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Jurnal Kedokteran
Published by Universitas Mataram
ISSN : 23015977     EISSN : 25277154     DOI : -
Core Subject : Health,
Health Professions Medicine & Pharmacology
The Unram Medical Journal managed by the Medical Faculty of Mataram University is a scientific journal to publish the results of the latest research in the field of medical and health related. This journal promote medical sciences generated from basic sciences, clinical, and community research to integrate researches in all aspects of human health. This journal publishes original articles, reviews, and also case reports.
Arjuna Subject : Kedokteran - Kedokteran (Lain-Lain)
Articles 408 Documents
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Gambaran Preferensi Mahasiswa Tahap Preklinik Fakultas Kedokteran Universitas Lampung Terhadap Berbagai Metode Pengajaran Atica Ramadhani Putri
Unram Medical Journal Vol 11 No 4 (2022): volume 11 no 4
Publisher : Faculty of Medicine Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jku.v11i4.849

Abstract

Background: Recent literature has compared the use of specific teaching methods with the lecture method. Millennial students tend to prefer team-based learning, and suggest a preference for collaborative and technology-based learning approaches, But according to some literatures, medical students prefer the lecture method which is a passive teaching method. Objective: to find out the description of the pre-clinical stage preference of the Faculty of Medicine, University of Lampung towards various teaching methods. Methods: This research is a descriptive study with a survey method, sampling method is by total sampling. The variable in this study is the preference of preclinical students of the Faculty of Medicine, University of Lampung towards various teaching methods. The data was taken directly using a questionnaire for students in 2016 and 2017. The data will be entered into Microsoft Excel and then converted into tabular form and the mean will be calculated for each variable. Results: From the research, results obtained the highest mean of 4.134 for the CSL method, the second is lectures with a mean of 3.717, after that there is PAL with a mean of 3.481, PBL with a mean of 3.334, practicum with a mean of 3.286, CBL with a mean of 3.218, TBL with a mean of 3.184, and the last plenary with a mean of 2.673. Conclusion Preferences of students to a various teaching methods from the highest mean are CSL, lecture, PAL, PBL, practicum, CBL, TBL, and plenary.
Hubungan Kadar D-dimer dan C-Reactive Protein terhadap Berat Gejala pada Pasien COVID-19 Sang Ayu Nyoman Putri Pradnyasari; Moulid Hidayat; Prima Belia Fathana
Unram Medical Journal Vol 11 No 4 (2022): volume 11 no 4
Publisher : Faculty of Medicine Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jku.v11i4.864

Abstract

Background: Coronavirus disease 19 (COVID-19) is an acute respiratory infectious disease by SARS-CoV-2. This disease was discovered in Wuhan, China. In some cases, COVID-19 can be life-threatening due to an uncontrolled inflammatory phase characterized by increased levels of D-dimer and C-reactive protein (CRP) in the body. This condition can lead to complications such as ARDS, shock, and even death. This study aims to determine the relationship between D-dimer and CRP levels with the disease severity in COVID-19 patients at the Mataram University Hospital. Methods: This study is an observational analytic study with a cross-sectional design. Data collection took place in March-May 2022 at the Mataram University Hospital. Subjects were selected using consecutive sampling methods through medical record data. The statistical test used the Chi-square and Mann-Whitney comparative tests. Results: A total of 64 subjects were selected, of which 48 subjects underwent a D-dimer examination and 58 underwent a CRP examination. Most subjects were in the age group 18-59 years (64.1%), with the male gender (56.3%). There were 10 subjects (20.8%) had normal D-dimer levels, and 38 subjects (79.2%) had elevated D-dimer levels. Normal CRP levels were found in 6 subjects (10.3%), and 52 subjects (89.7%) had elevated CRP levels. The results of the bivariate test analysis showed p-value = 0.002 for D-dimer levels with severe symptoms, and CRP levels with severe symptoms showed p-value = 0.02. Conclusion: There is a significant correlation statistically and clinically between D-dimer and C-reactive protein levels with the disease severity in COVID-19 patients.
Rapid Diagnostic Test (RDT) Prototype Validation Test for SARS CoV-2 Antigen in Comparison With RT-PCR Assay Devi Rahmadhona
Unram Medical Journal Vol 11 No 4 (2022): volume 11 no 4
Publisher : Faculty of Medicine Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jku.v11i4.866

