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All Journal Jurnal Penelitian Kesehatan Suara Forikes Jurnal Ilmu dan Teknologi Kesehatan INDONESIAN JOURNAL OF MEDICAL LABORATORY SCIENCE AND TECHNOLOGY Journal of Indonesian Medical Laboratory and Science (JoIMedLabS) CENDEKIA : Jurnal Ilmu Pengetahuan HEALTHY: Jurnal Inovasi Riset Ilmu Kesehatan Journal of Global Pharma Technology Termometer: Jurnal Ilmiah Ilmu Kesehatan Dan Kedokteran Analis Kesehatan Sains (e-Journal) Jurnal Sains Student Research Media Penelitian dan Pengembangan Kesehatan
Krihariyani, Dwi
Poltekkes Kemenkes Surabaya
Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Education Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Social Sciences Other

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In silico evaluation of brazilin (Caesalpinia sappan L.) as a Dpre1 Mycobacterium tuberculosis inhibitor Entuy Kurniawan; Sulaeman Sulaeman; Dwi Krihariyani; Evi Diah Woelansari
Media Penelitian dan Pengembangan Kesehatan Vol. 36 No. 2 (2026): MEDIA PENELITIAN DAN PENGEMBANGAN KESEHATAN
Publisher : Poltekkes Kemenkes Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34011/jmp2k.v36i2.4564

Abstract

Background: The increasing incidence of drug-resistant Mycobacterium tuberculosis (Mtb) necessitates the identification of novel molecular targets and therapeutic candidates. Decaprenylphosphoryl-β-D-ribose 2′-epimerase subunit 1 (DprE1) is a key enzyme in Mtb cell wall biosynthesis and represents a promising therapeutic target. Brazilin, a natural compound derived from Caesalpinia sappan L., has been reported to exhibit diverse biological activities; however, its interaction with DprE1 remains insufficiently explored, highlighting a gap for computational-based investigation. Objective: To evaluate the binding affinity and molecular interaction profile of brazilin against DprE1 through an in silico approach. Methods: Molecular docking was performed using the crystal structure of DprE1 (PDB ID: 5OEP) with Molegro Virtual Docker. Key parameters included an active-site grid radius of 15 Å, grid resolution of 0.30 Å, and 10 independent docking runs per ligand to ensure reproducibility. Method validation was performed via redocking of the native ligand, yielding an RMSD <2.0 Å. Binding affinity and interaction patterns of brazilin were compared with rifampicin, isoniazid, and the native ligand. Results: Brazilin exhibited a rerank score of −71.287, indicating moderate binding affinity, stronger than isoniazid but lower than rifampicin and the native ligand. Notably, brazilin consistently occupied the catalytic binding pocket and established hydrogen bonding and hydrophobic interactions with key residues, suggesting a stable and functionally relevant binding orientation. This represents the first target-specific computational evidence linking brazilin to DprE1 inhibition. Conclusion: Brazilin from Caesalpinia sappan L. shows potential as a natural DprE1 of Mycobacterium tuberculosis inhibitor, although further experimental validation is required to confirm its biological efficacy.
In Silico Analysis of Antiviral Activity and Pharmacokinetic Prediction of Brazilein Sappan Wood (Caesalpinia sappan L.) Against SARS-CoV-2 Spike Glycoproteins Dwi Krihariyani; Edy Haryanto; Retno Sasongkowati
JURNAL INDONESIA DARI ILMU LABORATORIUM MEDIS DAN TEKNOLOGI Vol 3 No 1 (2021): Laboratory innovation : The challenge for medical laboratory
Publisher : Universitas Nahdlatul Ulama Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33086/ijmlst.v3i1.1854

