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All Journal Journal of Tropical Life Science : International Journal of Theoretical, Experimental, and Applied Life Sciences Berkala Kedokteran Acta Biochimica Indonesiana Smart Society Empowerment Journal Homeostasis: Jurnal Mahasiswa Pendidikan Dokter
Dona Marisa, Dona
Departemen Biomedik Divisi Fisiologi Fakultas Kedokteran Universitas Lambung Mangkurat, Banjarmasin
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Public Health Other

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POTENSI ANTIINFLAMASI JUS BUAH BELIMBING (Averrhoa carambola L.) TERHADAP DENATURASI PROTEIN IN VITRO Erianti, Farizka; Marisa, Dona; Suhartono, Eko
Jurnal Berkala Kedokteran Vol 11, No 1 (2015): Februari 2015
Publisher : Pendidikan Dokter Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jbk.v11i1.183

Abstract

Starfruit (Averrhoa carambola L.) is an Asian tree that has been used in traditional medicine. Flavonoids, saponins, and tannins is thought to have antiinflammatory in inhibiting protein denaturation. Protein denaturation is a cause of inflammation.  This study aims to determine the antiinflammatory potential of starfruit in inhibiting protein denaturation in vitro. This study is a quasi experimental, using a model reaction between 5 % BSA were heated to form protein denaturation by two groups: the juice as the test group and diclofenac sodium as the standard group, which is divided to a concentration of 10%, 20%, and 30%. Potential inhibition of protein denaturation is known to determine the value of IC50 . The results of this study indicate that the starfruit juice has the IC50 value of 11.896 % (r=0.842), whereas for diclofenac sodium by 11.872 % (r=0.866). Positive r values indicate the existence of a positive relation between  concentration and inhibiting protein denaturatiom potential. These results indicate that the starfruit juice as a potential inhibitor of protein denaturation for inflamamatory process in vitro. Keywords: antiinflammatory, Averrhoa carambola L., protein denaturatin
Gambaran Isolat Bakteri Aerob Diare pada Anak yang Dirawat di RSUD Ulin Banjarmasin Tahun 2015 Muttaqin, Gusti Muhamma Edy; Hartoyo, Edi; Marisa, Dona
Berkala Kedokteran Vol 12, No 1 (2016): Februari 2016
Publisher : Fakultas Kedokteran Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jbk.v12i1.360

Abstract

Abstract: Diarrhea is one of the major health problems in children, especially children under five in developing countries because the mortality and morbidity rate is still high. In the world, 4 to 6 million children die every year from diarrhea, most of these deaths occur in developing countries. In general, the cause of diarrhea can not be separated from the bacterial infection. Bacteria that cause diarrhea varies by age, place, and time. The purpose of this study is analyzing anaerobic bacterial isolate in patients hospitalized children with diarrhea in general hospital ulin Banjarmasin. This study was an observational study with cross sectional design. Types of bacteria in pediatric patients in hospitals Ulin Banjarmasin period August-October 2015 at most is Escherichia coli by 26 samples (72.22%), Salmonella typhi by 7 samples (19.44%), and Shigella sp by 3 samples (8, 33%). Keywords: aerobic bacterial isolate, hospitalized children, diarrhea Abstrak: Diare merupakan salah satu masalah kesehatan utama pada anak terutama balita di negara berkembang karena angka kematian dan kesakitannya masih tinggi. Di dunia, sebanyak 4 sampai 6 juta anak meninggal tiap tahunnya karena diare, dimana sebagian besar kematian tersebut terjadi di negara berkembang. Pada umumnya penyebab diare tidak terlepas dari infeksi bakteri. Bakteri penyebab diare berbeda-beda berdasarkan umur, tempat, dan waktu. Tujuan penelitian ini adalah untuk Mengidentifikasi isolat bakteri aerob diare pada pasien diare anak yang dirawat di RSUD Ulin Periode Agustus – November 2015. Penelitian ini adalah penelitian observasional dengan rancangan cross sectional. Sampel diambil adalah feses dari seluruh populasi anak penderita diare yang dirawat di RSUD Ulin Banjarmasin dengan menggunakan metode total sampling. Dari hasil penelitian didapatkan bahwa jenis isolat bakteri pada pasien anak di RSUD Ulin Banjarmasin periode Agustus – Oktober 2015 dengan total 36 sampel paling banyak adalah Eschericia coli dengan jumlah 26 (72,22%) sampel, Salmonella typhi dengan jumlah 7 (19,44%) sampel, kemudian Shigella sp. 3 (8,33%) sampel. Kata-kata kunci: isolate bakteri aerob, anak yang dirawat, diare
Hubungan Tonsilitis Kronis dan Otitis Media Efusi di Bagian THT RSUD Ulin Banjarmasin Tahun 2014 Fachir, Farisa Shauma; Qamariah, Nur; Marisa, Dona
Berkala Kedokteran Vol 12, No 1 (2016): Februari 2016
Publisher : Fakultas Kedokteran Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jbk.v12i1.353

