cover
Article Per Year (5 Year)
All
Home Page
OAI Link
Editorial Team
Contact
Reviewer
Google Scholar
Contact Name
-
Contact Email
-
Phone
-
Journal Mail Official
pharmacon@ums.ac.id
Editorial Address
Jl. A. Yani 1 Pabelan Kartasura Surakarta 57162 INDONESIA
Location
Kota surakarta,
Jawa tengah
INDONESIA
Pharmacon
Published by Universitas Muhammadiyah Surakarta
ISSN : 14114283     EISSN : 26855062     DOI : -
Core Subject : Health,
Health Professions Medicine & Pharmacology
Pharmacon: Jurnal Farmasi Indonesia is a collection of publication journals, covering all aspects of Pharmaceutical sciences, including Technology of Formulations, Excipients Optimization, Extract and Herbal Standardizations, Pharmacological activity determination on natural sources, Drug Synthesize and Development, Molecular Biology, Antibiotic Screening, Metabolite Profiling and Quantification, Clinical Pharmacy, Health and Environmental issues, published by Faculty of Pharmacy, Muhammadiyah University of Surakarta. We look forward to working with pharmaceutical community of researchers as we are intended to serve as a major resource for pharmaceutical information.
Arjuna Subject : -
Articles 17 Documents
 1   2 
Search results for , issue "Vol 21, Special Issue 1, 2024" : 17 Documents clear
Antioxidant Activity of the Herbal Combination of Black Cumin (Nigella sativa L.) with Soursop Leaves (Annona muricata L.) OR Celery (Apium graveolens L.) Wardatun, Sri; Sofihidayat, Trirakhma; Noorlaela, Ella; Agustin, Vina
Pharmacon: Jurnal Farmasi Indonesia Vol 21, Special Issue 1, 2024
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/pharmacon.v21i0.23466

Abstract

Excessive free radicals in the body can cause various degenerative diseases; antioxidants can reduce the impact of free radical injury. Several plants have been tested for antioxidant activity, including black cumin (Nigella sativa L.), soursop leaves (Annona muricata L.), and celery (Apium graveolens L.). Black cumin is easy to find in several finished products on the market in Indonesia alone or in combination with other ingredients, including soursop leaves and celery. This study aimed to explore the interaction of laboratory-prepared and commercial combinations of black cumin extract with soursop or celery extract. The antioxidant activity of each extract was determined, and the combined antioxidant activity was calculated. The interactions of the combinations were identified based on the interaction factor values. The antioxidant activities were measured using DPPH (2,2-diphenyl-1-picrylhydrazyl) reagent. The results revealed nearly all exhibited strong antioxidant activity, except for black cumin–based commercial combination preparations, which demonstrated weak had antioxidant activity. Moreover, all combination extracts—laboratory made or commercial—had an IF value of 1. Conclusion: The combination of black cumin extract with soursop or celery leaf extract resulted in an antagonistic effect (IF 1) on the antioxidant ability.
Rungia pectinata (Linn.) Nees: A Review of Phytochemical Analysis and Pharmacological Activities Forid, Md. Shaekh; Azuri, Muhammad Saupi bin; Wan Ishak, Wan Maznah; Hossain, Md. Sanower
Pharmacon: Jurnal Farmasi Indonesia Vol 21, Special Issue 1, 2024
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/pharmacon.v21i0.23596

Abstract

Rungia pectinata L. is an herbaceous weed traditionally used for many years for various disease conditions. Nevertheless, these indigenous medical practices are frequently regarded as self-limiting, necessitating a thorough examination of their purported benefits. This review aims to consolidate existing scientific insights and identify domains requiring additional research. The literature was searched using the keyword "Rungia pectinata" OR "Comb Rungia" in well-known scientific databases, including PubMed, Web of Science, and Scopus, and relevant papers were selected for this review. The leaf juice is used as a cooling agent and to treat smallpox in children, reducing pain and swelling. A paste made from the fresh leaves blended with castor oil can heal tinea capitis, a scaly fungoid scalp infection. This plant has a rich tradition of use in treating different disease conditions, such as hepatitis, acute conjunctivitis, children's dyspepsia, dysentery, and lymphoid tuberculosis. Additionally, it exhibits diverse pharmacological activities like antipyretic, anti-inflammatory, diuretic, analgesic, antifungal, and antibacterial effects. This study found that it has secondary metabolites, such as amino acids, glycosides, phenolics, terpenes, phytosterols, tannins, flavonoids, and carbohydrates. Additionally, a total of 38 isolated compounds were identified in essential oils, with the dominant compounds being trans-phytol, hexahydrofarnesyl acetone, and isophytol. However, the phytochemical compositions varied depending on the type of extraction process. R. pectinata presents a promising avenue for medicinal exploration, deeply rooted in traditional practices. This review underscores the need for a more thorough investigation into its diverse therapeutic applications and encourages further research to unlock the plant's full potential.
Reducing Activity of Interleukin-8 (IL-8) Extract of Sea Cucumber (Holothuroidea sp.) in Experimental Animals Induced by Carrageenan Aurum, Mursalina Nanda; Suhendi, Andi; Da'i, Muhammad; Fauzi, Ahmad
Pharmacon: Jurnal Farmasi Indonesia Vol 21, Special Issue 1, 2024
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/pharmacon.v21i0.23471

