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MNJ (Malang Neurology Journal)

MNJ
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Published by Universitas Brawijaya

ISSN : 24076724 EISSN : 24425001 DOI : -

Core Subject : Science,

Neuroscience

Malang Neurology Journal is a peer-reviewed and open access journal that focuses on promoting neurological sciences generated from basic neurosciences and clinical neurology. This journal publishes original articles, reviews, and also interesting case reports. Brief communications containing short features of medicine, latest developments in diagnostic procedures of neurology disease, treatment, or other health issues related to neurology that is important also acceptable. Letters and commentaries of our published articles are welcome.

Arjuna Subject : -

Articles 278 Documents

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BRAIN NEURON REGENERATION IN POST-STROKE REHABILITATION TREATMENT USING GRAPE PEEL AND SEED EXTRACT (Vitis vinifera) IN INDUCING ERK1 / 2 PATHWAY Lie, Zanella Yolanda; Tandiono, Meliantha; Pricillia, Lucy; Lukito, Astrid Nandikasari; Gasmara, Cakra Parindra
Malang Neurology Journal Vol 2, No 1 (2016): January
Publisher : Malang Neurology Journal

Background. Ischemic stroke can cause hypoxia in brain tissue and damage the neuron. The defense ability and plasticity is activated by ERK1/2 pathway. Grape peel and seed extract (Vitis vinifera can induce release neurotrophic factor that contribute in ERK1/2 pathway mechanism.Objective. To prove that grape peel and seed extract can regenerate neuron in anatomical and functional view.Methods. This research use true experimental design with sample in this research is 20 male 8-10 weeks old wistar strain rats which are induced stroke by internal and external carotid artery occlusion method.Results. The repairment is monitored from four parameters, namely cylinder test score, ladder rung walking test score, extensive infarct volume, and number of damaged neuron. Conclusion. The result is 50mg/KgBW is effective in repairing neuron. It is seen from the result of improvement in four parameters explained above.

NEURAL PAIN PATHWAY TRACING OF RABBIT ISCHEMIC HEART BY DOUBLE-RETROGRADE NEUROTRACING Dapamede, Theodorus; Paundralingga, Obed Trinurcahyo Kinantyo; Rahayu, Masruroh; Soemantri, Bambang
Malang Neurology Journal Vol 1, No 1 (2015): January
Publisher : Malang Neurology Journal

Background. Myocardial ischaemiaÂ leads to angina pectoris or referred pain, whichhappens because of theÂ inability of the brain to distinguish the visceral afferent inputs from the somatic afferent inputs since theyÂ run along a common pathway via the dorsal root ganglia.Objective. To distinguish specific areas of the rabbit heart that are projected to specific dorsalÂ root ganglia, which then associates to its specific dermatomes.Methods. A double-retrograde neurotracing method was used, with True Blue and Nuclear Yellow as theÂ neurotracers. Rabbits were divided into 3 groups, which the first and second groups were ligated at theÂ left anterior descending artery and at the left circumflex artery, respectively.The third group acted as theÂ control group, without ligation.Results. There is significant association between the site of ligation to the projection of the neurotracers atÂ specific dorsal root ganglia (p<0.05). The first group showed high tendency to be projected to T2 and theÂ second group showed a high tendency to project to T1.Conclusion. This study shows that the rabbit heart can be specifically projected neuronally to specificÂ dorsal root ganglia, following coronary artery ligation.

THE EFFECT OF BETA GLUCAN OF SACCHAROMYCES CEREVISAE ON THE INCREASE OF THE NUMBER OF BRAIN CELLS IN SUBSTANTIA NIGRA BRAIN OF PARKINSONâ€™S WISTAR STRAIN RAT (RATTUS NORVEGICUS) MODEL INDUCED WITH ROTENONE Rahayu, Masruroh; Kurniawan, Shahdevi Nandar; Anggraini, Dini Jatiya
Malang Neurology Journal Vol 1, No 1 (2015): January
Publisher : Malang Neurology Journal

Background.Â BetaÂ glucan from Saccharomyces cerevisae is very potential to be used as a regenerative therapy of Parkinson'sÂ disease. Beta glucan can increase the mobilization of hematopoietic stem cells (HSCs) from the boneÂ marrow into the damaged tissues.Objective.Â To find out the effects of the addition of Saccharomyces cerevisae toward the number ofÂ brain cells in substantia nigra Parkinsonâ€™s rat model.Methods. Experimental researchÂ in vivo using the draft of randomized post test only controlledÂ group design.Results. Treatment Group 3 (72 mg/kgBB) was a group with the largest number of brain cells than the other treatment groups. Statistical data obtained showed that the average number of brain cells in negative control group was 192.00 cells; positive control amounted to 116.80 cells; Treatment 1 amounted to 135.40 cells; Treatment 2 amounted to 140.80 cells; and Treatment 3 amounted to 161.80 cells.Conclusion.Â The addition of Saccharomyces cerevisae with a dose of 18mg/kgBB, 36mg/kgBBdan 72mg/kgBB is able to increase the number of brain cells in the substantia nigra of the brain of Parkinsonâ€™sÂ Strain Wistar rat model significantly.

