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Biology, Medicine, & Natural Product Chemistry
Published by Universitas Islam Negeri Sunan Kalijaga Yogyakarta
ISSN : -     EISSN : -     DOI : -
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Medicine & Pharmacology Public Health
BIOLOGY, MEDICINE, & NATURAL PRODUCT CHEMISTRY, this journal is published to attract and disseminate innovative and expert findings in the fields of plant, animal, and microorganism secondary metabolite, and also the effect of natural product on biological system as a reference source for researchers in these fields, and with the aim to set international standards in their methodology.
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Articles 452 Documents
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Cover, Editorial Board, Guidance for Authors, & Table of Contents | Vol. 11 No. 2 October 2022 Muhammad Ja'far Luthfi
Biology, Medicine, & Natural Product Chemistry Vol 11, No 2 (2022)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2022.112.%p

Abstract

Chemical Compositions and Antioxidant Activity of Volatile Oils from Morinda citrifolia and Beta vulgaris Leaves from Nigeria Adesegun Olusimba Onanuga; Ejike Onwudiegwu Okpala
Biology, Medicine, & Natural Product Chemistry Vol 11, No 2 (2022)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2022.112.161-167

Abstract

Morinda citrifolia L. and Beta Vulgaris L leaves are both ethnomedicinal use for the treatment of arthritis, indigestion and skin infections with no reports on their essential oils compositions. The colourless volatile oils with a percentage yield of 0.6 and 0.4 (w/w) for Morinda citrifolia L. and Beta Vulgaris L respectively were obtained. Forty-five compounds representing 94.31 % of the total percentage compositions were identified in the leaf essential oil of M. citrifolia with the most abundant compound as 14-beta-H-pregna- (33.13%). Forty-eight compounds representing 74.18% of the total oil composition were identified in the leaf oil of B. Vulgaris with phytol (24.20%) as the dominant compound. The essential oils showed good free radical scavenging activity when compared to ascorbic acid used as control, with % inhibition varying from 88.74 ± 0.010 to 96.61 ± 0.004 as compared to 95.68 ± 0.010 to 97.31±0.003 of the ascorbic acid at (100 to 6.25 mg/ml) concentrations. The leaves essential oils of Morinda citrifolia L. and Beta Vulgaris L contains chemical compounds that might be responsible for their antioxidant activity. This result validates the traditional usage of these plants in the treatment of arthritis, indigestion and skin infections.
Acute Toxicity LD50 Fraction Ethyl Acetate Aquilaria malaccensis, Ficus benjamina, Mikania micrantha, and Fraction Water Cinnamomum burmanii in Mus Musculus Rizky Yulion; Santi Perawati; Barmi Hartesi; Lia Anggresani; Lili Andriani; Lesra Indriani; Lara Syahila; Suci Ramadani; Nadia Monika
Biology, Medicine, & Natural Product Chemistry Vol 12, No 1 (2023)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2023.121.55-60

Abstract

Research on the acute toxicity of LD50 had been carried out on the ethyl acetate fraction of Gaharu leaves (Aquilaria malaccensis), beringin leaves (Ficus benjamina), sembung rambat leaves (Mikania micrantha), and kayu manis cortex (Cinnamomum burmanii) water fraction the base of use as traditional treatment by the Suku Anak Dalam (SAD) empirically obtained from ancestors. This research methodwas experimental and it used male and female mice. The control group was given a 1% NaCMC doses of 625 mg/kg body weight, 1,250 mg/kg body weight, 2,500 mg/kg body weight, and 5,000 mg/kg body weight. The test preparation was administered orally once per day. The Thomson-Weil method was used for the measurement of LD50 values. The weight ratio of organs was applied for heart, liver, lungs, kidneys, and stomach. The results showed that the LD50 value for male mice was 2454mg/kg body weight; 2454mg/kg body weight; 1546 mg/kg body weight and 2065mg/kg body weight respectfully. The LD50 value for female mice was a pseudo LD50. The value of the organ weight ratio in each sample showed P<0.05 values that were obtained in gaharu leaves in the liver and kidney organs (male); heart in females. Beringin leaves value P<0.05 lung organs (male). Sembung rambat leaves P<0.05 values of the heart, liver, and stomach organs (male); heart and stomach (female). Cinnamomum cortex value P<0.05 liver and stomach organs (male). The conclusions showed that the LD50 value of the ethyl acetate fraction of gaharu leaf, sembung rambat leaf, beringin leaf, and kayu manis cortex in male mice was slightly toxic, while in female mice it could not be counted.
Proximate Composition, Levels of Some Essential Mineral Elements and Anti-Nutritional Components of Some Yam Species Found in Minna, Niger State Godfrey, Eneogwe Okechukwu; Esther, Ibrahim Izihyi; Faith, Obuye
Biology, Medicine, & Natural Product Chemistry Vol 12, No 1 (2023)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2023.121.9-16

