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Majalah Obat Tradisional
Published by Universitas Gadjah Mada
ISSN : 14105918     EISSN : 24069086     DOI : -
Core Subject : Health,
Health Professions Medicine & Pharmacology Public Health
raditional Medicine Journal (Majalah Obat Tradisional), or Trad. Med. J. (ISSN 1410-5918 (print) and ISSN 2406-9086 (online)), is an international scientific journal published by Faculty of Pharmacy, Universitas Gadjah Mada, three times annually. Collaborating with Indonesian Pharmacist Association, Daerah Istimewa Yogyakarta, and we dedicate our journal to researches and development in traditional medicine. The journal receives papers on research laboratory, field research, and case studies of traditional medicine and its constituent, covering research topics including raw materials, cultivation, phytochemical, pharmacological effects and toxicology, formulation, and biotechnology.
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Articles 10 Documents
 1 
Search results for , issue "Vol 26, No 3 (2021)" : 10 Documents clear
Gel Formulation from Ethanol Extract of The Leaf of White Guava (Psidium guajava L.) Rety Setyawaty; Gustin Gustin; Ragil Setiyabudi
Majalah Obat Tradisional Vol 26, No 3 (2021)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/mot.59725

Abstract

White guava is a plant that can grow easily in Indonesia. As a source of vitamin C, white guava leaves have been used as antidiarrheal drugs. Some studies state that white guava leaves contain antioxidants. Aside from having a selling value, white guava leaves are also used as raw materials for facial cosmetics, namely as raw materials for gel. Flavonoids are a large family of plant secondary metabolites that have various and amazing biological functions, including as antioxidants. The study aims to determine the gel preparation formulation of the white guava leaf extract (Psidium guajava L.) as a good antioxidant and the characteristics of the preparation. To extract the active substance in simplicia, maceration is used by using ethanol extract processes. The gel making uses a CMC-Na base. Formulation I uses a concentration of CMC-Na 0.1 gram. Formulation II uses a concentration of CMC-Na 0.3 grams. Formulation III uses a concentration CMC-Na 0.6 gram. The main raw material is 0.2 grams of white guava leaf ethanol extract for each formulation. The maceration process uses 70% ethanol. 250 grams of white guava leaves are used. The yield obtained was 13.92%. The gel product was analyzed organoleptic test, pH test, dispersion test, homogeneity test, and adhesion test. The results showed that the CMC-Na 0.1-grams, 0.3 grams CMC-Na, and 0.6-grams CMC-Na had a distinctive odor of white guava leaves, brownish color, and thick concentration. The gelling product is homogeneous and pH of 6. The formulations under CMC-Na 0.6 grams have good dispersibility. All formulations have good adhesion. The adhesion is more than 4 seconds. The conclusions are the formulation with CMC-Na 0.6 grams fulfills the requirements for topical gel preparation.
In Vivo Antihypercholesterolemic Potential of Uncaria cordata (Lour.) Merr as Ethanolic Extract Meiriza Djohari; Mira Febrina; Tri Wahyuni
Majalah Obat Tradisional Vol 26, No 3 (2021)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/mot.64531

Abstract

The present investigation aims to evaluate the antihypercholesterolemic potential of Uncaria cordata (Lour.) Merr. as an ethanolic extract in diet-induced hypercholesterolemic male white mice model. In this study, white mice were segregated into 6 groups; all the groups except the normal control group were given a high-fat diet to induce hypercholesterolemia. After induction of cholesterolemia, normal and negative control groups were treated with NaCMC, the positive control group was treated with atorvastatin, and the remaining three groups received ethanolic extract Uncaria cordata (Lour.) Merr. in three doses (100, 200, and 400 mg/Kg BW) for a treatment period of 29 days. Measurement of cholesterol levels was performed on days 0, 15, 22, and 29 using EasyTouch® GCU digital devices. The results were analyzed by one way ANOVA test and ANOVA Repeated test. The results showed that the ethanol extract of the Uncaria cordata (Lour.) Merr. root plant dose 100, 200, and 400 mg/Kg BW effect in lowering total cholesterol in male white mice significantly (P <0,05). Ethanol extract from Uncaria cordata (Lour.) Merr. a dose of 200 mg/Kg BW showed a better decrease in cholesterol levels on day 29 compared to day 22.
The Effect of Red Betel Leaf (Piper crocatum) and Moringa Leaf Extracts on Endometritis Levels in Aceh Cows Rosmaidar Rosmaidar; Meutia Handayani; Fadillah Fadillah; Teuku Armansyah; Tongku Nizwan Siregar; Hafizuddin Hafizuddin; Husnurrizal Husnurrizal
Majalah Obat Tradisional Vol 26, No 3 (2021)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/mot.64626