NEURONAL SIGNALING Kurniawan, Shahdevi Nandar
Malang Neurology Journal Vol 1, No 2 (2015): July
Publisher : Malang Neurology Journal

Intracellular processes in neurons begins when the extracellular chemical signals such as neurotransmitters, attached at specific receptors which then activates a cascade of intracellular reactions included herein are proteins GTP, second messengers, protein kinases, ion channels, and other effector proteins that will change the instantaneous state of the physiology of the cell the target. The intracellular signal will also change the long-term performance by interfering with the transcription of genes that will change the protein composition of the target cell. Many components are involved in intracellular signal that will control the neurons, so that the necessary coordination of electrical and chemical signals in the nervous system. Also discussed here regarding the conducting various signals in neurons, including signaling pathways, type receptors, G proteins and molecular targets, second messengers, the target of second messengers, NGF/TrkA, long-term depression (LTD), and tyrosine phosphorylation hidrosilase.Â

OCCIPITAL LOBE SYNDROME Kurniawan, Shahdevi Nandar
Malang Neurology Journal Vol 2, No 1 (2016): January
Publisher : Malang Neurology Journal

The ability to recognize objects and words is not just depend on the integrity of visual pathway andÂ primary vision area on cerebral cortex (Brodmann area 17), but also secondary vision area 18 and tertiary vision area 19 on occipital lobe. Lesion in occipital lobe could disturb of human visual function such as visual field defects, inability to recognize colors, inability to recognize words, visual hallucinations and illusions, occipital lobe epilepsy, and Antonâ€™s syndrome. Some causes of occipital lobe lesion are head trauma, chemical intoxicity, neoplasma, stroke, degenerative disease, and vascular disease. Prognosis of occipital lobe syndrome is depend on the initial condition but prognosis from the majority of cases with occipital lobe lesions is not good because the exact intervention is not discovered yet and included one ofirreversible disease.

THE RELATIONSHIP OF CARPAL TUNNEL SYNDROME CLINICAL SYMPTOMPS AND ELECTRONEUROMYOGRAPHY RESULTS IN RSSA MALANG Kurniawan, Shahdevi Nandar; Husna, Machlusil; Rasyid, Harun Al; Bilqis, Nadiya Elfira
Malang Neurology Journal Vol 2, No 1 (2016): January
Publisher : Malang Neurology Journal

Background. Carpal tunnel syndrome (CTS) is caused by entrapment neuropathy of the median nerve in the carpal tunnel that can be detected with electroneuromyography (ENMG).Objective. To determine whether there are significant differences in parameters of ENMG examination between CTS groups with mild-to-moderate and severe clinical symptoms.Methods. The study design was observational analytic using cross sectional design approach of the patient's medical record data as many as 61 samples.Results. From 61 samples, there were dominancy of age â‰¥ 40 years old as many as 80.32% and gender female as many as 88.52%. There was no significant differences in age and gender between the two groups (p=0.073 and p=1.000 respectively). Sensory amplitude, MSDL, and Ring Diff are significantly different between the two groups (p=0.005, p=0.020, and p=0.031 respectively). There are no significant difference of motor amplitude and MMDL between the two groups (p=0.384 and p=0.196 respectively).Conclusion. Sensory amplitude value having a relationship with the severity of clinical symptoms. ENMG examination and clinical symptoms of CTS were independent parameters, that should not be used alone to make a diagnosi both of them could enhance the accuracy of diagnosis.

INFECTION-ASSOCIATED DEMENTIA Harahap, Herpan Syafii; Rianawati, Sri Budhi
Malang Neurology Journal Vol 1, No 1 (2015): January
Publisher : Malang Neurology Journal

Central nervous system infection may decrease cognitive function in broad spectrum, ranged from mild cognitive impairment to infection-associated dementia. Infection-associated dementia is a dementia which develops concomitantly or lately after central nervous system infection by any microorganism. Some study showed infection-associated dementia was likely developing as the secondary neuronal response to the activation of immune cell in the brain activated by infectious agent. Screening and formal neuropsyichological testing are the most important examination modalities for the diagnosis of infection associated dementia. The availability of functional radiological examination techniques are useful for identifying of brain function and visualizing the brain activities in vivo. The recent modality treatments for infection-associated dementia are insignificantly different with the modality treatments for other dementia. These treatment are consists of pharmacological and non-pharmacological treatments.

