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All Journal Jurnal Penelitian Kesehatan Suara Forikes Jurnal Ilmu dan Teknologi Kesehatan INDONESIAN JOURNAL OF MEDICAL LABORATORY SCIENCE AND TECHNOLOGY Journal of Indonesian Medical Laboratory and Science (JoIMedLabS) HEALTHY: Jurnal Inovasi Riset Ilmu Kesehatan Journal of Global Pharma Technology Termometer: Jurnal Ilmiah Ilmu Kesehatan Dan Kedokteran Analis Kesehatan Sains (e-Journal) Jurnal Sains Student Research
Krihariyani, Dwi
Poltekkes Kemenkes Surabaya
Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Social Sciences Other

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EFEKTIVITAS PEMBERIAN TABLET TAMBAH DARAH TERHADAP KADAR HEMOGLOBIN PADA SISWI Susanti, Reni; Krihariyani, Dwi; Endarini, Lully Hanni; Suliati, Suliati
HEALTHY : Jurnal Inovasi Riset Ilmu Kesehatan Vol. 4 No. 2 (2025)
Publisher : Pusat Pengembangan Pendidikan dan Penelitian Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51878/healthy.v4i2.6391

Abstract

ABSTRACT Iron deficiency anemia is a common nutritional problem among adolescent girls in developing countries such as Indonesia, affecting both health and academic performance. The government has implemented a school-based iron supplementation program to address this issue. This study aims to evaluate the effectiveness of iron tablet supplementation in increasing hemoglobin levels among 10th-grade female students at MAN 3 Magetan. The study used a quasi-experimental design with a one-group pre-test and post-test approach. A total of 122 students aged 15–18 years participated based on inclusion criteria and parental consent. The intervention involved weekly iron tablet supplementation for three months. Hemoglobin levels were measured before and after the intervention using a HemoCue device, and data were analyzed using the Wilcoxon Signed-Rank test. The results showed a significant increase in hemoglobin levels after the intervention (p < 0.05). Prior to supplementation, 39% of the students were anemic, which decreased to 8% after the intervention, with 92% having normal hemoglobin levels. These findings indicate that regular iron supplementation effectively improves hemoglobin levels and reduces anemia prevalence. The program should be continued with sustained nutrition education and monitoring of compliance to ensure long-term effectiveness. ABSTRAK Anemia defisiensi zat besi merupakan masalah gizi yang umum pada remaja putri di negara berkembang seperti Indonesia, berdampak pada kesehatan dan prestasi belajar. Pemerintah telah menjalankan program pemberian tablet tambah darah (TTD) di sekolah sebagai upaya pencegahan. Penelitian ini bertujuan mengevaluasi efektivitas pemberian TTD terhadap peningkatan kadar hemoglobin pada siswi kelas X di MAN 3 Magetan. Desain penelitian menggunakan kuasi eksperimen dengan pendekatan one group pre-test dan post-test. Sebanyak 122 siswi usia 15–18 tahun menjadi responden berdasarkan kriteria inklusi dan persetujuan orang tua. Intervensi berupa pemberian TTD dilakukan seminggu sekali selama tiga bulan. Kadar hemoglobin diukur sebelum dan sesudah intervensi menggunakan alat HemoCue, dan data dianalisis dengan uji Wilcoxon Signed-Rank. Hasil menunjukkan peningkatan signifikan kadar hemoglobin setelah intervensi (p < 0,05). Sebelum intervensi, 39% siswi mengalami anemia, sementara setelahnya hanya 8%, dengan 92% memiliki kadar hemoglobin normal. Temuan ini menunjukkan bahwa pemberian TTD secara rutin efektif meningkatkan kadar hemoglobin dan menurunkan prevalensi anemia. Program ini perlu dilanjutkan secara berkelanjutan dengan edukasi gizi dan pemantauan kepatuhan konsumsi untuk hasil jangka panjang.
In Silico Analysis of Antiviral Activity and Pharmacokinetic Prediction of Brazilein Sappan Wood (Caesalpinia sappan L.) Against SARS-CoV-2 Spike Glycoproteins Krihariyani, Dwi; Haryanto, Edy; Sasongkowati, Retno
JURNAL INDONESIA DARI ILMU LABORATORIUM MEDIS DAN TEKNOLOGI Vol 3 No 1 (2021): Laboratory innovation : The challenge for medical laboratory
Publisher : Universitas Nahdlatul Ulama Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33086/ijmlst.v3i1.1854

Abstract

Brazilein is one of the secondary sappan wood metabolites which can be used empirically as an antivirus. The SARS-CoV-2 spike (S) glycoproteins play significant roles in attaching and entering the virus into the host cell. This study aims to predict the antiviral activity and pharmacokinetic properties of brazilein of the sappan wood against the in-silico SARS-CoV-2 S glycoproteins with vitamin C as the reference compound. Molegro Virtual Docker 5.5 was used to predict antiviral activity by docking process. SARS-CoV-2 S glycoprotein with NAG ligand available in Protein Data Bank (PDB) (PDB ID: 7C01) was the receptor used. The pkCSM online tool was used to predict the pharmacokinetic properties and toxicity of brazilein. Data were analyzed on the target receptors by comparing the docking bond energies between NAG, brazilein, and vitamin C. The smaller the ligands’ bond energy to the target receptor, the more stable the bonds are. The bond energy of NAG, brazilein, and vitamin C was -59.2864 kcal/mol, -65.8911 kcal/mol, and -53.9093 kcal/mol, respectively. These results suggested that brazilein has a greater capacity as an antivirus compared to NAG and vitamin C. In silico test using the pkCSM online tool demonstrated that brazilein had strong pharmacokinetic properties and relatively low toxicity.
Co-Authors ., Pestariati A'yunin, Zahratin Nisa' Arifin, Hidayat Ariyani, Ahna Fitri Edy Haryanto Edy Haryanto Endarini, Lully Hanni Entuy Kurniawan Kurniawan Evy Diah Woelansari Farah Adilah Ambar Sari Istanto, Wisnu Kusnanto Kusnanto Reni Susanti Retno Sasongkowati Roni Yuliwar S.Pd. M Kes I Ketut Sudiana . Sasongkowati, Retno Sholihah, Irodatus Suhariyadi Suhariyadi Suliati Suliati Syamsul Arifin Syamsul Arifin Wisnu Istanto Yulia Hermawati