Abstract

Abstract: Chronic tonsillitis is an inflammation of the tonsil was settled as a result of recurrent of acute or subclinical infection which is marked by the widening of the tonsil crypts and size can be enlarged (hypertrophy) or shrink (atrophy). Otitis media effusion is a state of the serous secretion in the middle ear with an intact tympanic membrane without symptoms and signs of acute inflammation. Primary mechanism that role in the occurrence of otitis media with effusion is eustachian tube disruption, and it is could due to enlarged tonsils. The aims of this study were to determine the relationship between chronic tonsillitis and otitis media with effusion in otorhinolaryngology (ENT) at Ulin general hospital Banjarmasin in 2014. The study was an observational analytic with cross sectional approach. Samples were 526 patients who fulfilled the inclusion criteria. Relationship between chronic tonsillitis and otitis media with effusion was tested using Fisher test with Epi info application and the result showed that p=0,245. It was concluded that there is no relationship between chronic tonsillitis and  otitis media with effusion.Keywords: chronic tonsillitis, otitis media with effusion Abstrak: Tonsilitis kronis adalah peradangan tonsil yang menetap sebagai akibat infeksi akut atau subklinis yang berulang yang tandai oleh adanya pelebaran kripta dan ukuran tonsil yang dapat membesar (hipertrofi) ataupun mengecil (atrofi). Otitis media efusi adalah sebuah keadaan adanya sekret nonpurulen di dalam telinga bagian tengah dengan membran timpani yang utuh, tanpa adanya gejala dan tanda inflamasi akut. Mekanisme utama yang berperan dalam terjadinya otitis media efusi adalah terganggunya fungsi tuba eustachius, salah satunya akibat ukuran tonsil yang membesar. Penelitian ini bertujuan untuk mengetahui hubungan tonsillitis kronis dan otitis media efusi di bagian THT RSUD Ulin Banjarmasin tahun 2014. Penelitian ini merupakan penelitian observasional analitik dengan pendekatan cross sectional. Sampel berjumlah 526 orang pasien yang memenuhi kriteria inklusi. Hasil uji Fisher dengan aplikasi Epi info, didapatkan p=0,245. Kesimpulan tidak terdapat hubungan yang bermakna antara tonsilitis kronis dan otitis media efusi di bagian THT RSUD Ulin Banjarmasin tahun 2014. Kata-kata kunci: tonsilitis kronis, otitis media efusi
THE AMOUNT OF LYMPHOCYTES BEFORE AND AFTER CEMOTHERAPY IN BREAST CANCER AT ULIN GENERAL HOSPITAL BANJARMASIN Dohamid, Firdinia Gafuri; Prenggono, M. Darwin; Marisa, Dona
Berkala Kedokteran Vol 13, No 2 (2017)
Publisher : Fakultas Kedokteran Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jbk.v13i2.4066

Abstract

Abstract: Breast cancer is the most common malignancies among woman in Indonesian. One of breast cancer treatment is chemotherapy which resist cancer’s cells to grow. But chemotherapy also cause DNA damage that interfere lymphocyte proliferation. Depletion on lymphocyte counts will increased patient’s susceptibility to opportunistic infection. The aim of this research was to knowing the difference of lymphocyte counts because of chemotherapy on breast cancer patients in general hospital Ulin Banjarmasin. This research was an observational analytic with cross sectional approach. The sampling technique was non-probability sampling followed by consecutive sampling. Total samples were 61 patients that match with inclusion criteria. Paired T-test was used to analyze the hypothesis with the result of pvalue=0.000 (ρ<0.05), that means there’s a significant decrease in the number of lymphocyte counts after receiving chemotherapy in general hospital Ulin Banjarmasin, January 2014 to December 2015 period. Keywords: chemotherapy, lymphocyte, breast cancer
POTENSI ANTIINFLAMASI JUS BUAH BELIMBING (Averrhoa carambola L.) TERHADAP DENATURASI PROTEIN IN VITRO Farizka Erianti; Dona Marisa; Eko Suhartono
Berkala Kedokteran Vol 11, No 1 (2015)
Publisher : Fakultas Kedokteran Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (303.463 KB) | DOI: 10.20527/jbk.v11i1.183

