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INDONESIAN JOURNAL OF PHARMACY

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Published by Universitas Gadjah Mada

ISSN : 23389427 EISSN : 23389486 DOI : -

Core Subject : Health,

Medicine & Pharmacology

Indonesian Journal of Pharmacy (ISSN-e: 2338-9486, ISSN-p: 2338-9427), formerly Majalah Farmasi Indonesia (ISSN: 0126-1037). The journal had been established in 1972, and online publication was begun in 2008. Since 2012, the journal has been published in English by Faculty of Pharmacy Universitas Gadjah Mada (UGM) Yogyakarta Indonesia in collaboration with IAI (Ikatan Apoteker Indonesia or Indonesian Pharmacist Association) and only receives manuscripts in English. Indonesian Journal of Pharmacy is Accredited by Directorate General of Higher Education (DGHE) DIKTI No. 58/DIKTI/Kep/2013.

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Articles 706 Documents

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Cytotoxic effects of an acidic Ribosome-inactivating Protein like protein isolated from Mirabilis jalapa L. leaves on cancer cell-lines ., Sudjadi; Witasari, Lucia D.; Sadarum, Modesta T.; Nastity, Nia; ., Sismindari
Indonesian Journal of Pharmacy Vol 18 No 1, 2007
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Most purification approaches of Ribosome-inactivating Proteins (RIPs) used a cation exchange chromatography resulting highly basic proteins, such as MJ-30 isolated from Mirabilis jalapa leaves. The M.jalapa unbounded protein fractions of the column showed cleavage activity on supercoiled double stranded DNA and possesed cytotoxic effects on cancer cell lines. So the purification and characterization of the acidic protein was needed to be done.Total proteins of M.jalapa leaves was collected from precipitating process of the extract using ammonium sulphate untill saturated. After dialysis, the proteins was applied into the weak base anion exchanger Ionenaustaucher Typ II. The bounded proteins was eluted with 0.0 to 0.5 M NaCl gradient in phosphate buffer. Active protein fractions were determined by supercoilded DNA cleavage activity and then cytotoxic activity was testes.Results showed that protein fraction eluted at 0.35 – 0.40 M NaCl possesed cleavage activity on supercoiled DNA. The acidic protein, MJ-C, was toxic on HeLa, Myeloma and T47D cell lines, with the LC50 of 14.3 μg/mL, 7.4 μg/mL and 27.8 μg/mL, respectively. The MJ-C was more potent than the basic protein MJ-30.Key words: acidic RIP, cytotoxic, Mirabilis jalapa

Isolation and identification of kaempferol from jangkang (Homalocladium platycladum (F. Muell) Bailey) leaves and its antibacterial activity Maulita Cut Nuria; Wahyono .; Ratna Asmah Susidarti
Indonesian Journal of Pharmacy Vol 22 No 1, 2011
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Isolation and identification of kaempferol from jangkang (Homalocladium platycladum (F. Muell) Bailey) leaves and its activity against B. subtilis ATCC 9466 dan S. typhi ATCC 1408 has been done. The dried ground leaves (300.04 gram) were macerated with petroleum ether, chloroform and methanol respectively. The methanol extract was the most active extract against both bacteria. Further separations of this extract using preparative thin layer chromatography yielded flavonoid glycoside. Its aglicon was identified as kaempferol based on its spectroscopic data (MS, IR, and UV-Vis) and UV spectrum (densitometry). This compound shows iradical zone of 6.62 mm (Bacillus subtilis) and 6.27 mm (Salmonella typhi) at concentration of 200 µg/disk.Key words : kaempferol, jangkang, glycoside, aglicon

