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Mutiara Medika: Jurnal Kedokteran dan Kesehatan
Published by Universitas Muhammadiyah Yogyakarta
ISSN : 14118033     EISSN : 26140101     DOI : 10.18196/mm
Core Subject : Health,
Health Professions Medicine & Pharmacology
Jurnal Mutiara Medika Fakultas Kedokteran dan Ilmu Kesehatan (MMJKK) Universitas Muhammadiyah Yogyakarta is a peer-reviewed and open access journal that focuses on promoting medical sciences generated from basic sciences, clinical, and community or public health research to integrate researches in all aspects of human health.
Arjuna Subject : -
Articles 934 Documents
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Antioxidant Activity from the Combination of Ethanolic Extract of Tea Leaves (Camellia sinensis) and Soursop Leaves (Annona muricata l.) and Optimation of the Effervescent Granule Production Masitha, Fatma Sari; Febriansah, Rifki
Mutiara Medika: Jurnal Kedokteran dan Kesehatan Vol 19, No 2: July 2019
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/mm.190230

Abstract

Soursop Leaves (Annona muricata L.) and Tea Leaves (Camellia sinensis) are plants that contain flavonoids which are considered to act as antioxidants and can become chemopreventive agents. This study aims to identify the potential of Soursop Leaves and Tea Leaves as chemopreventive agents. The first stage of this research was to determine the presence of flavonoids in both of ethanolic extract using TLC method. The second stage is to examine the antioxidant activity of the combination of ethanolic extract of soursop leaves and tea leaves against free radical DPPH (1,1-diphenyl-2-pikrihidrazil). Docking molecular test of acetogenin and catechin compounds at HER-2 and ER-α receptors which are biomarkers of breast cancer. Furthermore, the optimization of effervescent granule production using moist granulation method is carried out. The result shows that ethanolic extract of soursop leaves and tea leaves contains flavonoid shown with Rf value of 0.66 and 0.68, and the comparison of Rf 0.66. The combination of both ethanolic extract has very strong antioxidant activity with IC50 value 26,90 μg/mL. The result of molecular docking of acetogenin and catechin compounds at HER-2 receptors shows respective docking score of -6.3 kcal/mol and -6.7 kcal/mol while ER-α receptors shows a docking score of -6.5 kcal/mol and -7.6 kcal/mol. In addition, the most optimal effervescent granule production is formula four with physical test result such as moisture content of 1.07% with a dissolve time of 45.5 seconds and acidity of 6.18. The result shows that ethanolic extract of soursop leaf (Annona muricata L.) and Tea Leaves (Camellia sinensis) have potential activity as chemopreventive agents and can be formulated into effervescent granule production.
The Effect of Zam-zam Water to the Lipid Profile (HDL & LDL) at White Mouse (Rattus novergicus) Tama, Yhang Lidi; Sagiran, Sagiran
Mutiara Medika: Jurnal Kedokteran dan Kesehatan Vol 19 No 2: July 2019
Publisher : Universitas Muhammadiyah Yogyakarta

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Abstract

The estimates from the experts of the World Health Organization (WHO) indicate that 50% of the 12 million world population die from coronary heart disease & blood vessel disease. Low-Density Lipid (LDL) and High-Density Lipid (HDL) ratios are often calculated to estimate the risk of coronary heart disease. Zam-zam water is thought to be efficacious in reducing blood lipid profile levels. This study aims to know the effect of Zam-zam Water on the lipid profile (HDL & LDL) on a white mouse (Rattus Novergicus). The type of this research is an experimental laboratory design with a pre-post control group conducted for 28 days. The subjects of this study were 25 Rattus norvegicus wistar strains, divided into five groups namely control (aquades) group and four treatment groups (concentrations of 25%, 50%, 75% and 100%). The data were obtained by measuring the level of LDL and HDL before and after receiving the treatment of Cholesterol Oxidase Para Aminophenazone (CHODPAP). Also, the data were analyzed using ANOVA test and paired t-test. The Anova analysis showed that the administration of Zam-zam water affected the level of HDL and LDL as proven by the significance of differences among study groups (p <0.05). It is obtained that zam-zam water is 100% proven to have the most influence on HDL and LDL levels. The analysis of paired T-test showed that there were significant differences before and after treatment (p <0.05). Therefore, it can be concluded that the administration of zam-zam water affected the level of HDL and LDL of Rattus norvegicus blood lipid profiles.
Life Quality of Pediatric Patient with Dengue Hemorrhagic Fever (DHF) Who Received Crystalloid and Colloid Fluid Treatment in PKU Muhammadiyah Hospital Yogyakarta Nasriyah, Chotijatun; Perwitasari, Dyah Aryani; Kurniawan, Nurcholid Umam
Mutiara Medika: Jurnal Kedokteran dan Kesehatan Vol 19, No 2: July 2019
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/mm.190229