Abstract

Samples of Dioscorea dumenturom, Dioscorea rotundata and Dioscorea cayenensis were investigated for their proximate composition, anti-nutritional and mineral contents using standard analytical methods. These varieties of Dioscorea analysed showed a significant difference (P≤0.05) amongst them. However, from the results, it was observed that Dioscorea rotundata had the highest ash (8.05±0.05 %) and crude fibre content (13.11±0.10 %) which indicates that it contains more mineral stuffing and is best for softening of stool. Dioscorea cayenensis had the highest fat content (16.31±0.30 %), indicating that it is a better source of calories than other yam species analysed. Dioscorea dumenturom had the lowest moisture content (3.51±0.01 %) as well as the highest crude protein (12.29±0.01 %) and carbohydrates (69.04±0.10 %) than other yam species analysed, indicating its longer shelf-life, high bodybuilding capacity and better source of energy than other yam species analysed. The anti-nutritional constituent of alkaloid and tannin were lowest in Dioscorea cayenensis while Dioscorea rotundata had the least cyanide, phytate and oxalate content. This implies that these particular yams are safer for consumption. The elemental analysis in mg/100g indicated that the yam species contained appreciable levels of essential minerals, with Dioscorea dumenturom having the highest sodium, calcium, iron, potassium, phosphorous and magnesium concentration of 32.05±0.07 mg/100g,190.57±0.01mg/100g, 5.98±0.03 mg/100g, 80.12±0.17 mg/100g, 237.10±0.48 mg/100g and 100.22±0.03 mg/100g respectively. All these mineral concentrations exist within the permissible limit of WHO and hence indicate that the yam species can serve as a good source of minerals.
The Weight Performance Stability of Mice on Modeling Obesity-Associated Hyperglycemia Induced by Dextrose Monohydrate Deksa Yudha Syach Putra; Setiyo Budi Santoso; Heni Lutfiyati
Biology, Medicine, & Natural Product Chemistry Vol 11, No 2 (2022)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2022.112.169-173

Abstract

Previously, streptozotocin and alloxan were employed to imitate hyperglycemia in mice. High doses of sucrose were also induced as an alternative. Due to body mass index has been associated with hyperglycemia, the evidence of weight body index in various induction alternate kinds, however, have not been fully reported. Here-in, we report on the weight performance stability of mice body weight induced by dextrose, streptozotocin, and alloxan. To begin, all mice were divided into six groups of five, with one reserve in each. Following seven days of acclimatization, the mice were induced for nine days of hyperglycemia modeling; alloxan (Groups A and D), streptozotocin (Group B and E), dextrose monohydrate (Groups C and F). On preclinical research animals modelling related to obesity-associated hyperglycemia in mice, dextrose monohydrate induction was most successful than streptozocotin and alloxan induction, which performed best during the induction period (31% weight growth) and after metformin intervention (36% weight growth). Overall, dextrose monohydrate is most suitable to be used for modeling type 2 diabetes mellitus test animals rather than alloxan and streptozocotin.
Synthesis, Characterization and Activity Test of Natural Zirconium Zeolite (Zr-ZA) Catalyst in The Esterification Reaction of Glycerol with Acetic Acid Anhydride Didik Krisdiyanto; Tutik Farihah; Hikmah Supriyati
Biology, Medicine, & Natural Product Chemistry Vol 12, No 1 (2023)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2023.121.61-67

Abstract

Synthesis of Zr-ZA catalystused as catalyst for esterification reaction of glycerol with acetic acid anhydrous has been done. Catalysts are characterized using an infrared spectrophotometer, X-ray diffraction, and measurement of surface acidity, while reaction products are characterized using a gas chromatography-mass spectrometer. Effect of catalyst acidity, reaction time and re-addition of acetic acid anhydrous studied by glycerol conversion and selectivity value of triacetin were yielded. Infra-red spectrophotometer and X-ray diffraction analysis of the catalyst showed that the synthesized catalyst was zirconium zeolite (Zr-ZA), while esterification analysis using a gas chromatography-mass spectrometer showed a triacetin product.
The Effect of Pumpkin Fruit Ripeness (Cucurbita moschata. D) on Total Flavonoid Levels and Antioxidant Activity Astutik, Linda; Yanti, Eka Fitri
Biology, Medicine, & Natural Product Chemistry Vol 12, No 1 (2023)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2023.121.17-23

Abstract

Pumpkin fruit (Cucurbita moschata. D) belongs the Cucurbitaceae family which is a functional vegetable widely distributed in Indonesia because it has nutritional value and health benefits. This study aims to determine the value of total flavonoid content and antioxidant activity in the ethanol extract of unripe, mature and ripened pumpkin. Simplicia powder was extracted by maceration method using 96% solvent. Testing the total flavonoid content with the addition of AlCl3 at a wavelength of 425 nm and the antioxidant activity test was carried out using DPPH (1-1-diphenyl-2-picrylhydrazyl) as a free radical with a maximum wavelength of 515 nm using microplate reader. The results of the study concluded that the ethanolic extract of pumpkin flesh had a total flavonoid content of 0,146 mgQE/100g in unripe fruit, 0,221 mgQE/100g in mature pumpkin, 0,191 mgQE/100g in ripened pumpkin. The antioxidant activity of the ethanol extract of unripe, mature, and ripened pumpkin fruit obtained was not active or did not completely reduce free radicals.
Inhibitory Effect of Mammea africana on Alpha-Amylase and Alpha-Glucosidase Enzymes of Rats Nwakaego Omonigho Ebong; Jude Efiom Okokon; Jesse Idakwoji
Biology, Medicine, & Natural Product Chemistry Vol 11, No 2 (2022)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2022.112.175-180