Abstract

Brazilein is one of the secondary sappan wood metabolites which can be used empirically as an antivirus. The SARS-CoV-2 spike (S) glycoproteins play significant roles in attaching and entering the virus into the host cell. This study aims to predict the antiviral activity and pharmacokinetic properties of brazilein of the sappan wood against the in-silico SARS-CoV-2 S glycoproteins with vitamin C as the reference compound. Molegro Virtual Docker 5.5 was used to predict antiviral activity by docking process. SARS-CoV-2 S glycoprotein with NAG ligand available in Protein Data Bank (PDB) (PDB ID: 7C01) was the receptor used. The pkCSM online tool was used to predict the pharmacokinetic properties and toxicity of brazilein. Data were analyzed on the target receptors by comparing the docking bond energies between NAG, brazilein, and vitamin C. The smaller the ligands’ bond energy to the target receptor, the more stable the bonds are. The bond energy of NAG, brazilein, and vitamin C was -59.2864 kcal/mol, -65.8911 kcal/mol, and -53.9093 kcal/mol, respectively. These results suggested that brazilein has a greater capacity as an antivirus compared to NAG and vitamin C. In silico test using the pkCSM online tool demonstrated that brazilein had strong pharmacokinetic properties and relatively low toxicity.
SCREENING PASIEN SUSPEK DEMAM TIFOID DENGAN WIDAL TES DAN RAPID TEST IgM ANTI-SALMONELLA DAN RASIO MONOSIT–LIMFOSIT (MLR) Marshanda Pratiwi Miftahurrahma; Evy Diah Woelansari; Museyaroh Museyaroh; Dwi Krihariyani
HEALTHY : Jurnal Inovasi Riset Ilmu Kesehatan Vol. 5 No. 4 (2026)
Publisher : Pusat Pengembangan Pendidikan dan Penelitian Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51878/healthy.v5i4.14375

Abstract

Typhoid fever is an infectious disease caused by Salmonella typhi and remains a major public health problem in Indonesia. The diagnosis of typhoid fever is generally confirmed through serological tests such as the Widal test and the anti-Salmonella IgM rapid test. Both tests are commonly used, but they have limitations in sensitivity and specificity. The monocyte-lymphocyte ratio (MLR) is a hematological parameter that has the potential to serve as a supportive indicator because it reflects both innate and adaptive immune responses. The objective of this study was to analyze the relationship between the monocyte-lymphocyte ratio (MLR) and the Widal test and anti-Salmonella IgM rapid test in patients with suspected typhoid fever. This study was conducted using an observational analytical method with a cross-sectional design. The study sample consisted of 29 patients with suspected typhoid fever at the Klinik Ultra Medica in Tulungagung, selected through purposive sampling. The results showed that MLR values fell into the low category in 79.3% of cases, moderate in 17.2%, and high in 3.4%. The anti-Salmonella IgM rapid test results showed 37.9% positive and 62.1% negative. The Widal test results were dominated by a titer of 1/80 (79.3%) and a titer of 1/160 (13.8%). Spearman's rank correlation test yielded r = 0.200 (p = 0.298) between MLR and anti-Salmonella IgM rapid test, and r = -0.133 (p = 0.490) between MLR and Widal test. In conclusion, there is no significant association between the monocyte-to-lymphocyte ratio (MLR) and the results of either the Widal test or the anti-Salmonella IgM rapid test in patients with suspected typhoid fever (p > 0.05). ABSTRAK Demam tifoid merupakan penyakit infeksi yang disebabkan oleh bakteri Salmonella typhi dan hingga saat ini masih menjadi masalah kesehatan masyarakat di Indonesia. Penegakan diagnosis demam tifoid umumnya dilakukan melalui pemeriksaan serologi seperti tes Widal dan rapid test IgM anti-Salmonella. Keduanya masih sering digunakan, namun memiliki keterbatasan sensitivitas dan spesifisitas. Rasio monosit-limfosit (Monocyte-Lymphocyte Ratio / MLR) merupakan parameter hematologi yang berpotensi menjadi indikator pendukung diagnosis demam tifoid karena mencerminkan respons imun bawaan dan adaptif. Penelitian ini bertujuan untuk menganalisis hubungan rasio monosit-limfosit (MLR) dengan tes Widal dan rapid test IgM anti-Salmonella pada pasien suspek demam tifoid. Penelitian ini menggunakan metode observasional analitik dengan desain cross-sectional. Sampel penelitian berjumlah 29 pasien suspek demam tifoid di Klinik Ultra Medica Tulungagung yang dipilih secara purposive sampling. Hasil penelitian menunjukkan nilai MLR berada pada kategori rendah 79,3%, sedang 17,2%, dan tinggi 3,4%. Hasil rapid test IgM anti-Salmonella menunjukkan 37,9% positif dan 62,1% negatif. Hasil tes Widal didominasi oleh titer 1/80 sebesar 79,3% dan titer 1/160 sebesar 13,8%. Hasil uji korelasi Spearman Rank antara MLR dengan rapid test IgM anti-Salmonella menghasilkan  ( ), sedangkan antara MLR dengan tes Widal menghasilkan  ( ). Dengan demikian, tidak terdapat hubungan yang signifikan antara rasio monosit-limfosit (MLR) dengan hasil tes Widal maupun rapid test IgM anti-Salmonella pada pasien suspek demam tifoid ( ).    
GAMBARAN PEMERIKSAAN RHEUMATOID FACTOR PADA LANSIA DI WILAYAH KERJA PUSKESMAS PUCANG SEWU SURABAYA Widya Kartika Sari; Evy Diah Woelansari; Museyaroh Museyaroh; Dwi Krihariyani
CENDEKIA: Jurnal Ilmu Pengetahuan Vol. 6 No. 4 (2026)
Publisher : Pusat Pengembangan Pendidikan dan Penelitian Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51878/cendekia.v6i4.14049

