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Fakultas Kedokteran Universitas Mataram Jl. Pendidikan No. 37 Mataram, Nusa Tenggara Barat
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INDONESIA
Jurnal Kedokteran
Published by Universitas Mataram
ISSN : 23015977     EISSN : 25277154     DOI : -
Core Subject : Health,
Health Professions Medicine & Pharmacology
The Unram Medical Journal managed by the Medical Faculty of Mataram University is a scientific journal to publish the results of the latest research in the field of medical and health related. This journal promote medical sciences generated from basic sciences, clinical, and community research to integrate researches in all aspects of human health. This journal publishes original articles, reviews, and also case reports.
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 408 Documents
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Penatalaksanaan Sinus Preaurikular Kongenital Yudhanto, Didit
Jurnal Kedokteran Vol 6 No 1 (2017)
Publisher : Faculty of Medicine Universitas Mataram

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Abstract

Sinus preaurikular kongenital adalah kelainan akibat tidak sempurnanya perkembangan arkus brankial pertama dan kedua yang membentuk telinga luar dan telinga tengah, berupa kista atau fistula yang terjadi pada jaringan lunak preaurikular. Kelainan ini disebut juga dengan pit preaurikular, kista preaurikular atau fistula preaurikular. Kelainan ini biasanya bersifat asimptomatik, dan sebagian besar penderita datang ke pelayanan kesehatan setelah terjadi obstruksi dan infeksi fistel, baik infeksi yang terjadi pertama kali ataupun infeksi yang berulang. Sinus preaurikular asimptomatik tidak memerlukan tindakan khusus kecuali tindakan pencegahan terhadap infeksi dengan menghindari manipulasi dan melakukan pembersihan muara dari sumbatan dengan alkohol atau cairan antiseptik lainnya secara rutin. Penanganan yang tidak tepat pada pasien dengan sinus terinfeksi yang sudah terjadi komplikasi dengan sekret kronik atau abses pada sinus dapat mengakibatkan infeksi berulang, sepsis dan kemungkinan bekas luka pasca-operasi yang berat. Sinus preaurikular yang pertama kali terinfeksi dapat dilakukan tindakan konservatif berupa pemberian antibiotik serta kompres hangat pada sinus yang terinfeksi. Pemberian antibiotik disesuaikan dengan bakteri penyebab dan uji sensitivitasnya, sedangkan pada keadaan dimana terdapat abses maka perlu dilakukan insisi dan drainase abses. Terdapat berbagai macam teknik pembedahan untuk mengeksisi sinus preaurikular. Teknik pembedahan dikembangkan dan dimodifikasi untuk menurunkan angka rekurensi. Katakunci Sinus Precurikular Kongenitas, Infeksi Sinus, Tehnik Pembedahan
Glaukoma Sekunder pada Aniridia Nintyastuti, Isna Kusuma
Jurnal Kedokteran Vol 6 No 1 (2017)
Publisher : Faculty of Medicine Universitas Mataram

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Abstract

A 12 year-old boy present with a history of slowly progressive blurred vision since 8 years ago. From the anamnesis revealed that his father and sister diagnosed as having secondary glaucoma due to aniridia. The visual acuity was 6/45 cc S-2,00D became 6/20 maximal for the right eye and 6/20, ccS-1,75D became 6/12 maximal. The anterior chamber was deep with pupil diameter 9 mm with a small iris stump. A subcapsular cataract was present. The cup-disc ratio was 0.5 with glaucomatous signs papil for the right eye and 0.4 for the left eye. The intraocular pressure was 36 mmHg for the right eye and 31 for the left eye. The gonioscopy examination result was closed angle for the both eye. The average thickness of the retinal nerve fiber layer was 103,82 µm and 90,42µm for the right and left eye respectively. The visual field examination for the right eye was very severe general depression with inferior acuate defect and for the left eye was severe general depression with nasal defect. The initial management was medical treatment with timolol 0.05% eyedrops followed by trabeculectomy with MMC application. A flat anterior chamber complication was found on the right eye and successfully treated with intracameral injection of sodium hyaluroniate 1.5% viscoelastic. The IOP was decrease immediately on the first day after surgery and well controlled until 6 months after surgery.
Sindrom CREST Anggoro, Joko
Jurnal Kedokteran Vol 6 No 1 (2017)
Publisher : Faculty of Medicine Universitas Mataram

