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Pharmacon
Published by Universitas Muhammadiyah Surakarta
ISSN : 14114283     EISSN : 26855062     DOI : -
Core Subject : Health,
Health Professions Medicine & Pharmacology
Pharmacon: Jurnal Farmasi Indonesia is a collection of publication journals, covering all aspects of Pharmaceutical sciences, including Technology of Formulations, Excipients Optimization, Extract and Herbal Standardizations, Pharmacological activity determination on natural sources, Drug Synthesize and Development, Molecular Biology, Antibiotic Screening, Metabolite Profiling and Quantification, Clinical Pharmacy, Health and Environmental issues, published by Faculty of Pharmacy, Muhammadiyah University of Surakarta. We look forward to working with pharmaceutical community of researchers as we are intended to serve as a major resource for pharmaceutical information.
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Articles 345 Documents
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Edisi Khusus: RAKERDA, SEMINAR, PD IAI JATENG 2021 Erindyah Retno Wikantyasning
Pharmacon: Jurnal Farmasi Indonesia Edisi Khusus: RAKERDA, SEMINAR, PD IAI JATENG 2021
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/pharmacon.v0i0.16182

Abstract

Karakterisasi Fisik dan Aktivitas Antioksidan Masker Wajah Gel Pell Off Yang Mengandung Sari Buah Naga (Hylocerus polyrhizus) Ririn Setiawati; Anita Sukmawati
Pharmacon: Jurnal Farmasi Indonesia Vol 15, No 2 (2018)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/pharmacon.v15i2.7245

Abstract

Damaged skin due to free radicals from ultraviolet radiation can be prevented using antioxidants. Red dragon fruit (Hylocereus polyrhizus) containing antioxidants can be made into a peel off gel face mask using gelatin as a gelling agent to be applied easily to the skin. The purpose of this study is to determine the effect of various gelatin concentrations on the physical properties and antioxidant activity of peel off gels containing red dragon fruit juice. The peel off gels face mask were made using various gelatin concentration i.e 7.5% w/w (F1); 10% w/w (F2); and 12.5% w/w and containing 10% w/w red dragon fruit. The peel off gels then evaluated for physical properties and antioxidant activity using DPPH. The result showed that the increasing of the gelatin concentration would increase the drying time and adhesive ability of the peel off gels. The escalation of gelatin concentration from 7.5% w/w (F1) to 10% w/w (F2) did not affect the spreading ability of the peel off gel. However, the spreading ability of the peel off gel decreased with the increasing concentration of gelatin from 10% w/w (F2) to 12.5% w/w (F3). The antioxidant test of peel off gel had an average percentage of inhibition of 9.101% (F1); 12.469% (F2); and 15.109% (F3). Based on the results of physical properties and antioxidant activity showed that formula 2 was recomended.
Front Matters Vol.17 No.1 Erindyah Retno Wikantyasning
Pharmacon: Jurnal Farmasi Indonesia Vol 17, No 1 (2020)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/pharmacon.v17i1.11492

Abstract

POTENSI DAUN SALAM (Syzigium polyanthum Walp.) DAN BIJI JINTEN HITAM (Nigella Sativa Linn) SEBAGAI KANDIDAT OBAT HERBAL TERSTANDAR ASAM URAT Muhtadi Muhtadi
Pharmacon: Jurnal Farmasi Indonesia Vol 13, No 1 (2012)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/pharmacon.v13i1.24

Abstract

Pengujian aktivitas antihiperurisemia secara in vivo dari ekstrak tunggal dan kombinasi ekstrak serta standarisasi ekstrak dari daun Salam (Syzigium polyanthum Walp) dan biji Jinten Hitam (Nigella sativa Linn) telah dilakukan. Ekstraksi daun Salam dan Jinten Hitam dilakukan metode infundasi. Ekstrak dari masing-masing bahan,  diuji antihiperurisemia secara in vivo terhadap mencit putih jantan galur Balb-C yang diinduksi dengan potasium oksonat dosis 250 mg/kgBB. Kadar asam urat setelah pemberian ekstrak tunggal daun Salam dan Jinten Hitam dosis 200 mg/kgBB masing-masing adalah sebesar 0,640 dan 1,20 mg/dL. Sedangkan kombinasi ekstrak daun Salam-Jinten Hitam adalah sebesar 0,840 mg/dL. Ekstrak Secara keseluruhan berdasarkan hasil pemeriksaan standar umum ekstrak tumbuhan obat, kedua bahan yang diteliti telah memenuhi persyaratan yang dipersyaratkan oleh Badan POM RI Kata kunci : Syzigium polyanthum Walp, Nigella sativa Linn, antihiperurisemia, standarisasi ekstrak 
ANALISIS MUTU MINYAK ATSIRI BUNGA CENGKEH (Syzygium aromaticum (L.) Meer. & Perry) DARI MALUKU, SUMATERA, SULAWESI DAN JAWA DENGAN METODE METABOLOMIC BERBASIS GC-MS Rima Munawaroh
Pharmacon: Jurnal Farmasi Indonesia Vol 11, No 2 (2010)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/pharmacon.v11i2.56