Abstract

Interleukin-8 is a pro-inflammatory cytokine that plays a role in the inflammatory response. Sea cucumbers (Holothuria sp.) are used as alternative medicines that have anti-inflammatory activity. The study aims to determination of Sea cucumber (Holothuria sp.) as anti inflammation activty based on capability of reducing interleukin-8 (IL-8) on Rats induced by Carrageenan. Experimental research used was a post-test-only control group design. A total of 25 rats were divided into 5 groups, namely negative control, positive control (Na. Diclofenac), and treatment groups given Sea cucumber extract (doses of 45, 90, and 180 mg/ g BW). Carrageenan-induced mouse paw edema model was used for induction of inflammation. IL-8 of Paw tissue were measured by an ELISA reader at 450 nm wavelength. The result showed that treatrment groups has anti-inflammation activity based on IL-8 levels compared to negative and positive controls. The lowest levels of IL-8 showed at a dose of 90 mg/g BW. Based on One-way ANOVA, there were no significant differences of between groups. Sea cucumber has anti-inflammation activity by reducing IL-8 at all dose tested
Cytotoxic of Ethanol Extract of Leaves and Bark Mareme (Glochidion Arborescens Blume.) Against 4T1 Cancer Cells Haryoto, Haryoto; Saputri, Luki Rahmadani Tulus
Pharmacon: Jurnal Farmasi Indonesia Vol 21, Special Issue 1, 2024
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/pharmacon.v21i0.23587

Abstract

Mareme plant (Glochidion arborescens Blume.) is a plant that has the potential to treat cancer. In a study on the leaves and bark of the Mareme (Glocidion arborescens Blume.) plant, tests for antioxidant, antidiabetic, and anti-inflammatory activities were previously carried out. Secondary metabolites that play a role in cytotoxic activity in Mareme plants are flavonoids, and these compounds can specifically kill the progression of cancer cells. This study aims to determine the content of compounds, examine cytotoxic activity, and determine the percentage of living cells in the leaves and bark of Mareme (Glochidion arborescens Blume.). The leaves and bark of Mareme (Glochidion arborescens Blume.) were extracted by maceration using a 96% ethanol solvent, then identification of the compounds was carried out to determine the content contained in the ethanol extract of the leaves and stem bark of Mareme, and then a cytotoxic test was carried out using the MTT assay method. The compounds contained in Mareme leaves are flavonoids, tannins, steroids, saponins, and polyphenolics, while the chemical compounds in Mareme stem bark are flavonoids, tannins, saponins, and polyphenolics. Tests were carried out at concentrations of 500, 600, and 800 µg/mL. The results of the cytotoxic test showed that the value of live cells in the ethanol extract of Mareme leaves (Glochidion arborescens Blume.) was 114.21, 106.21, and 78.91%, respectively. While the value of live cells in the ethanol extract of Mareme stem bark (Glochidion arborescens Blume.) was 59.56, 56.37, and 42.85%, respectively. The higher the concentration, the smaller the living cells produced.
Antidiabetic Activity of Ethanol Extract of Red Castor Roots (Jatropha gossypiifolia L.) in White Wistar Rats Induced by Alloxan Putri, Annisa Nur Lathifah Amanda; Haryoto, Haryoto
Pharmacon: Jurnal Farmasi Indonesia Vol 21, Special Issue 1, 2024
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/pharmacon.v21i0.23467