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Abstract

Sindrom CREST (calcinosis, Raynaud phenomenon, esophageal dysmotility, sclerodactyly, dan telangiectasia) syndrome adalah anggota kelompok heterogen skleroderma. Frekuensi di Amerika Serikat, insidensi sklerosis sistemik berkisar antara 2,7-19,3 kasus baru per juta orang dewasa per tahun. Peningkatan yang tampak dalam insidensi dan prevalensi selama 50 tahun terakhir kemungkinan besar karena klasifikasi yang lebih baik, diagnosis yang lebih dini, dan survival yang lebih baik. Beberapa penelitian antibodi serum menunjukkan bahwa sindrom CREST mungkin mencakup sekitar 22-25% dari semua kasus sklerosis sistemik; tetapi, penelitian epidemiologis yang mencari secara spesifik pada sindrom CREST masih belum ada. Naskah ini mengupas lebih dalam tentang sindrom CREST mulai aspek klasifikasi penyakit ini dalam skleroderma, patogenesis, gambaran klinis, prognosis, dan terapi yang terbaru. Katakunci Sindrom CREST, patogenesis, klinis, terapi
Herpes Genitalis pada Kehamilan 32-33 Minggu Hendrawan, I Wayan; Sakti, Pandu Tridana
Jurnal Kedokteran Vol 6 No 1 (2017)
Publisher : Faculty of Medicine Universitas Mataram

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Abstract

Herpes genitalis disebabkan oleh virus herpes simpleks (Herpes Simplex Virus atau HSV) tipe 1 (HSV-1) atau oleh tipe 2 (HSV-2). HSV tipe 1 lebih sering berhubungan dengan kelainan oral, dan HSV tipe 2 berhubungan dengan kelainan genitalia. Rute primer penularan infeksi HSV-2 ialah melalui kontak seksual (genital-genital) dengan partner seksual yang terinfeksi. Laporan kasus : penulis melaporkan 1 laporan kasus herpes genitalis pada pasien usia 19 tahun dengan G2P1A0H0 32-33 minggu. Pada pemeriksaan didapatkan vesikel berisi cairan seropurulen dan ulkus dangkal tertutup cairan purulen, dasar eritema disertai nyeri dan hangat pada perabaan. Pemeriksaan penunjang yang dilakukan yakni tzank test untuk mengetahui secara sitologi. Pasien ditatalaksanai dengan antiviral, analgetika, roborantia, serta edukasi. Katakunci herpes genitalis, kehamilan
Penggunaan Psikotropika pada Anak dan Remaja Penderita Asma di Belanda 1999-2006 Aini, Siti Rahmatul
Jurnal Kedokteran Vol 1 No 1 (2012)
Publisher : Faculty of Medicine Universitas Mataram

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Abstract

Introduction: To determine the association between asthma and the use of psychotropic drugs by focusing on whether the asthmatic children receive more often psychotropic drugs compared with non asthmatic children in the population based cohort design. Method: Using InterAction Database (IADB), drug dispensing data from Dutch community pharmacies (55 community pharmacies) in 1999 – 2006, children and adolescents aged 0 to 19 years in the study period (1 Januari 1999 to 31 Desember 2006 were divided into two groups; the index (asthmatic children and adolescents) and the reference (antibiotic children and adolescents) groups. We calculated the incidences of psychotropic drugs use (in both groups) and the incidence risk ratio (IRR). Results: The incidences of psychotropic drug use were 0.058 cases/1000 person-days in index group and 0.048 cases/1000 person-days in reference group. The incidence risk ratio of anti psychotropic drug use was 1.21 ( CI 1.18-1.29). Conclusions : Asthmatic patients are 1.21 times more likely than non asthmatic patients to receive psychotropic drugs over the 8 years period in this study.
Kadar Glutation Pasca Pemberian Provitamin B5 pada Mencit BALB/c Terinfeksi Plasmodium berghei Ekawanti, Ardiana
Jurnal Kedokteran Vol 1 No 1 (2012)
Publisher : Faculty of Medicine Universitas Mataram