Abstract

Cengkeh (Syzygium aromaticum (L.) Meer. Perry) merupakan salah satu tanaman penghasil minyak atsiri. Mutu minyak cengkeh ditentukan oleh sifat fisik dan kandungan metabolit. Penelitian ini dilakukan bertujuan untuk mengetahui metabolit yang ada di dalam minyak kuncup bunga cengkeh dari Maluku, Sumatera, Sulawesi, dan Jawa. Kuncup bunga cengkeh kering didestilasi uap dan air. Destilasi direplikasi 3 kali untuk setiap daerah. Minyak atsiri diuji indeks bias, organoleptis, bobot jenis dan dianalisis menggunakan GC-MS dengan kolom RxiTM-1MS, flow rate helium 5,3 mL/menit, dengan temperature programming 50–245oC (kenaikan 10oC/menit). Penentuan metabolit dilakukan dengan cara membandingkan spektra massa sampel dengan internal Willey Library. Hasil yang diperoleh dianalisis menggunakan metode analisis Cluster. Pengelompokan didasarkan pada keberadaan senyawa dan %area masing-masing senyawa. Hasil penelitian menunjukkan minyak atsiri bunga cengkeh dari Maluku dan Jawa mempunyai metabolit yang lebih banyak dan mempunyai kadar senyawa mayor yang lebih tinggi dibanding minyak atsiri bunga cengkeh dari Sumatera dan  Sulawesi. Kata kunci: Cengkeh (Syzygium aromaticum (L.) Meer. Perry), metabolit, kuncup bunga, GC-MS.
Kajian Drug Related Problems (DRPs) Terhadap Pengobatan Pasien Stroke Iskemik di Rumah Sakit Pusat Otak Nasional Jakarta Periode Januari – Desember 2015 S Okpri Meila; Handika Indri Rochana
Pharmacon: Jurnal Farmasi Indonesia Vol 14, No 2 (2017)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/pharmacon.v14i2.5765

Abstract

This study aims to determine the percentage of DRPs of ptients with ischemic stroke at Brain Center National Hospital Jakarta. Based on data from the WHO 2006, each year there are approximately 13 million new stroke patients of which approximatelly 4,4 million of them die within 12 months.When patients undergo a treatment, most patients achieve optimal results that heal diseases suffered by patients but not least the failure in therapy. Therefore, the contribution required to identify, resolve and prevent problems in drug therapy known as Drug Related Problems (DRPs). The method used in this study is cross sectional. Total sample data obtained as many as 360 samples. The results showed indications without drugs of 55.62%, drugs without indication of 15.17%, drug interactions of 10.11%, patients fail to receive the drug of 7.86%, side effects of 6.18% and less drug selection right of 5.06%. Data show that the highest percentage of DRPs are indications without drugs.
Penggunaan Obat Off-Label dan Unlicensed pada Bayi dan Neonatus di Bangsal Anak Zakky Cholisoh; Siti Alfiatur Rohmah
Pharmacon: Jurnal Farmasi Indonesia Vol 17, No 1 (2020)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/pharmacon.v17i1.10828

Abstract

The prescription of medications outside the listed marketing authorizations (MA) is considered off-label. This practice is still frequently occurs in clinical practice. One of the reasons is because the lack of clinical trials and research in babies and neonates. This study was conducted to evaluate the off-label and unlicensed medications, their level of use and further describe the level of evidence of the commonly prescribed off-label and unlicensed medication in this population. Medications prescription and administration to hospitalised babies and neonates were recorded. Medication record data in a year were collected. Medication- licensing status of all drugs administered was determined according to marketing authorization information from monograph. The data then were categorised as off-label and unlicensed if the indication, dosage regimens, age category, and route of administration were not listed in the market authorization of the products. Furthermore the administrations of the most commonly used off-label medications were reviewed based on published journal articles to determine their level of evidence. Total medications administered during a year were 2,576 which were obtained from 139 patients. Of all, 15.25% (339) and 2.69% (69) medications administered were categorised as off-label and unlicensed respectively. Off-label of dosage regimens and route of administration were not identified, but 1.63% (42) medications were used for indications that were not listed in the (MA), and 13,63% (351) were prescribed out of age category of the listed marketing authorization. Off-label drug that often prescribed are salbutamol which had no evidence to support its use; valproic acid which had high level of evidence against its use on baby and neonates; and ondancetron which had high level of evidence to be used outside its marketing authorization.
UJI AKTIVITAS PENANGKAP RADIKAL BEBAS DAN PENETAPAN KADAR FENOLIK TOTAL EKSTRAK ETANOL TIGA RIMPANG GENUS CURCUMA DAN RIMPANG TEMU KUNCI (Boesenbergia pandurata) Muhammad Da'i
Pharmacon: Jurnal Farmasi Indonesia Vol 12, No 1 (2011)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/pharmacon.v12i1.47