Abstract

Starfruit (Averrhoa carambola L.) is an Asian tree that has been used in traditional medicine. Flavonoids, saponins, and tannins is thought to have antiinflammatory in inhibiting protein denaturation. Protein denaturation is a cause of inflammation.  This study aims to determine the antiinflammatory potential of starfruit in inhibiting protein denaturation in vitro. This study is a quasi experimental, using a model reaction between 5 % BSA were heated to form protein denaturation by two groups: the juice as the test group and diclofenac sodium as the standard group, which is divided to a concentration of 10%, 20%, and 30%. Potential inhibition of protein denaturation is known to determine the value of IC50 . The results of this study indicate that the starfruit juice has the IC50 value of 11.896 % (r=0.842), whereas for diclofenac sodium by 11.872 % (r=0.866). Positive r values indicate the existence of a positive relation between  concentration and inhibiting protein denaturatiom potential. These results indicate that the starfruit juice as a potential inhibitor of protein denaturation for inflamamatory process in vitro. Keywords: antiinflammatory, Averrhoa carambola L., protein denaturatin
Hubungan Tonsilitis Kronis dan Otitis Media Efusi di Bagian THT RSUD Ulin Banjarmasin Tahun 2014 Farisa Shauma Fachir; Nur Qamariah; Dona Marisa
Berkala Kedokteran Vol 12, No 1 (2016)
Publisher : Fakultas Kedokteran Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (225.135 KB) | DOI: 10.20527/jbk.v12i1.353

Abstract

Abstract: Chronic tonsillitis is an inflammation of the tonsil was settled as a result of recurrent of acute or subclinical infection which is marked by the widening of the tonsil crypts and size can be enlarged (hypertrophy) or shrink (atrophy). Otitis media effusion is a state of the serous secretion in the middle ear with an intact tympanic membrane without symptoms and signs of acute inflammation. Primary mechanism that role in the occurrence of otitis media with effusion is eustachian tube disruption, and it is could due to enlarged tonsils. The aims of this study were to determine the relationship between chronic tonsillitis and otitis media with effusion in otorhinolaryngology (ENT) at Ulin general hospital Banjarmasin in 2014. The study was an observational analytic with cross sectional approach. Samples were 526 patients who fulfilled the inclusion criteria. Relationship between chronic tonsillitis and otitis media with effusion was tested using Fisher test with Epi info application and the result showed that p=0,245. It was concluded that there is no relationship between chronic tonsillitis and  otitis media with effusion.Keywords: chronic tonsillitis, otitis media with effusion Abstrak: Tonsilitis kronis adalah peradangan tonsil yang menetap sebagai akibat infeksi akut atau subklinis yang berulang yang tandai oleh adanya pelebaran kripta dan ukuran tonsil yang dapat membesar (hipertrofi) ataupun mengecil (atrofi). Otitis media efusi adalah sebuah keadaan adanya sekret nonpurulen di dalam telinga bagian tengah dengan membran timpani yang utuh, tanpa adanya gejala dan tanda inflamasi akut. Mekanisme utama yang berperan dalam terjadinya otitis media efusi adalah terganggunya fungsi tuba eustachius, salah satunya akibat ukuran tonsil yang membesar. Penelitian ini bertujuan untuk mengetahui hubungan tonsillitis kronis dan otitis media efusi di bagian THT RSUD Ulin Banjarmasin tahun 2014. Penelitian ini merupakan penelitian observasional analitik dengan pendekatan cross sectional. Sampel berjumlah 526 orang pasien yang memenuhi kriteria inklusi. Hasil uji Fisher dengan aplikasi Epi info, didapatkan p=0,245. Kesimpulan tidak terdapat hubungan yang bermakna antara tonsilitis kronis dan otitis media efusi di bagian THT RSUD Ulin Banjarmasin tahun 2014. Kata-kata kunci: tonsilitis kronis, otitis media efusi
Gambaran Isolat Bakteri Aerob Diare pada Anak yang Dirawat di RSUD Ulin Banjarmasin Tahun 2015 Gusti Muhamma Edy Muttaqin; Edi Hartoyo; Dona Marisa
Berkala Kedokteran Vol 12, No 1 (2016)
Publisher : Fakultas Kedokteran Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (128.892 KB) | DOI: 10.20527/jbk.v12i1.360

