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All Journal Pharmacon Majalah Obat Tradisional Jurnal Penelitian Farmasi Indonesia Jurnal Bakti Untuk Negeri Borneo Journal of Pharmacy Medical Sains : Jurnal Ilmiah Kefarmasian
Mira Febrina
Sekolah Tinggi Ilmu Farmasi Riau
Dentistry Health Professions Medicine & Pharmacology Nursing Public Health

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Microemulsion Formulation of Combination of Virgin Coconut Oil and Rice Bran Oil for Hair Growth Wira Noviana Suhery; Mira Febrina; Ivone Permatasari
Majalah Obat Tradisional Vol 23, No 1 (2018)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (330.606 KB) | DOI: 10.22146/mot.29213

Abstract

Research on micro emulsion formulation of combination of virgin coconut oil (VCO) and rice bran oil (RBO) as a hair growth promoter has been done. The purpose of this study was to formulate and produce the best formula that is physically stable and optimally promoting the hair growth by varying the content of VCO and RBO in the form of micro emulsions. These dosage formulations were prepared in three formulas using 45% tween 80 as surfactants and 20% glycerin as co surfactant i.e.: F,I containing a combination of VCO and RBO 1:1; FII (1:2) and FIII (2:1). Physical evaluation of the preparation was carried out for 8 weeks of storage which included organoleptic examination, pH, homogeneity, density, globule particle size, phase freeze thaw, and rabbit hair growth activity test for 18 days. Based on the results of the evaluation, it was found that the FI, FII and FIII micro emulsion formulations were physically stable for 8 weeks of storage with a pH ranging from 6.7 to 7.0, density of 1.085-1.088 g/mL, average globul particle size of FI (34.6 nm ), FII (54 nm) and FIII (68.8 nm). The best formulas is FIII for hair growth length of 1.26 cm for 18 days.
In Vivo Antihypercholesterolemic Potential of Uncaria cordata (Lour.) Merr as Ethanolic Extract Meiriza Djohari; Mira Febrina; Tri Wahyuni
Majalah Obat Tradisional Vol 26, No 3 (2021)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/mot.64531

Abstract

The present investigation aims to evaluate the antihypercholesterolemic potential of Uncaria cordata (Lour.) Merr. as an ethanolic extract in diet-induced hypercholesterolemic male white mice model. In this study, white mice were segregated into 6 groups; all the groups except the normal control group were given a high-fat diet to induce hypercholesterolemia. After induction of cholesterolemia, normal and negative control groups were treated with NaCMC, the positive control group was treated with atorvastatin, and the remaining three groups received ethanolic extract Uncaria cordata (Lour.) Merr. in three doses (100, 200, and 400 mg/Kg BW) for a treatment period of 29 days. Measurement of cholesterol levels was performed on days 0, 15, 22, and 29 using EasyTouch® GCU digital devices. The results were analyzed by one way ANOVA test and ANOVA Repeated test. The results showed that the ethanol extract of the Uncaria cordata (Lour.) Merr. root plant dose 100, 200, and 400 mg/Kg BW effect in lowering total cholesterol in male white mice significantly (P <0,05). Ethanol extract from Uncaria cordata (Lour.) Merr. a dose of 200 mg/Kg BW showed a better decrease in cholesterol levels on day 29 compared to day 22.
PENGARUH PEMBERIAN INFUSA BATANG GELAGAH (Saccharum spontaneum L.) TERHADAP KADAR GLUKOSA DARAH MENCIT PUTIH (Mus musculus L.) JANTAN YANG DIINDUKSI GLUKOSA Mira Febrina
Jurnal Penelitian Farmasi Indonesia Vol. 10 No. 1 (2021): JPFI
Publisher : Lembaga Penelitian Sekolah Tinggi Ilmu Farmasi Jl. Kamboja Simpang Baru-Panam, Pekanbaru, Riau 28293 Telp. (0761) 588006, Fax. (0761) 588007 e-mail: editor-jpfi@stifar-riau.ac.id

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51887/jpfi.v10i1.976

Abstract

A study on the effect of reeds infusion (Saccharum spontaneum L.) on glucose levels of male white mice (Mus musculus) given glucose load. This study aims to see the effect of reeds infusion (Saccharum spontaneum L.) to blood glucose levels of male white mice (Mus musculus) given glucose load as much as 2g/KgBB. This research used Oral Glucose Tolerance Test (TTGO) method. Animal experiments were divided into 6 groups. The negative control group was given only aquadest, the comparison group was given 2g/KgBB glucose solution, the positive group was given metformin with the dosage of 65mg/KgBB, the treatment group was given reeds infusion (Saccharum spontaneum L.) with concentration 10, 20 and 30 %. After each test animal was given 30 minutes treatment then given glucose 2g/KgBB orally. Then measured blood glucose levels of mice at minute 30-180. Based on the results of testing the infusion of reeds (Saccharum spontaneum L..) showed that the concentrations of 10, 20 and 30% had decreased levels of white mice blood glucose (Mus musculus L.). However, the results of the two way ANOVA assay continued with the Post Hoc Tukey test showed the results obtained that the duration of administration may affect the decrease in blood glucose levels of mice (p <0.05).
KONSELING PENYAKIT DEGENERATIF MASYARAKAT KOTA PEKANBARU Ferdy Firmansyah; Enda Mora; Mira Febrina; Ihsan Ikhtiarudin
Jurnal Bakti untuk Negeri Vol 1 No 2 (2021)
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (143.784 KB)