Abstract

Background: The diagnosis of Coronavirus Disease-2019 (COVID-19) is established based on Real-time reverse transcription-polymerase chain reaction (RT-PCR). However, due to the availibity, high cost and length of time of RT-PCR, a reliable alternative is needeed. Rapid Diagnostic Test (RDT) costs cheaper, near-patient use, and if performed and interpreted correctly can be used in areas without RT-PCR or if immediate diagnosis is needed. Objective : To evaluate the quality of RDT SARS CoV-2 prototype compared to RT-PCR. Methods: The patients in this study were patients with RDT antigen and or RT-PCR SARS-CoV-2 examination at Mataram University Hospital who had approved to be research subject. Nasopharyngeal swab sample was used for RDT Antigen SARS-CoV-2 Prototype. Whereas, nasopharyngeal and oropharyngeal swab sampel were used for RT-PCR SARS-CoV-2. The value of sensitivity, specificity and accuray of RDT prototype were assessed based on the RT-PCR result. Results: Total of 124 samples were included in this study. Approximately 39 (31.4%) were positive and 85 (68.5%) were negative. The sensitivity, specificity and accuracy of the SARS CoV-2 RDT prototype were 92.31% (79.13 - 98.38 %, 95% CI), 97.65% (91.76 - 99.71%, 95% CI) and 97.63 % (93.16 - 99.52 %, 95% CI), respectively. There were 5 discrepancies in RDT prototype results compare to the RT-PCR result. Conclusion: The RDT SARS-CoV-2 Antigen prototype showed good sensitivity, specificity and accuracy. Hence, this RDT has the potential to be used for screening or diagnosis, especially in areas with high disease prevalence and low rescorce setting.
Dinamika Ekspresi Cox1 dan Cox2 Sebagai Landasan Tatalaksana Nyeri dan Inflamasi Mohammad Fathul Qorib
Unram Medical Journal Vol 11 No 4 (2022): volume 11 no 4
Publisher : Faculty of Medicine Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jku.v11i4.868

Abstract

Siklooksigenase (COX) merupakan enzim yang sangat penting dalam menjaga homeostasis organ tubuh manusia. Enzim ini berperan pada kondisi fisiologis dan patologis khususnya saat terjadi inflamasi. Enzim ini memiliki 3 isoform yaitu Cox1, Cox2, dan Cox3. Isoform yang banyak diteliti dan terbukti sangat berperan dalam tubuh manusia adalah Cox1 dan Cox2, sedangkan Cox3 masih banyak perbedaan pendapat. Ekpresi Cox1 dan Cox2 dapat ditemukan pada berbagai organ dalam tubuh manusia, akan tetapi dalam naskah ini akan dibatasi pembahasannya pada lambung, ginjal, saraf, kardiovaskular, dan platelet. Hal ini dikaitkan dengan peran Cox sebagai target pengobatan nyeri dan inflamasi serta resiko efek samping yang mungkin ditimbulkannya. Perbedaan struktur kimia, karakter, serta perannya dalam menjaga homeostasis sangat perlu dipahami sebagai dasar penyusunan strategi pengobatan dan kewaspadaan terhadap efek samping yang dapat ditimbulkannya.
STRES OKSIDATIF YANG DIINDUKSI OLEH LATIHAN FISIK Ida Ayu Eka Widiastuti
Unram Medical Journal Vol 11 No 4 (2022): volume 11 no 4
Publisher : Faculty of Medicine Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jku.v11i4.900

Abstract

Aktivitas dan latihan fisik yang teratur dapat membantu untuk tetap sehat Namun demikian di sisi lain, latihan fisik sendiri berperan sebagai pemicu stres oksidatif. Jika pertahanan antioksidan kurang maka kerusakan dapat terjadi pada berbagai jaringan. Produksi oksidan yang berkaitan dengan latihan fisik dapat terjadi melalui beberapa jalur, yaitu: Kebocoran elektron dari rantai transfer elektron mitokondria, xanthine oxidase mengubah hypoxanthine menjadi asam urat, namun dengan menggunakan oksigen sebagai akseptor elektron untuk membentuk superoksida selama reperfusi, produksi radikal bebas oleh NADPH oxidase, pembentukan superoksida pada mitokondria otot akibat peningkatan temperatur dan autooksidasi oksihemoglobin menjadi methemoglobin, menyebabkan produksi superoksida
KARAKTERISTIK KELAINAN REFRAKSI PADA ANAK USIA SEKOLAH DI POLI MATA RSUD PROVINSI NTB TAHUN 2019 I Gusti Ayu Ratih Chantika Nariswari; Ni Nyoman Geriputri; Marie Yuni Andari
Unram Medical Journal Vol 11 No 4 (2022): volume 11 no 4
Publisher : Faculty of Medicine Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jku.v11i4.843

