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INDONESIA
PROSIDING SEMINAR KIMIA
Published by Universitas Mulawarman
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Core Subject : Science,
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Articles 502 Documents
PENGARUH MODEL PEMBELAJARAN FLIPPED BERBANTUAN GOOGLE CLASSROOM TERHADAP HASIL BELAJAR SISWA PADA MATERI HUKUM DASAR KIMIA Kasik, Olivia Clara; Masruhim, Muh. Amir; Erika, Farah
PROSIDING SEMINAR KIMIA Vol 3 No 2 (2025): Prosiding SNKT 2024
Publisher : Jurusan Kimia Fakultas Matematika dan Ilmu Pengetahuan Alam Universitas Mulawarman

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Abstract

Students' lack of activity in participating in chemistry learning due to learning models that are used too often and lack of variety by teachers causes students to feel bored during learning, resulting in low student learning outcomes. The type of research used was quantitative experimental research, namely quasi-experimental design. Samples were taken by purposive sampling consisting of class X-4 (experimental class) and class X-2 (control class), with a total of 72 students. Data collection techniques use observation, documentation and tests. The data was analyzed using a parametric test, namely the independent sample t-test showing a sig value. 0.00 < 0.05, then HO is rejected and Ha is accepted. This means that there is an influence of the flipped learning model assisted by Google Classroom on student learning outcomes in basic chemical law material. Keywords : Flipped Classroom, Google Classroom, student learning outcomes
SKRINING FITOKIMIA, UJI ANTIOKSIDAN DAN UJI TOKSISITAS EKSTRAK ETANOL DAUN BINTARO (Cerbera manghas) DENGAN METODE BRINE SHRIMP LETHALITY TEST (BSLT) Ramadani, Andi Deffi; Aditya, Adrian Maulana; T, Nurnaningsi; Erwin, Erwin
PROSIDING SEMINAR KIMIA Vol 3 No 2 (2025): Prosiding SNKT 2024
Publisher : Jurusan Kimia Fakultas Matematika dan Ilmu Pengetahuan Alam Universitas Mulawarman

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The purpose of this study was to determine the results of phytochemical tests of bintaro leaf ethanol extract and to determine the results of antioxidant tests using the DPPH (1,1-diphenyl-2-picrylhydrazyl) method with a concentration variation of 100; 80; 60; 40; and 20 ppm obtained from bintaro leaf ethanol extract by testing its toxicity using the Brine Shrimp Lethality Test (BSLT) method. The results showed that the ethanol extract of bintaro leaves (Cerbera manghas) contains steroid compounds, saponins, and quinones. Furthermore, the IC50 value of the ethanol extract of bintaro leaves (C. manghas) was 41.68 ppm with a very strong category and the results of the toxicity test obtained the LC50 value of the ethanol extract of bintaro leaves (C. manghas) of 30.44 ppm with a very toxic category. An extract with an LC50 value ≤ 30 ppm has the potential as an anticancer drug candidate because of the correlation between the level of toxicity and anticancer activity so that these results can be concluded that the ethanol extract of bintaro leaves (C. manghas) has the potential to have bioactivity because it is toxic to Artemia salina L. shrimp larvae. Keywords: Antioxidant, Brine Shrimp Lethality Test (BSLT), Bintaro Leaves, Phytochemical Test
UJI FITOKIMIA, TOKSISITAS DAN AKTIVITAS ANTIOKSIDAN PADA EKSTRAK ETANOL DAUN SIRSAK (Annona Muricata L.) Shadrina, Alyani Nur; Tomagola, Azmi Sakina; Ramadhandita, Jauzaa Lisgia; Erwin, Erwin
PROSIDING SEMINAR KIMIA Vol 3 No 2 (2025): Prosiding SNKT 2024
Publisher : Jurusan Kimia Fakultas Matematika dan Ilmu Pengetahuan Alam Universitas Mulawarman

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Abstract

Sirsdak (Annona muricata L.), is a plant whose fruit is edible and the leaves and fruit have been used by the community as traditional medicine. This study aims to test the chemical content, toxicity, and antioxidant activity of ethanol extract of soursop leaves (Annona muricata L.). Phytochemical tests were carried out to identify bioactive compounds contained in the extract, while toxicity tests used the Brine Shrimp Lethality Test (BSLT) method to determine toxic potential. Antioxidant activity was evaluated using the DPPH (2,2-diphenyl-1-picrylhydrazyl) method to measure the ability to scavenge free radicals. The results showed that the ethanol extract of soursop leaves contained steroid, saponin and quinone compounds, had significant toxicity potential with an LC50 value of 31.19 ppm, and showed weak antioxidant activity with an IC50 value of 111.27 mg/L Keywords : Soursop Leaves., Phytochemical Analysis Antioxidant and Toxicit.
BEBERAPA JENIS METABOLIT SEKUNDER YANG BERPOTENSI SEBAGAI ANTI KANKER : A MINI REVIEW Rizkirullah, Muhammad Adhitya; Kartika, Rudi; Aswat, Raihan; Mahrus, Muhammad Haissul; Rahman, Fatur; Kurniawan, Andi; Azka, Andi Aulia Urrahman; Sanian, Sanian
PROSIDING SEMINAR KIMIA Vol 3 No 2 (2025): Prosiding SNKT 2024
Publisher : Jurusan Kimia Fakultas Matematika dan Ilmu Pengetahuan Alam Universitas Mulawarman

