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Majalah Obat Tradisional

TradMedJ
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Published by Universitas Gadjah Mada

ISSN : 14105918 EISSN : 24069086 DOI : -

Core Subject : Health,

Health Professions Medicine & Pharmacology Public Health

raditional Medicine Journal (Majalah Obat Tradisional), or Trad. Med. J. (ISSN 1410-5918 (print) and ISSN 2406-9086 (online)), is an international scientific journal published by Faculty of Pharmacy, Universitas Gadjah Mada, three times annually. Collaborating with Indonesian Pharmacist Association, Daerah Istimewa Yogyakarta, and we dedicate our journal to researches and development in traditional medicine. The journal receives papers on research laboratory, field research, and case studies of traditional medicine and its constituent, covering research topics including raw materials, cultivation, phytochemical, pharmacological effects and toxicology, formulation, and biotechnology.

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Articles 10 Documents

Search results for , issue "Vol 23, No 2 (2018)" : 10 Documents clear

Gastroprotective Effect of Combinations of Cincau Leaves and Mangosteen Peel on Ethanol-Induced Gastric Damage Wahyu Widyaningsih; Eka Novyyanti Sary; Dessy Nur Halimah; Wa Ode Miftahul Jannah
Majalah Obat Tradisional Vol 23, No 2 (2018)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Gastric ulcer is still a health problem in Indonesia. The leaves of cincau (Cyclea barbata Miers) and mangosteen peel (Garcinia mangostana Linn) have been investigated to have gastroprotective effects. This study aims to determine the effect of gastroprotector from the combination of Cincau leaves and mangosteen peel. This study used the post test only control group design. Wistar male rats were divided into 6 groups. Group I was a healthy control group and the second group was an untreated negative control. Group III is positive group treated with Ranitidine (0.016 g / kg BW). Groups IV, V, and VI were given green leaves of cincau (13.5 g / kg BW), mangosteen peel (25 g / kg BW) and 1: 1 combination. Treatment was performed for 14 days. On day 14 1 hour after treatment, all groups (except group I) were given 96% oral ethanol induction at a dose of 5 g / kg BW. On the 15th day the animals were sacrificed by means of anesthesia using chloroform. The area of the tukak is calculated by ImageJ and then calculates the index parameters of the ulcer and the protection ratio. The stomach is made of a hitopathologic preparation with Hematoxylin and Eosin (HE) and Immunohistochemistry (IHC) preparations to observe COX-2 expression. The index data of ulcer, protection ratio, gastric mucosal damage score and number of cells expressing COX-2 were statistically analyzed by SPSS program. The results showed that the combination of green leaves and mangosteen leaf ratio of 1: 1 had a gastroprotective effect by inhibiting the gastric induced index, increasing the ratio of protection, reducing total mucosal damage and inhibiting the expression of COX-2 protein in rat stomach cells significantly (p <0 , 05). Giving combination of Cincau leaf and mangosteen peal of 1: 1 able to give gastroprotective effect.

Antinociceptive Activity of Aqueous Fraction of Kratom Leaves Mitragyna speciosa Korth.) on Male Swiss Albino Mice Widia Indri Nugraha; Robiyanto Robiyanto; Sri Luliana
Majalah Obat Tradisional Vol 23, No 2 (2018)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Kratom (Mitragyna speciosa Korth.) has been known to have an analgesic opioid effect (antinociceptive). The major compound of kratom leaf is mitraginin, which has strong affinity on opioid receptor. The aim of this research is to prove antinociceptive effect of aqueous fraction of kratom leaf and its effective dose. The simplicia of kratom leaf was extracted with methanol 96%. Methanol extract fractioned with n-hexane, dichloromethane, ethyl acetate, and aquadest. This research used hot plate method on male Swiss Albino mice. The subject divided to 5 groups, negative control group, morphine 5,46 mg/kgBW, aqueous fraction 140, 240 and 560 mg/kgBW. Latency time was measured every 15 minutes over 2 hours period. Analytic statistical of latency time using One Way ANOVA shows that the aqueous fraction at the dose of 140, 280 and 560 mg/kgBW significantly differentiate with negative control group and positive control group. The antinociceptive effect increases with increasing doses. The three doses showed that the antinociceptive effect was no better than the positive control (Morphine)

