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MNJ (Malang Neurology Journal)

MNJ
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Published by Universitas Brawijaya

ISSN : 24076724 EISSN : 24425001 DOI : -

Core Subject : Science,

Neuroscience

Malang Neurology Journal is a peer-reviewed and open access journal that focuses on promoting neurological sciences generated from basic neurosciences and clinical neurology. This journal publishes original articles, reviews, and also interesting case reports. Brief communications containing short features of medicine, latest developments in diagnostic procedures of neurology disease, treatment, or other health issues related to neurology that is important also acceptable. Letters and commentaries of our published articles are welcome.

Arjuna Subject : -

Articles 278 Documents

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PARKINSON AND STEM CELL THERAPY Gunawan, Gerry; Dalhar, Mochamad; Kurniawan, Shahdevi Nandar
Malang Neurology Journal Vol 3, No 1 (2017): January
Publisher : Malang Neurology Journal

Parkinson's disease is a neurodegenerative disorder that is progressive about the movement or control of movement. The disease often occurs in people over the age of 60 years. The etiology of Parkinson's disease caused by a combination of genetic and environmental factors. Because overall life expectancy increases, the number of people with Parkinson's disease will increase in the future. Treatment of Parkinson's disease can be used with pharmacological therapy and nonpharmacological therapy. Pharmacological therapy can use levodopa, monoamine oxidase-B inhibitors, dopamine agonists, anticholinergics and amantadine, while nonpharmacological therapies may use the method of stem cell therapy. Stem cells are master cells that have two important characteristics that can perform self-renewing through cell division and can be induced to become cells with specific functions. The aim of Stem cell therapy in Parkinson's disease to replace the damaged dopaminergic cells.

DESIGN OF EXPERT SYSTEM AS A SUPPORT TOOL FOR EARLY DIAGNOSIS OF PRIMARY HEADACHE Azzahra, Zahwa Arsy; Purwanti, Endah; Hidayati, Hanik Badriyah
Malang Neurology Journal Vol 3, No 2 (2017): July
Publisher : Malang Neurology Journal

Background. Headache is the top ranked with 42% percentage of all complaints neurologyâ€™s patients.Â Focused and systematic approach is needed in making a diagnosis of primary headache type becauseÂ management of headache is different for each type.Objective. Enabling users to identify the type of headache.Methods. The experiment was conducted using NaÃ¯ve Bayes classifier method which is the principle is multiplying the percentage likelihood of each variable for each parameter for each class.Results. The percentage value of each parameter obtained from the data of headache patients at neurology polyclinic poly of Dr. Soetomo Hospital within 1 year from the year 2014 to 2015. The percentage value of each class likelihood sought highest value which is the output or decision-diagnosis program. Analysis of each of the input parameters, gender, age, location of head pain, headache characteristics, appeared least autonomous signs, and scale of headache may indicate that each of the options selected by the user influence the decision of the diagnosis program.Conclusion. The design of early detection of primary headaches with the input parameters as mentioned before derived from the raw data as electronic medical records to be analyzed based on methods NaÃ¯ve Bayes classifier resulted in the decision diagnosis of migraine, cluster and TTH have accuracy values by 92 %.

EFFECTS OF GENISTEIN EXPOSURE TOWARD INITIAL DEVELOPMENT OF CENTRAL NERVOUS SYSTEM IN CHICKEN EMBRYO MODEL (GALLUS GALLUS) AGE 48 HOURS Rahayu, Indriati Dwi; Paundralingga, Obed Trinurcahyo Kinantyo; Sari, Vidia Purnama
Malang Neurology Journal Vol 4, No 1 (2018): January
Publisher : Malang Neurology Journal

Background. The safety of genistein consumption in the first trimester of pregnancy and its effect on embryonic development, especially in the development of Central Nervous System (CNS) is still not widely known.Objective. To determine the effect of genistein exposure to the early development of the Central Nervous System.Methods. The animal model used in this research is chick embryo (Gallus gallus). Genistein at a dose of 5 ÂµM, 10 ÂµM and 20 ÂµM in ovo injected into the yolk sac of the eggs before incubation. The eggs were then incubated for 48 hours at a temperature of from 37.50 to 38.50 C. After 48 hours, broken egg shell, embryos are taken and carried out using Toluidine Blue staining. The evaluation was done on the neural tube, anterior neuropore, posterior neuropore and somites.Results. It was found neural tube defects in the group treated with genistein more than the control group but the result was not statistically significant.Conclusion. For the somites, in the group treated with a dose of 10 ÂµM genistein, the number of somites more than the control group and statistically the number is significant.