NUTRITIONAL STATUS RELATION TOWARD DEVELOPMENT OF NEURODEVELOPMENTAL TO INFANTS AGED 0-6 MONTHS WHO RECEIVED BREAST MILK EXCLUSIVELY AND NONEXCLUSIVELY (IN PUSKESMAS KEDUNGKANDANG MALANG) Ida, Brigitta; Nugroho, Fajar Ari; Arysanthi, Inke Triana
Malang Neurology Journal Vol 2, No 2 (2016): July
Publisher : Malang Neurology Journal

Background. Breastfeeding is an important activity to maintain and prepare the next generation in the future. The low of exclusive breastfeeding at the family is one of the triggers for low of nutritional status and it associated with neurodevelopmental delays of infants.Objective. To identify and analyze the correlation of nutritional status on neurodevelopmental development in infants aged 0-6 months who are exclusive and non-exclusive breastfeeding in Kedungkandang Health Center Malang.Methods. An observational analytic using a cross-sectional approach . The samples were taken by Consecutive Sampling technique. Data were analyzed by Spearman Rank correlation test.Results. There is a significant correlation between nutritional status with neurodevelopmental development in infants aged 0-6 months with significance value p = 0.000 ( 0.000 < 0.05 ) and the strength of correlation (r=0,552) is medium.Conclusion. There is a positive correlation between nutritional status with neurodevelopmental progress of infants aged 0-6 months who are exclusively breastfed . Exclusive breastfeeding affects the nutritional status better, then a good nutritional status affected neurodevelopmental development also better.

CORRELATION OF C-REACTIVE PROTEIN LEVELS WITH CLINICAL OUTCOME INTRACEREBRAL HEMORRHAGE STROKE PATIENTS Setianto, Catur Ari; Purnomo, Hari; Marhaendraputro, Eko Arisetijono; Santoso, Widodo Mardi
Malang Neurology Journal Vol 1, No 1 (2015): January
Publisher : Malang Neurology Journal

Background. Increased levels of markers of inflammatory factors after hemorrhage stroke was able to predict poor clinical outcome. Until now, the role of C Reactive Protein (CRP) in the local inflammatory response and clinical determinants output remains unclear.Objective. To investigate the correlation of CRP level with poor clinical outcome as measured by Barthel Index. Methods. This study was an observasional cohort porspective study performed on haemorrhage stroke patients in Saiful Anwar General Hospital in Februari 2014 until April 2014.Results. There was significant correlation (p=0,01, r=0,613) between CRP levels to poor clinical outcome measured by Barthel Index.Conclusion. C Reactive Protein levels could predict poor clinical outcome as measured by Barthel Index in intracerebral hemorrhage patients.

EFFECT OF THE RADIATION OF GAMMA RAYS ON CASPASE-3 EXPRESSION IN RATTUS NORVEGICUS WISTAR MALE VARIANT BRAIN CELL WITH IMMUNOHISTOCHEMISTRY METHOD Alam, Ahmad Bayhaqi Nasir; Rahayu, Masruroh; Islani, Ahmad Zaki Sukma
Malang Neurology Journal Vol 1, No 2 (2015): July
Publisher : Malang Neurology Journal

Â Background. The brain is an organ that has an important function potentially exposed to bad influences of radiation, especially on the head neck tumors. Gamma rays interact with body molecules causing damage to DNA and subsequently apoptosis. Caspase-3 plays an important role in apoptosis as effector caspase. Objective. To prove that the radiation of cobalt-60 gamma rays in Rattus norvegicus Wistar male variant causes brain cell apoptosis by the number of apoptotic cells more than in the single-dose fractionation. Methods. This Experimental research using animals were randomly divided into 3 groups: control, single and fractionation.Results. An increase in apoptotic index in the irradiated brain cells in single dose and fractionation dose compared by control group were significant (ANOVA, p > 0.05 ). Sequentially, the highest apoptotic index in a single group, fractionation, and control.Conclusion. The provision of radiation Cobalt - 60 gamma rays cause brain cell apoptosis Rattus norvegicus Wistar male variant and a single dose to cause apoptosis of brain cells more than the dose fractionation.

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