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Biology, Medicine, & Natural Product Chemistry
Published by Universitas Islam Negeri Sunan Kalijaga Yogyakarta
ISSN : -     EISSN : -     DOI : -
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Medicine & Pharmacology Public Health
BIOLOGY, MEDICINE, & NATURAL PRODUCT CHEMISTRY, this journal is published to attract and disseminate innovative and expert findings in the fields of plant, animal, and microorganism secondary metabolite, and also the effect of natural product on biological system as a reference source for researchers in these fields, and with the aim to set international standards in their methodology.
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Articles 452 Documents
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Effect of Diabetes Mellitus and Hypertension on Osmotic Fragility and Hemorheological Factors in Male Wistar Rats David Ehikhuemen Okonofua; Jerome Ndudi Asiwe; Kenneth Kelechi Anachuna; Emuesiri Goodies Moke; Kamaldeen Olalekan Sanusi; Ebunoluwa Oluwabusola Adagbada; Mariam Onono Yusuf; Damilola Ifeoluwa Alawode; Adesoji Adedipe Fasanmade
Biology, Medicine, & Natural Product Chemistry Vol 10, No 2 (2021)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2021.102.73-79

Abstract

Diabetes mellitus is a common risk factor for erythrocyte osmotic stress. This study was aimed at exploring the effect of streptozotocin (STZ)-induced diabetes mellitus and salt-induced hypertension on osmotic fragility and hemorheological variables in male Wistar rats. Thirty male rats were grouped into five groups of six animals each as follows: negative control (zero salt in diet); positive control (normal salt diet - 0.3% salt); high salt diet (8% salt) (HSD only); STZ induced diabetes and normal salt diet (STZ only); STZ induced diabetes and high salt diet (STZ + HSD). At the end of a 4 weeks period, hematological variables, osmotic fragility, rheology and cardiovascular responses were assessed. There was an increase (p<0.05) in the mean arterial pressure and heart rate of HSD, STZ and HSD + STZ groups indicating a salt induced hypertension. There was a decrease in the body weight of STZ and HSD +STZ groups. There was significant increase (p<0.05) in the haematocrit, platelets estimates and fibrinogen concentrations in the experimental groups when compared with the controls. The STZ and STZ + HSD groups showed a reduced clotting time which corresponded to the increased platelet estimates and fibrinogen concentration. The increase in haematocrit, platelet and plasma protein resulted in the increased blood viscosity and a decreased flow rate. The osmotic fragility test was also observed to be increased (p<0.05) in HSD, STZ only and STZ + HSD groups. Diabetes mellitus and hypertension increase the rate of hemolysis of erythrocyte, as well as increase blood viscosity.
Repurposing Dihydroartemisinin-Piperaquine-Doxycycline as an Antimalarial Drug: A Study in Plasmodium berghei-Infected Mice Udeme Owunari Georgewill; Elias Adikwu
Biology, Medicine, & Natural Product Chemistry Vol 10, No 2 (2021)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2021.102.135-140

Abstract

Artemisinin-based combination (ACT) therapy is the mainstay for malaria treatment. However, Plasmodium parasite with decreased susceptibility to ACT has emerged. Hence, it is imperative to discover new drugs or explore new drug combinations that can decrease Plasmodium parasite resistance. This study assessed the antiplasmodial activity of dihydroartemisinin-piperaquine- doxycycline (D-P-DX) on mice infected with Plasmodium berghei. Swiss albino mice (25-30g) of both sexes inoculated with 1x107 Plasmodium berghei intraperitoneally were used. The mice were randomly grouped and orally treated with DX (2.2 mg/kg), D-P (1.71/13.7 mg/kg) and D-P-DX daily in curative, suppressive and prophylactic studies. The negative and the positive controls were treated daily with normal saline (0.2mL) and chloroquine (CQ) (10mg/kg), respectively. After treatment, blood samples were assessed for percentage parasitemia, hematological and lipid parameters. Also, the mice were observed for mean survival time. D-P, DX, and D-P-DX produced significant decreases in percentage parasitemia at p<0.05, p<0.01 and p<0.001, respectively when compared to negative control. In the curative study, D-P, DX, and D-P-DX produced 64.9%, 71.1%, and 93.6% parasitemia inhibitions when compared to 70.0% inhibition produced by CQ. Plasmodium berghei -induced alterations in packed cell volume, white blood cells, red blood cells, hemoglobin, high-density lipoprotein cholesterol, total cholesterol, low-density lipoprotein cholesterol, and triglyceride levels were significantly restored by DX (p<0.05) and D-P (p<0.01) and D-P-DX (p<0.001) when compared to the negative control. D-P-DX showed significant antiplasmodial activity against Plasmodium berghei- infected mice. It may be clinically useful for the treatment of malaria.
Cover, Editorial Board, Guidance for Authors, & Table of Contents | Vol. 10 No. 2 October 2021 Muhammad Ja&#039;far Luthfi
Biology, Medicine, & Natural Product Chemistry Vol 10, No 2 (2021)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2021.102.%p