Abstract

Rheumatoid Factor (RF) is an autoantibody commonly used as a supporting laboratory test for the identification of Rheumatoid Arthritis (RA). Rheumatoid Arthritis is an autoimmune disease characterized by chronic inflammation of the joints and may occur among older adults. This study aimed to describe the results of Rheumatoid Factor examination among elderly individuals in the working area of Pucang Sewu Public Health Center, Surabaya. This study employed a descriptive design involving 34 elderly respondents selected using purposive sampling based on predetermined inclusion and exclusion criteria. Rheumatoid Factor examination was performed using the latex agglutination method. Samples with reactive results were subsequently examined using a semi-quantitative method to determine the Rheumatoid Factor titer. Data were analyzed descriptively and presented in frequency distribution tables based on Rheumatoid Factor results, sex, and age group. The results showed that 31 respondents (91.2%) had negative Rheumatoid Factor results, while 3 respondents (8.8%) had positive results. All respondents with positive results had a Rheumatoid Factor titer of 16 IU/mL. Based on sex, all positive results were found among male respondents. Based on age group, positive results were found among respondents aged 60–69 years and 80–89 years. It can be concluded that most elderly individuals in the working area of Pucang Sewu Public Health Center, Surabaya, had negative Rheumatoid Factor results, while a small proportion had positive results with low titers. ABSTRAK Rheumatoid Factor (RF) merupakan salah satu autoantibodi yang digunakan sebagai pemeriksaan penunjang dalam identifikasi Rheumatoid Arthritis (RA). Rheumatoid Arthritis merupakan penyakit autoimun yang ditandai dengan peradangan kronis pada sendi dan dapat ditemukan pada kelompok lanjut usia. Penelitian ini bertujuan untuk mengetahui gambaran hasil pemeriksaan Rheumatoid Factor pada lansia di wilayah kerja Puskesmas Pucang Sewu Surabaya. Penelitian ini menggunakan desain deskriptif dengan melibatkan 34 responden lansia yang dipilih menggunakan teknik purposive sampling berdasarkan kriteria inklusi dan eksklusi. Pemeriksaan Rheumatoid Factor dilakukan menggunakan metode aglutinasi lateks. Sampel dengan hasil reaktif selanjutnya diperiksa secara semikuantitatif untuk menentukan titer Rheumatoid Factor. Data dianalisis secara deskriptif dan disajikan dalam bentuk tabel distribusi frekuensi berdasarkan hasil pemeriksaan Rheumatoid Factor, jenis kelamin, dan kelompok usia. Hasil penelitian menunjukkan bahwa 31 responden (91,2%) memiliki hasil Rheumatoid Factor negatif, sedangkan 3 responden (8,8%) menunjukkan hasil positif. Seluruh responden dengan hasil positif memiliki titer Rheumatoid Factor sebesar 16 IU/mL. Berdasarkan jenis kelamin, seluruh hasil positif ditemukan pada responden laki-laki. Berdasarkan kelompok usia, hasil positif ditemukan pada kelompok usia 60–69 tahun dan 80–89 tahun. Dapat disimpulkan bahwa sebagian besar lansia di wilayah kerja Puskesmas Pucang Sewu Surabaya memiliki hasil Rheumatoid Factor negatif, sedangkan sebagian kecil menunjukkan hasil positif dengan titer rendah.
Uji Efektivitas Daya Hambat Ekstrak dan Perasan Lidah Buaya (Aloe barbadensis Miller) pada Bakteri Staphylococcus Aureus dengan Metode Difusi Farah Adilah Ambar Sari; Suliati Suliati; Syamsul Arifin; Dwi Krihariyani
Termometer: Jurnal Ilmiah Ilmu Kesehatan dan Kedokteran Vol. 2 No. 4 (2024): Oktober : Termometer: Jurnal Ilmiah Ilmu Kesehatan dan Kedokteran
Publisher : Lembaga Pengembangan Kinerja Dosen