Abstract

Radikal bebas bersifat sangat reaktif sehingga sangat mudah menyerang sel- sel sehat di dalam tubuh yang berujung pada timbulnya suatu penyakit. Tubuh memerlukan antioksidan dari luar untuk melindungi tubuh dari serangan radikal bebas. Beberapa jenis curcuma dan rimpang temu kunci mengandung senyawa fenolik yang mempunyai aktivitas antioksidan. Penelitian ini dilakukan untuk mengetahui korelasi antara aktivitas penangkap radikal bebas dan kadar fenolik yang terdapat dalam rimpang kunyit (Curcuma domestica), rimpang temulawak (Curcuma xanthorriza), rimpang temu putih (Curcuma zedoaria) dan rimpang temu kunci (Boesenbergia pandurata). Penentuan potensi aktivitas penangkap radikal bebas menggunakan metode DPPH dengan pembanding vitamin E. Kadar fenolik total diukur sebagai GAE menggunakan pereaksi Folin-Ciocalteu. Besarnya korelasi dihitung menggunakan persamaan regresi linear dan dilihat nilai R2. Aktivitas penangkap radikal bebas (IC50) ekstrak etanol rimpang kunyit (29,64 µg/mL) memiliki aktivitas paling tinggi, tetapi lebih rendah dari vitamin E (12,55 µg/mL). Kadar fenolik total (GAE) tertinggi adalah ekstrak etanol rimpang rimpang kunyit (179,71 mg/g). Terdapat korelasi positif antara aktivitas penangkap radikal bebas dan kadar fenolik total dalam empat ekstrak tersebut dengan koefisien korelasi R2 = 79,56 %. Kata kunci: antioksidan, fenolik total, DPPH, korelasi.
EFFECT OF BLACK RICE BRAN EXTRACT (Black Rice Bran) TO DECREASE DECREASE OF GLUCOSE LEVEL IN DIABETIC RATS Novita Sari; Arifah Sri Wahyuni
Pharmacon: Jurnal Farmasi Indonesia Vol 14, No 1 (2017)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/pharmacon.v14i1.539

Abstract

Black rice bran is one of processed foods derived from plants and has a decreasing effect of blood glucoselevels. Major component of anthocyanin in black rice bran that functions in lowering blood glucoseconcentration is cyanidin 3-glucoside. Fifteen male rats Sprague-Dawley strain were selected randomly anddivided into 5 groups with the same number in each groups. These groups were consisted of normal control,negative control, and black rice bran extract treatment with dose of 50, 100 and 200 mg/kg of bodyweight(b.w.). Each of them were induced to experience diabetes by alloxan 150 mg/kg of b.w. Measurement ofblood glucose levels was done by using visible spectrophotometer at 546 nm. The samples were collectedbefore and after alloxan injection, and after 4, 7, and 10 days later to observe the changes of blood glucoselevels. The results showed that black rice bran at 200 mg/kg of b.w. was able to lower the glucose levels,which amounted for 131,33 ± 8,08 mg/dL after 10 days of injection.
Efek Pemberian Ekstrak Etanol Buah Adas (Foenicullum vulgare Mill.) terhadap Kadar Hormon Prolaktin Tikus Putih Betina Post Partum Ahwan Abdul; Fridah Wahyu Safitri; Rantika Purbowati
Pharmacon: Jurnal Farmasi Indonesia Vol 17, No 1 (2020)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/pharmacon.v17i1.9245

Abstract

Fennel plants are plants that have various traditional properties, such as facilitating breast milk or lactagogum. The aim of this research was to give ethanol extract of fennel fruit to increase the level of the hormone prolactin in lactating mice, so that the milk produced was increased. Subjects consisted of 12 postpartum female rats, divided into 1 control group (1% CMC Na) and 3 treatment groups (doses of 100, 500 and 1000 mg / Kg BW). Fennel fruit extract was given orally for each group for 14 days, after the treatment of blood samples were taken and centrifuged, the serum was read by Elisa Reader. The data obtained were analyzed using the Kolmogorov-Smirnov test, one-way ANAVA and Tukey's Multiple Comparison (post hoc test). Fennel fruit extract given from a dose of 100; 500 and 1000 mg / kg BW can significantly increase levels of the hormone prolactin (p 0.05) in nursing mice, respectively by 42.11; 44.26 and 43.83 ng / mL compared to controls (32.64 ng/mL).

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