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Biomedical Journal of Indonesia
Published by Universitas Sriwijaya
ISSN : 24077097     EISSN : -     DOI : -
Core Subject : Health, Science,
Biochemistry, Genetics & Molecular Biology Medicine & Pharmacology
Biomedical Journal of Indonesia is an open access, peer-reviewed journal that focus on basic medical sciences, emphasizing on providing the molecular studies of biomedical problems and molecular mechanisms to integrate researches in all aspects of human health. BJI is dedicated to publishing original research and review articles covering all aspects of biomedical sciences.
Arjuna Subject : Kedokteran - Anatomi
Articles 6 Documents
 1 
Search results for , issue "Vol. 12 No. 2 (2026): Vol 12, No 2, 2026, In Press" : 6 Documents clear
Promama Complementary Therapy: Impact on Hemoglobin, Weight, Anxiety, Nausea and Vomiting of Pregnancy (NVP) Hurin'in, Nur Maziyah; Damayanti, Tri Yunita Fitria; Cholila, Nur; Masfufah, Gita Aprilia Ayu; Nuriyawati, Tuadhatun
Biomedical Journal of Indonesia Vol. 12 No. 2 (2026): Vol 12, No 2, 2026, In Press
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bji.v12i2.294

Abstract

Introduction. Nausea and vomiting are among the most common discomforts experienced by pregnant women in the first trimester, often leading to decreased nutritional intake, weight loss, and anemia, which may ultimately affect maternal and fetal health. Various complementary interventions, including acupressure, moxibustion, and ginger aromatherapy, have been developed as supportive therapies to reduce these symptoms. This aimed to analyze the effectiveness of PROMAMA is a combined intervention of acupressure, moxibustion, and ginger aromatherapy for nausea and vomiting of pregnancy in reducing nausea, vomiting, anxiety, and anemia, as well as improving weight gain. Methods. This quasi-experimental study employed a pre-test-post-test control group design with 120 first-trimester pregnant women who met the inclusion criteria. Participants were divided into three groups: control, Standard, and intensive intervention. Data were collected using the PUQE-24 (Pregnancy-Unique Quantification of Emesis and Nausea), GAD-7 (Generalized Anxiety Disorder-7), hemoglobin measurements, and maternal weight records. Statistical analyses included One-Way ANOVA, ANCOVA, and Independent Sample T-Test. Results. The findings revealed significant differences between the groups in reducing nausea and vomiting, anxiety, and hemoglobin levels at post-test 1 and post-test 2 (p < 0.05). Intensive interventions combining acupressure, moxibustion, and ginger aromatherapy showed greater effectiveness compared to Standard and control groups. However, no significant differences were observed in weight gain across the groups (p > 0.05). Conclusion. Acupressure, moxibustion, and ginger aromatherapy are effective for managing nausea, vomiting, anxiety, and anemia in first-trimester pregnant women. These interventions can be recommended as non-pharmacological approaches to improve maternal well-being and pregnancy outcomes.
Effect of Penta Herbs Forte on Antioxidant Capacity and Cardiac Protein Carbonyl Levels in a Hypoxia-Induced Rat Model Widiarto, Sentanu; Gunawan, Shirly; Limanan, David; Ferdinal, Frans; Yulianti, Eny
Biomedical Journal of Indonesia Vol. 12 No. 2 (2026): Vol 12, No 2, 2026, In Press
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bji.v12i2.304