Abstract

Mammea africana Sabine (Guttiferae), a medicinal plant used traditionally in the treatment of diseases including diabetes was evaluated for effect on alpha-amylase and alpha-glucosidase enzymes in vivo. The stembark extract (30, 60 and 90 mg/kg) of M. africana were investigated in vivo for inhibitory effect on alpha-amylase and alpha-glucosidase enzymes using starch, sucrose and maltose as substrates. Acarbose was used as reference drug. The stembark extract caused significant (p<0.05) reduction in blood glucose levels of treated rats with the various substrates used. The results suggest that the stembark extract of M. africana have the potentials to inhibit alpha-amylase and alpha-glucosidase in rats.
Combined Anthocleista vogelii and Alstonia boonei Stem Barks Extract Alleviates Hyperlipidaemia and Renal Malfunctions in Benign Prostatic Hyperplasia-Induced Rats Robert Ikechukwu Uroko; Mercylyn Ezinne Uche; Paul Chukwuemaka Nweje-Anyalowu; Ikenna Obiwuru; Chinedu Aguwamba; Chinomso Friday Aaron
Biology, Medicine, & Natural Product Chemistry Vol 12, No 1 (2023)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2023.121.69-78

Abstract

Benign prostatic hyperplasia (BPH) is a urological disease prevalent among the ageing male population, which impairs the quality of life, including hyperlipidaemia and a decline in renal functions. Combining Anthocleista vogelii and Alstonia boonei stem bark extract has effectively managed BPH and its associated complications. This study evaluated the effects of a combined Anthocleista vogelii and Alstonia boonei stem bark extract (CAASBE) on the lipid profile and renal functions of rats induced benign prostatic hyperplasia with testosterone propionate injection. The study comprised five treatment groups, with groups 1 5 being the normal control, BPH control, standard control, BPH+200 mg/kg CAASBE, and BPH+400 mg/kg CAASBE, respectively. BPH was induced in the groups 2 4 rats by subcutaneous administration of testosterone propionate injection (5 mg/kg) for 28 days, and treatment with Finasteride and CAASBE were administered orally. The BPH control rats exhibited a significant (p < 0.05) increase in the total serum cholesterol, triacylglycerol (TAG), low-density lipoprotein cholesterol (LDL-C), urea, creatinine and significant (p < 0.05) decline in the serum high-density lipoprotein cholesterol (HDL-C) compared to the normal control. Conversely, treatment of the BPH rats with 200 and 400 mg/kg of CAASBE significantly (p < 0.05) reversed the altered total serum cholesterol, TAG, LDL-C, HDL-C, urea and creatinine to normal levels comparable to that of the normal control and standard control respectively. These findings show that CAASBE alleviates hyperlipidaemia and renal malfunctions in the BPH rats suggesting it could be effective in managing BPH complication.
Antioxidative Stress and Hepatoprotective Activities of Leaf Extract and Fractions of Setaria megaphylla in Plasmodium berghei Infected Mice Ndanti Bartholomew William; Augustine Lawrence Bassey; John Akpan Udobang; Jude Efiom Okokon
Biology, Medicine, & Natural Product Chemistry Vol 12, No 1 (2023)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2023.121.25-32

Abstract

Setaria megaphylla (Steud) Dur & Schinz (Poaceae), a perennial grass used traditionally in the treatment of various diseases such as malaria was, investigated for antioxidative stress activity in Plasmodium berghei-infected mice. The leaf extract (200-600 mg/kg) and fractions (hexane, dichloromethane, ethyl acetate and methanol; 400 mg/kg) of S. megaphylla were investigated for antioxidative stress and hepatoprotective activities in Plasmodium berghei-infected mice using a modified suppressive test model. Antioxidative stress and hepatoprotective potentials were assessed by determining oxidative stress markers levels, liver function indices and histopathology of liver. The extract/fractions progressively reduced parasitaemia induced by chloroquine-sensitive P. berghei infection with the methanol fraction exerting the highest activity. The leaf extract and fractions caused significant (p<0.05 0.001) increases in the levels of oxidative stress markers enzymes and molecules (SOD, CAT, GPx, GSH) and also reduced MDA level significantly (p<0.05) in the livers of the treated-infected mice. The extract/fractions treatment caused reduction in liver enzymes (ALT, AST and ALP), total and conjugated bilirubin. Histology of livers revealed absence or significant reductions in pathological features in the treated infected mice compared to untreated infected mice. The leaf of S. megaphylla may possess antioxidative stress and hepatoprotective effects which may in part be mediated through the chemical constituents of the plant.

Page 13 of 46 | Total Record : 452

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