Abstract

This study aims to determine the ability of red betel leaf (Piper crocatum) or Moringa leaf extracts to reduce the endometritis level in Aceh cattle. In this study, six Aceh cows aged 3-5 years, weighing 150-250 kg from the Experimental Animal Technical Implementation Unit of Faculty of Veterinary Medicine of Syiah Kuala University were used. The cows were divided into two treatment groups, namely cows with endometritis that were given red betel leaf extract (T1) and cows with endometritis that were given Moringa leaf extract (T2). Examination of the endometritis levels was carried out before and after treatment using the White Side Test (WST) method. The collection of estrus cervical mucus was needed for the WST examination, and heat induction was performed with prostaglandin F2 alpha (PGF2α) at a dose of 25 μg. Collection of cervical mucus was performed 8-12 hours after the initiation of heat. All cows with endometritis were given intrauterine extracts of red betel leaves or Moringa leaves at a concentration of 20% every 24 hours for a week at a solution volume of 20 ml. The data were then analyzed using a paired t test. The mean endometritis levels before and after treatment on K1 vs. K2 were 3.0 and 1.7 vs. 2.7 and 2.7, respectively (P<0.05). It was concluded that red betel leaf extract at a concentration of 20% was more effective in reducing the endometritis level of Aceh cows than Moringa leaf extract.
The Extract of Purple Sweet Potato Against Heat-Shock Protein 70 Expression in White Male Rat of Atherosclerosis Model Meddy Setiawan; Fitriana Yulanda
Majalah Obat Tradisional Vol 26, No 3 (2021)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/mot.66254

Abstract

Shock protein 70 (Hsp-70) molecule is pro-inflammatory mediator cytokine that trigger atherosclerosis. The purple sweet potato has many natural antioxidants such as flavonoids (anthocyanins) and is valuable for reducing Hsp-70 expression due to its antioxidant content.This study aims to determine the effect of purple sweet potato (Ipoema batatas L.) extract in reducing the Hsp-70 levels in the white male rat atherosclerosis model.This study was a posttest-only control group design with normality, homogeneity, ANOVA, post hoc test, correlation, and regression tests. There were five groups in this study. Groups 1 (negative control) and 2 (positive control) were given 2 ml/day of high-cholesterol diet for eight weeks, and the other three groups were given purple sweet potato extract at 24, 48, and 96 mg/kg doses weight per day for eight weeks. Results: The purple sweet potato extract affected the Hsp-70 levels in Wistar strain rats (p < 0.05). There was a significant difference in the Hsp-70 level between the positive control group and the group with purple sweet potato extract. The highest Hsp-70 level reduction was seen in the group with a 96 mg/day dose of purple sweet potato extract. In conclusion, theadministration of purple sweet potato extract (I. batatas L.) reduced the Hsp-70 levels. The dose of 96 mg/kg BW/day had the highest effect on decreasing Hsp-70 levels in the male rat atherosclerosis model.
Coffea: The Application of green Components in Cosmetics Formulation Liza Pratiwi
Majalah Obat Tradisional Vol 26, No 3 (2021)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/mot.66626