Abstract

Abstract: Diarrhea is one of the major health problems in children, especially children under five in developing countries because the mortality and morbidity rate is still high. In the world, 4 to 6 million children die every year from diarrhea, most of these deaths occur in developing countries. In general, the cause of diarrhea can not be separated from the bacterial infection. Bacteria that cause diarrhea varies by age, place, and time. The purpose of this study is analyzing anaerobic bacterial isolate in patients hospitalized children with diarrhea in general hospital ulin Banjarmasin. This study was an observational study with cross sectional design. Types of bacteria in pediatric patients in hospitals Ulin Banjarmasin period August-October 2015 at most is Escherichia coli by 26 samples (72.22%), Salmonella typhi by 7 samples (19.44%), and Shigella sp by 3 samples (8, 33%). Keywords: aerobic bacterial isolate, hospitalized children, diarrhea Abstrak: Diare merupakan salah satu masalah kesehatan utama pada anak terutama balita di negara berkembang karena angka kematian dan kesakitannya masih tinggi. Di dunia, sebanyak 4 sampai 6 juta anak meninggal tiap tahunnya karena diare, dimana sebagian besar kematian tersebut terjadi di negara berkembang. Pada umumnya penyebab diare tidak terlepas dari infeksi bakteri. Bakteri penyebab diare berbeda-beda berdasarkan umur, tempat, dan waktu. Tujuan penelitian ini adalah untuk Mengidentifikasi isolat bakteri aerob diare pada pasien diare anak yang dirawat di RSUD Ulin Periode Agustus – November 2015. Penelitian ini adalah penelitian observasional dengan rancangan cross sectional. Sampel diambil adalah feses dari seluruh populasi anak penderita diare yang dirawat di RSUD Ulin Banjarmasin dengan menggunakan metode total sampling. Dari hasil penelitian didapatkan bahwa jenis isolat bakteri pada pasien anak di RSUD Ulin Banjarmasin periode Agustus – Oktober 2015 dengan total 36 sampel paling banyak adalah Eschericia coli dengan jumlah 26 (72,22%) sampel, Salmonella typhi dengan jumlah 7 (19,44%) sampel, kemudian Shigella sp. 3 (8,33%) sampel. Kata-kata kunci: isolate bakteri aerob, anak yang dirawat, diare
Prevalence and Determinant Factors of Coronary Heart Disease Status in Patients with Heart Failure Anwari Delmi; Dwi Laksono Adiputro; Dona Marisa; Alfi Yasmina
Berkala Kedokteran Vol 17, No 1 (2021)
Publisher : Fakultas Kedokteran Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (285.453 KB) | DOI: 10.20527/jbk.v17i1.10249

Abstract

Abstract: As a cardiovascular disease, heart failure is one of prime mortality cause in the world. Coronary heart disease has a role in development of heart failure so that it becomes one of heart failure’s major clinical risk factor. This study aimed to calculate the prevalence of and identify the factors that influence coronary heart disease status of heart failure patients at Alamanda ward of RSUD Ulin Banjarmasin in 2016. Factors that were studied consisted of age, sex, family history of heart disease, smoking, diabetes mellitus, and hypertension. This study used analytical observation with cross-sectional approach on medical records that were obtained by purposive sampling method. The result showed 46.4% of 263 heart failure patients had coronary heart disease status. Multivariate analysis inferred hypertension as the factor that influences the coronary heart disease status of heart failure patients (OR = 1.98, 95% CI = 1.06 – 3.71, P = 0.033). Keywords: cardiovascular disease, heart failure, coronary heart disease, hypertension
THE AMOUNT OF LYMPHOCYTES BEFORE AND AFTER CEMOTHERAPY IN BREAST CANCER AT ULIN GENERAL HOSPITAL BANJARMASIN Firdinia Gafuri Dohamid; M. Darwin Prenggono; Dona Marisa
Berkala Kedokteran Vol 13, No 2 (2017)
Publisher : Fakultas Kedokteran Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (159.825 KB) | DOI: 10.20527/jbk.v13i2.4066

Abstract

Abstract: Breast cancer is the most common malignancies among woman in Indonesian. One of breast cancer treatment is chemotherapy which resist cancer’s cells to grow. But chemotherapy also cause DNA damage that interfere lymphocyte proliferation. Depletion on lymphocyte counts will increased patient’s susceptibility to opportunistic infection. The aim of this research was to knowing the difference of lymphocyte counts because of chemotherapy on breast cancer patients in general hospital Ulin Banjarmasin. This research was an observational analytic with cross sectional approach. The sampling technique was non-probability sampling followed by consecutive sampling. Total samples were 61 patients that match with inclusion criteria. Paired T-test was used to analyze the hypothesis with the result of pvalue=0.000 (ρ<0.05), that means there’s a significant decrease in the number of lymphocyte counts after receiving chemotherapy in general hospital Ulin Banjarmasin, January 2014 to December 2015 period. Keywords: chemotherapy, lymphocyte, breast cancer
Molecular docking of phytosterols in Stenochlaena palustris as anti-breast cancer Dona Marisa; Lisda Hayatie; Siti Juliati; Eko Suhartono; Noer Komari
Acta Biochimica Indonesiana Vol. 4 No. 2 (2021): Acta Biochimica Indonesiana
Publisher : Indonesian Society for Biochemistry and Molecular Biology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32889/actabioina.59