Abstract

Introduction. Hypoxia, a state of inadequate oxygen supply in tissues, can induce the generation of reactive oxygen species (ROS), leading to oxidative stress and damage to biomolecules such as proteins. This damage can be quantified by measuring protein carbonyl levels. Penta Herbs Forte (PHF), a polyherbal formulation composed of Andrographis paniculata, Blumea balsamifera, Phyllanthus urinaria, Zingiber officinale, and Curcuma xanthorrhiza, is rich in bioactive compounds with known antioxidant properties. This study aimed to evaluate the antioxidant activity of PHF extract and its effects on cardiac protein carbonyl levels in hypoxia-induced rats. Methods. This experimental study included 32 male Sprague-Dawley rats, divided into eight groups: control and treatment groups under normoxia, 1-day hypoxia, 7-day hypoxia, and 14-day hypoxia, either with or without PHF extract administration. Antioxidant capacity was determined using the ABTS and DPPH assays, and cardiac protein carbonyl levels were measured using a spectrophotometer. Results. PHF extract showed an antioxidant activity yielding LC50 values of 22.135 μg/mL (ABTS) and 105.04 μg/mL (DPPH), indicating strong antioxidant potential. PHF-treated groups exhibited lower cardiac protein carbonyl levels than their respective controls across all hypoxic durations. Conclusion. Administration of PHF extract reduced cardiac protein carbonyl levels via its antioxidant activity, suggesting its potential as an exogenous antioxidant source to protect against hypoxia-induced oxidative damage.
Exploring Associations Lipid Profiles, Body Composition, Anthropometry, and Osteoarthritis Index Dinali, Diana; Dzakwan, Muhammad Fikri; Bustam, Steve Geraldo; Gunawan, Shirly; Santoso, Alexander Halim; Firmansyah, Yohanes
Biomedical Journal of Indonesia Vol. 12 No. 2 (2026): Vol 12, No 2, 2026, In Press
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bji.v12i2.307

Abstract

Introduction. Osteoarthritis (OA) is a joint disorder and is considered one of the leading causes of disability worldwide. It is commonly associated with aging and characterized by chronic pain, joint stiffness, and limitations in daily activities. This study aimed to evaluate the association between lipid profile and body composition with the severity of OA, as measured by the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) score. Methods. This cross-sectional study involved 67 community-dwelling older adults. Assessments included fasting lipid profiles (HDL, LDL, total cholesterol, Apo A, Apo B, and triglycerides), body fat distribution and muscle mass, anthropometric measurements (body mass index, waist circumference, and hip circumference), and handgrip strength. Associations between variables were analyzed using Spearman’s correlation test with a significance level of 5%. Results. Correlation analysis demonstrated associations between lipid profile levels and worsening OA symptoms. Higher Apo B levels were associated with increased trunk fat (r=0.47, p<0.001) and greater joint pain (r=0.35, p=0.004). Lower HDL levels were associated with increased visceral fat (r=−0.37, p=0.002) and greater joint stiffness (r=0.26, p=0.038). Greater upper extremity muscle mass was associated with less severe pain (r=−0.38, p<0.001), while higher body mass index and waist circumference were associated with higher WOMAC scores (r=0.32, p=0.009). Conclusion. These findings support the concept that OA is a systemic condition influenced by metabolic and biomechanical pathways. OA management should therefore include metabolic control, optimization of body composition, and routine monitoring of lipid profiles and anthropometric indices as part of non-pharmacological therapy and preventive strategies.
Optimization of Duplex Real-time PCR to Detect Corynebacterium ulcerans and C. pseudotuberculosis from Patients with Suspected Diphtheria in Jakarta Usman, Doni; Rosana, Yeva; Yasmon, Andi
Biomedical Journal of Indonesia Vol. 12 No. 2 (2026): Vol 12, No 2, 2026, In Press
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bji.v12i2.319