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Abstract

Introduction: Malaria was one of the health problem in developing country including Indonesia. Three hundred to five hundred million people suffered from malaria, and causing more than one million death annually. The objective of this study was to find out erythrocyte GSH level and compared to parasitemiapercentage due to provitamin B5 administration to Plasmodium berghei infected BALB/c mice. Method: 32 males BALB/c mice were infected by 200 µL blood which contain 106 Plasmodium berghei intraperitoneally. Then, samples were separated randomly into four groups, namely control group, group P1, group P2 and group P3. As soon as parasitemia reached 1 – 5 % the treatment should begin. Control group was administered aquades by gavage, group P1 administered 0.14 g/kgBW provitamin B5, group P2 administered 1.4 g/kgBW provitamin B5, group P3 administered 2.8 g/kgBW provitamin B5, all were treated by gavage. Provitamin B5 treatment followed the protocol in the 4-days suppressive test of blood schizontocidal action. On the fourth day the mice were terminated and blood samples from intracardiac was taken. Thus, blood samples conducted erythrocyte GSH measurement using Anderson method. Result: The results were analysed by using Anova α = 0.05, and continued by LSD if the result showed a significant difference. Erythrocyte GSH level decreased in all groups. Erythrocyte GSH in group P3 increased significant compared to group P1 ( P<0.05). Parasitemia measurement using Percent method showed a significant decrease in group P1 ( 48 % ) and in group P2 ( 62 % ) (P<0.05), while in group P3 no significant difference from control group. Conclusion: Erythrocyte GSH level decreased in administration of Provitamin B5 by increasing dosage, in contrast to parasitemia percentage.
Improvements of PCR Amplification of Guanine plus Cytosine-Rich Constructs of Mycobacterium tuberculosis Gene using DMSO Sabrina, Yunita; Lestarini, Ima Arum; Ekawanti, Ardiana; Sriasih, Made; Depamede, Sulaiman N.; Ali, Muhamad
Jurnal Kedokteran Vol 1 No 1 (2012)
Publisher : Faculty of Medicine Universitas Mataram

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Vaccine research entered a new era when several useful molecular research tools were established. Instead of attenuated virulent microorganisms or killed virulent microorganisms, effective subunit vaccines were developed using recombinant DNA technology. By using the technology, selected genes of the virulent microorganisms can be amplified, cloned, expressed, and evaluated as vaccine components in challenge studies. However, a major bottleneck with the amplification of functional genes from Mycobacterium tubeculosis containing guanine plus cytosin-rich templates is often hampered by the formation of secondary structures like hairpins and higher melting temperatures. To solve this problem in this research, the amplification reaction was modified by addition of dimethyl sulfoxide (DMSO) into amplification reaction mixtures. It was found that 10% (v/v) of DMSO in the reaction mixture improved the amplification of GC-rich template of M. tuberculosis gene. This result indicating that amplification of unbalanced content of G and C deoxyribonucleotides genome could be improved using low-cost organic molecule, DMSO. Therefore, the DMSO should be widely useful as an enhancer to improve the amplification of GC rich construct from other genome. Keywords: Mycobacterium tubeculosis,vaccine, dimethyl sulfoxide, Guanine-Cytosine
Faktor-faktor yang Mempengaruhi Kualitas Hidup Pasien Tinitus di RSUD Provinsi NTB Primaditha, Dara; Kadriyan, Hamsu; Widiastuti, Ida Ayu Eka
Jurnal Kedokteran Vol 1 No 1 (2012)
Publisher : Faculty of Medicine Universitas Mataram