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/termometer.v2i4.4307

Abstract

Aloe vera is a plant that is rich in minerals, vitamins, and antibacterial properties. A study to analyze the antibacterial effectiveness of aloe vera in inhibiting the growth of Staphylococcus aureus bacteria isolated from acne pus. This study was an experimental laboratory study using the disc diffusion method, located at the Bacteriology Laboratory, Department of Medical Laboratory Technology, Poltekkes Kemenkes Surabaya, from February to May 2024. There were 6 sample treatments with 4 replications, 4 treatments of extract and juice concentration variations, namely concentrations of 70%, 80%, 90%, 100%, positive control using penicillin antibiotics, and negative control using clean distilled water. The results of this study show that at aloe vera extract concentrations of 70%, 80%, 90%, and 100%, the average diameter of the inhibition zone was 9 mm, 10 mm, 11 mm, and 12 mm, respectively, while in aloe vera juice, these concentrations did not form an inhibition zone. So it was concluded that aloe vera extract is more effective than aloe vera juice, the most successful test material to slow the growth of Staphylococcus aureus bacteria in this study was aloe vera extract with a concentration of 100%. This study also conducted qualitative phytochemical testing on aloe vera extract which has antibacterial compounds, namely saponins, tannins, flavonoids, and terpenoids. The results of the study on the effectiveness of the inhibitory power of aloe vera extract and juice against Staphylococcus aureus bacteria using the disc diffusion method were analyzed using quantitative descriptive and presented in tabulation form in the form of the diameter of the inhibition zone formed.
KORELASI MEAN PLATELET VOLUME (MPV), HBA1C, DAN TEKANAN DARAH PADA PASIEN DIABETES MELITUS DENGAN HIPERTENSI Noer Widy Astutik; Dwi Krihariyani; Musholli Himmatun Nabilah
HEALTHY : Jurnal Inovasi Riset Ilmu Kesehatan Vol. 5 No. 4 (2026)
Publisher : Pusat Pengembangan Pendidikan dan Penelitian Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51878/healthy.v5i4.15196

