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MNJ (Malang Neurology Journal)

MNJ
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Published by Universitas Brawijaya

ISSN : 24076724 EISSN : 24425001 DOI : -

Core Subject : Science,

Neuroscience

Malang Neurology Journal is a peer-reviewed and open access journal that focuses on promoting neurological sciences generated from basic neurosciences and clinical neurology. This journal publishes original articles, reviews, and also interesting case reports. Brief communications containing short features of medicine, latest developments in diagnostic procedures of neurology disease, treatment, or other health issues related to neurology that is important also acceptable. Letters and commentaries of our published articles are welcome.

Arjuna Subject : -

Articles 278 Documents

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THE COMPARISON BETWEEN DEFICIT FUNCTIONAL NEUROLOGIST WITH VON WILLEBRAND FACTOR LEVELS IN ACUTE THROMBOTIC STROKE PATIENTS Sari, Ita Muharram; Islam, Mohammad Saiful
Malang Neurology Journal Vol 2, No 1 (2016): January
Publisher : Malang Neurology Journal

Background. There are limited studies of von Willebrand factor (vWF) and thrombotic stroke, escpecially the relationship between level of vWF and functional neurological deficit. Objective. To determine the difference between functional neurological deficit; measured by the NIHSS scale with the vWF level. Methods. Design study was cross sectional, sampling by consecutive admission according to inclusion and exclusion criteria. Blood samples were taken for vWF measurement. Patients are divided into two categories, low vWF level and high vWF levels. Deficit functional neurologist was measured by NIHSS scale.Results. The results were analyzed by chi square. From 80 patients, the result compares the level of NIHSS scale. In grup with mild NIHSS and low vWF levels (50 %) higher than grup with mild NIHSS and high vWF levels (27,27 %). In other side, grup with moderate NIHSS and low vWF levels (50 %) lower than grup with moderate NIHSS and high vWF levels (72,73 %). The difference is not significant statistically (p=0.067).Conclusion. There was no difference between deficit functional neurologist measured by NIHSS scale with von Willebrand factor levels in acute thrombotic stroke patients.

ASSOCIATION BETWEEN CARBAMAZEPINE INDUCED SEVERE CUTANEOUS ADVERSE DRUG REACTION AND HLA POLIMORPHISMS Ratnaningrum, Safrina Dewi
Malang Neurology Journal Vol 2, No 1 (2016): January
Publisher : Malang Neurology Journal

Carbamazepine as an antiepileptic drug that is used widely and was known can cause severe cutaneous adverse drug reactions like SJS-TEN. These adverse drug reactions is known to be associated with some specific HLA polymorphism in European populations (HLA-A*31: 01), China (HLA-A*31: 01; HLA-B*15: 02), Japan (HLA-A*31 : 01; HLA-B*15: 11), Korea HLA-A*31: 01; HLA-B*15: 02; HLA-B*15: 11), India (HLA-B*15: 02), Thailand (HLA-B*15: 02), and Malaysia (HLA-B*15: 02). Information related to certain HLA polymorphism is important to prevent adverse drug reaction but there is no sufficient data on the population of Indonesia.

THE PROFILE OF COGNITIVE FUNCTION OF PATIENTS HIV/AIDS IN Dr. SAIFUL ANWAR MALANG HOSPITAL Harahap, Herpan Syafii; Rianawati, Sri Budhi
Malang Neurology Journal Vol 1, No 1 (2015): January
Publisher : Malang Neurology Journal

Background.Â HIV/AIDS caused cellular immunodeficiency (the depletion of CD4+).Â This, in turn, raised many complications, such as HIV-associated dementia (HIV-D).Objective. To know the profile of cognitive function of patients of HIV/AIDS tretaed in Dr. Saiful AnwarÂ Malang Hospital.Methods. This was a descriptive study using cross-sectional design. This study was conducted to 41Â patients of HIV/AIDS treated in Dr. Saiful Anwar Malang Hospital during January to February 2012 (n=41).Â The cognitive function was assessed by using Mini Mental State Examination (MMSE) and Clock DrawingÂ Test (CDT) instruments.Results. In MMSE, Number of patients showing total score 0-16 were 9 (21.95%), those showing totalÂ score 17-23 were 25 (60.98%), and those showing total score 24-30 were 7 (17.07%) . In CDT, 37 patientsÂ showed decrease of cognitive function (CDT<4), the remainder showed normal cognitive function. All ofÂ patients showing total score of both MMSE and CDT below normal limit, showed low level of CD4 (< 200Â sel/ÂµL). Patients showing normal cognitive function on CDT, also showing the same result on MMSE.Conclusion.Â Most of patients in this study showed the decrease of cognitive function.