Abstract

Dengue hemorrhagic fever (DHF) in the community can have an impact of panic, death, and reduced age of hope in the family. Research on the quality of life of DHF pediatric patient who got the treatment of crystalloid and colloid fluids has never been done before. The purpose of this study was to determine the quality of life of DHF pediatric patients who received crystalloids and colloids with PedsQL instruments. The study design was a cohort with block randomization. The inclusion criteria in this study were hospitalized DHF pediatric patients aged one month -18 years from February to May 2018. The exclusion criteria were DHF patients who came with referrals from other hospitals who had received fluid therapy. Research data include the length of stay (LOS) and quality of life score with the PedsQL questionnaire. The statistical analysis was using an independent t-test and the Mann Whitney test. The length of stay for the crystalloid group is five days longer than the colloid group, which is four days. From a total of 48 subjects studied, the score for the physical function of the crystalloid fluid group 84.54 ± 9.90 was higher than the colloid group of 77.58 ± 19.30 (p = 0.125). The emotional functions in the crystalloid group obtained a score of 81.88 ± 12.14 higher than the colloid group, i.e., 79.17 ± 18.5 (p = 0.552). The social function in the crystalloid group had a score of 92.08 ± 8.84 higher than the colloid group of 86.67 ± 13.96 (p = 0.232). The school functions in the crystalloid group had a score of 50.42 ± 33.68 higher than in the colloid group of 37.92 ± 36.62 (p = 0.225). The results of this study showed that the crystalloid group had a higher quality of life score compared to the colloid group, although it was not significant. 
THE RELATIONSHIP BETWEEN KNOWLEDGE, INFORMATION SOURCES, FAMILY SUPPORT AND IMPLEMENTATION OF PROVIDER-INITIATED TESTING AND COUNSELING IN PREGNANT WOMAN Ciptiasrini, Uci
Mutiara Medika: Jurnal Kedokteran dan Kesehatan Vol 20 No 1: January 2020
Publisher : Universitas Muhammadiyah Yogyakarta

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Abstract

The discovery of cases of HIV and AIDS at the age of under four years old in Indonesia indicates that there is still HIV transmission from mother to child. This study aims to identify the relationship between knowledge, information sources, family support, and the implementation of Provider-Initiated Testing and Counseling (PITC) examinations in pregnant women. This research was analytic descriptive with a cross-sectional approach conducted in August 2018, with 85 respondents selected by accidental sampling. The population in this study were all pregnant women who visited the community health center. Data was collected by giving questionnaires directly to respondents. Relationships between variables were tested with chi-square analysis. The results showed that 36 (62.1%) respondents have good behavior and good knowledge, and the chi-square test results obtained p-value=0.025. Thirty (68.2%) respondents have good behavior and have access to information sources and p-value=0.007. Thirty-three (67.3%) respondents have good behavior and have family support with the p-value=0.004. It can be concluded that there is a relationship between knowledge, information sources, family support, and the implementation of the PITC examination of pregnant women.
THE RATIONALITY OF ANTIBIOTIC USE ON PATIENTS OF TYPHOID FEVER Hudi, Riefki Indira; Ranti, Imaniar
Mutiara Medika: Jurnal Kedokteran dan Kesehatan Vol 20 No 1: January 2020
Publisher : Universitas Muhammadiyah Yogyakarta