Production of D6,7-anhidroeritromisin-A from Saccharopolyspora erythraea ATCC 11635 culture Khairan .; Umar Anggara Jenie; Retno S. Sudibyo
Indonesian Journal of Pharmacy Vol 19 No 4, 2008
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Erythromycin has been used widely to prevent infection diseases which caused by Staphylococcus. However erythromycin is unstable and decomposed in an acid condition. This unstability erythromycin is conducted by due to a nucleophylic attack of the C6-hydroxyl group of erythromycin to its C9-carbonyl group. This Decomposition can be avoided by modification the erythromycin structure; such as omitting the C6-hydroxyl group. Biomodification for omitting the C6-hydroxyl group can be conducted by inhibition the activity of enoyl reductase in fourth step of the biosynthesis 6- deoxyerythronolid-B. The inhibition process could carried out by an addition of an antimetabolite isonicotonic hidrazide (INH) into the fermentation of erythromycin production. By the enoyl reductase inhibition, the microbe will produce D6,7-Anhydroerythromycin-A which is more stable in an acidcondition than erythromycin-A. This research is to produce derivative D6,7-Anhydroerythromycin-A by addition of INH into a culture of Saccharopolyspora erythraea ATCC 11635 in medium basal and Hutchinson. Selection of medium for fermentation of Sac. erythraea ATCC 11635 for D6,7-Anhydroerythromycin-A production was done out of two media: basal medium with palm oil and Hutchinson medium. The two media were treated with an additional 0,2% INH as an antimetabolite.Hutchinson medium yielded the highest product of D6,7-Anhydroerythromycin-A. The FT-IR spectrometric analyzes of metabolite showed a stretching vibration of C=C conjugated group at wave number 1602,7 cm-1. This C=C conjugated vibration indicated the existence of double bond between C6 and C7 (D6,7), this confirmed that isolate-C contained D6,7-Anhydroerythromycin-A (the possibility of D6,7 was positive).Key words: enoyl reductase, D6,7-anhydroerythromycin-A, isoniazid (INH)

EFFECT OF PENTAGAMAVUNON-0 TO THE THEOPHYLLINE PHARMACOKINETICS IN RATS Hakim, Arief Rahman; Hakim, Lukman; Margono, Supardjan A.
Indonesian Journal of Pharmacy Vol 14 No 1, 2003
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

The research was aimed to observe pentagamavunon-0 activities to theophylline pharmacokinetics in rats. The study of interaction pentagamavunon-0 and theophylline was conducted employing a completely randomized design using male Wistar rats which were divided into 5 groups (6 rats for each group). The groups were given a single oral theophylline 25 mg/kg BW as a control group and were administered single oral pentagamavunon-0 2, 5, 10 and 40 mg/kg BW each dose 4 hours before treatment with theophylline. Serial blood samples (0,2 ml) were withdrawn at various interval via the tail vein for HPLC analysis of unchanged theophylline in blood. The concentration of theophylline was determined based on a standard curve. The concentration-time data determines theophylline pharmacokinetics i.e. Ka, Cmaks, tmaks, AUC0-, Vdss, t1/2 elimination, Clt and MRT. The results indicated that pentagamavunon-0 was found to be able to decrease theophylline clearance 40-51% (P<0.05). The decrease in clearance causes the prolonged life of theophylline in the body.Key words : Pentagamavunon-0, Theophylline, Pharmacokinetics

Determination of antioxidant activity of dehydrozingerone through hydroxy radical scavengers using deoxyribosa method Agung Endro Nugroho; Nunung Yuniarti; Enade Perdana Estyastono; Supardjan .; Lukman Hakim
Indonesian Journal of Pharmacy Vol 17 No 3, 2006
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Dehydrozingerone (4-(4-hydroxy-3-methoxyphenyl)-3-buten-2-one) is an analog of curcumin which is termed as half-curcumin. The compound is isolated from ginger (Zingiber officinale). Nevertheless, this compound still has a phenolic hydroxy moiety responsible for antioxidant activity. The research was performed to obtain information on the antioxidant activity of dehydrozingerone through hydroxy radical scavengers.The study was performed according to a hydroxy radical scavenging procedur. In this method, reaction between hydroxy radical, resulted from phenton reaction, and deoxyribosa produces malonedealdehyde. Incubation in thiobarbituric acid at low pH produced violet-coloured solution (complex MDA-TBA).The results showed that dehydrozingerone has antioxidant activity through hydroxy radical scavengers with ES15 value of 48.36 μM. The antioxidant activity of dehydrozingerone was lower than curcumin, with ES15 value of 25.01 μM. Besides, exchange of phenolic hydroxy moiety by salting with potassium could deplete its antioxidant activity. Based on these facts, it can be concluded that phenolic hydroxy moiety of dehydrozingerone was important for its antioxidant activity through hydroxy radical scavengers.Key words : dehydrozingerone, curcumin, antioxidant, radical hydroxy, Zingiber