Abstract

Background: Stenochlaena palustris, also known as kelakai or lemidi, is frequently linked to anti-inflammatory, anti-bacterial, anti-fungal, and antioxidant properties. S. palustris phytosterols are suggested to suppress the progression of breast cancer. Objective: The objective of this study is to evaluate the potential of phytosterols found in S. palustris to act as estrogen receptor (ER) inhibitors. Methods: Phytosterols (alpha-tocopherol, beta-sitosterol, campesterol, stigmasterol, fucosterol) were docked to estrogen receptor (PDB ID: 7KBS). Molecular docking parameters included Gibb's free energy and interactions between ligand and protein. ADMET properties were analyzed using pkCSM and SwissADME. Results: Alpha-tocopherol showed the highest interaction with the estrogen receptor with ΔG value -8. 9254 kcal/mol (the native ligand, raloxifene, had a G value of -12.052 kcal/mol). Leu387 (hydrogen bond); Phe404 (Phi-phi-T shaped), Leu391, Leu346, Trp383, Leu354, Ala350, Leu525, Leu349 (Alkyl) were among the residues by which a-tocopherol interacted with ER. Alpha-tocopherol has no hepatotoxicity and no skin sensitization. Conclusion: By suppressing ERa, phytosterols from S. palustris may have potential anti-breast cancer activity and may be used to prevent estrogen-dependent human cancers like breast cancer.
Co-Authors Abdian Purnapita Pambudi Achmad Rofii Ahmad Husairi Ahmad Husairi Ahmad Husairi Ajeng Dwi Novitasari Alfi Yasmina Anggia Ayunanda Arrafieka Annisa Susilo Anwari Delmi Ariewardana, Angger Asnawati Asnawati Asnawati Asnawati Asnawati Asnawati Athiya Nadifa Azzahra, Wikha Bagus Maulana Akbar Cibro, Impana Dewi Indah Noviana Pratiwi, Dewi Indah Noviana Diah Mutia Rahmawati Didik Dwi Sanyoto Diva Aurellia Rosa Dohamid, Firdinia Gafuri Dwi Laksono Adiputro Dwi Laksono Adiputro Dwi Laksono Adiputro Dwi Laksono Adiputro Edi Hartoyo Edyson Edyson Effiyana, Arika Eka Dewi Yanti Eko Suhartono Farisa Shauma Fachir Farisa Shauma Fachir, Farisa Shauma Farizka Erianti Farizka Erianti, Farizka Fauzan Muttaqien Fauzan Muttaqien Fauzan Muttaqien Finna Rahmiati Firdaus, Muhammad Reyhan Firdinia Gafuri Dohamid Firman Raudana Gusti Muhamma Edy Muttaqin Gusti Muhamma Edy Muttaqin, Gusti Muhamma Edy Handono Kalim Haryati Haryati Hasna, Usratul Hayati, Azka Islami, Shafira Aulia Istiana Istiana Ivana Ellenora Ellenora June Astri Nijka Khan, Muhammad Fawwaz Kusworini Handono Lisda Hayatie, Lisda M Naufal Firdaus M. Iqbal Hisyam Qiroth Mohammad Bakhriansyah Mohammad Bakhriansyah Mohammad Rudiansyah Muhammad Farid Adlirrahman Muhammad Hasan Ridhoni Muhammad Marwan Muhammad Muzain Azhar Muhammad Welly Dafif Muhammad Welly Dafif Munirah, Nida Nanang Miftah Fajari Nasywa Maharani Yudiantara Noer Komari Nur Qamariah Oski Illiandri Oski Illiandri Pagan Pambudi Panghiyangani, Roselina Prenggono, Muhamad Darwin Putri Nur Aini Rafida Ikhsania Camalis Ramadan, Yoga Aditya Noor Rizki Amalia Sari Rizky Frida Monica Santrino, Syifa Nurafifah Sanyoto, Didik Dwi Septiyan Dimas Putra Akbar Sherly Limantara Sherly Limantara Siddik, Muhammad Siti Juliati Siti Kaidah Theresa Tyra Sertani Vini Yulia Anhar Vivin Nurul Islami Widi Aurelia Mirmaningtyas Wiwit Agung Sri Nur Cahyawati Yusril Gunawan Zairin Noor Zulfikar, Muhammad Rakha