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Introduction: Based on previous studies in Asia, the incidence of tinnitus was about 10.9%. Tinnitus shows a close association with psychological and social disorders and leads to a decline in quality of life. Most patients complain of sleep disorders, anxiety, and even depression. There are several factors that allegedly affect the quality of life of tinnitus patients such as age, sex and location of tinnitus. This study aims to prove the influence of these factors on the quality of life of tinnitus patients. Method: This is an analytic descriptive research with cross sectional design. The sample of this study was 37 patients tinitus who visited the ENT outpatient clinic of NTB Provincial Hospital that has met the inclusion and exclusion criteria. The respondents then filled out the Tinnitus Handicap Inventory (THI) questionnaire. The data obtained are then tested for validity and reliability, followed by Mann-Withney and Kruskall-Wallis tests to determine the effect of age, sex, and tinnitus on quality of life. Results: Based on the THI score, 86.8% of tinnitus patients experienced quality of life disorders of varying degrees. From the analysis of data about the effect of age on the quality of life, p = 0.957 (p> 0,05) means that there is no difference in the quality of life of tinnitus patients in all four age groups. The test results on the sex variables gave p = 0.430 (p> 0,05), this also means there is no difference in quality of life between men and women. The test of tinnitus location variable gives p value = 0,631 (p> 0,05). This means there is no difference in the quality of life between patients with bilateral and unilateral tinnitus. Conclusion: The quality of life of tinnitus patients is not affected by age, sex, and location of tinnitus.
Pengelolaan Nyeri Kanker Kresnoadi, Erwin
Jurnal Kedokteran Vol 1 No 1 (2012)
Publisher : Faculty of Medicine Universitas Mataram

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Patients with cancer have diverse symptoms, impairments in physical and psychological functioning, and other difficulties that can undermine their quality of life. If inadequately controlled, pain can have a profoundly adverse impact on the patient and his or her family. The critical importance of pain management as part of routine cancer care has been forcefully advanced by WHO, international and national professional organizations, and governmental agencies.
Korelasi antara Dosis Eksposur Timbal dengan Kadar Ureum dan Kreatinin Serum pada Wistar (Rattus norvegicus) Atmawati, Baiq Jatna; Syamsun, Arfi
Jurnal Kedokteran Vol 1 No 1 (2012)
Publisher : Faculty of Medicine Universitas Mataram

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Introduction: Clean air is hard to find these days, especially in big cities where industries and motor vehicles contribute to air pollution. It is almost about 85% of air pollution is caused by the emission of motor vehicles. One of the contaminants which are produced is lead. The lead which accumulates inside the tissues of the body will cause disorder mainly to the urinarius system (kidneys), liver, hematopoetic system, cardiovascular, and reproduction system. The objective of this research is to find out the correlation between the dosage of lead exposure with the level of serum ureum and creatinine on wistar rats (Rattus norvegicus). Method: This research applies a simple experimental research design which is called the post-test only control group design. This research participates with 6 research groups, that is, 4 for the treatment groups and 2 for the control groups. On the treatment groups, firstly, wistar rats are treated in a way which they are given a gradable dosageof acetic leads per orally. The level of acetic leads given in Treatment 1 (P1) is 1.1 ml, Treatment 2 (P2) is 0.825 ml, Treatment 3 (P3) is 0.55 ml, and Treatment 4 (P4) is 0.25 ml. After 24 hours (of acute exposure), the rats are anethesized by diethyl ether and then continue take the blood through the intracardiac. On control, on the other hand, no treatment at all is given to the rats. On Control 1, previously, the rats are anethesized with diethyl ether. On Control 2, however, they are not anesthesized but do decapytation. Result: Researchers have found the result that there is no significant correlation between the dosage of lead exposure towards the level of serum ureum and creatinine on wistar rats from the experiment of Control 1 and Control 2 (p>0.05). Researchers have found that the more reduced the dosage of the acetic lead, the more increasing the average of serum ureum. As for the creatinine, researchers have seen that there is no significant difference in the value between the treatment group and control group. Researchers have also found that there is no significant difference between the level of serum ureum and the level of creatinine on control group 1 and control group 2 (p>0.05). On the other hand, it is seen that there is difference on the value of ureum and creatinine in control 1 and in control 2. Conclusion: After conducting the experiment, researchers have found the result that there is no significant correlation between the dosage of lead exposure towards the level of serum ureum and creatinine on wistar rats from the experiment of Group 1 and Group 2 (p>0.05). On the other hand, it is seen that there is difference on the value of ureum and the value of creatinine in control group 1 (anesthesized with ether) and in control group 2 (without ether).

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