Performance evaluation of pharmacy x in Yogyakarta using balanced scorecard approach ., Satibi; Furdiyanti, Nova Hasani; Rahmawati, Maya
Indonesian Journal of Pharmacy Vol 18 No 2, 2007
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

The research to evaluate the performance of Pharmacy X in Yogyakarta using balanced scorecard approach has been performed. The goal of the present work was to find out the performance of the Pharmacy, evaluated by four perspectives, i.e. finance, customer, internal business process, and learning and growth.This research implemented non experiment at design by evaluative descriptive approach. Data consist of primary and secondary data. The primary data was obtained from observation of prescribing service process, i.e. average of dispensing time drug information service, drug available, identification of Drug Related Problem (DRP), customer satisfaction, and interview. Secondary data is taken from pharmacy documents, i.e. pharmacy finance report, pharmacy labor, and the patients-prescription in 2003-2005.The results show that pharmacy X condition is not good. The performance of finance perspective indicated the Return on Investment in 2003-2005 was bellow the average (1,45.%, 0.% and 0.%).Net profit margin (0,80.%, 0.% and 0.%) and turn over ratio (4,86 x, 4,48 x and 3,85 x). Performance of customer perspective indicates good customer satisfaction, but the number of prescription decreased. Learn – growth perspective analysis indicated a high level of employee motivation and productivity; Performance in internal business process perspective showed: level of drug availability 86,21%, average of dispensing time 16,97 minutes (for compounding drugs) and 4,78 minutes (for non compounding drugs), drugs information weren’t appropriate with standard of Kepmenkes No.1027/MENKES/SK/IX/2004. Drug Related Problems identified were prescription under dose (29.%), over dose (7.%), and drugs interaction (64.%).Key words : pharmacy X, performance, balanced scorecard

DEVELOPMENT THE VALIDATION OF INDONESIAN VERSION OF SF-36 QUESTIONNAIRE IN CANCER DISEASE Dyah Ariani Perwitasari
Indonesian Journal of Pharmacy Vol 23 No 4, 2012
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

A Cancer patients need long term therapy in the treatment of their disease. One of the outcome of cancer treatment in patients of quality of life. Because of the limited instrument for measuring cancer patients’ quality of life in Indonesian version, thus this study is aimed to develop the validation of Indonesian version of Short Form-36 questionnaire in cancer patients. The observational study was carried out in this study. Data were collected from cancer patients in the Oncology Department of Sardjito Hospital, Yogyakarta, Indonesia, who were treated with cisplatin at the dosage of ≥ 50mg/m2 as monotherapy or in combinations. The validation process involved known-group validity, discriminant validity, convergent validity and factor analysis. About 203 subjects who were diagnosed with cancer were recruited in this study. Theknown-group validity test showed that there were no significant differences of SF-36 domains among different diagnosa. All of the questions met the criteria of convergent validity except for the questions number 26, 28, 30 and 32. Furthermore, the questions number 2 and 28 did not meet the criteria of discriminant validity. This study presents that many questions are needed to be reconstructed, due to the result of factor analysis which showed that those questions are loaded significantly with other domain’s questions. The development of Indonesian version of SF-36 scales in cancer disease is still less unstatisfactory. According to the result of this study, future study with new construction of questions in this version is still necessary.Key words: validation, SF-36, Indonesia, cancer

Synthesis of 5-ethyl-carbamyl-2,2-dimethyl-1,3 benzodioxoles as an insecticide ., Sumantri
Indonesian Journal of Pharmacy Vol 16 No 1, 2005
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