Abstract

Diabetes mellitus with hypertension may increase the risk of cardiovascular complications through endothelial dysfunction and increased platelet activity. Mean Platelet Volume (MPV) is a hematological parameter that describes platelet size and activity. This study aimed to analyze the correlation of MPV with HbA1c levels and blood pressure in patients with diabetes mellitus and hypertension at Syarifah Ambami Rato Ebu Regional General Hospital, Bangkalan. An observational analytic study with a cross-sectional design was conducted involving 21 patients selected using purposive sampling from October 2025 to May 2026. MPV was measured using a Sysmex XN-550 Hematology Analyzer, while HbA1c data were obtained from medical records and blood pressure was measured using a digital device. Spearman correlation analysis was used to examine the relationships among variables. The results showed that 15 respondents (71%) had MPV >10.5 fL, with a mean value of 10.7 fL. The mean HbA1c level was 9.7%, while the mean blood pressure was 166/107 mmHg. No significant correlation was found between MPV and HbA1c (p=0.370), systolic blood pressure (p=0.108), or diastolic blood pressure (p=0.336). In conclusion, elevated MPV was not significantly correlated with HbA1c or blood pressure in the studied patients. ABSTRAK Diabetes melitus dengan hipertensi dapat meningkatkan risiko komplikasi kardiovaskular melalui gangguan fungsi endotel dan peningkatan aktivitas trombosit. Mean Platelet Volume (MPV) merupakan parameter hematologi yang menggambarkan ukuran dan aktivitas trombosit. Penelitian ini bertujuan menganalisis korelasi MPV dengan kadar HbA1c serta tekanan darah pada pasien diabetes melitus dengan hipertensi di RSUD Syarifah Ambami Rato Ebu Bangkalan. Penelitian menggunakan desain observasional analitik dengan pendekatan cross-sectional. Sebanyak 21 pasien yang memenuhi kriteria inklusi dan eksklusi dipilih menggunakan purposive sampling selama Oktober 2025–Mei 2026. Pemeriksaan MPV dilakukan menggunakan Hematology Analyzer Sysmex XN-550, sedangkan kadar HbA1c diperoleh dari rekam medis dan tekanan darah diukur menggunakan alat digital. Analisis korelasi dilakukan dengan uji Spearman. Hasil penelitian menunjukkan 15 responden (71%) memiliki MPV >10,5 fL dengan rata-rata 10,7 fL. Rata-rata HbA1c sebesar 9,7% dan tekanan darah sebesar 166/107 mmHg. Tidak terdapat korelasi signifikan antara MPV dengan HbA1c (p=0,370), tekanan darah sistolik (p=0,108), maupun diastolik (p=0,336). Disimpulkan bahwa peningkatan MPV tidak berkorelasi signifikan dengan HbA1c maupun tekanan darah pada kelompok pasien yang diteliti.
ANALISIS KORELASI KADAR HIGH DENSITY LIPOPROTEIN (HDL) DAN LOW DENSITY LIPOPROTEIN (LDL) TERHADAP Hs-CRP PADA PASIEN PROLANIS HIPERTENSI Sindi Afrilia Dewi; Anik Handayati; Wisnu Istanto; Dwi Krihariyani
HEALTHY : Jurnal Inovasi Riset Ilmu Kesehatan Vol. 5 No. 4 (2026)
Publisher : Pusat Pengembangan Pendidikan dan Penelitian Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51878/healthy.v5i4.15643

Abstract

Hypertension is a major risk factor for cardiovascular disease and is associated with lipid metabolism disorders and systemic inflammation. Therefore, analyzing the relationship between lipid profiles and inflammatory markers is important for supporting cardiovascular risk monitoring in patients enrolled in the Chronic Disease Management Program (Prolanis) with hypertension. This study aimed to analyze the correlation of High-Density Lipoprotein (HDL) and Low-Density Lipoprotein (LDL) levels with high-sensitivity C-reactive protein (Hs-CRP) levels. An observational analytical study with a cross-sectional design was conducted involving 30 hypertensive patients enrolled in Prolanis. HDL and LDL levels were measured using the Homogeneous Enzymatic Colorimetric method, while Hs-CRP levels were measured using the Fluorescence Immunoassay (FIA) method. Data were analyzed using Spearman’s correlation test with a significance level of 0.05. The results showed mean HDL, LDL, and Hs-CRP levels of 35.9 mg/dL, 109.9 mg/dL, and 2.6 mg/L, respectively. No significant correlation was found between HDL and Hs-CRP (r = 0.126; p = 0.507) or between LDL and Hs-CRP (r = 0.055; p = 0.771). In conclusion, HDL and LDL levels were not significantly correlated with Hs-CRP levels in the study participants. These findings suggest that the relationship between lipid profiles and inflammation warrants further investigation, considering other clinical factors. ABSTRAK Hipertensi merupakan faktor risiko utama penyakit kardiovaskular yang berkaitan dengan gangguan metabolisme lipid dan inflamasi sistemik. Oleh karena itu, analisis hubungan profil lipid dengan penanda inflamasi penting untuk mendukung pemantauan risiko kardiovaskular pada pasien Program Pengelolaan Penyakit Kronis (Prolanis) hipertensi. Penelitian ini bertujuan menganalisis korelasi kadar High-Density Lipoprotein (HDL) dan Low-Density Lipoprotein (LDL) dengan kadar high-sensitivity C-reactive protein (Hs-CRP). Penelitian ini menggunakan desain analitik observasional dengan pendekatan cross-sectional pada 30 pasien Prolanis hipertensi. Pemeriksaan HDL dan LDL menggunakan metode Homogeneous Enzymatic Colorimetric, sedangkan Hs-CRP diperiksa menggunakan metode Fluorescence Immunoassay (FIA). Data dianalisis menggunakan uji korelasi Spearman dengan tingkat signifikansi 0,05. Hasil penelitian menunjukkan rerata kadar HDL sebesar 35,9 mg/dL, LDL sebesar 109,9 mg/dL, dan Hs-CRP sebesar 2,6 mg/L. Tidak ditemukan korelasi yang signifikan antara HDL dan Hs-CRP (r = 0,126; p = 0,507) maupun antara LDL dan Hs-CRP (r = 0,055; p = 0,771). Dengan demikian, kadar HDL dan LDL tidak berhubungan secara signifikan dengan kadar Hs-CRP pada responden penelitian. Temuan ini menunjukkan bahwa hubungan profil lipid dan inflamasi perlu dikaji dengan mempertimbangkan faktor klinis lainnya.
KORELASI ANTARA KADAR HEMOGLOBIN DAN INDEKS ERITROSIT PADA PASIEN DIABETES MELITUS Nina Aulia Santi; Dwi Krihariyani; Anita Dwi Anggraini
HEALTHY : Jurnal Inovasi Riset Ilmu Kesehatan Vol. 5 No. 4 (2026)
Publisher : Pusat Pengembangan Pendidikan dan Penelitian Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51878/healthy.v5i4.15650

