine, & Natural Product Chemistry Vol 12, No 1 (2023)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2023.121.109-117

Abstract

Lips are a part of the face that does not have hair follicles making them easily dry and crack. Lipbalm is a beauty product that could be used to solve this problem by increasing lip moisture. However, the synthetic ingredient in commercial lip balm can have side effects on the body in the long term. Pomegranate fruit is one of the natural ingredients containing anthocyanin which can be used as a natural dye, antioxidant, and antibacterial. Therefore, this study was performed to study the potency of pomegranates as natural dyes, antioxidants, and antibacterial in lip balm. Pure pomegranate juice was obtained through squeeze step. Lip balm was prepared in several concentrations of pomegranate juice which were 0%, 12.5%, 18.75%, and 25%. Phytochemical screening shows the content of anthocyanin, saponin, tannin, and flavonoid. In this study, pomegranate juice has low antioxidant activity with IC50 449 ppm. Lip balm formula with 18.75% and 25% of pomegranate juice can inhibit the growth of the bacteria Staphylococcus aureus.
Lupenone Isolated from Diospyros melanoxylon Bark Non-competitively Inhibits alpha-amylase Activity Mohan Krishna Durgam; Praveen Kumar Vemuri; Vijaya Lakshmi Bodiga; Sreedhar Bodiga
Biology, Medicine, & Natural Product Chemistry Vol 12, No 1 (2023)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2023.121.171-176

Abstract

Diabetes mellitus is a chronic disease that poses a serious global health problem, due to its associated effects on obesity and aging. Therapeutic strategies for targeting diabetes include the downregulation and/or inhibition of enzymes such as a-amylase and a-glucosidase, hydrolyzing the dietary carbohydrates in intestine. There is increasing interest for a-amylase inhibitors from natural sources. Our objective was to undertake the phytochemical screening of bark extracts of Diospyros melanoxylon for potential a-amylase inhibitory activity and further identification of the active principle and the underlying mechanisms of inhibition. Enzyme-assay guided fractionation of the Diospyros melanoxylon bark extract led to the isolation of a triterpene, Lupenone as a potential inhibitor of a-amylase, with a non-competitive inhibition and inhibitor constant = 30 mM. Lupenone-mediated inhibition of a-amylase responsible for the breakdown of dietary sugar may be effective in preventing postprandial hyperglycemia in the diabetic subjects.
Comparative Assessment of the Proximate Composition, Functional Properties and Amino Acid Profile of Dioscorea bulbifera, Dioscorea alata and Dioscorea rotundata Found in Minna, Niger State Eneogwe Okechukwu Godfrey; Obuye Faith; Ibrahim Izihyi Esther
Biology, Medicine, & Natural Product Chemistry Vol 12, No 1 (2023)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2023.121.177-185

Abstract

The proximate composition, functional properties and amino acid profile of samples of Dioscorea alata, Dioscorea rotundata and Dioscorea bulbifera were investigated using standard analytical methods. The results showed that Dioscorea alata had the highest ash (5.590.06 %) and crude fiber content (12.120.20 %), indicating that it has more mineral stuffing and is best to reduce the risk of obesity. Dioscorea rotundata had the highest fat content (11.630.04 %) as well as the lowest moisture content (7.040.06 %), indicating that it is a better source of calories and has a longer shelf-life than other yam species analysed. Dioscorea bulbifera also had the highest crude protein (8.640.03 %) and carbohydrates (77.510.08 %) than other yam species analysed, indicating high bodybuilding capacity and a better source of energy than other yam samples analysed. Dioscorea alata showed the highest bulk density (0.870.02 g/cm3) and swelling capacity (15.250.03 g/g). It is indicating its usefulness in the reduction of paste thickness and water-holding capacity of starch granules respectively while Dioscorea rotundata, showed the highest water absorption capacity (164.020.02 %), oil absorption capacity (149.760.02 %) and dispersibility (72.170.01 %). This indicates its importance in the consistency and bulking of products, flavour retaining in food and reconstitution of flour samples in water to give a fine consistent paste during mixing. The yam species were also rich in amino acids which are building blocks of protein. However, Dioscorea rotundata was the richest in amino acid content, as it had 36.320.16 g/100g and 36.490.16 g/100g, for essential and non-essential amino acids respectively.

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