Acute Tocixity of Sterculia quadrifida R.Br Bark Ethanol Extract on Sprague-Dawley Rats Siswadi Siswadi; Grace S. Saragih
Majalah Obat Tradisional Vol 23, No 2 (2018)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Faloak (Sterculia quadrifida R.Br) is a medicinal plant used by people in the province of East Nusa Tenggara to treat hepatitis. This study aims to determine the acute toxicity of faloak (Sterculia quadrifida R. Br) bark ethanol extract in Sprague-Dawley (SD) male white rats. The method used is experimental using post-test only control group design. In this study the parameters used are body weight, clinical symptoms, clinical biochemistry (ALT & AST), histopathology of liver organ and mortality in rats. Twenty male Sprague-Dawley rats were randomly assigned to 5 groups, group 1 as control, group 2 was administered orally faloak bark ethanol extract at dose of 40 mg / kg body weight, group 3 at dose of 200 mg / kg body weight, group 4 at dose of 1000 mg / kg body weight and group 5 at dose of 5000 mg / kg body weight. Results of observation for 24 hours there are no dead rats, so the value of LD50 extract ethanol faloak is > 5,000 mg / kg body weight. Observations were conducted for 14 days to observed delayed occurrence of toxic effects. Oral administration of the faloak bark ethanol extract reduced the level of AST and ALT. The histopathology observation of rats liver cells showed liver cell necrosis at treatment doses of 200 - 5,000 mg / kg body weight.

Physical and Chemical Stability Test of SNEDDS (Self-nanoemulsifying Drug Delivery System) and Nanoemulsion Ethyl Acetate Fraction of Garcinia mangostana L. Liza Pratiwi; Achmad Fudholi; Ronny Martien; Suwidjiyo Pramono
Majalah Obat Tradisional Vol 23, No 2 (2018)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

The mangosteen peels (Garcinia mangostana L.) has high free radical scavengers activity. This study aims to determine the physical and chemical conditions that are formulated in SNEDDS and nanoemulsion preparations. SNEDDS was made with various concentrations of Tween 80, PEG 400, and Virgin Coconut Oil (VCO) with a ratio of 4,98:1,02:1. Nanoemulsions were made with the addition of water to SNEDDS. Stability observation results were analyzed by statistics. The results of physical stability test show that all test samples in the research, in nanoemulsion, SNEDDS fraction, base SNEDDS, SNEDDS vitamin E did not undergo separation, precipitation, cracking, and creaming. On the chemical stability test of nanoemulsion and SNEDDS fraction there is no difference between IC50 before and after storage. While on basic SNEDDS and vitamin E nanoemulsion there is a difference between IC50 before and after storage.

Apium graveolens Prevents Intrauterine Growth Restriction via Suppression of Antiangiogenic Factor Production Exma Mu'tatal Hikmah; Paulus Liben; Widjiati Widjiati
Majalah Obat Tradisional Vol 23, No 2 (2018)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Preeclampsia is the worldwide leading cause of fetomaternal morbidity and mortality which involves the placental dysfunction. A poor placentation and formed of non-dilated spiral artery caused utero-placental circulation insufficiency, resulted in inadequate supply of nutrients and oxygen to support normal aerobic growth of the fetus. Apium graveolens or celery has been widely known as antioxidant, antiinflammation and antihypertensive with flavonoid-apigenin as main active compound. Apigenin can inhibit TNF-α, HIF-1α and nitric oxide blocking as major pathophysiological pathway of preeclampsia. This study was aimed to find how the Apium graveolens can improve intrauterine growth and its correlation with suppression of anti-angiogenic factor sFlt-1 in anti-Qa2 preeclampsia animal model. Twenty female BALB/c Mus musculus were divided into 4 groups: control, anti-Qa2 and anti-Qa2 with 500 and 1000 mg/kgBW celery herbs extract. The fetal weights and lengths, placental weights and serum sFlt-1 levels were measured and analyzed with One Way ANOVA and further tested with Least Significance Difference in 95% confidence interval. The result showed a difference between control and treatments group (p≤0.05) with 1000 mg/kgBW significantly increase intrauterine growth and decrease sFlt-1, then there is a negative correlation between intrauterine weight and serum sFlt-1. This study suggests that celery herbs extract (CHE) has an apigenin-flavonoid compound which can prevent intrauterine growth restriction (IUGR) via suppression of antiangiogenic factor production in preeclampsia mice model.