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Abstract

Typhoid fever is an infectious disease caused by Salmonella typhi bacteria. The administration of antibiotics in typhoid fever is needed as a causative therapy to eradicate the bacteria based on the principles of rational therapy to avoid antibiotic resistance. However, there are still a considerable amount of cases of unnecessary antibiotic administration. This study aims to examine the rationality of antibiotic use on patients of typhoid fever. This research is a non-intervention study with descriptive analytic methods. Data were retrieved retrospectively by identifying the medical records of patients treated in the X Hospital Salatiga from January to August 2016 with a purposive sampling method based on the inclusion and exclusion criteria of 67 cases. The data was analyzed by using Gyssen criteria based on the standard of typhoid fever service of WHO 2011. The result showed that the percentage of female typhoid fever patients was higher than the male with the most prolonged 3-day hospitality. The most commonly used antibiotics are ceftriaxone, ciprofloxacin, and cefixime with the result of the rationality analysis of category 0 (55.22 %), category IIIA (1.49%), category IIIB ( 8.96% ), category IVA (17.91%), and category IVC (4.48%). It can be concluded that  the rationality of antibiotics used in patients with typhoid fever at X Hospital Salatiga based on Gyssen criteria showed a good result.
ADAPTATION AND VALIDATION OF SAFETY ATTITUDE QUESTIONNAIRE AMBULATORY (SAQ-A) IN INDONESIAN PRIMARY HEALTH CARE FACILITIES Rohmani, Ngatoiatu; Sari, Ike Winahyu
Mutiara Medika: Jurnal Kedokteran dan Kesehatan Vol 19 No 2: July 2019
Publisher : Universitas Muhammadiyah Yogyakarta

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Abstract

Prevention of patient safety incidence needs to be pursued by the management committee of healthcare institutions by changing the behavior of healthcare providers to create a patient safety culture. Also, safety culture evaluation needs to be done to assess the implementation of the culture by healthcare providers. For this reason, a valid and reliable instrument is required in order to be accepted and used in Indonesia as a tool to measure of safety culture attitude in healthcare facilities. This study aimed to adopt the Safety Attitude Questionnaire ? Ambulatory (SAQ-A) instrument to Indonesian. The study was carried out in 5 stages, they were: The translation stage, translation result synthesis, back-translated, review of 3 experts to obtain content validity index (CVI) and questionnaires trial which is conducted in 6 Puskesmas, i.e., Puskesmas Pandak I, Puskesmas Pajangan, Puskesmas Godean I, Puskesmas Kalasan, Puskesmas Tempel I and Puskesmas Minggir. Purposive sampling technique was selected to obtain 30 respondents based on inclusion criteria: She/he works in research location and has experience at least for one month, permanent/ contract employee, and not on sabbatical leave or other permission. Data were analyzed using the Content Validity Index (CVI) and Alpha Cronbach Coefficient. The validity test result of the Indonesian version of SAQ-A based on I-CVI and S-CVI was 1.00 with Cronbach?s alpha reliability value from the six dimensions in the questionnaire within range of ? 0.612 ? 0.881. The reliability test result of the full item on the Indonesian version of the SAQ-A questionnaire was ? 0,914. It was concluded that the Indonesian version of the SAQ-A questionnaire is a valid and reliable questionnaire which can be used as a tool to measure safety culture attitudes of healthcare providers in primary healthcare facilities.
The Difference in Incidence of Scabies between Conventional and Modern Boarding School Ratnaningrum, Kanti; Avidah, Amanatum
Mutiara Medika: Jurnal Kedokteran dan Kesehatan Vol 20, No 1: January 2020
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/mm.200141

Abstract

The prevalence of scabies in children is still high in Indonesia, especially in children who live in dormitories such as Islamic boarding schools. Rise of modern boarding school that is claimed to be better than conventional boarding school makes researchers moved to find out whether there are differences in the occurrence of scabies in conventional boarding school and modern boarding school. This study is a descriptive observational study. The sample used was 95 respondents in each boarding schools that obtained by a simple random sampling technique. Research data were collected in the form of questionnaires and examination of the diagnosis of scabies using a dermoscope. The data was analyzed using data tabulation. From 190 respondents, most of the samples were in the age range of 14-16 years (46.8%). Scabies occurred in conventional boarding school were 35.3% (46 respondents), and 9.8% (5 respondents) occurred in modern boarding school. It can be concluded that the occurrence of scabies in modern boarding school is less than in conventional boarding school.
Structured Physical Activity can Increase High-Density Lipoprotein Cholesterol Levels Dharaindas, Hanna Kumari
Mutiara Medika: Jurnal Kedokteran dan Kesehatan Vol 20, No 1: January 2020
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/mm.200134

