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Mutiara Medika: Jurnal Kedokteran dan Kesehatan
Published by Universitas Muhammadiyah Yogyakarta
ISSN : 14118033     EISSN : 26140101     DOI : 10.18196/mm
Core Subject : Health,
Health Professions Medicine & Pharmacology
Jurnal Mutiara Medika Fakultas Kedokteran dan Ilmu Kesehatan (MMJKK) Universitas Muhammadiyah Yogyakarta is a peer-reviewed and open access journal that focuses on promoting medical sciences generated from basic sciences, clinical, and community or public health research to integrate researches in all aspects of human health.
Arjuna Subject : -
Articles 934 Documents
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Suweg Flour (Amorphophallus Campanulatus) Potential Reducing TNF-α Levels in Model Diabetic Rats Setyawati, Ika
Mutiara Medika: Jurnal Kedokteran dan Kesehatan Vol 20, No 2: July 2020
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/mm.200246

Abstract

Diabetes mellitus (DM) is a chronic disease and it is called as a silent killer because this disease is unrecognized by the diabetics. However, when it is already known the complication is occurred. It is recognized by the increase of blood glucose level (hyperglycemia) as the main character of Diabetes Mellitus (DM). This condition causes the increase of the Reactive Oxygen Species (ROS) in a chronic condition.  Then, insulin resistance is caused by the oxidative stress in fat, muscle and liver tissue. Moreover, insulin resistance produces several oxidative stress mediators including  (TNF- α). This research aims to determine the effect of suweg flour (Amorphophallus campanulatus) on TNF-α level in rats diabetic model. The method used in the research was an experimental laboratory of pre-post control group test conducted in 28 days. The subjects of this research were 25 Rattus Novergicus wistar strains, (P1) positif control (P2), standart (P3) and two treatment groups (P4 and P5). The data were gained by measuring the level of TNF-α before and after receiving the suweg flour enzyme-linked immunosorbent assay (ELISA). The data were analyzed by paired sample t-test. This research showed a significant correlation between suweg flour and TNF-α levels (p = 0.000). A significant correlation was discovered in all treatment groups (P4 and P5). The results of this research can be concluded that the administration of suweg flour (Amorphophallus campanulatus) can decrease of TNF-α levels in rats diabetic model.
Comparison of Serum Interleukin 10 Levels between Leprosy and Non-Leprosy Population Kodrati, Adika; Salim, Eddy Mart; Hafy, Zen
Mutiara Medika: Jurnal Kedokteran dan Kesehatan Vol 21, No 1: January 2021
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/mmjkk.v21i1.6514

Abstract

Leprosy is a chronic granulomatous infectious disease that attacks the peripheral nerves, skin, and other organs. The cytokine IL-10 can deactivate macrophages, inhibit IL-12 production, which also inhibits IFN-ϒ production. IL-10 directly inhibits CD4+T cells and antigen-presenting cell (APC) function in cells infected with M. leprae. The purpose of this study was to determine the differences in IL-10 levels in leprosy patients and non-patients at dr. Mohammad Hoesin Palembang Hospital. This study used a case-control design for comparing 2 groups. Respondents in this study were 80 people. The case samples were all leprosy patients who were treated at the dr. Mohammad Hoesin Hospital, Palembang for the period of January 16 - February 16, 2019, while the control group was medical personnel and paramedics who worked at the same hospital. The examination was carried out using the ELISA Sandwich method. The results showed that there was a significant difference in IL-10 levels between leprosy patients and non-leprosy leprosy (p=0.000). The average IL-10 level in leprosy patients (13.24 pg/ml) was lower than that in non-patients (40.15 pg/ml). It is concluded that there is a difference in IL-10 levels between leprosy patients and non-leprosy patients in leprosy sufferers are lower than non-leprosy persons. 
Perbandingan Efikasi Obat Nyamuk Bakar dengan Zat Aktif Metofluthrin dan D-D-Allethrin terhadap Culex quinquefasciatus Hodijah, -; Kesetyaningsih, Tri Wulandari
Mutiara Medika: Jurnal Kedokteran dan Kesehatan Vol 14, No 2 (2014)
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/mmjkk.v14i2.9383