Topical Anti-inflammatory Activity of Bangle (Zingiber cassumunar Roxb). Ethanolic Extract in Mice Induced By Carrageenan Endang Dwi Wulansari; Subagus Wahyuono; Marchaban Marchaban; Sitarina Widyarini
Majalah Obat Tradisional Vol 23, No 2 (2018)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Rhizome of bangle (Zingiber cassumunar Roxb.) is one of the materials that are traditionally used in the traditional preparation to maintain skin from redness. The content of chemical compound in bangle rhizomes has many benefits, including inhibition of the inflammatory processes. This study aims to determine the topical anti-inflammatory activity of ethanolic extract of bangle rhizomes in mice induced by carrageenan. Thirty five female Swiss mice were used in this study. Animals were divided into 7 group of five: normal group, carrageenan 2% group, carrageenan 2% group plus control of basis (Biocream®), carrageenan 2% group plus 2.5% hydrocortisone cream, and carrageenan 2% group plus cream of ethanolic extract of bangle rhizomes with the concentration of 1%, 2.5% and 5% w/w. Carrageenan 2% was injected subcutaneously in all treatment group except normal group. The skinfold thickness of mice was measured every 1 hour for 6 hours after carrageenan injection. Results of this study shows that there is a significant differences between treatment groups (p <0.05) compared to carrageenan 2% treated group. To conclude, ethanolic extract of bangle rhizomes has topical anti-inflammatory in mice induced by carrageenan.

Effects of Centella asiatica L. Capsul on Muscle Disfunction on Elderly People I Dewa Putu Pramantara; Nyoman Nyoman Kertia; Mae Sri Hartati Wahyuningsih; Nur Arfian
Majalah Obat Tradisional Vol 23, No 2 (2018)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Pegagan (Centella asiatica L) has been traditionally used to treat wounds, disordered nerve system, blood circulation, and prevent muscle disorders. Extract of Pegagan was considered safe and non-toxic as the acuut and chronic toxicity tests on male SD rats were not significant. It meant that further study was potential to be proceeded. Study of C.asiatica on muscle function of the elderly has not been done, therefore this study is aimed to observe effects of C.asiatica extract on muscle masses, holding hands, walking speed (4.57 meter), walking test (6 minutes), and Time Up and Go test of the elderly. This study is designed for clinical double blind study with 2 groups of people, these are C. asiatica (18 people) treated with capsul (550 mg C. asiatica extract/day for 90 days) and placebo (17 people). This study is performed in the RSUP Dr. Sardjito hospital at the geriatric division. Subjects for this study were healthy elderly people and fit with the criteria of subjects for experiment. Result of the study, muscle masses do not decrease and all the measurements are not different with that of placebo. Except that the walking speed (6 minutes) of the treated subjects is better than that of the placebo. The conclusion of the study, the capsul containing C. asiatica extract (550 mg, once a day for 90 days) increases the strengh of hands holding, and the walking test (6 minutes) almost twice better than that of the placebo although the muscle masses does not increase significantly.

Effect of Leaf Syzygium aromaticum on Lymphocytes and Macrophages Mice Balb/c Syahran Wael; Theopilus Wilhelmus Watuguly; Didik Wahyudi
Majalah Obat Tradisional Vol 23, No 2 (2018)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Syzygium aromaticum as an immunomodulator contains main active compound eugenol which is able to stimulate lymphocyte proliferation and the production of macrophages. Lymphocytes have a very important role to provide protection in the body against infection. This study aims to prove the effects of extract Syzygium aromaticum leaf against increased proliferation of lymphocytes, lymphoblast and macrophages of mice Balb/c of induced Salmonella typhimurium. The method used in this study was experimental with post test only control group. Mice Balb/c were divided into 4 groups as a control group and treatment induced of Salmonella typhimurium. The first treatment group were administrated extracts of 15mg /kgbw, the second treatment 75mg/kgbw, the third treatment of 150mg/kgbw for 12days. ANOVA test showed a significant difference in lymphocyte proliferation but not lymphoblast and macrophages.

