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Mutiara Medika: Jurnal Kedokteran dan Kesehatan
ISSN : 14118033     EISSN : 26140101     DOI : 10.18196/mm
Core Subject : Health,
Jurnal Mutiara Medika Fakultas Kedokteran dan Ilmu Kesehatan (MMJKK) Universitas Muhammadiyah Yogyakarta is a peer-reviewed and open access journal that focuses on promoting medical sciences generated from basic sciences, clinical, and community or public health research to integrate researches in all aspects of human health.
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Articles 934 Documents
Risk Factors of Ovarian Cancer in PKU Muhammadiyah Teaching Hospital Yogyakarta Wenang, Supriyatiningsih; AN, Alfun Dhiya; Pratiwi, Witri Andi; Lelle, Ralph J.; Haier, Joerg
Mutiara Medika: Jurnal Kedokteran dan Kesehatan Vol 20, No 2: July 2020
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/mm.200247

Abstract

Introduction: Ovarian cancer is non-communicable diseases that has a high mortality rate. In PKU Muhammadiyah Teaching Hospital Yogyakarta in 2014-2017, ovarian cancer is 5th out of all types cancers diagnosed. Most of them are asymptomatic in early stage and come to hospital at late stage. Recognize and identify the risk factors of ovarian cancer are very important to prevent the patient from morbidity and mortality. The purpose of this study was to know the relationship between low parity, infertility, age, and family history with ovarian cancer in PKU Muhammadiyah Teaching  Hospital Yogyakarta.Methods: This study was an observational analytical study with cross sectional design. The sample was medical record of women with ovarian cancer and non ovarian cancer in PKU Muhammadiyah Teaching Hospital Yogyakarta period of April 2014-September 2017 with inclusion and exclusion criteria. Data analysis used chi-square test.Result: The bivariat analysis showed that there is no relationship between low parity with ovarian cancer (p=0,790 OR=0,87; 95% CI 0,305-2,466), there is no relation between infertility with ovarian cancer (p=0,104 OR=2,48; 95% CI 0,815-7,545), and there is no relation between family history with ovarian cancer (p=0,304 OR=3,18; 95% CI 0,315-32,039). But there is a relationship between age with ovarian cancer (p=0,01 OR=0,11; 95% CI 0,022-0,510).Conclusion: There are no relations between low parity, infertility, and family history with ovarian cancer. But there is a relationship between age with ovarian cancer.
Expression Level of Cyclin-D1 between Endometriomas and Ovarian Carcinomes Dhiya An, Alfun; Supriyatiningsih, Supriyatiningsih
Mutiara Medika: Jurnal Kedokteran dan Kesehatan Vol 21, No 1: January 2021
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/mmjkk.v21i1.7212

Abstract

Endometrioma on the ovaries is a benign gynecological disorder that is often found in women of reproductive age. The approach was made to the malignant transformation through the study of cyclin-D1 expression. This research aim to analyze differences in the level of Cyclin-D1 expression in ovarian endometriosis and ovarian carcinoma associated with the pathogenesis of endometrioma and ovarian carcinoma. Analytical observational study with cross sectional approach to cyclin-D1 expression between endometrioma and ovarian carcinoma with good and bad differentiation. The research subjects were 20 cases of endometrioma, each of the 20 cases of ovarian carcinoma were well and poorly differentiated. Statistical analysis using the ANOVA test on the level of cyclin-D1 expression between groups. The mean cyclin-D1 expression in endometrioma was 67.25. The mean of well-differentiated ovarian carcinoma was 132.41. The mean of poorly differentiated ovarian carcinoma was 128.83. Anova test resulted in a significant difference between the expression of cyclin-D1 endometrioma and ovarian carcinoma with good and bad differences (p = 0.00 0.05). There is a significant difference between endometrioma and ovarian carcinoma with good and bad differentiation. Endometrioma cyclin-D1 expression was lower than ovarian carcinoma with good and bad differentiation.
Proporsi dan Karakteristik Korban dengan Pelaku Pembunuhan yang ditangani di Instalasi Kedokteran Forensik RSUP Dr Sardjito tahun 2003-2013 Pidada, Ida Bagus Gede Surya Putra; Sista, Kanina
Mutiara Medika: Jurnal Kedokteran dan Kesehatan Vol 14, No 2 (2014)
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/mmjkk.v14i2.9382