Abstract

Diabetes mellitus is a metabolic disorder indicated by high blood glucose levels. Red castor is a plant that has potential in the treatment of diabetes mellitus. This study aims to measure the impact of ethanol extract from the roots of the red castor plant (Jatropha gossypiifolia L.) in reducing blood glucose levels in male white Wistar rats that have been induced with alloxan at a dose of 150 mg/kgBW. The study used 25 male mice divided into 5 treatment groups. The negative control group was given distilled water as a substitute for the substance being tested, while the positive control group was given a dose of glibenclamide of 5 mg/kgBW. Apart from that, there were 3 treatment groups that were given extract from red castor root at doses of 25, 50 and 100 mg/kgBW respectively. Treatment was given for 14 days. Alloxan 150 mg/kgBW was used so that mice experienced an increase in blood glucose levels exceeding 200 mg/dL. The results of decreasing blood glucose levels respectively at doses of 25, 50, and 100 mg/kgBW were 101.0 mg/dL, 81.6 mg/dL, and 79.4 mg/dL. The percentage reduction in blood glucose levels obtained at doses of 25, 50, and 100 mg/kgBB was 73.63%, 77.89%, and 80.10%. Based on the results of statistical tests, the effect of using ethanol extract of red castor root at doses of 25 mg/kgBB, 50 mg/kgBB, and 100 mg/kgBB is comparable to using 5 mg/kgBB glibenclamide
The Antihyperglycemic Effects of Glibenclamide and Matoa Leaves Extract (Pometia pinnata J.R. Forst & G. Forst) On Alloxan-Induced Rat Niam, Muhammad Labib Qotrun; Ziah, Nur Khalida; Fadhilah, Arini
Pharmacon: Jurnal Farmasi Indonesia Vol 21, Special Issue 1, 2024
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/pharmacon.v21i0.23665

Abstract

Glibenclamide (GLI) orally treatment for diabetes mellitus has adverse effects, such as hypoglycemia and weight gain. A synergistic effect achieved through the combination of natural constituents provides an alternative method for reducing adverse effects. The aim of this study was to investigate the contribution of 50% ethanol leaves extract (EEDM) to the administration of GLI in alloxan induced rats. A total of 20 rats were divided into 4 groups, namely normal control (NC), negative control, GLI 5 mg/KgBW group, and the combination of GLI 5 mg/KgBW and EEDM 100 mg/KgBW. Fasting blood sugar data (FBG), body weight, urine chemistry for 15 days of treatment measured. The results show that the ability of the GLI-EEDM combination to lower FBG is more effective and can withstand the hypoglycemic effects of GLI, in addition to improving the secretion of glucose in the urine.
Acute Toxicity Test Oral Effervecent Tablet Ethanol Extract of Ramania Leaves (Bouea macrophylla Griffith.) from South Kalimantan Aryzki, Saftia; Budi, Setia; Yanti, Yanti
Pharmacon: Jurnal Farmasi Indonesia Vol 21, Special Issue 1, 2024
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/pharmacon.v21i0.23472

Abstract

Ramania (Bouea macrophylla Griffith.) is a herbal plant that has antioxidant properties and inhibits free radicals. This research aims to evaluate the safety of effervescent tablets of the ethanol extract of ramania leaves with acute toxicity test. The experimental animals used in this research were female Wistar white rats. The acute toxicity test was carried out orally using the fixed dose method in 4 groups of animals with dose groups of 50 (I), 300 (II), 2000 (III) and 5000 mg/kgBW (IV) respectively. Observations were made on the LD50, clinical condition, body weight and pathological condition of the test animals. The results of this study were that there were no animal deaths in all groups of test animals during observation. In clinical conditions, the 4 groups experienced discoloration and hair loss, while in groups III and IV the animals were inactive (weak). Based on the body weight of the test animals from the 4 observation groups, the sig value 0.05 means there is no significant change in the weight of the test group, on day 7 the values are 0.921 and 0.314, meaning there is no significant change in the weight of the test group. However, in the weight group 14 day with a value of 0.031, it means there is a significant difference to the weight of the test group. It can be concluded that the effervescent tablets of the ethanol extract of ramania leaves have an LD50 5000 mg/kg BW with a classification of non-toxic to animals.

Page 2 of 2 | Total Record : 17

 1   2 

Filter by Year

2024 2024


Reset
Filter By Issues
All Issue Vol 21, Special Issue 1, 2024 Vol 20, No 2 (2023) Vol 20, No 1 (2023) Vol 19, No 2 (2022) Vol 19, No 1 (2022) Vol 18, No 2 (2021) Vol 18, No 1 (2021) Edisi Khusus: RAKERDA, SEMINAR, PD IAI JATENG 2021 Vol 17, No 2 (2020) Vol 17, No 1 (2020) Vol 16, No 2 (2019) Vol 16, No 1 (2019) Vol 16, No 1 (2019) Vol 15, No 2 (2018) Vol 15, No 2 (2018) Vol 15, No 1 (2018) Vol 15, No 1 (2018) Vol 14, No 2 (2017) Vol 14, No 2 (2017) Vol 14, No 1 (2017) Vol 14, No 1 (2017) Vol 13, No 2 (2012) Vol 13, No 2 (2012) Vol 13, No 1 (2012) Vol 13, No 1 (2012) Vol 12, No 2 (2011) Vol 12, No 2 (2011) Vol 12, No 1 (2011) Vol 12, No 1 (2011) Vol 11, No 2 (2010) Vol 11, No 2 (2010) Vol 11, No 1 (2010) Vol 11, No 1 (2010) Edisi Khusus: RAKERDA, SEMINAR, PID IAI More Issue