Toxicity Study of Volatile Oil Boesenbergia pandurata (Roxb) Schlecht Rhizome to Larvacide of Aedes aegypti and GC-MS Profile Widyasari Putranti; Saiful Bachri
Majalah Obat Tradisional Vol 23, No 2 (2018)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Boesenbergia pandurata (Roxb) Schlecht has been recognized by society as traditional drug for a long time. The active constituent of this plants especially the volatile oil, which contains monoterpenes and sesquiterpenes. The use of Boesenbergia pandurata (Roxb) Schlecht rhizome which is a botanical insecticide shows higher safety because the molecule is easily broken down into harmless compounds against the environment. The aim of this research were to know about the activity of larvacide from the volatile oil of Boesenbergia pandurata (Roxb) Schlecht rhizome and also to analyze its chemical compounds using GC-MS. The volatile oil was isolated from Boesenbergia pandurata (Roxb) Schlecht with steam and water destillation method. The volatile oil in the aqueous ethanol 70 % v/v was made as the test solution for larvacide. The concentrations of the volatile oil of Boesenbergia pandurata (Roxb) Schlecht rhizomes used were 150 ppm; 201 ppm; 270 ppm; 362 ppm; 485 ppm; 650 ppm. Abate was used as positive control at concentration 0,001 ppm; 0,0025 ppm; 0,0065 ppm; 0,016 ppm; 0,04 ppm; 0,1 ppm while aqueous ethanol 70 % v/v was used as negative control. Each treatment were used 20 larvaes of Aedes aegypti and was observed during 24 hours. The data of died larvae were counted to estimate the values of LC50 with probit analysis method. The chemical compound of volatile oil of Boesenbergia pandurata (Roxb) Schlecht was analyzed by the GC-MS. The results of this research showed that the volatile oil of Boesenbergia pandurata (Roxb) Schlecht have clear-brass colour, bitter taste, typically aromatic, rendemen equal to (0,25 ± 0,011) % v/w and refractive index 1,4818. The value of LC50 for the volatile oil of Boesenbergia pandurata (Roxb) Schlecht rhizome is (407,06 ± 31,6985) ppm while abate equal to (0,0132 ± 0,0013) ppm. This matter indicates that abate more potent to larvae of Aedes aegypti. The result of analyze the component of the volatile oil of Boesenbergia pandurata (Roxb) Schlecht by the GC-MS obtained of 15 peak chromatogram and 6 peak which has identified showed the possibility the existence of champene, eucalyptol, ocimene, camphora, geraniol, methyl cinnamate.

Determination of γ-oryzanol, Phenolic total content, and (2,2-difenil-1-picrylhydrazyl) Radical Scavenging Activity in Different Varieties of Rice (Oryza sativa) in Yogyakarta, Indonesia Erna Prawita Setyowati; Andayana Puspitasari Gani
Majalah Obat Tradisional Vol 23, No 2 (2018)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

In Indonesia, beras (Oryza sativa) has become the main ingredient in natural beauty products such as masks, scrubs, and cold powder. γ-oryzanol and phenolic compounds are the major components in beras that have many benefits, one of which as antioxidants. This study aims to determine the content of γ-oryzanol and total phenolic compounds in different beras cultivars in the area of Yogyakarta. The leveling was done by a TLC-densitometry method and Folin Ciocalteu. The results showed that the largest γ-oryzanol content found in red beras was 0.0843% by weight of the sample. The highest total phenolic content was found in red beras as much as 1.92% by weight of the sample. The antioxidants activity IC50 Red Beras is 0.591.

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Pudyastuti Kusumaningrum

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Kab. sleman,

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