Abstract

Penyakit yang ditularkan melalui nyamuk masih banyak di Indonesia, termasuk filariasis dan encephalitis yang ditularkan oleh Culex quinquefasciatus. Upaya pencegahan infeksi dari penyakit tersebut di masyarakat antara lain dengan menggunakan obat nyamuk bakar. Kandungan bahan aktif obat nyamuk bakar umumnya adalah kelompok piretroid sintetik antara lain metofluthrin dan d-allethrin. Penelitian ini bertujuan untuk mengetahui efektifitas obat nyamuk bakar berbahan aktif metofluthrin dan d-allethrin dengan parameter LT50 dan LT90. Subyek penelitian nyamuk Culex quinquefasciatus diperoleh dari alam. Metode penelitian adalah eksperimental laboratorium. Nyamuk dibagi menjadi 3 kelompok yaitu kelompok dengan pemaparan obat nyamuk bakar metofluthrin (perlakuan 1), kelompok dengan pemaparan obat nyamuk bakar d-allethrin (perlakuan 2) dan kelompok tanpa pemaparan (kontrol) dengan replikasi sebanyak 3 kali. Hasil pengamatan berupa persentase rata-rata nyamuk uji yang jatuh dianalisis probit berdasarkan jumlah knockdown nyamuk pada tiap 5 menit selama 50 menit pemaparan. Hasil analisis menunjukkan LT50 selama 20 menit (metofluthrin) dan 17 menit (d-allethrin) serta LT 90 selama 37 menit (metofluthrin) dan 31 menit (d-allethrin). Obat nyamuk bakar dengan zat aktif d-d-allethrin pada penelitian ini menunjukkan LT50 dan LT 90 yang lebih singkat dibandingkan metofluthrin.
Perbandingan Status Kesehatan Gingiva dan Kebersihan Mulut pada Perokok Aktif dan Bukan Rifa, Rizky; Dewi, Anne Handrini
Mutiara Medika: Jurnal Kedokteran dan Kesehatan Vol 8, No 1 (S) (2008): Januari
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/mmjkk.v8i1 (S).9423

Abstract

Background: Smoking represents one of inveterate habit in everyday life. Smoking cause some disease for example cardiovascular; lungs cancer; esophagus, laryng, and oral cavity. Smokers have more calculus, plaque, debris, gingivitis, and periodontitis than non smoker.Purpose: The purpose of this research is to know the gingival health status and oral hygiene status between active smoker and non smoker.Research Method: Target design used analytic survey with the approach of cross sectional. This subject is a student in faculty of dentistry UIVIY that include in criteria. This research using 30 subject. Consisted 0f15 smokers and I5 non smokers. Every subject examine the GI and OHIS. The result was analyzed with t-test independent. Conclusion and Result: In the GI and OHIS of active smoker and non smoker there are diflerence which significant cause an the GI and OHIS assess p 0. 05. It means that there are diflerent on gingival health and oral hygiene health between active smoker and non smoker: Active smoker has less gingival and oral health status than non smoker: 
The Density of Dermatophagoides sp. in Households and its Correlation with the Score for Allergic Rhinitis in Jember, East Java Sulistyaningsih, Erma; Laili, Elisa Fadia; Abrori, Cholis
Mutiara Medika: Jurnal Kedokteran dan Kesehatan Vol 21, No 1: January 2021
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/mmjkk.v21i1.7925

Abstract

The prevalence of allergic rhinitis (AR) in Indonesia is an estimated 24.3% and increasing each year. The majority cause of AR is house dust mites (HDMs) allergens, especially Dermatophagoides sp. The screening tool to estimate the prevalence and diagnose AF in a population setting is the Score for Allergic Rhinitis (SFAR) questionnaire. This study aimed to investigate the correlation between the density of Dermatophagoides sp. in households and the SFAR in Jember, East Java. The study enrolled 30 housewives as respondents, which were selected by stratified random sampling. Respondents were interviewed using the SFAR questionnaire. The dust sample from each house of the respondent was collected, the HDMs either Dermatophagoides sp. or others were identified and the density of Dermatophagoides sp. was calculated. Data were analyzed using the Pearson Test. Dermatophagoides sp. were found in 21 out of 30 samples and 11 out of 30 respondents had an SFAR of ≥ 7. The Pearson analysis showed the value of p = 0.555 and r = 0.136. Dermatophagoides sp. was the majority of species of HDMs, but there was no significant correlation between the density of Dermatophagoides sp. in households and the SFAR among housewives  in Jember.
Perbedaan Efektivitas Sikat Gigi Bulu Sikat Konvensional Dengan Bulu Sikat Kombinasi Karet Dalam Pembersihan Plak Dengan Metode Roll Fardani, Arafita Putri; Pintadi, Hastoro
Mutiara Medika: Jurnal Kedokteran dan Kesehatan Vol 7, No 2 (s) (2007): Juli
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/mmjkk.v7i2 (s).9426