Abstract

High levels of low-density lipoprotein (LDL) cholesterol and low levels of high-density lipoprotein (HDL) are risk factors for coronary heart disease (CHD). Early research has proven that physically active people have higher HDL levels, and it is obtained by doing regular physical exercise in both men and women. One of the exercises that have an anti-CHD effect is an aerobic exercise. This study aims to identify the effect of structured physical activity on increasing HDL cholesterol. This research is pre-experimental research with one group pretest-posttest design. Interventions given were aerobic exercise conducted at least 150 minutes per week and monitored for three months. The population and sample were members of the R and K gymnastics studio in Central Jakarta, who were 18-60 years old. Samples were selected using the purposive sampling method. Data was collected by taking the respondent's blood serum and the HDL cholesterol levels examined by enzymatic methods in the laboratory, while the data analysis used paired t-test statistical tests. The results showed an increase in HDL cholesterol levels in 18 out of 25 respondents with the results of the paired t-test p=0.001. The conclution is structured physical activity has significant effect on increasing HDL cholesterol levels among gymnastics members.
Long-Term Predictors of Disease Free Survival (DFS) in Ovarian Cancer Sensitive to Platinum Based Chemotherapy selvyana, Dita Ria; Kurnianda, Johan
Mutiara Medika: Jurnal Kedokteran dan Kesehatan Vol 19, No 2: July 2019
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/mm.190232

Abstract

Until now, there has been progress in the treatment of ovarian cancer, but ovarian carcinoma is still a cause of high mortality. Various factors have been known to be associated with a poor prognosis, such as the absence of symptoms, lack of an effective screening tool, diagnosis of the disease that was only detected after an advanced stage, high recurrence of disease resistant to chemotherapy. There are more than 70% of cases detected in advanced stage, with long-term survival of only 15-30%; while those detected in early stages, the survival reaches 90%. The recurrence risk of IIIC stage disease is as high as 40% -50%. However, there is a small group of patients who can recover after standard therapy. There is variability in the recurrence-free period and survival, so it is difficult to predict the outcome with certainty. Ovarian cancer patients with the same characteristics can show a different prognosis, related to high molecular heterogeneity of tumor genetics. We report a rare case that is a 56-year-old woman who has experienced a 5-year free disease after complete remission after standard chemotherapy from stage IIIC ovarian cancer. The disease-free period of up to 5 years after therapy may be related to factors that can be predictors of prognosis, such as age at diagnosis, body mass index, physical performance, cancer cell biology, and the success of surgical response and chemotherapy in these patients.
The Relationship between Anxiety and the Level of Joint Stiffness in Colles Fracture Patients Ariffudin, Muhammad; Az Zahra, Zainab
Mutiara Medika: Jurnal Kedokteran dan Kesehatan Vol 20, No 1: January 2020
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/mm.200138

Abstract

Colles fracture is 15% of the whole fracture incidents in adults, and joint stiffness is the most common complication. Anxiety is one of a variety of factors strongly associated with an increased risk of disability and pain intensity in patients with musculoskeletal disorders. This study aims to identify the relationship between anxiety and the level of joint stiffness in Colles fracture patients. This research is an observational analytic study with a cross-sectional design. Data collection was carried out in the physiotherapy of PKU Muhammadiyah Gamping Hospital from March to October 2018 by interview using a questionnaire. Data were analyzed using the Spearman correlation test. The result of the study with 13 respondents showed 9 people (69.2%) did not experience anxiety, one person (7.7%) experienced mild anxiety, one person (7.7%) was in moderate anxiety, and two others were in severe anxiety (15.4%). Meanwhile, in terms of the level of joint stiffness, three people (23.1%) were in mild stiffness, three people (23.1%) were in moderate stiffness, six people (46.2%) were in severe stiffness, and one person (7.7%) was in highly severe stiffness. Statistical test of the relationship between anxiety and the level of joint stiffness in patients with Colles fracture showed no significant correlation (p=0.808). It can be concluded that there was no relationship between anxiety and the level of joint stiffness in fracture patients.

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