Abstract

Pembunuhan yang berkaitan dengan kekerasan merupakan masalah global. Tingkat pembunuhan di Amerika dan Afrika selatan empat kali lebih tinggi dari rata-rata global, sedangkan daerah Eropa, Asia dan Ocenia kasus pembunuhan tergolong rendah. Ini berarti kasus pembunuhan di Indonesia juga lebih rendah dari rata-rata global, walaupun begitu di Daerah Istimea Yogyakarta (DIY) kasus pembunuhan meningkat pada tahun 2013 dibandingkan tahun sebelumnya. Penelitian ini bertujuan untuk mengetahui gambaran dan karakteristik korban dan pelaku pembunuhan. Penelitian ini merupakan penelitian analitik observasional dengan desain cross sectional. Subyek penelitian ini adalah korban pembunuhan yang ditangani di Instalasi kedokteran Forensik RSUP Dr Sardjito tahun 2003-2013. Pada penelitian ini terdapat 339 korban pembunuhan, yang terdiri dari 56,3% korban laki-laki dan 59% berusia dewasa. Sebanyak 81,1% dilakukan otopsi, penyebab kematian terbanyak  77,3% karena trauma tumpul, dengan lokasi tersering di kepala yaitu 47,8%, sebanyak 34,2% korban dibunuh dengan cara dipukul dan 38,6% ditemukan luka tangkis pada korban, korban lebih banyak ditemukan di luar rumah (68,4%) dan terdapat perbedaan yang bermakna (p=0,000) pada tempat kejadian perkara antara laki-laki dan perempuan. Pelaku lebih banyak dilakukan oleh keluarga korban (11,5%) dengan motif terbanyak karena dendam (10,6%). Disimpulkan selama 10 tahun yaitu tahun 2003-2013 didapatkan korban pembunuhan yang ditangani 339 korban, dengan korban laki-laki dan berusia dewasa lebih banyak, penyebab kematian terbanyak karena trauma tumpul di kepala, korban lebih banyak ditemukan di luar rumah, sedangkan pelaku pembunuhan banyak dilakukan oleh keluarga korban dengan motif karena dendam.
Tingkat Kebersihan Mulut (OHI-S) pada Anak SD Kelas VI Di Desa Wonokromo Purwanti, Sari; Widjijono, Widjijono
Mutiara Medika: Jurnal Kedokteran dan Kesehatan Vol 8, No 1 (S) (2008): Januari
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/mmjkk.v8i1 (S).9421

Abstract

Oral hygiene is ones of local factor that has a dominant determination in oral disease. In spite of it, the childrens oral health has an influence on good behavior to oral health status. The behavior is a very complex any thing that involves internal or external aspect, even psychological and physical. Elementary at the age of II -1 2 years of school student has already able to think rationally and precisely based on their mperience, along with the family support, in order to keep oral hygiene, but in the village, the reality of oral hygiene is still low.Based on those thoughts the aim of this research is to found the level of children oral hygiene at the age of II-I2 years. The object of this research is Wonokromo village in the border city of Kebulnen confine between Sawangan village and Kaliputih village. The samples of this research are I13 students that consist of 56 boys and 57 girls from three elementary schools in Wonokromo village. This research uses cross sectional survey to see the level of Oral hygiene in children in the 6"’ year of elementary school. The parameter of this research is oral hygiene index. This research is analyzed by descriptive statistic method with SPSS 14. The result of this research showed that 1.0 as the lowest number of OHI-S, and the highest on 5.6. The average from all of the samples was 2.9 :1: 0.835 (moderate criteria). The good criteria of oral hygiene was found in boys, beside the moderate and low criteria was found in girls, the chi-square result showed that p = 0.835, that means there is no difference between boys and girls (p 0.05). The conclusion of the research that the children in 6th years of elementary school in the Wonokromo village are on the moderate criteria of oral hygiene (OHI-S) level
Effects of AntiMycobacterium Tuberculosis Nanoherbal Legundy Leaf Extract (Vitex trifolia) Dwiyanti, Atika; Mulyani, Siti; Yulhan, Oche Axena; Lubis, Humairah Medina Liza; Roslina, Ance
Mutiara Medika: Jurnal Kedokteran dan Kesehatan Vol 21, No 1: January 2021
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/mmjkk.v21i1.6497