The imported insecticides which are commonly used such as carbamate, organophosphate and organochlorine insecticides, have a high level of toxicity, and persist in the environment for a long period of time. The research aims to synthesize a possible insecticide that is 5-ethyl-carbamyl-2,2-dimethyl-1,3- benzodioxole, which is expected to perform a low level toxicity since it contains benzodioxole moiety which has natural antioxidant activity and also functions as insecticide synergist.The compound was synthesized by nitration of 2,2-dimethyl-1,3-benzodioxole as the condensation product between catechol and propanon-2, which was followed by reduction with Zn and HCl, and acylation using ethylchloroformate in triethylamine. The product obtained from the synthesis was purified by column chromatography, then elucidation of structure was carried out by spectroscopic method. The products obtained were also analysed by gas chromatographic and GCMS methods.The results indicate that the product 5-ethylcarbamyl-2,-dimethyl-1,3- benzodioxole can be synthesized by condensation reaction of 2,2-dime-thyl-1,3-benzodioxole, then folowed by nitration of 2,2-dimethyl-1,3-benzodioxole, reduction of 5-nitro-2,2-dimethyl-1,3-benzodioxole, and acylationof 5- amino-2,2- dimethyl-1,3-benzodioxole. The yield obtained was 15,02%.Key words: synthesis, 5-ethylcarbamyl-2,2-dimethyl-1,3-benzodioxole, insecticide

Effect of Curcuma zedoaria Rosc. ethanolic extract on the lung tumor growth on post initiation phase in female mice induced by Benzo(a)pyrene Retno Murwanti; Edy Meiyanto; Arief Nurrochmad; Susi Ari Kristina
Indonesian Journal of Pharmacy Vol 15 No 1, 2004
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Curcuma zedoaria Rosc. rhizomes has been used as a traditional cancer medicine since a long time ago, but the so far researches performed on the pharmacological mechanism were lacking. This present research has been done to determine the effect of ethanolic extract of Curcuma zedoaria Rosc. rhizomes on lung cancer of female mice previously induced by Benzo[a]pyrene (B[a]P).Newborn mice were induced by B[a]P and then were separated between male and female mice. On 30th day after birth, female mice were given the ethanolic extract of Curcuma zedoaria Rosc. rhizomes and divided into five groups. Three groups were given 200, 500 and 750 mg/kgBB extract, a group was given solvent (DMSO) as negative control, and another group was given nothing as positive control.The results of this present research shown that the ethanolic extract of Curcuma zedoaria Rosc. rhizomes has proved to posses inhibition effect on lung cancer growth in female mice, at dose of 250 mg/kgBB (49,63%), 500 mg/kgBB (73,33%) and 750 mg/kgBB (77,78%).Keywords : Newborn Mice, Benzo[a]piren, Curcuma zedoaria Rosc.

STUDIES ON THROMBOLYTIC AND ANTI-HELMINTIC ACTIVITY OF Cocccinea grandis B Deepti
Indonesian Journal of Pharmacy Vol 25 No 1, 2014
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Traditional system of medicine consists of large number of plants with various medicinal and pharmacological values and hence represents a priceless tank of new bio active molecules. Coccinea grandis belongs to the family Cucurbitaceae, is a rapidly growing, perennial climber or trailing vine. Traditionally different parts of this plant namely roots, leaves, and fruits are used in folklore medicine for several purposes like jaundice, diabetes, wound healing, ulcers, stomach ache, skin disease, fever, asthma, cough. Development of anthelmintic resistance and high cost of conventional anthelmintic drugs led to the evaluation of medicinal plants as an alternative source of anthelmintics. As no scientific data was available on this plant hence, the present study was carried out for the investigation of antihelmintic activity and thrombolytic activity of bark of Coccinea grandis. Antihelmintic activity was done on pheritima posthuma. The results obtained were compared with standard albendazole and control groups respectively, the parameters evaluated are time of paralysis and time of death. On the other hand thrombolytic activity was done by using aqueous extract of Coccinea grandis bark. Thrombi or emboli can lodge in a blood vessel and block the flow of blood in that location depriving tissues of normal blood flow and oxygen. This can result in damage, destruction (infarction), or even death of the tissues (necrosis) in that area. Streptokinase is an antigenic thrombolytic agent used for the treatment of acute myocardial infarction, served as standard. This study was conducted on human blood sample and compared with standard and control groups respectively. The parameters studied are percentage of clot lysis. From the present study we found that various extracts of this plants showed significant thrombolytic and antihelmintic properties.Key words: thrombolysis, helminthes, coccinea, albendazole, streptokinase.

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