Abstract

Plak merupakan salah satu faktor utama terjadinya dan berkembangnya penyakit karies dan gingivitis. Menyikat gigi merupakan salah satu cara untuk menghilangkan plak secara mekanis. Efektivitas menyikat gigi tergantung pada desain sikat gigi, metode, frekuensi dan lamanya menyikat gigi. Banyaknya variasi dan desain sikat gigi kini muncul di pasaran. Tujuan penelitian ini untuk mendapatkan gambaran sikat gigi yang lebih efektif dalam membemihkan plak dengan metode roll antara sikat gigi bulu sikat konvensional dengan sikat gigi bulu sikat kombinasi karet.Penelitian ini adalah penelitian eksperimental klinis semu yang dilakukan pada 3 0 subjek berumur 18-24 tahun dengan pretes t-postest design. Kriteria sampel antara lain tidak memakai alat onodontik, tidak memakai gigi tiruan, j umlah karies sedikit, dan tidak memiliki tambalan menggantung. Setiap subj ck diminta menyikat gigi 2 kali sehari dengan sikat gigi bulu sikat konvensional dengan metode roll selama 1 minggu. Perlakuan kedua dengan sikat gigi bulu sikat kombinasi karet dengan metode roll selama 1 minggu Diukur nilai plak sebelurn dan setelah perlakuan. Indeks plak menggunakan O ’Leary Plaque Index. Hasil dianalisis dengan paired t-test dan independent sample t- test.Nilai rata-rata skor plak sebelum menggunakan sikat gigi bulu sikat konvensional adalah 35, 19 dan setelah menyikat sebesar 33,14. Sedangkan sikat gigi bulu sikat kombinasi karet sebelum menyikat memiljki nilai rata-rata skor plak sebesar 38,16 clan skor plak setelah menyikat 26,71 . Dapat dikatakan bahwa penumnan nilai plak lebih banyak telj adi pada sikat gigi bulu sikat kombinasi karet. Kemudian dari nilai rerata selisih nilai plak antara sebelum dan setelah memakai sikat gigi didapatkan sikat gigi bulu sikat konvensional memiliki rerata selisih sebesar 2,0410 dan sikat gigi bulu sikat kombinasi karet memiliki rerata selisih sebesar 11,4550. Dapat dikatakan pula selisih nilai plak sebelum dan setelah menyikat lebih banyak teij adi pada sikat gigi bulu sikat kombinasi karet. Kesimpulannya, penggunaan sikat gigi bulu sikat kombinasi karet lebih efektif dalam pembersihan plak dengan metode roll daripada sikat gigi bulu sikat konvensional.
Pengaruh Status Kebersihan Gigi dan Mulut (OHI-S) pada Lansia yang Menggunakan Gigi Tiruan Sebagian Lepasan Berdasarkan Tingkat Pendidikan Merdekawati, Putri Dewi; Sugiatno, Erwan
Mutiara Medika: Jurnal Kedokteran dan Kesehatan Vol 8, No 2 (s) (2008): Juli
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/mmjkk.v8i2 (s).9410

Abstract

The aim of this research is to know the influence of oral hygiene status (OHI-S) of elderly people wear removable partial denture base on education level. Removable partial denture is denture to replace one or more tooth, but it is not replace all of the tooth and it surrounds tissue and supported by tooth and the tissue under it, and it can overhaul to the mouth of the user: Data analysis of this research by using chi-square with 3 0 sample elderly people wear removable partial denture which is divided 10 elderly people graduated from base education level, l 0 elderb1 people graduated from middle education level, and 1 0 elder people graduated from high education level on Umbulharjo Yogyakarta. The result of OHI-S examination showed elderly people graduated from base education level have good 1 (3,3%), middle I (33%), bad 8 (26, 7%), elderly people graduated from middle education level have good 2 (6, 7%), middle 3 (10, 0%), bad 5 (16,7%), and elderly people graduated from high education level have good 6 (20,0%), middle 3 (10, 0%), bad I (3,3%). The result showed that p 0,05 and get chi-square count (11,095) chi-square table (9,49) with significant 0,026, it means that have the influence of oral hygiene status (OHI-Q of elderbi people wear removable partial denture base on education level.
The Duration of Reading the Qur'an with the Stress Levels in Medical Faculty Students in Palembang Ghiffari, Ahmad; Muhammad, Syahrul; Ababil, M. Avif
Mutiara Medika: Jurnal Kedokteran dan Kesehatan Vol 21, No 1: January 2021
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/mmjkk.v21i1.8488