Abstract

In recent years, the use of green components has attracted significant attention because of their safety, various pharmacological effects, various possible formulation applications, and renewable sources. Regarding its development, coffee is a potential candidate for alternatives of synthetic chemicals in cosmetic preparations because it contains active compounds including polyphenols, caffeine, chlorogenic acid, flavonoids, and alkaloids, which are effective for use on the skin as an antioxidant, anti-aging, sunscreen, moisturizer, anti-cellulite, and face brightener. The stratum corneum is the outer layer of skin that is so impenetrable that requires a formulation to help active compounds penetrate its deeper layers. The development of formulation, type, area of origin, part of the coffee used, and the extraction method affects the characteristics of obtained cosmetics.
Antibacterial activity of Laja Gowah (Alpinia malaccensis (Brum.f) Roscoe) oil in Reducing the Number of Staphylococcus aureus Colonies in Hospital Wards Khoirun Nisyak
Majalah Obat Tradisional Vol 26, No 3 (2021)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/mot.68323

Abstract

Staphylococcus aureus is one of the pathogenic bacteria that cause nosocomial infections in hospitals. The use of essential oil-based antibacterials for hospital wards was developed to prevent nosocomial infections. Laja gowah oil is an essential oil isolated from the Alpinia malaccensis plant, which belongs to the Zingiberaceae plant group. The purpose of this study was to determine the antibacterial activity of laja gowah oil in reducing the number of S. aureus colonies in hospital inpatient rooms through the air diffusion method. The compound content in laja gowah oil was analyzed with GC-MS. The study of antibacterial activity using the total plant counts continued with the colony count test, Gram staining, catalase test, and coagulase test. Laja gowah oil contains methyl cinnamate and 1,8-cineole. The installation time of the diffuser containing laja gowah oil affects the number of colonies of S. aureus bacteria in hospital wards. The antibacterial activity of laja gowah oil was influenced by the synergistic effect of methyl cinnamate and 1,8-cineole compounds.
Supplementation of Garcinia mangostana Linn and Vasconcellea pubescens A.DC extract reduced exercise-induced oxidative stress in rats Heru Sasongko; Sugiyarto Sugiyarto; Renita Wahyu Nur Hidayati; Bayu Anggoro Saputro
Majalah Obat Tradisional Vol 26, No 3 (2021)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/mot.68517

Abstract

The objective of this study was to see how supplementation with Garcinia mangostana extract (GME) and Vasconcellea pubescens extract (VPE) affected exercise performance and oxidative stress in intensely exercised rats. Twenty-five male rats were used in the study. Rats were divided into five groups: normal, stress oxidative control, combination GME:VPE (50:50), combination GME:VPE (75:25), and combination GME:VPE (25:75) groups. The antioxidant activity of a single extract from the literature was used to make the percentage comparison between extracts. The chronic exercise was done by swimming at 10 m/day for two weeks. Rats in the acute exercise groups were treated by swimming on the pail containing water. Blood samples were collected from the orbital sinus to determine hematological parameters. Liver tissue samples for the analysis of malondialdehyde (MDA) and glutathione (GPx)  markers. Data analysis was performed statistically using One Way ANOVA. The combination of GME and VPE was shown to be effective in reducing oxidative stress and increasing MDA and GPx enzyme activity. The administration of both extracts also showed changes in the hematological profile.
Modeling and Optimization of Mitragyna speciosa Extraction using Box Behnken Design Azka M. Rusydan; Endang Lukitaningsih; Nanang Fakhrudin
Majalah Obat Tradisional Vol 26, No 3 (2021)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/mot.68610

Abstract

The extraction of kratom (M. speciosa) leaf powder was optimized with preliminary extraction to be further optimized with the Box-Behnken experimental design. The individual and interactive effects of process variables (sample-to-solvent ratio, extraction time, solvent concentration) were assessed. The preliminary extraction results showed that ultrasound-assisted extraction (UAE) and methanol were chosen for further optimization. The experimental data were analyzed by Pareto analysis of variance (ANOVA) and second-order polynomial models were developed using multiple regression analysis. The model developed showed a good fit with the experimental data with a high coefficient of correlation (R2) and predictive ability (predicted R2). An optimization study was performed and the optimal extraction conditions were sample-to-solvent ratio value 1.5:10; extraction time of 10 minutes, and methanol concentration of 100%.
Renal Protective and Lipid Profile Modulatory Effects of Ethanol Extract of Anthocleista vogelii Stem Bark (EASB) in Renal Injury Rats Induced with Carbon-tetrachloride (CCl4) Robert Ikechukwu Uroko; Nnanna Charles Chukwu; Paul Chukwuemaka Nweje-anyalowu; Chinonso Friday Aaron
Majalah Obat Tradisional Vol 26, No 3 (2021)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/mot.69540