Abstract

Tuberculosis is an infectious disease caused by Mycobacterium tuberculosis. Indonesia ranks 2nd largest in the world after India. Resistance to anti-tuberculosis drugs is one of the difficulties in treating tuberculosis. This research aim to determine the effectiveness of legundi (Vitex trifolia) leaf extract nanoherbal in killing Mycobacterium tuberculosis. This study was conducted with an experimental design using M. tuberculosis colonies taken from 25 samples of aspirate of tuberculosis patients with lymph nodes and then given the ethanol extract of legundi leaves (70% and 90%) with the process of making nanoparticle extracts. The evaluation of the observations was in the form of measuring the inhibition zone for bacterial growth which were categorized as weak ( 5mm), moderate (6-10mm), strong (11-20 mm) and very strong ( 21mm). The results of the study from 6 repetitions found that the inhibition zone category was 0% weak, 39% moderate, strong 52.3%, and very strong 8.7%. Comparison of the concentration of legundi leaf extract to the diameter of the bacterial growth inhibitory zone was analyzed using the Kruskal Wallis test, which found a significant relationship with p value = 0.000 ( 0.05). Legundi's leaf extract can be used as an antibacterial agent for M. tuberculosis. 
Correlation between Body Mass Index to Hypertension in A Rural Area in East Java Kurniawan, Alvin Hartanto; Suwandi, Benedictus Hanjaya; Prakoso, Dicky Teguh; Moksidy, Reynaldy Cliftianto; Talitha, Irma; Anggraeni, Maharani Kartika; Zulkifli, Danang
Mutiara Medika: Jurnal Kedokteran dan Kesehatan Vol 21, No 1: January 2021
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/mmjkk.v21i1.7385

Abstract

Hypertension is one of the most commonly encountered problems in primary health care and a major risk factor for other lethal diseases. Obesity, another arising problem in developing and developed countries, is another major risk factor for metabolic disease. However, studies about both diseases and their intercorrelation in rural areas are still limited. Therefore, we conducted this study to investigate the correlation between body mass index (BMI) and blood pressure in a rural area. This study was an observational, cross-sectional study performed in outpatients at Community Health Care of Ngronggot, a rural area in East Java for one month with inclusion criteria aged 18 years old, systole blood pressure (SBP) ≥140 and/or diastole blood pressure (DBP) ≥90, or a history of anti-hypertensive treatment. Information including age, gender, SBP, DBP, mean arterial pressure (MAP), body weight, and height was collected and calculated for its distribution and correlation using the Spearman rank-order correlation test. There were 201 subjects in this study, 65.7% of which were female, while 34.3% of which are male, and the median age was 59 years old. We also found that more than 60% of our participants were overweight and obese. The results of the Spearman test showed that BMI significantly correlated with SBP (p=0.029), DBP (p=0.016), and MAP (p=0.008). In conclusion, BMI had a positive correlation with blood pressure, and obesity was prevalent in our rural area population.
Knowledge Level about Thalassemia among High School Students in Pontianak City, West Kalimantan, Indonesia Noeriman, Aisya Rezki; Fitrianingrum, Iit; Armyanti, Ita
Mutiara Medika: Jurnal Kedokteran dan Kesehatan Vol 20, No 2: July 2020
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/mm.200248