Abstract

The level of stress in each education programs differ between medical students and other scholars. Students should able to cope to normalize their stress. The study aims to determine the relationship between the duration of reading the Qur'an with the level of stress on students. The study design was a cross-sectional study, with a simple random sampling. The collecting data technique was using the Depression Anxiety Stress Scale (DASS) questionnaires and duration questionnaires followed by the chi-square analysis. The respondents are 90 medical students of Universitas Muhammadiyah Palembang. The results showed that the duration of reading the Qur'an among students is poor, and the moderate duration is correlated with a good stress level (p=0,002). Concluded that there is a relation to the duration of reading The Qur'an with the level of stress in medical students.
Pengaruh Gigi Molar Tiga Atas pada Kejadian Perikoronitis Gigi Molar Tiga Bawah Harniati, Etny Dyah; Rahayoe, Poerwati Soetji
Mutiara Medika: Jurnal Kedokteran dan Kesehatan Vol 8, No 1 (S) (2008): Januari
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/mmjkk.v8i1 (S).9420

Abstract

The impaction of the lower third molar is an impaction that commonly happens, approximately 98% of 10.979 impacted molars found in the study on 5.000 cadets. The condition of the impaction tend to cause several pathological conditions, which one of them is pericoronitis, where this condition at once becomes one of the most reasonable reasons for extraction on the involved impacted molars to be performed. The aim of this research was to identlfv the eflects of the upper third molar on the existence of pericoronitis of the lower third molar: Design of this research was an analytical observational study using the cross sectional approach over 6 months. This research was conducted through the direct observation and roentgen photo on 62 patients with the impaction of the lower third molar either with pericoronitis or without pericoronitis in the hospital of RSU PKU Muhammadiyah Yogyakarta. The observation was done to the patients with pericoronitis to idenhjy the correlation between the traumatic occlusion with the appearance of pericoronitis. The observation was also conducted to identijjz the correlation between the level of impaction with the traumatic occlusion and the correlation between the position of the upper third molar with the traumatic occlusion. During the research, there gained 62 sampels was gained, divided into 29 samples with pericoronitis and 33 samples without pericoronitis. The occurrence of the pericoronitis with trauma was mostly seen on the level A of impaction with the position of the upper third molar is bucoversion (90,9%), while the occurrence of pericoronitis without trauma was mostly seen on the vertical upper third molar with level B of impaction (83,3%). From the analysis test of Chi-Square, showed a significant correlation between the traumatic occlusion with the occurrence of pericoronitis (z2 0, 05) and there was an efiect of the upper third molar position and the impaction level with trauma (p 0,05), while the upper third molar with pericoronitis and the impaction level with pericoronitis did not show any significant influence Q2 0,05). The analysis test of Man-Whitney showed that the bucoversion upper third molar position mostly caused trauma (p 0, 05). Upper third molar; the impaction level and the trauma with recurrent pericoronitis or first pericoronitis did not show any significant influence (p 0, 05).
Kematian Mendadak akibat Hemoragi Cerebral yang Meluas Agni, Idha Arfianti Wira; Suciningtyas, Martiana
Mutiara Medika: Jurnal Kedokteran dan Kesehatan Vol 14, No 2 (2014)
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/mmjkk.v14i2.9385

Abstract

Salah satu penyebab dari kematian mendadak adalah perdarahan pada sistem saraf pusat. Tujuan dari studi ini adalah untuk menguraikan terjadinya kematian mendadak pada penderita diabetes melitus yang mengalami perdarahan otak. Dilaporkan kasus kematian mendadak pada laki-laki usia 54 tahun, berat badan 63 kg, panjang badan 170,5 cm dengan riwayat diabetes melitus kronik. Pada pemeriksaan otak, terdapat perdarahan epidural, subdural, intrakranial dan intraventrikular. Pada pemeriksaan mikroskopik jaringan otak ditemukan tanda kongesti, kalsifikasi tunika mediana vassa otak dan tanda degeneratif otak. Pemeriksaan racun yang dilakukan terbukti negatif. Disimpulkan bahwa perdarahan pada otak pada diabetes melitus, kemungkinan disebabkan karena terjadinya hipertensi. Hipertensi disebabkan karena adanya vaskulopati dan pemekatan darah sehingga kerja jantung pada pasien diabetes semakin berat.

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