EFFECTS OF BRAIN AGE TO INCREASE COGNITIVE FUNCTION IN ELDERLY Agoes, Achdiat; Lestari, Retno; Alfaruqi, Saifullah
Malang Neurology Journal Vol 2, No 2 (2016): July
Publisher : Malang Neurology Journal

Background. The concept of cognitive (from Latin cognosere, to know or to recognize) refers to the ability to process information, applying knowledge, and change the trend. cognitive function of the elderly can be optimized through a variety of ways, one of that way is the brain training game (Brain Age). The game was created specifically to train the cognitive function of elderly.Objective. To determine the effect of Brain Ag) to the improvement of cognitive function in the elderly in Malang. Methods. Quasi-experimental pretest-posttest approach, the treatment and control groups, and the sampling is done with purposive sampling to obtain the 20 respondents. Data collection instrument in this study are in general cognitive tests by using a measuring instrument MMSE. Then the data were analyzed by Mann-Whitney test showed p value 0.000 <Î± 0.05. Results. There is the effect of therapy brain training game (Brain Age) on increasing cognitive function of elderly in Malang.Conclusion. Therapy of brain training game (Brain Age) can be used as an alternative method of nursing actions that can be implemented in nursing geriatric and to consider inter-community cooperation between the elderly or nursing home.

CORRELATION BETWEEN LEUKOCYTE COUNT WHEN ADMITTED IN EMERGENCY ROOM (ER) WITH CLINICALLY ACUTE ISCHEMIC STROKE PATIENTS Husna, Machlusil; Kusworini, Kusworini; Wulansari, Dian Ayu
Malang Neurology Journal Vol 1, No 2 (2015): July
Publisher : Malang Neurology Journal

Background. Stroke is a local or extensive disorder of brain function that occurs suddenly and rapidly, can cause death without another cause except vascular. Based on pathophysiology of acute ischemic stroke, leukocytes play an important role against deterioration and clinical manifestations in patients by releasing three inflammatory mediators, plugging mechanism in microcirculation, and vasoconstriction. Objective. To investigate the relationship between the clinical manifestations of acute ischemic stroke (incoming, outgoing, and improvement) as measured by the NIHSS score with the number of leukocytes . Methods. The study design was a retrospective cohort sampling. Samples were taken from 62 patients with acute ischemic stroke (31 patients who have normal leukocytes and 31 patients who showed leukocytosis) in Dr. Saiful Anwar (RSSA) Malang hospital that met the inclusion criteria of the study.Results. The results of the statistical test used is Kolmogorov-Smirnov test for incoming NIHSS (p = 0.999), and Chi-Square Test for outcoming NIHSS (p = 0.000) and improved patient (p = 0.001).Conclusion. Patients who have normal leukocyte count at the beginning of treatment is likely to have clinical manifestations by category of incoming NIHSS similar to patients who showed leukocytosis, and tend to have clinical manifestations by category of outcoming NIHSS and improvement or significantly better than patients which showed leukocytosis.

UCAO (UNILATERAL CEREBRAL ARTERY OCCLUSSION) METHOD INCREASES THE LEVEL OF MMP- 9 BRAIN TISSUE IN RATS MODEL OF ISCHEMIC STROKE Indra, Muhamad Rasjad; Gasmara, Cakra Parindra
Malang Neurology Journal Vol 2, No 2 (2016): July
Publisher : Malang Neurology Journal

Background. UCAO (Unilateral Cerebral Artery Occlusion) is a stroke induction method by ligating miceâsÂ carotid artery for 45 minutes. Thus giving a hypoxic condition similar to stroke attacks to human. This method is less complicated and far more efficient. MMP-9 is a stroke marker which is assayed by ELISA from the blood of test animal.Objective. To prove UCAO method is capable to raise MMP-9 concentration in miceâs blood.Methods. This research was an experimental laboratory research with post-test only controlled group design. 8 male rats (8-10 weeks) were divided into 2 groups. A day after the treatment group had been induced to stroke, both group were tested to measure the MMP-9 blood concentration through ELISA.Results. In this research, UCAO method had increased MMP-9 blood concentration in treatment group, compared to the control group. It is proved by the statistic tests, Mann-Whitney and Kruskal-Wallis, which showed a significant increase in treatment group (p < 0.05).Conclusion. UCAO method is accepted as a method to create an ischemic stroke mice model.

THE EFFECT OF BETA GLUCAN OF SACCHAROMYCES CEREVISAE ON THE DECREASE OF ALPHA SYNUCLEIN EXPRESSION IN THE BRAIN SUBSTANTIA NIGRA OF PARKINSONâ€™S WISTAR STRAIN RATS (Rattus novergicus) MODEL INDUCED WITH ROTENONE Rahayu, Masruroh; Kurniawan, Shahdevi Nandar; Husna, Machlusil; Hermawan, Hanestya Oky
Malang Neurology Journal Vol 2, No 1 (2016): January
Publisher : Malang Neurology Journal

Background. One of the regenerative therapy modalities in Parkinson is using the beta glucan effect contained in Saccharomyces cerevisae.Objective. To identify the effect of reduction in alpha synuclein expression on the brain substantia nigra in Parkinson's rat model after given Saccharomyces cerevisae. Methods. This research applied true experimental design by in vivo with draft randomized post test only controlled group design. The sample was divided into five groups, each of them consisted of 5 rats. Variables measured were the decreasing level of alpha synuclein. Results. There was a significant difference between positive control and negative control group.Conclusion. The addition of Saccharomyces cerevisae is able to lower the alpha synuclein expression in Parkinsonâ€™s Wistar strain rat models significantly with maximum at the dose of 72 mg/kgBB.