Abstract

Peptide Fractions from Chymotrypsin-hydrolyzed Moringa oleifera Seed Proteins Inhibit α-amylase and α-glucosidase in vitro Oluwafemi Emmanuel Ekun; Augustine Olusegun Olusola; Joseph Adaviruku Sanni; Feyisayo Ishola
Biology, Medicine, & Natural Product Chemistry Vol 11, No 1 (2022)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2022.111.7-16

Abstract

This study attempts to investigate the activities of chymotrypsin-digested M. oleifera seed proteins and their peptide fractions on carbohydrate-hydrolyzing enzymes. Proteins from M. oleifera seeds were isolated using isoelectric point precipitation and hydrolyzed using chymotrypsin. The hydrolysates obtained were fractionated into peptide fractions of
Kidney Evaluation in Hyperuricemia Rats Treated with Green Tea Leaves (Camellia sinensis L.) Extract Putranty Widha Nugraheni; Chanif Mahdi
Biology, Medicine, & Natural Product Chemistry Vol 11, No 1 (2022)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2022.111.17-26

Abstract

Uric acid is an oxidation product of the xanthine oxidase enzyme found in extracellular fluid, and when it exceeds, uric acid will build up and cause hyperuricemia. TNF-α is released by epithelial cells and mesangial cells when inflammation occurs and causes apoptosis in epithelial cells, causing damage to kidney structures and initiating acute kidney poisoning. Green tea extract (Camellia sinensis L.) contains many antioxidants, especially flavonoids with potent antioxidant properties such as lipid peroxidase and free radical absorbers, inhibiting xanthine oxidase. This study expresses the potential of green tea extract on kidney repair caused by HUA. Twenty-four male albino rats (175-225 g) of Wistar strain being fed a high purine diet in 60 consecutive days and divided into six groups randomly, I: negative control, II: positive control, III: allopurinol, IV: green tea extract 150mg of body weight, V: green tea extract 300mg of body weight, and VI: green tea extract 600mg of body weight. Treatment was done for 14 days and measured by total creatinine levels, malondialdehyde levels, and kidney histopathology. The statistical analysis using One Way ANOVA and Post Hoc Tukey analysis by SPSS 23.0 proved that green tea extract with a dose of 600 mg/kg of body weight green could lower levels malondialdehyde of the kidney as much as 58.85% (p<0.01), decreased creatinine level by 24.5% (p>0.05), and improved kidney histopathology. This study proved that green tea extract is a promising alternative for hyperuricemia while improving kidney tissues and lowering malondialdehyde and creatinine levels.
The Bioprospecting of Mangrove Red Snapper Cultivation (Lutjanus argentimaculatus Forsskål, 1775) Using Floating Cages Angga Puja Asiandu; Achmad Gusti Malayudha
Biology, Medicine, & Natural Product Chemistry Vol 11, No 1 (2022)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2022.111.27-33

Abstract

Mangrove red snapper is one of the potential and valuable aquaculture products. The high demand for this fish causes high fishing activities. This condition can threaten their existence in the environment. It is necessary to have aquaculture activities to preserve their existence and meet market demand. Indonesia as a country with wide marine waters should be able to take advantage of the potential of fish farming by using a floating cage system. Thus, this article was written to analyze the bioprospecting of red snapper aquaculture. Based on the literature study, the floating net system has the potential to be developed on a large scale because the system has various advantages over fishing directly from nature. Things that must be considered in the cultivation of mangrove red snapper using floating nets are the area and quality of the floating nets, the composition of the feed, and the chemical components of the feed given to the fish. Based on economic potential, mangrove red snapper cultivation has high prospects which can be used as one of Indonesia's leading export products.
Liver and Renal Cell Damage Following Excess Bee Honey Consumption in Male Wistar Rat Akpevwoghene Agbatutu; Jerome Ndudi Asiwe; Olusegun Gafar Adebayo
Biology, Medicine, & Natural Product Chemistry Vol 11, No 1 (2022)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2022.111.35-43

Abstract

Honey is a widely used natural product with several health benefits. However, there is paucity of information on its excessive usage. The present study investigated the effect of excess honey consumption on hepato-renal functions in male wistar rats. Twenty-eight adult male Wistar rats were selected into four groups (n=7) and treated with distilled water (control) and 1ml, 2ml and 3ml of honey respectively for 5 weeks. Thereafter, the animals were euthanised and blood as well as kidney and liver were collected for further studies. There was a significant increase in Creatinine, Bilirubin, Urea AST, ALP, total protein as well as a significant decrease in RBC, WBC, haemoglobin, lymphocyte and PCV. Histology of the liver and kidney revealed a significant degeneration and necrosis in a dose dependent manner. This study suggest that excess honey consumption causes liver and renal cellular damage as well as haematological alterations.
Potential Antimalarial Activity of Artemether/Lumefantrine/Doxycycline: A Study in Mice Infected with Plasmodium berghei Udeme Owunari Georgewill; Elias Adikwu
Biology, Medicine, & Natural Product Chemistry Vol 11, No 1 (2022)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2022.111.1-6