Abstract

Latar Belakang: Kelainan refraksi merupakan gangguan pada mata yang menyebabkan fungsi mata menjadi menurun. Prevalensi kelainan refraksi di Indonesia mencapai 61,71% dan menjangkiti semua kalangan usia termasuk anak-anak dengan prevalensi kejadian sekitar 10%. Gambaran refraksi anak di Provinsi Nusa Tenggara Barat masih kurang banyak diteliti. Tujuan dari penelitian ini adalah untuk mengetahui karakteristik pasien berdasarkan demografi, jenis dan klasifikasi kelainan, lateralitas, tatalaksana, dan komplikasi kelainan refraksi pada anak di RSUD Provinsi NTB. Metode: Penelitian dilakukan di RSUD Provinsi NTB menggunakan data rekam medis periode tahun 2019. Metode yang digunakan adalah deskriptif dengan desain penelitian cross sectional. Hasil: Data yang memenuhi kriteria yaitu sebanyak 77 orang. Karakteristik demografi yang paling banyak ditemukan adalah kelompok usia 13-15 tahun sebanyak 31 orang (40,2%) dan jenis kelamin perempuan sebanyak 53 orang (67,5%). Astigmatisma sebagai kelainan refraksi terbanyak (58,5%) dengan jenis astigmatisma miopia kompositus sebanyak 43,7%. Berdasarkan karakteristik klinis mayoritas bilateral sebanyak 65 orang (84,4%), diberi tatalaksana kacamata sebanyak 65 orang (84,4%), dan mengalami ambliopia sebanyak 14 orang (87,5%). Kesimpulan: Karakteristik kelainan refraksi pada anak usia sekolah di RSUD Provinsi NTB memiliki karakteristik yang serupa dengan teori yang ada.
Karakteristik Pasien Amnesia Pasca Cedera Otak di Rumah Sakit Umum Daerah Provinsi Nusa Tenggara Barat Lalu Wahyu Alfian Muharzami; Rohadi Muhammad Rosyidi; Ilsa Hunaifi; Bambang Priyanto
Unram Medical Journal Vol 11 No 3 (2022): volume 11 no 3
Publisher : Faculty of Medicine Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jku.v11i3.653

Abstract

Background: Traumatic Brain Injury (TBI) is a brain disorder caused by a traumatic process such as an impact, blow, or stab to the head, causing impaired brain function. Several external causes of TBI, such as falls, road traffic accidents, and beatings/assaults. Impaired memory function is one form of the neuropsychological disorder that can occur after injury. Post-Traumatic Amnesia (PTA) is a post-injury condition characterized by difficulty remembering things that were happened before or retaining information that has just happened. Methods: This research was conducted at West Nusa Tenggara Province General Hospital using a cross-sectional design and has passed the review of the research ethics team (ethical clearance). The number of research samples was 40 people with brain injury. We collected head CT scan results and interviews using the Galveston Orientation and Amnesia Test (TOAG) questionnaire. Sampling using a consecutive sampling method. Data are presented descriptively. Results: Of the 40 TBI patients, 33 patients had PTA (82.5%). Most patients with PTA are between 18 and 30 years of age (45.46%), most of them were male (81.8%), and most patients had high school educational levels (42.43%). Based on the severity of brain injury, most PTA patients had a mild brain injury (57.58%). Based on the head ct scan, most PTA patients had diffuse lesions (51.52%). Conclusion: TBI patients who experienced PTA were dominated by men aged 18 to 30 years and had a high school education level. In addition, the location of diffuse lesions is often seen in TBI patients with PTA.
Losartan sebagai Regimen Penurun Serum Asam Urat pada Penderita Gout dengan Hipertensi: Florence Pribadi; Ronald Torang Marsahala Panggabean; Angelarita Djami Raga; Ellysia Yuvena Maheswari; Berlian Ester Wakas; Almer Fathoni Syahda; Lola Adriani; Kevin Luke
Unram Medical Journal Vol 11 No 3 (2022): volume 11 no 3
Publisher : Faculty of Medicine Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jku.v11i3.739

Abstract

Asam urat (AU) merupakan produk akhir dari metabolisme purin yang terdistribusi pada plasma dan cairan synovial. Solubilitas AU pada air sangat rendah, sehingga pada konsentrasi 6.8 mg/dL dapat membentuk kristal, yaitu monosodium urat. Kristal yang mengendap di sendi dapat memicu proses inflammasi yang disebut dengan gout artritis (GA). Penatalaksanaan GA yang tidak optimal menyebabkan penurunan kualitas hidup yang signifikan. Losartan merupakan obat hipertensi yang bekerja dengan memblokade reseptor Angiotensin I, sekaligus memiliki efek menurunkan kadar AU. Losartan diduga menghambat transporter URAT1 pada tubulus ginjal, sehingga menganggu reabsorbsi AU dan menyebabkan efek urikosurik. Tinjauan ini akan membahas potensi Losartan sebagai regimen terapi penurun AU pada penderita gout dengan hipertensi.

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