Abstract

Introduction: Thalassemia is a genetic disorder that affect the formation of hemoglobin and has high prevalent in Indonesia. Awareness of genetic screening as one of steps to prevent thalassemia require adequate knowledge about thalassemia. There is no data refers to knowledge about thalassemia among high school student in Pontianak City meanwhile that data is important as initial data to planning thalassemia prevention program. Objective: This study assessed knowledge about thalassemia among high school students in Pontianak City. Method: This descriptive study assessed 100 high school students in Pontianak City chosen by propotionated stratified random sampling according to the number of high school students in each district. Result: Most respondents have poor knowledge about thalassemia (49%) with more female students have good knowledge (27,1%) than male students (10%). Sources of information used by respondents are internet (44%), school (17%), health workers (17%), seminars (10%), relatives/friends (6%), and print media (6%). Conclusion: Many high school students in Pontianak City has poor knowledge about thalassemia (49%) therefore spreading information about thalassemia is essential to be done through the most information source that used by students which is internet (44%) or health education program with school and health workers are involved (17%).       
Gambaran Diet Anak Usia Sekolah di Desa Sidoharjo, Kulon Progo, terhadap Standar Normal Pertumbuhannya Yoni Astuti; Nur Shani Meida
Mutiara Medika: Jurnal Kedokteran dan Kesehatan Vol 8, No 1 (2008)
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/mmjkk.v8i1.1650

Abstract

Child growth and development are influenced by several factors including hereditary and environment factors. The environment factors that potentially influence child growth and differentiation are diet and health. Diet intake in children is expected to meet the Recommended Dietary Allowance (RDA) to enable good growth and development. The aim of this research is to identify diet description of school children in Sidoharjo District, Kulon Progo towards their normal standard of growth. The research subjects were 63 school children consisting of 33 girls and 30 boys aged 7-12 years old. This research was carried out by filling out a questionnaire consisting of respondent identity and diet survey form to record diet intake for 7 consecutive days. Subjects then underwent general physical examination i.e. bloodpressure, pulse, respiration rate, body height and weight. The results of this research showed that most children ( 80 %) had growth and development under 50% of percentile. The calorie intake was 50 % of RDA. The intake of carbohydrate, protein and lipid of the group of boys was 85,32%; 5,2%; 9,48% respectively. The intake of carbohydrate, protein and lipid of the group of girls was 83,2%; 6,5%; and 10,3% respectively. Therefore, the school children diet was below the RDA level.Pertumbuhan dan perkembangan anak dipengaruhi oleh banyak faktor diantaranya faktor herediter dan lingkungan. Faktor lingkungan yang potensial mempengaruhi pertumbuhan dan perkembangan anak antara lain diet dan kesehatannya. Asupan makanan pada anak di harapkan sesuai dengan RDA(Recommended Dietary Allowance) nya, agar pertumbuhan dan perkembangan anak dapat baik. Penelitian ini bertujuan untuk mengetahui gambaran diet anak usia sekolah (SD) di dusun Sidoharjo Kulon Progo terhadap standard normal pertumbuhannya. Subyek penelitian ini sebanyak 63 anak terbagi atas 33 anak perempuan dan 30 anak laki - laki, dengan kisaran umur 7-12 tahun. Penelitian dilakukan dengan cara mengisi kuesioner yang berisi identitas dan blangko survey diet untuk mencatat semua makanan yang dimakan berturut- turut selama 7 hari. Selanjutnya subjek diperiksa kesehatannya secara umum dengan pemeriksaan tekanan darah, nadi, respirasi, tinggi dan berat badan. Hasil penelitian menunjukkan bahwa pertumbuhan dan perkembangan anak baik perempuan dan laki - laki sebagian besar ( 80 %) di bawah persentil 50%.Asupan kalori hanya terpenuhi 50%nya. Kelompok perempuan asupan karbohidrat, protein dan lemak berturut - turut terpenuhi sebesar 85,32% , protein 5,2% dan lemak 9,48%, sedangkan pada kelompok laki - laki berturut turut 83,2%, 6,5%, dan 10,3%. Kesimpulan penelitian ini adalah diet anak - anak usia sekolah di dusun Sidoharjo, Kulon Progo berada di bawah Standar Normal Pertumbuhannya (RDA).
The Relationship between Knowledge, Information Sources, Family Support and Implementation of Provider-Initiated Testing and Counseling in Pregnant Woman Uci Ciptiasrini
Mutiara Medika: Jurnal Kedokteran dan Kesehatan Vol 20, No 1 (2020): January
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/mm.200140