BIOMOLECULAR ASPECTS AND UPDATE ON TREATMENT OF CEREBRAL MALARIA Husna, Machlusil; Prasetyo, Bowo Hery
Malang Neurology Journal Vol 2, No 2 (2016): July
Publisher : Malang Neurology Journal

Malaria is still becoming a health problem in the world and in Indonesia. Cerebral malaria is one of many features of severe and life threatening malaria. Many hypotheses underlying the pathophysiology of cerebral malaria have been disclosed, but the one that evolved nowdays is the hyphotesis of mechanical, permeability, humoral, and MMPs. These hypotheses proposed about biomolecular aspects of cerebral malaria and the mechanism is still not well understood. The understanding of this pathophysiology will aid the treatment of cerebral malaria. Current basic treatment of cerebral malaria is the ACT (artemisinin base combination treatment) drugs, supportive treatment and the management of its complications which is indispensable. Many research has been conducted and still in progress for finding the best optimal treatment.

EFFECT OF ALPHA LIPOIC ACID ON MDA LEVELS AND HISTOLOGY OF BRAIN IN TYPE 1 DM Mahfud, Rania Arif; Lyrawati, Diana; Sarwono, Imam
Malang Neurology Journal Vol 3, No 1 (2017): January
Publisher : Malang Neurology Journal

Background. Diabetic neuropaty is a condition that can affect pyramidal cells and neuronal cells in theÂ hippocampus. Alpha lipoic acid is effective in pathological conditions where ROS (Reactive Oxygen Species)Â have been implicated, include in brain.Objective. To investigate effects of ALA on oxidative stress in diabetic brain of male Wistar rats.Methods. True experimental design and Posttest Only Control Group are used in this study. Thirty male rats were randomly divided into 5 groups: normal rats without ALA (NTA), diabetic rats without ALA (DTA), diabetic rats with ALA 80 mg, ALA dose 200 mg, and ALA dose 500 mg/kg/day. ALA therapy in mice conducted orally once a day. Diabetes was induced in rats by single intraperitonial injection of streptozotocin (STZ) at 60 mg/kg body weight. The content of malondialdehyde (MDA) in the brain was measured by spectrophotometeric assays. Brain structure (pyramidal cell in hippocampus) was assessed by staining with hematoxylin and eosin.Results. MDA levels in the DTA, DA80 and DA200 is greater than the levels of MDA in the NTA group, but not statistically significant at the MDA values (p = 0,260). Test-Product Moment Pearson correlation showed a weak positive relationship and not significant (r = 0,327) between the groups of NTA, DA80 and DA200 with MDA. No differences pyramidal cell structure between NTA and DTA.Conclusion. The treatment for 4 weeks with ALA had not reduced oxidative stress in diabetic brain.

THE EFFECTS OF EARTHWORMSâ€™ (PHERETIMA ASPERGILLUM) ETHANOL EXTRACT TOWARD THE IMPROVEMENT OF NERVE FIBERS DENSITY IN DIABETIC ULCERS CARE DEGREE II OF RATS WISTAR Kristianto, Heri; Mardiati, Ni Putu Jeny
Malang Neurology Journal Vol 3, No 2 (2017): July
Publisher : Malang Neurology Journal

Background. Diabetic ulcer is a chronic complication of diabetes mellitus which lead to infection and lowerÂ extremity amputation. Earthworm (Pheretima aspergillum) has bioactive substance of IGF-1 (insulin likeÂ growth factor 1) to promote Schwann cell proliferation, survival, and migration into the distal end in theÂ injured nerve area to support axonal re-growth.Objective. To investigate the effect of earthworm extract (Pheretima aspergillum) on the enhancement of nervous fibers density in rats induced diabetic ulcer stage II.Methods. This study applied a true-experimental posttest only controlled group design. Samples were divided into five groups: Normal Saline as a negative control group, Hydrogel as a positive control group, and the three treatment groups received earthworm extract via topical, oral, and topical-oral. The patterns of nervous fibers connecting to hair follicles were identified using silver impregnation stain.Results. The result shows the groups receiving earthworm extract have significantly higher nervous fibers density compared to the control groups (p=0.000). The administered of earthworm extract via topical has an optimal effect on improving nervous fibers density.Conclusion. Earthworm extract promote regeneration of peripheral nerve in rats model of diabetic.

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