Abstract

Introduction. Diphtheria infection remains a serious public health problem in many countries with low vaccine coverage. Molecular detection plays an important role in controlling disease dissemination. Among more than 122 Corynebacterium species, only three are potentially toxigenic: C. diphtheriae, C. ulcerans, and C. pseudotuberculosis. Infections caused by C. ulcerans and C. pseudotuberculosis in humans usually involve close animal contact. Due to the many difficulties in identifying C. ulcerans and C. pseudotuberculosis, this study aimed to optimize Duplex Real-time PCR for rapid and precise detection. Method. Duplex real-time PCR was performed by using 2 pairs of primers and a probe to detect C. ulcerans and C. pseudotuberculosis. All parameters were optimized to maximize PCR amplification. Then, the primer set's specificity was tested against some microorganisms. The sensitivity test of DNA was conducted to get the detection limit. Results: Optimization of real-time PCR was conducted to achieve optimal amplification conditions.  Annealing temperature 57 °C, Optimization of primer and probe concentration of 0.45 μM and 0.50 μM for C. ulcerans, Primer and probe concentrations of 0.35 μM for C. pseudotuberculosis yielded optimal results. The detection limit of DNA of duplex real-time PCR for C. ulcerans was 4.49 DNA copy number and 1.06 DNA copy number for C. pseudotuberculosis. Conclusion. Duplex Real-time PCR optimization result can be used as a detection of C. ulcerans and C. pseudotuberculosis for effective control of dissemination in the population. PCR results showed that all 108 clinical specimens suspect diphtheria were negative for C. ulcerans and C. pseudotuberculosis.
Shared Mattresses, Combs, and Residential Sanitation Associated with Pediculosis Capitis in Orphanages Istanta, Qoonitah Salsabiil Putri; Rohani, Siti; Anwar, Chairil
Biomedical Journal of Indonesia Vol. 12 No. 2 (2026): Vol 12, No 2, 2026, In Press
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bji.v12i2.325

Abstract

Introduction. Head lice infestation (pediculosis capitis) continues to be a widespread health issue among children, especially in orphanages. Pediculosis capitis often occurs due to sharing personal items and poor residential sanitation conditions. Methods. This study applied an observational analytic design using a cross-sectional approach, conducted across nine orphanages in South Sumatra Province. Independent variables included sharing personal items and residential sanitation factors such as occupancy density, ventilation, lighting, temperature, and humidity, while the dependent variable was pediculosis capitis occurrence. Results. Pediculosis capitis prevalence reached 37.7%. Sharing mattresses (p = 0.038) and combs (p = 0.016) showed a significant association with pediculosis capitis, while sharing bed sheets, blankets, pillows, towels, headscarves, prayer garments, and caps was not significantly associated. In terms of residential sanitation, occupancy density (p = 0.002), ventilation (p < 0.001), and lighting (p < 0.001) were significantly related to the occurrence of pediculosis capitis. Meanwhile, temperature (p = 0.678) and humidity (p = 0.585) did not show a significant relationship. Conclusion. Pediculosis capitis occurrence is linked to sharing certain personal items and various residential sanitation factors.
Relationship of Resting Heart Rate Variability to Physical Fitness Levels in Adolescents Fatoni, Fatoni; Raswadi, Mohammad Dika
Biomedical Journal of Indonesia Vol. 12 No. 2 (2026): Vol 12, No 2, 2026, In Press
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bji.v12i2.327

Abstract

Introduction. Physical fitness is an important indicator of adolescent health, closely related to cardiovascular function and the body's ability to perform physical activity. One physiological parameter reflecting cardiovascular system regulation is resting heart rate variability, which has the potential to serve as an objective indicator of physical fitness. This study aimed to examine the relationship between resting heart rate variability and physical fitness levels in adolescents. Methods. This study used a quantitative approach with a cross-sectional correlational design. Fifty-eight students from SMP Negeri 3 Gowa were selected using a purposive sampling technique. Resting heart rate variability was measured using a digital heart rate monitor, while physical fitness levels were assessed using the Cooper test. Data were analyzed descriptively and inferentially using the Pearson correlation test with SPSS version 25 at a significance level of 0.05. Results. The findings revealed a positive and significant relationship between resting heart rate variability and physical fitness levels (r = 0.462; p = 0.001). Adolescents with better resting heart rate variability tended to demonstrate higher levels of physical fitness. Conclusion. Resting heart rate variability is significantly associated with physical fitness levels in adolescents and shows potential as an objective physiological indicator for monitoring physical fitness.

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