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NOOR HUBDRYAWATI
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Jurnal Kimia Mulawarman
Published by Universitas Mulawarman
ISSN : 16935616     EISSN : 24769258     DOI : DOI: https://doi.org/10.30872/jkm
Core Subject : Science,
Chemistry
Journal of Kimia Mulawarman is a peer-reviewed, open access journal that publishes original research articles, review articles, as well as short communication in all areas of chemistry, including educational chemistry and applied chemistry.
Arjuna Subject : Kimia(semua kategori) - Kimia (Lain-Lain)
Articles 8 Documents
 1 
Search results for , issue "Vol 19 No 2 (2022)" : 8 Documents clear
Uji Aktivitas Penghambatan Enzim α-Amilase dan Glukoamilase dari Ekstrak Etanol Daun Kirinyuh (Chromolaena odorata L.) Nelson Gaspersz; Eirene Grace Fransina; Anancy Reza Ngarbingan
JURNAL KIMIA MULAWARMAN Vol 19 No 2 (2022)
Publisher : Jurusan Kimia Fakultas Matematika dan Ilmu Pengetahuan Alam Universitas Mulawarman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30872/jkm.v19i2.1120

Abstract

Research has been carried out to test the inhibitory activity of α-amylase and glucoamylase enzymes in the ethanolic extract of kirinyuh (Chromolaena odorata L.) leaves. The use of kirinyuh leaf ethanol extract as a diabetes drug in vivo has been carried out, but its mechanism of action have never been researched before, so further research is needed on the specific mechanism of ethanolic extract of kirinyuh leaves in reducing blood sugar levels, especially through inhibition of α-amylase and glucoamylase enzymes in vitro. The purpose of this study was to test the antidiabetic activity of the ethanol extract of kirinyuh leaves in vitro using α-amylase and glucoamylase inhibition methods. This research uses DNS spectrophotometric method. The results showed that kirinyuh leaf ethanol extract proved to have inhibitory activity against α-amylase and glucoamylase enzymes with IC50 values of 3730.15 ± 28.91 ppm or 3730.15 ± 28.91 µg/mL and 2510.78. ± 383.37 ppm or 2510.78 ± 383.37 µg/mL. From the results, it can be concluded that the ethanolic extract of kirinyuh leaves has inhibitory activity against α-amylase and glucoamylase enzymes. Telah dilakukan penelitian uji aktivitas penghambatan enzim α-amilase dan glukoamilase ekstrak etanol daun kirinyuh (Chromolaena odorata L.). Penggunaan ekstrak etanol daun kirinyuh sebagai obat diabetes secara in vivo telah dilakukan,tetapi belum diketahui mekanisme kerjanya, sehingga perlu dilakukan penelitian lebih lanjut mengenai mekanisme spesifik ekstrak etanol daun kirinyuh pada penurunana kadar gula darah terutama melalui aktivitas penghambatan terhadap enzim α-amilase dan glukoamilase secara in-vitro. Tujuan penelitian ini untuk untuk menguji aktivitas antidiabetes ekstrak etanol daun kirinyuh secara in vitro menggunakan metode penghambatan enzim α-amilase dan glukoamilase. Penelitian ini menggunakan metode DNS secara spektrofotometri. Hasil penelitian menunjukkan ekstral etanol daun kirinyuh terbukti memiliki aktivitas penghambatan terhadap enzim α-amilase dan glukoamilase dengan nilai IC50 masing-masing, yaitu sebesar 3730,15 ± 28,91 ppm atau 3730,15 ± 28,91 μg/mL dan 2510,78 ± 383,37 ppm atau 2510,78 ± 383,37 μg/mL. Dari hasil dapat disimpulkan bahwa ekstrak etanol daun kirinyuh memiliki aktivitas penghambatan terhadap enzim α-amilase dan glukoamilase.
Molecular Structure And Electronic Properties Of Eugenol And Its Analogues Using Dft Mirella Fonda Maahury; Muhammad Abdulkadir Martoprawiro; Veliyana Londong Allo
JURNAL KIMIA MULAWARMAN Vol 19 No 2 (2022)
Publisher : Jurusan Kimia Fakultas Matematika dan Ilmu Pengetahuan Alam Universitas Mulawarman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30872/jkm.v19i2.1123

Abstract

Eugenol is the active molecule naturally found in clove oil. The calculations have been done for the eugenol and its derivatives computationally. This computational calculation aims to obtain a stable structure and electronic properties of eugenol, methyl eugenol, and acetyl eugenol. The computational calculation used DFT for geometry optimization in the gas phase using B3LYP functional and 6-31G(d) as the basis set. The optimized structure of eugenol and its derivatives is not planar. The presence of methoxy replacing hydroxy increases the bond length and decreases the bond angle and the dihedral. The electronic properties such as atomic charge and density of HOMO-LUMO show the difference between the three molecules.
Sintesis Silika Gel dari Abu Sekam Padi Termodifikasi Kitosan serta Aplikasinya sebagai Adsorben Methylene blue Harum Widyastuti; Aman Sentosa Panggabean; Dirgarini Julia Nurlianta Subagyono
JURNAL KIMIA MULAWARMAN Vol 19 No 2 (2022)
Publisher : Jurusan Kimia Fakultas Matematika dan Ilmu Pengetahuan Alam Universitas Mulawarman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30872/jkm.v19i2.933