Abstract

The discovery of cases of HIV and AIDS at the age of under four years old in Indonesia indicates that there is still HIV transmission from mother to child. This study aims to identify the relationship between knowledge, information sources, family support, and the implementation of Provider-Initiated Testing and Counseling (PITC) examinations in pregnant women. This research was analytic descriptive with a cross-sectional approach conducted in August 2018, with 85 respondents selected by accidental sampling. The population in this study were all pregnant women who visited the community health center. Data was collected by giving questionnaires directly to respondents. Relationships between variables were tested with chi-square analysis. The results showed that 36 (62.1%) respondents have good behavior and good knowledge, and the chi-square test results obtained p-value=0.025. Thirty (68.2%) respondents have good behavior and have access to information sources and p-value=0.007. Thirty-three (67.3%) respondents have good behavior and have family support with the p-value=0.004. It can be concluded that there is a relationship between knowledge, information sources, family support, and the implementation of the PITC examination of pregnant women.
Peroksidasi Lipid dan Aktivitas Enzim Pembersih pada Diabetes yang Diinduksi Streptozotocin Yoni Astuti
Mutiara Medika: Jurnal Kedokteran dan Kesehatan Vol 2, No 1 (2002)
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/mmjkk.v2i1.1505

Abstract

Penelitian ini dilakukan dengan tujuan untuk menguji peroksidasi lipid dan aktivitas ensim pembersih pada diabetes yang diinduksi Streptozotocin. Penelitian ini juga dilakukan untuk menetapkan apakah dosis sedang vitamin E sebagai antioksidan nonensimatik berperan utama dalam sistem pertahanan tubuh oleh antioksidan pada tikus hamil dan bayinya. Subyek yang terlibat pada penelitian ini terdiri dari 30 ekor tikus galur Wistar betina normal, yang diberi dosis tunggal Streptozotocin (40 mg/Kg BB) dan dikawinkan 7 hari kemudian. Selanjutnya tikus yang diabetikdibagi dalam 2 kelompok yang sesuai yaitu,kelompok I diberi suplemen vitamin E dengan dosis (30 mg/100 g pakan), dan kelompok II diberi pakan dengan diet standart rendah vitamin E Kelompok kontrol terdiri dari 15 ekor tikus hamil. Pada hari pertama setelah kelahiran tikus di dekapitasi dan hepar induknya dihomogenat dan uterus maupun paru - paru bayi tikus dan hepar di preparasi. Kemudian dilakukan pengukuran untuk parameter - parameter berikut: konsentrasi Malondialdehid (MDA) pada homogenat dan serum darah, kadar Glutathione(GSH), aktivitas superoksida-CuZn dismutase dan Glu¬tathione peroksidase (G-Px) dan Glikemia. Dari hasil yang diperoleh ternyata bayi tikus diabetik lebih kecil dari pada bayi tikus normal,dan kadar gula serumnya jauh lebih tinggi pada bayi tikus diabetik. Kadar MDA meningkat bermakna sedangkan GSH, SOD,dan GPx jauh berkurang pada tikus dewasa diabetik dan bayinya dibandingkan dengan kelompok kontrol. Pada tikus yang diberi suplemen vitamin E, kadar MDA lebih rendah bermakna, Kadar GSH dan aktivitas SOD sangat meningkat pada jaringan-jaringan yang diamati sedangkan aktivitas GPx tetap tidak berubah. Penelitian ini berkesimpulan bahwa dengan mengamati aktivitas ensim - ensim pembersih tertentu, informasi adanya stress oksidatif secara biologi yang terjadi terus menerus serta status janin/bayi dapat diamati. Hasil penelitian ini menunjukkan bahwa tikus hamil diabetik dan anaknya terpapar stress oksidatif yang meningkat, dan suplemen vitamin E mampu menurunkan pengaruh yang menggangu dari stress tersebut

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