Abstract

Degenerative a disease that continues to grow and can affect a person's productivity and quality of life. Usually, people only check themselves after their symptoms, even though early detection is important. The aim of the service is to provide an overview and improve the status of the community both promotively, preventively, or curatively by providing counseling about degenerative diseases. The method used is to conduct a health examination and continued with the provision of counseling. The activity was attended by 42 people in the Car Free Day area of Pekanbaru city. The activity begins with a health check that is tailored to the symptoms felt and continues with counseling. Many factors cause degenerative diseases, such as genetics, age, physical activity, and diet. This activity can increase public insight and knowledge about degenerative diseases.
Uji Aktivitas Wound Healing Ekstrak Etanol Buah Averrhoa bilimbiL. (Belimbing Wuluh) pada Mencit Putih Jantan (Mus musculus) Rahmayati Rusnedy; Mira Febrina; Cindy Patika Sari
Pharmacon: Jurnal Farmasi Indonesia Vol 20, No 1 (2023)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/pharmacon.v20i1.22677

Abstract

Wound healing is a complex process, delays in wound healing increase the chances of infection, improper healing, and unpleasant scarring. Belimbing wuluh (Averrhoa bilimbi L.) fruit contains various active compounds that are beneficial to health and have the potential to be used as medicinal preparations for treating wounds. In this test, incisions were made on the skin of the mice's back area using a scalpel 1 cm long and 0.3 cm deep. Observation of the length of the incision was carried out every day for 12 days using a caliper. Significant wound healing activity was observed from administration of 10% concentration of ethanol extract of belimbing wuluh (Averrhoa bilimbi L.) fruit which contains chemical compounds such as flavonoids, saponins, tannins and triterpenoids as well as minerals, one of which is zinc and Vitamin C is also proven to help speed up the healing process of incisions with a percentage of wound healing on day 12, which is 100%, the same percentage value as the group of test animals given Povidone Iodine 10% (Betadine®) as a comparator drug. The presence of zinc (zinc) and vitamin C in the extract of star fruit (Averrhoa bilimbi L.), is predicted to also contribute to the wound healing process in this test.
Cytotoxic Activity of Ethyl Acetate Extract from Voacanga foetida (Bl.) Rolfe Leaves Against T47D Breast Cancer Cells Adriani Susanty; Mira Febrina; Dian Sanita Putri; Ihsan Ikhtiarudin; Fatma Sri Wahyuni; Dachriyanus Dachriyanus
Borneo Journal of Pharmacy Vol. 6 No. 1 (2023): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v6i1.3499

Abstract

The cytotoxicity of ethyl acetate extract from Tampa badak (Voacanga foetida (Bl.) Rolfe) leaves against Artemia salina leach larvae was determined using the brine shrimp lethality test (BSLT) method and was evaluated against T47D breast cancer cells using MTT assay method. The result of BSLT showed a consistent result with MTT assay, which is the result obtained that ethyl acetate extract is very toxic against A. salina Leach larvae with LC50 value of 8.61 µg/mL and very cytotoxic against T47D breast cancer cells with IC50 values of 0.87; 0.66; and 0.95 µg/mL at the 24, 48 and 72 hours of incubation times, respectively. The MTT assay data were analyzed using a two-way ANOVA statistical method to see the effect of the dependent variable (concentration and time) on the independent variable (% viability). Based on the statistical test result, there is a difference in % viability between concentrations of 0.1; 1; and 10 µg/mL (p <0.05), but the length of incubation does not affect % viability (p >0.05).
EVALUATION OF ANTIBIOTIC USE USING THE ATC/DD AND DU 90% METHODS IN OUTPATIENT PATIENTS IN PUSKESMAS RI TENAYAN RAYA Novia Sinata; Delvi Regika; Mira Febrina
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 9 No 1 (2024)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v9i1.1047

Abstract

Infectious diseases are one of the health problem that threaten developing countries, including Indonesia. Riau as one of the provinces with its coastal coverage is not spared from this problem. Inaccurate use of antibiotics is found in the wider community, which can be a cause of negative risks such as antibiotic resistance. Antibiotics are drugs that are used to treat diseases caused by microbes. The improper use of antibiotics can lead to a risk of resistance. Resistance can be avoided using antibiotics. This study aimed to classify antibiotic use using ATC codes and determine the quantity of antibiotic use in outpatients by calculating the DDD. This research method was observational, with a descriptive design and retrospective data collection using secondary data by searching medical records. The sample in this study consisted of outpatients at the Tenayan Raya Inpatient Health Center Outpatient Installation between January and December 2022 who received antibiotic therapy with an ATC code and DDD value in accordance with the provisions of the WHO Collaborating Center, using a total sampling technique.The results of the study showed that based on the ATC/DDD and DU 90% methods, there were 3 antibiotics with the highest quantity of use, namely amoxicillin at 165,92 DDD/1000 KPRJ with a percentage of 67,02%, ciprofloxacin at 41,07 DDD/1000 KPRJ with a percentage of 16,59 %, and cefixime as much as 14,69 DDD/1000 KPRJ with a percentage of 5,93%.  Keywords: antibiotics, ATC/DD, DU 90%, resistance
Co-Authors Adriani Susanty agistia, nesa Cindy Patika Sari Dachriyanus Delvi Regika Dian Sanita Putri Enda Mora Fatma Sri Wahyuni Ferdy Firmansyah Ihsan Ikhtiarudin Ivone Permatasari Meiriza Djohari, Meiriza Putri Qurnia Pratiwi Ratna Sari Dewi Rusnedy, Rahmayati Sinata, Novia Tri Wahyuni Wira Noviana Suhery