Abstract

ABSTRACT Synthesis of silica gel from chitosan-modified rice husk ash and its application as an adsorbent of methylene blue have been studied. The stages of this research included the preparation of rice husk samples, the synthesis of silica ash of rice husks, sodium silicate, chitosan solution, and synthesis of silica gel - chitosan - tripolyphosphate, and the characterization of silica gel material from chitosan-modified rice husk ash. The results showed that silica gel adsoerben from chitosan modified rice husk ash was able to adsorb methylene blue dyes with an optimum pH of 5, optimum contact time for 60 minutes and adsorption capacity of 16.4554 mg/g. Keywords: rice husk, silica gel, chitosan, methylene blue.
UJI TOKSISITAS AKUT SENYAWA ASAM p-METOKSISINAMAT YANG DISINTESIS DARI ETIL p-METOKSISINAMAT Sara Nurmala; Indah Zahara
JURNAL KIMIA MULAWARMAN Vol 19 No 2 (2022)
Publisher : Jurusan Kimia Fakultas Matematika dan Ilmu Pengetahuan Alam Universitas Mulawarman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30872/jkm.v19i2.901

Abstract

Kencur (Kaempferia galanga L.) is a plant that grows in Indonesia and is often used as a traditional spice. The main content of Kencur is ethyl p-methoxycinamic has a mild level of toxicity. Hydrolysis results from Ethyl p-methoxycinamic namely p-methoxycinamic acid have been widely studied as having antibacterial activity against S. aureus with MIC of 125 ppm. P-methoxycinamic acid has anti-inflammatory activity, topical anti-inflammatory power of 8.7% p-methoxycinamic acid based on molar equality with 1% Na-diclofenac. Cinnamic acid compounds have greater potential as an inhibitor of cervical cancer cells compared to methyl cinnamon because they have more hydrogen bonds. Hydrolysis of ethyl p-methoxycinamic to p-methoxycinamic acid has been carried out, then identification tests have been carried out covering the melting distance obtained values ​​of 172–173ºC. The results of TLC analysis with the mobile phase of methanol: acetone (2: 1) p-methoxycinamic acid compound gave an Rf value of: 0.67. The results of infrared spectrum analysis of hydrolysis compounds provide information on the presence of specific functional groups, namely carbonyl groups of acids (C = O) which are shown by the absorption band at wave number 1690.49 cm-1. Hydrogen bonding in carboxylic acid dimers weakens the C = O bond, resulting in absorption at lower wave numbers. In this spectrum CO groups of acids are shown at absorption of 1029.92 cm-1, aromatic C = C groups are shown by uptake at wave numbers 1602.74 cm-1 and 1627.81 cm-1, while bands at wave number 828.37 cm-1 indicates the presence of para-substituted aromatic nuclei. Acute toxicity test of p-methoxycinamic acid compound which was carried out in a span of 24 hours showed that p-methoxycinamic acid had a moderate level of toxicity.
Identifikasi Kandungan Kimia Kulit Sirsak (Annona Muricata) Riska Yudhistia Asworo; Elok Widayanti; Abdullah Arief Agatha
JURNAL KIMIA MULAWARMAN Vol 19 No 2 (2022)
Publisher : Jurusan Kimia Fakultas Matematika dan Ilmu Pengetahuan Alam Universitas Mulawarman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30872/jkm.v19i2.1140

Abstract

Pemanfaatan ekstrak bahan alam dalam biosintesis nanopartikel berkaitan dengan kandungan senyawa metabolit sekunder yang memiliki aktifitas antioksidan. Salah satu tanaman yang mengandung banyak antioksidan adalah sirsak (Annona muricata Linn). Sirsak merupakan tumbuhan yang memiliki banyak manfaat baik dari batang, kulit batang, daun maupun buahnya. Banyak penelitian telah melakukan pemanfaatan dari bagian-bagian dari tumbuhan sirsak. Tetapi belum banyak yang melakukan penelitian pada kulit buah sirsak. Seperti halnya buah manggis baik buah dan kulitnya ternyata memiliki kandungan antioksidan yang cukup tinggi. Antioksidan berasal dari senyawa metabolit sekunder yang ada di tanaman. Keberadaan metabolit sekunder ini dapat diambil dengan cara ekstraksi menggunakan pelarut yang sesuai dengan kepolaran senyawa yang akan diekstrak. Pada penelitian ini digunakan pelarut etanol dan campuran etanol:aquadest . Hasil yang didapatkan rata-rata rendemen menggunakan pelarut etanol:aquadest lebih tinggi (11,64%) dibandingkan menggunakan etanol saja (9,64%). Ekstrak yang didapatkan kemudian dilakukan uji fitokimia secara kualitatif dan didapatkan hasil adanya triterpenoid, saponin, polifenol dan tanin pada ekstrak yang didapat.
Pengaruh Ukuran Simplisia Dan Lama Kontak Pada Ekstraksi Senyawa Aktif Simplisia Kayu Jawa (Lannea Coromandelica) Menggunakan Metode Maserasi Hanandayu Widwiastuti; Riska Yudhistia Asworo; Yustina Suhandini Tjahjaningsih; Niken Cahyaning Wulandari; Abriyanti Dewi
JURNAL KIMIA MULAWARMAN Vol 19 No 2 (2022)
Publisher : Jurusan Kimia Fakultas Matematika dan Ilmu Pengetahuan Alam Universitas Mulawarman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30872/jkm.v19i2.1141