ATTENTION AND INTERNATIONAL HIV DEMENTIA SCALE (IHDS) DO NOT CORRELATE WITH CD4 COUNT IN HIV PATIENTS Arofah, Annisa Nurul; Rianawati, Sri Budhi; Rasyid, Harun Al; Rahayu, Masruroh
Malang Neurology Journal Vol 4, No 2 (2018): July
Publisher : Malang Neurology Journal

Background. Despite it is common neurocognitive domain that affected in patient with Human Immunodeficiency Virus (HIV) infection, attention domain is not assessed using International HIV Dementia Scale (IHDS), a common screening test to diagnose HIV-associated cognitive disorder. Detection of attention deficit in HIV patient is important as it can maintain the capacity to adherence to antiretroviral therapy and essential to activity daily living. CD4 is one of the markers for severity of HIV infection. Objective. We aims to correlate between CD4 with IHDS and CD4 with attention performance test, such as forward digit span test (FWD), backward digit span test (BWD), and trail making test A test (TMA).Methods. This is an analytic study using cross sectional design. 20 respondents are collected for the study using purposive sampling. Data is collected using instrument IHDS, FWD, BWD, and TMA.Results. Using the correlation of Eta, Eta 2 of CD4 and IHDS, CD4 and FWD, CD4 and BWD, also CD4 and TMA are 0.025, 0.022, 0.022 and 0.011.Conclusion. We concluded that CD4 have no correlation with test for attention domain and IHDS.

CLINICAL MANIFESTATIONS OF DELIRIUM IN ELDERLY Inche Mat, Liyana Najwa; Sulaiman, Wan Aliaa Wan; Kee, Hoo Fan; Baharin, Muhammad Afwan Shamsul; Ghenesan, Surendran; Ishak, Siti Nabila; Abidin, Wan Fairuzlina Zainal; Daud, Nor Liyana Farhan; Yun, Tan Hong
Malang Neurology Journal Vol 4, No 2 (2018): July
Publisher : Malang Neurology Journal

Delirium is commonly encountered in the elderly. It is important to recognize and subsequently treat delirium early to prevent morbidity and mortality. The primary objective of this article review is to gather specific information about each clinical manifestation of delirium in elderly. Sieving through numerous literature and studies regarding the topic of Delirium in the elderly. Majority of the article source were from Medline and PubMed as subscribed by the institution where there are more than 27 million citations in the field of biomedical articles. The articles include articles that was published in Malaysia and also international article due to the limitation in Malaysia itself. The articles were retrieved from publications in the year 1992 up to the current year 2017. Clinical manifestation of delirium that had been reviewed include disordered thinking, euphoric, language impairment, illusion, reversal of sleep wake cycle, inattention, disoriented and memory deficit. Most of the information is about prevalence, clinical diagnosis, and pathophysiology of each of the clinical manifestation. Delirium in elderly is very complex and complicated which involve physical, emotion feelings not only for the patient but also for people in their surroundings. Many articles reviewed explain about each of the symptoms in further details in term on how they act and how they interact with people surrounding.

THE EFFECT OF INFECTION OF MYCOBACTERIUM TUBERCULOSIS STRAIN H37RV TOWARDS THE EXPRESSION OF TNF- Î± IN THE BRAIN Santoso, Giovani Anggasta; Sujuti, Hidayat; Hidayati, Dwi Yuni Nur
Malang Neurology Journal Vol 3, No 1 (2017): January
Publisher : Malang Neurology Journal

Background. Tuberculosis caused by mycobacterium tuberculosis. The support of these inflamated factorsÂ contained in this focus determine the prognosis of TB towards Central Nervous System. One of theÂ inflammation factors is TNF-Î±.Objective. To find the expression of TNF-Î± on the brain which are infected by M. tuberculosis.Methods. Experimental study, Wild Mus musculus to compare the group which has got infected before. The similiar study has been conducted by Laksmi Wulandari, pulmonologist. The observation towards the expression of TNF-a into a mouseâ€™s brain was done by using the imunohistokimia method. It is marked by the brown color in the core, sitoplasma and the cell with upgrading size 100x times 20.Results. This is evident that significanly corelation (P = 0.000) between independent Mycobacterium tuberculosis infection at incubation periode 8 and 16 weeks) and dependent variabel (TNF-Î± expression on brain winstar tissue that infected by Mycobacterium tuberculosis for 8 and 16 weeks).Conclusion. Strong relationship between expression of TNF-a and the M. Tuberculosisâ€™ infection.

THE EFFECT OF HSP65 MYCOBACTERIUM TUBERCULOSIS ON THE VACCINATION TOWARDS AORTIC THICKNESS OF MICE THAT HAVE BEEN INDUCED ATHEROSCLEROSIS Sari, Dian Amelia
Malang Neurology Journal Vol 3, No 2 (2017): July
Publisher : Malang Neurology Journal

Background. Atherosclerosis is an inflammatory process of the blood vessels accompanied by immuneÂ activity which is signed by the enhancement of histopathologic. One of the protective proteins in theÂ human artery wall expressed when there is endothelial stress is HSP60. HSP65 is an HSP60 homologousÂ protein found in bacteria, such as Mycobacterium tuberculosis.Objective. To determine the effect of HSP65 through aorta thickness of mice.Methods. This research applied experimental study using post-test control group design in which subjects were divided into 5 groups. Each group consisted of 5 mice. Group I mice fed a diet normokolesterolemia (negative control), group II mice given atherogenic diet without vaccine (positive control), group III mice given atherogenic diet and 0,5Î¼g accination, group IV mice were given atherogenic diet and 0,75Î¼g vaccination, group V mice were given atherogenic diet and 1Î¼g vaccination.Results. There was a difference between the atherogenic diet and vaccination group (p <0.05). There was a significant decrease in aortic thickness of atherosclerosis mice with HSP65 vaccination dose 0,75Âµg (r= -0,449, p= 0,024).Conclusion. HSP65 Mycobacterium tuberculosis vaccination can reduce the thickness of the aorta in mice induced atherosclerosis and the effective dose is 0.75 mg dose.