Abstract

Antimalarial drug resistance is one of the greatest challenges towards eradicating malaria. Exploring new combination therapies can overcome resistance challenges. The present study examined the antiplasmodial effect of artemether/lumefantrine/doxycycline (A/L/D) on a mouse model infected with Plasmodium berghei. Adult Swiss albino mice (22-30g) intraperitoneally infected with blood containing 1x107 Plasmodium berghei were randomly grouped and orally treated daily with D (2.2 mg/kg), A/L (1.71/13.7 mg/kg) and A/L/D. The negative control was treated daily with normal saline (0.2ml) whereas the positive control was treated daily with chloroquine (CQ) (10mg/kg). After treatment, blood samples were assessed for percentage parasitemia and biochemical parameters. Mice were observed for mean survival time (MST). D, A/L and A/L/D produced significant decreases in percentage parasitemia levels at p<0.05; p<0.01 and p<0.001, respectively when compared to negative control. In the curative test, D, A/L and A/L/D produced 60.4%, 70.3%, and 90.0% parasitemia inhibitions, respectively whereas CQ produced 76.0% parasitemia inhibition. D, A/L, A/L/D and CQ produced 63.2 %, 80.1%, 92.3% and 83.6% parasitemia inhibitions, respectively in the suppressive test. D, A/L, and A/L/D prevented Plasmodium berghei-induced alterations in biochemical parameters by increasing packed cell volume, red blood cells, hemoglobin, and high-density lipoprotein and decreasing white blood cells, total cholesterol, low-density lipoprotein cholesterol, and triglyceride levels significantly at p<0.05 and p<0.01 and p<0.001, respectively when compared to the negative control. A/L/D produced significant antiplasmodial activity therefore, it may be used clinically for the treatment of malaria.
The Roles of the Fluorescent In Situ Hybridization (FISH) and Comparative Genomic Hybridization (CGH) Techniques in the Detection of the Breast Cancer Harem Othman Smail
Biology, Medicine, & Natural Product Chemistry Vol 11, No 1 (2022)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2022.111.45-54

Abstract

This paper aimed to understand and compare the two popular cytogenetic techniques of fluorescence in situ hybridization (FISH) and comparative genomic hybridization (CGH) in detecting breast cancer chromosomal abnormality. Several chromosomal anomalies play a role in the development of breast cancer, and the two above approaches play an important role in confirming fluorescence in situ hybridization in particular (FISH). However, comparative genomic hybridization has developed DNA copy number profiles for most of the publicly available breast cancer cell lines for the FISH methods rely on the fluorescent probes. Chromosomal profiles can be generated for the suspected chromosomal abnormality, copy number changes between the tumour and the DNA control can be compared, and the results can be registered. Today, modern cytogenetic tools such as fluorescence in situ hybridization (FISH) are more commonly used to detect any microdeletion that cannot be detected by conventional cytogenetic karyotypes that involve a high rate of cell division and good chromosomal morphology, which pose challenges for cytogeneticists, and a long period of testing and research. Usually, this is a problem for physicians, and there are still many drawbacks and disadvantages concerning the high benefits, such as false findings. Normal chromosome in situ hybridization requires the hybridization of a labelled DNA probe into denatured chromosomal DNA present in metaphase chromosomes in an air-dried microscope slide preparation. Metaphase spreads are used for traditional chromosome FISH (metaphase FISH). Positive and positive signs of hybridization also appear as a double spot, corresponding to the hybridized probe for both sister chromatids. A further extension of chromosome painting is comparative genomic hybridization (CCI-I). CCH involves simultaneous chromosome painting in two different colours using complete DNA from two similar sources as probes, which reveal variations concerning the benefit or loss of sub-chromosomal regions or even entire chromosomes.
A Mathematical Model of Cervical Cancer Treatment by Radiotherapy Followed by Chemotherapy Murtono Murtono; Sugiyanto Sugiyanto; Mansoor Abdul Hamid
Biology, Medicine, & Natural Product Chemistry Vol 11, No 1 (2022)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2022.111.55-63

Abstract

Cervical cancer is the second most common type of malignant tumor found in women aged 15-44 years worldwide. Radiotherapy is one form of treatment that uses radiation that can eliminate or kill cancer cells and one way to treat cervical cancer is quite popular. Chemotherapy is a cancer treatment using anticancer drugs designed to kill or slow the growth of cancer cells that divide rapidly in the body. The method used is to study mathematical model of cervical cancer with radiotherapy and radiotherapy treatment followed by chemotherapy. The results of this study are for the early stages of cervical cancer with radiotherapy is quite effective, while for the late stages of radiotherapy and chemotherapy is less effective. Therefore, the need for other treatments for end-stage cervical cancer in addition to radiotherapy and chemotherapy.

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