Abstract

Kayu Jawa atau Kayu Jaranan merupakan tanaman yang banyak tumbuh di Pulau Jawa dan umumnya digunakan sebagai pagar pembatas. Namun, di beberapa daerah di Indonesia, tanaman ini seringkali digunakan untuk pengobatan tradisional. Beberapa metabolit sekunder yang diketahui terkandung dalam Kayu Jawa adalah steroid, terpenoid, alkaloid, saponin, tanin, dan flavonoid. Bioaktivitas ekstrak senyawa – senyawa ini dipengaruhi oleh jumlah gugus aktif yang ada pada senyawa tersebut, salah satunya adalah gugus hidroksil. Salah satu senyawa aktif yang memiliki banyak gugus – OH adalah tanin. Gugus ortohidroksil tanin dapat membentuk kelat dengan ion logam. Fungsi tanin sangat dipengaruhi oleh konsentrasinya, apakah berfungsi sebagai agen pengompleks atau agen pengendap. Oleh karena itu, ekstraksi tanin perlu dilakukan secara optimum untuk memperoleh tanin dalam jumlah maksimal. Tujuan penelitian ini adalah untuk mengetahui pengaruh ukuran simplisia waktu kontak terhadap jumlah rendemen yang diperoleh dari ekstraksi Kayu Jawa dengan metode maserasi. Hasil penelitian menunjukkan bahwa jumlah rendemen terbesar dihasilkan pada maserasi dengan ukuran simplisia > 200 mesh dan lama kontak 50 jam, yaitu 23,79% dan 23,01%. Berdasarkan hasil tersebut dapat disimpulkan bahwa ukuran simplisia dan waktu kontak berpengaruh terhadap jumlah rendemen hasil maserasi simplisia Kayu Jawa.
Pengaruh Daya Serap Air Terhadap Porositas Dan Densitas Komposit Hdroksipatit Berpori Dan Selulosa Nata De Coco Silvia Anitasari; Abdul Mu’ti; Yetty Octavia Hutahaean
JURNAL KIMIA MULAWARMAN Vol 19 No 2 (2022)
Publisher : Jurusan Kimia Fakultas Matematika dan Ilmu Pengetahuan Alam Universitas Mulawarman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30872/jkm.v19i2.616

Abstract

The material that used to bone replacement is much needed. In the beginning, the material of bone replacement came from human or animal bones, but now, the development of synthetic materials as the bone replacement from natural materials increase very fast. The Aim of this study was synthesizing bone graft composite derived from hydroxyapatite and cellulose of nata de coco (HAP/cellulose nata de coco) which tested porosity, density, and water absorption and we expected the porosity, density, and water of the composite were approaching to human or animal bones. Based on statistical analysis by Kruskal Walis (p <0,05) and AUC showed HAp/cellulose of nata de coco with 25 hours precipitation time having bony-like human porosity and there were correlation between porosity and density with water absorption capacity of HAp / cellulose nata de coco our by linear correlation statistical analysis. Keywords: Hydroxyapatite, Cellulose nata de coco, Porosity, Density, Water absorption
Fermentasi Singkong Karet (Monihot carthagenensis MÜII) menjadi Etanol dengan Pemanfaatan Albumin Dari Ikan Gabus (Channa striata) Sebagai Sumber Nitrogen Bagi Mikroba Saputri Satriyana Widyaningrum; Rudi Kartika; Erwin Erwin
JURNAL KIMIA MULAWARMAN Vol 19 No 2 (2022)
Publisher : Jurusan Kimia Fakultas Matematika dan Ilmu Pengetahuan Alam Universitas Mulawarman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30872/jkm.v19i2.521

Abstract

Has been cassava rubber fermentation (M. carthagenensisMÜll) as a raw material for making ethanol with the utilization of fishcork albumin (Channastriata) as nitrogen Saccharomyces cerrevisiae with enzymatic hydrolysis result through 2 stages ieliquification using α-amylase and saccharification stage using gluco -amilase. The best reducing sugar content was obtained at 0.1307%. Based on this research, maximum ethanol content was obtained with 0.5% concentration of nutrient at fermentation time for 232 hours, obtained by result of 12,688% at 5.6 mL distillate volume using gas chromatography method.

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