Abstract

The study evaluated the effects of ethanol extract of Anthocleista vogelii stem bark (EASB) on renal function indices and lipid profile in rats induced renal injury with CCl4. Following a completely randomized experimental design, 30 rats were randomly distributed into 6 groups (n = 5). Group 1 was the normal control, group 2 was the negative control while group 3 was the silymarin control. Groups 4 – 6 were CCl4 induced but treated with 100, 200, and 400 mg/kg EASB/day respectively. The study was conducted using appropriate methods. The results showed that the negative control had a significant (P<0.05) increase in the serum urea, creatinine, cholesterol, triacylglycerol (TAG), low-density lipoprotein (LDL) concentrations, and a significant reduction in the serum high-density lipoprotein (HDL) concentration relative to the normal control. Treatments with EASB lowered the serum creatinine, urea, and TAG concentrations when compared with the negative and silymarin controls respectively. The EASB at 100 mg/kg restored the serum HDL concentration to a normal level but 200 and 400 mg/kg EASB/day caused no significant (P>0.05) increase in the serum HDL concentrations relative to the negative control. The rats treated with EASB had elevated serum LDL and cholesterol concentrations in comparison with the negative and silymarin controls. Treatments with EASB prevented the tubular necrosis, degeneration, and infiltration of inflammatory leucocytes observed in the kidney histomorphology of the negative control. These findings suggest that EASB improves renal function and some lipid profile parameters but could cause dyslipidemia when taken in excess dose.
Flavonoid Compounds of Buah Merah (Pandanus conoideus Lamk) as a Potent Oxidative Stress Modulator in ROS-induced Cancer: In Silico Approach Abd. Kakhar Umar; Faruk Jayanto Kelutur; James H. Zothantluanga
Majalah Obat Tradisional Vol 26, No 3 (2021)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/mot.70177

Abstract

Buah Merah, a typical fruit from Papua, Indonesia which is used empirically in cancer therapy is rich in carotenoids and flavonoids. However, the mechanisms by which Buah Merah ameliorates cancer remained unknown. Natural antioxidant enzymes and pro-oxidant enzymes modulation significantly suppressed ROS production and cancer growth. Therefore, the determination of target enzymes of Buah Merah contents was studied through an in silico approach. Carotenoid and flavonoid compounds from Buah Merah were docked to 7 ROS modulating enzymes using Autodock Vina and the interaction stability was studied using the CABS Flex 2.0 server. The crucial amino acids of each enzyme were determined using DockFlin and prediction of acute oral toxicity of each test ligand was studied using ProTox-II. Based on the molecular docking results, quercetin 3'-glucoside is the most potent compound in binding to CAT, GR, GPx, SOD, LOX, and NOX with binding energy values of -11.2, -9.7, -8.6, -10.2, -10.7, and -12.8 kcal/mol, respectively. Meanwhile, taxifolin 3-O-α-arabinopyranose produced the highest binding affinity of -10.0 kcal/mol at the XO. Each test ligand formed stable interactions with ROS modulating enzymes and formed bonds with crucial amino acids resulting in strong adhesion compared to native and reference ligands. The glucoside group of quercetin 3'-glucoside plays an essential role in determining the proper position in the attachment and supports the formation of hydrogen bonds with receptors. With low acute oral toxicity, it can be concluded that quercetin 3'-glucoside from Buah Merah is a potent oxidative stress modulator in cancer prevention and therapy.

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