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Cancer is one of the leading causes of death worldwide, including in Indonesia. This review explores the potential of various plants as sources of anticancer compounds through secondary metabolite analysis. Plants such as Rosa damascena, Wild Onion (Scorodocarpus borneensis Becc), and Acalypha Indica have been studied for anticancer activity using in vitro methods. The results showed that extracts from Rosa damascena had varying IC50 values ​​against various types of cancer cells, including 16.28 μg/mL in liver cancer cells (HepG-2) and 18.09 μg/mL in breast cancer cells (MCF-7). In addition, Wild Onion showed very strong anticancer activity with an IC50 value of 1.1061 μg/mL in L1210 leukemia cells. Secondary metabolites such as flavonoids, alkaloids, and tannins were identified as key components contributing to the anticancer effects. These findings highlight the importance of further research to develop more effective and safe plant-based cancer therapies. Keyword: Anticancer, Cancer, Secondary Metabolites, Plants
Ekstraksi dan Isolasi Bahan Alam Secara Klasik dan Modern Erwin, Erwin; Fadliannur, Fadliannur; Alimuddin, Alimuddin
PROSIDING SEMINAR KIMIA Vol 3 No 2 (2025): Prosiding SNKT 2024
Publisher : Jurusan Kimia Fakultas Matematika dan Ilmu Pengetahuan Alam Universitas Mulawarman

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Extraction and isolation of bioactive compounds from natural materials is an important process in the pharmaceutical, chemical, and biotechnology industries. This process aims to obtain active compounds from plants, microorganisms, or animals for various applications. Classical extraction has been used for years, while modern methods have developed along with technological advances. This paper discusses the differences between classical and modern methods in the extraction and isolation of natural materials, including techniques, advantages, disadvantages, and fundamental differences between the two. Understanding these methods is important to improve efficiency and sustainability in the process of isolating bioactive compounds. Keywords: Extraction, isolation, natural materials, classical methods, modern methods, bioactive compounds.
LITERATUR REVIEW: PENGARUH INJEKSI INTRACEREBROVENTRIKULAR STREPTOZOTOCIN PADA OTAK MENCIT SEBAGAI KANDIDAT HEWAN MODEL ALZHEIMER Daryanti, Edhita Putri; Anggadiredja, Kusnandar; Wibowo, Agung Eru; Santoso, Koekoeh
PROSIDING SEMINAR KIMIA Vol 3 No 2 (2025): Prosiding SNKT 2024
Publisher : Jurusan Kimia Fakultas Matematika dan Ilmu Pengetahuan Alam Universitas Mulawarman

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Background: Animal models of Alzheimer's have now been developed in various studies to become potential animal models suitable for clinical conditions. Alzheimer's in clinical conditions is characterized by Amyloid βeta (Aβ) plaques and intracellular tangles of neurofibrillary tangles as well as disorders of the acetylcholinesterase enzyme in the hippocampus. Rodents used include rats and mice. Mice are used because they are efficient and parts of the brain can be penetrated with a needle without requiring surgery. Objectives: Appropriate toxicant induction is needed so that the process of developing Alzheimer's pathology is known, namely the use of Streptozotocin. Intracerebroventricular induction of strepzotocin in mice needs to be further understood. Material and Methods: The research method uses literature review with identification, screening, evaluation and interpretation of all research results collected through online search engines such as; Sciencedirect, Pubmed, GoogleScholar with keywords and meet the inclusion criteria Results: The results of the synthesis obtained selected data from 8 articles. ICV-STZ has been proven from various studies to induce Alzheimer's pathology in both young and old male mice through neuroinflammatory pathways, oxidative stress, increasing Aβ expression and hyperphosphorylation of Tau as Alzheimer's markers which are similar to clinical patients. Keywords : Alzheimer, Hewan model, Literatur review, Mencit, Streptozotocin.
SKRINING FITOKIMIA, UJI ANTIOKSIDAN DAN UJI TOKSISISTAS EKSTRAK ETANOL DAUN SIRIH HUTAN (Piper aduncum L.) DENGAN METODE BRINE SHRIMP LETHALITY TEST (BSLT) Mahani, Aurellia Layla; Shalsabila, Desi Fitria; Supratman, Rafif Ghanifalah Dely; Erwin, Erwin
PROSIDING SEMINAR KIMIA Vol 3 No 2 (2025): Prosiding SNKT 2024
Publisher : Jurusan Kimia Fakultas Matematika dan Ilmu Pengetahuan Alam Universitas Mulawarman