CLINICAL AND RADIOLOGICAL APPROACH OF POSTERIOR REVERSIBLE ENCEPHALOPATHY SYNDROME ON ECLAMPSIA Fakhrurrazy, Fakhrurrazy; Surdhawati, Herly Maulida
Malang Neurology Journal Vol 3, No 2 (2017): July
Publisher : Malang Neurology Journal

Posterior reversible encephalopathy syndrome (PRES) is rare clinico-neuroradiologic condition and notÂ commonly reported in the literature, a recently recognized syndrome characterized clinically byÂ headache, confusion, seizure and visual loss associated, with imaging findings of bilateral cortical andÂ subcortical oedema, predominantly posterior cerebral lesions (mainly occipito-parietal). PosteriorÂ reversible encephalopathy syndrome is an uncommon complication of severe preeclampsia/ eclampsia.Â The objective of this study is to report PRES case on eclampsia with clinical and radiological approach. WeÂ report a case of woman, 34 years old woman, with chief complaint tonic clonic general seizure andÂ sudden headache previously. This patient had pregnancy 8 gestational month and had pregnancyÂ termination with cesarean section recently. Patient had loss of consciousness, vision disturbance, andÂ weakness of right extremities, all this symptom become well during treatment. The result of laboratoryÂ examination was HELLP syndrome (haemolysis, elevated liver enzymes and low-platelets). Head CT scanÂ showed hypodense lesion in left parietooccipital region and MRI on T2W and T2FLAIR ADC MAPS foundÂ hyperintens lesion in right and left parietooccipital. Then it can be concluded that it have been reportedÂ cases of eclampsia with PRES with symptom of headache, seizure, mental status disturbance, visualÂ disturbances. The pathological association between PRES and HELLP syndrome in a patient with eclampsiaÂ is poorly described.

AMPLITUDO SENSORY NEURON ACTION POTENTIAL USING AS INSTALLATION OF POLYNEUROPATHY DIAGNOSIS Kinesya, Billi; Husna, Machlusil; Kurniawan, Shahdevi Nandar; Ridwan, Mochammad
Malang Neurology Journal Vol 4, No 1 (2018): January
Publisher : Malang Neurology Journal

Background. Polyneuropathy is the pathologic changes and functional disturbances in the peripheral nervous system. These changes manifest as sign and symptoms such as numbness, burning, allodynia, atrophy, and lose of stimulation responses. Diagnosing polyneuropathy can use electrodiagnostic method like electroneuromyography (ENMG). One of the most sensitive ENMG parameters for polyneuropathy is SNAP amplitude which can be measured at Sural Nerve.Objective. The goal of this study is to know whether SNAP amplitude can be used to diagnose polyneuropathy.Methods. The study design is diagnostic test in cross-sectional method.Results. Samples were taken from 108 ENMG medical records of Neurology Department Saiful Anwar General Hospital during the whole 2014. Two variables which are compared are polyneuropathy diagnosis and SNAP amplitude. Fisher test shows significant differences between the two with p = 0.04. Diagnostic test shows sensitivity 68.3%, spesifisity 80%, positive predictive value 97.1%, and negative predictive value 20.5%.Conclusion. There is a significant relationship between SNAP amplitude reduction with the diagnosis of polyneuropathy.

COMPARISON OF ACUTE ISCHEMIC STROKE FUNCTIONAL OUTCOME IN SMOKERS AND NONSMOKERS MEASURED BY CANADIAN NEUROLOGICAL SCALE (CNS) AND NIHSS Putri, Nila Novia; Islam, Mohamad Saiful; Subadi, Imam
Malang Neurology Journal Vol 4, No 2 (2018): July
Publisher : Malang Neurology Journal

Background. Stroke is the worldâ€™s second leading cause of death and main cause of disability. Smoking is a well-known risk factor of stroke. However, the correlation between smoking and stroke outcome is still remains a controversy.Objective. To analyze the differences of functional outcome between smokers and non-smokers in acute ischemic stroke patients.Methods. The design used in this study is retrospective cross-sectional. The functional outcomes of acute ischemic stroke were measured by Canadian Neurologic Scale (CNS) and NIHSS over a period of seven days after the onset of stroke. Differences of CNS and NIHSS were analyzed using Mann-Whitney U test.Results. Median of CNS in smokers and non-smokers were 9.0 and 11.0, respectively. Median of NIHSS in smokers and non-smokers were 4.0 and 2.0, respectively. There were no significant differences in the analysis of CNS score between smokers and non-smokers and NIHSS score analysis between smokers and non-smokers.Conclusion. Smoking is not correlated with the functional outcome in acute ischemic stroke patients measured by CNS and NIHSS.

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