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Piper aduncum L. or better known as Sirih hutan (Indonesia) has been utilized by the community as a traditional medicine. Forest sirih leaves are commonly used in wound healing, facilitating digestion, as an antiseptic to beauty products. Therefore, the purpose of this study was to conduct phytochemical screening, antioxidant testing and toxicity testing of secondary metabolite compounds of sirih hutan leaves. On the extract of Piper aduncum L. leaves, phytochemical screening was carried out to determine the secondary metabolite compounds contained, toxicity testing using the brine shrimp lethality test (BSLT) method and antioxidant activity testing using the 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging method. Based on the results of phytochemical tests, the secondary metabolite compounds obtained were alkaloids, flavonoids, phenolics and quinones. The BSLT test of the ethanol extract of Piper aduncum leaves showed an LC50 value of 2,857.6 ppm, indicating that forest betel leaves (Piper aduncum L.) do not have toxic activity and have very significant antioxidant activity with an IC50 value of 0.977 ppm. Keywords: Antioxidants, Brine Shrimp Lethality Test (BSLT), Sirih hutan, Phytochemical Test
REVIEW ARTIKEL : ANALISIS KADAR SULFAT, pH, DAN OKSIGEN TERLARUT (DO) SERTA KONDUKTIVITAS SEBAGAI PARAMETER KUALITAS AIR MINUM Andriana, Nita; Yusuf, Bohari; Arif, Moh.Syaiful
PROSIDING SEMINAR KIMIA Vol 3 No 2 (2025): Prosiding SNKT 2024
Publisher : Jurusan Kimia Fakultas Matematika dan Ilmu Pengetahuan Alam Universitas Mulawarman

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Drinking water quality is critical to public health. This article reviews studies that evaluated sulfate, pH, conductivity, and dissolved oxygen (DO) levels as key parameters in determining drinking water quality. Various water sources, such as tap water, wells, and bottled water, were analyzed in several studies. Sulfate was measured using the spectrophotometric method with BaCl2 reagent and absorbance was measured at a wavelength of 420 nm, while pH used a digital pH meter, conductivity was measured with a conductometer, and DO was measured with the Winkler method. The results showed significant variations in sulfate and dissolved oxygen levels between water sources. Some samples had pH that was below the standard, while sulfate levels in some samples were close to the maximum limit allowed by Permenkes No.492/MENKES/PER/IV/2010 (250 mg/L) and Permenkes No. 32/2017 (400 mg/L). DO proved to be the most sensitive parameter in detecting changes in water quality, followed by pH, and conductivity plays an important role in assessing drinking water quality as it provides an early indication of the concentration of dissolved ions that could indicate contamination, while sulfate is more effective in detecting certain contamination. The combination of these four parameters is important to ensure safe drinking water. This article is expected to guide research and assist water providers in maintaining drinking water quality standards. Keywords : Conduktivity, Drinking Water Quality, Dissolved Oxygen (DO), pH , Sulfate
Uji Aktivitas Antibakteri Hasil Fermentasi Bakteri Endofit Umbi Talas (Colocasia esculenta L.) terhadap Bakteri: MINI REVIEW Azka, Andi Aulia Urrahman; Kartika, Rudi; Jofri, Dirga Hosea Seventeen; Rizkirullah, Muhammad Adhitya; Kurniawan, Andi; Aswat, Muhammad Raihan
PROSIDING SEMINAR KIMIA Vol 3 No 2 (2025): Prosiding SNKT 2024
Publisher : Jurusan Kimia Fakultas Matematika dan Ilmu Pengetahuan Alam Universitas Mulawarman

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Antibacterial agents are substances used to eliminate microorganisms, especially those harmful to humans. These antibacterial compounds can be directly extracted from plants, where the extracts contain secondary metabolite compounds with antibacterial activity. The antibacterial testing is conducted on gram-positive bacteria, such as Propionibacterium, Staphylococcus, and others. The research method employed is a literature review of 10 national and international articles published within the last 10 years. The cited articles focus on studies of plants with potential as antibacterial agents against several gram-positive bacteria, including the extraction solvents used, the metabolite compounds present in the extracts, and their effectiveness based on the inhibition zone diameter and/or minimum inhibitory concentration using the disc diffusion method. Keywords : Antibacterial, Diffusion Discs, Gram Positive, Secondary Metabolites
Front Matter SNK 2025 Widodo, Nanang Tri
PROSIDING SEMINAR KIMIA Vol 4 No 1 (2025): Prosiding SNK 2025
Publisher : Jurusan Kimia Fakultas Matematika dan Ilmu Pengetahuan Alam Universitas Mulawarman

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Abstract