Abstract

Diabetes mellitus is classified as a chronic metabolic disorder that causes various systemic complications, including hematological disturbances characterized by reduced hemoglobin levels. This study aimed to measure hemoglobin levels, determine erythrocyte indices specifically Mean Corpuscular Volume (MCV), Mean Corpuscular Hemoglobin (MCH), and Mean Corpuscular Hemoglobin Concentration (MCHC) and analyze the relationship between hemoglobin levels and erythrocyte indices in patients with diabetes mellitus at Dr. Iskak Regional General Hospital (RSUD), Tulungagung. The study employed an observational analytic design with a cross-sectional method, involving 35 patients with diabetes mellitus as respondents. Hemoglobin levels and erythrocyte indices were measured using an XN-1000 hematology analyzer. The results showed that reduced hemoglobin levels were observed in the majority of respondents, whereas most erythrocyte indices remained within the normal range. Spearman correlation analysis revealed no significant relationship between hemoglobin levels and MCV (r=0.191; p=0.270), MCH (r=0.254; p=0.141), or MCHC (r=0.236; p=0.173). All relationships showed weak correlations with significance values ​​greater than 0.05. Thus, there is no significant relationship between hemoglobin levels and erythrocyte indices in patients with diabetes mellitus. The decrease in hemoglobin levels was not consistently accompanied by changes in erythrocyte indices; consequently, the majority of respondents exhibited a normocytic-normochromic erythrocyte profile. ABSTRAK Diabetes melitus dikategorikan sebagai gangguan metabolik kronis yang menyebabkan berbagai komplikasi sistemik, termasuk gangguan hematologis yang ditandai dengan penurunan kadar hemoglobin. Penelitian ini bertujuan untuk mengukur kadar hemoglobin, menentukan indeks eritrosit meliputi Mean Corpuscular Volume (MCV), Mean Corpuscular Hemoglobin (MCH), dan Mean Corpuscular Hemoglobin Concentration (MCHC), serta menganalisis hubungan antara kadar hemoglobin dengan indeks eritrosit pada penderita diabetes melitus di RSUD Dr. Iskak Tulungagung. Penelitian ini dirancang secara observasional analitik dengan metode cross-sectional dan melibatkan 35 penderita diabetes melitus sebagai responden. Pengukuran kadar hemoglobin dan indeks eritrosit dilakukan menggunakan hematology analyzer XN-1000. Hasil penelitian menunjukkan bahwa penurunan kadar hemoglobin ditemukan pada sebagian besar responden, sedangkan sebagian besar indeks eritrosit masih berada dalam rentang normal. Berdasarkan uji korelasi Spearman, tidak terdapat hubungan yang signifikan antara kadar hemoglobin dengan MCV (r=0,191; p=0,270), MCH (r=0,254; p=0,141), maupun MCHC (r=0,236; p=0,173). Seluruh hubungan menunjukkan korelasi yang lemah dengan nilai signifikansi lebih dari 0,05. Dengan demikian, tidak terdapat hubungan yang signifikan antara kadar hemoglobin dengan indeks eritrosit pada penderita diabetes melitus. Penurunan kadar hemoglobin tidak selalu disertai perubahan indeks eritrosit, sehingga sebagian besar responden menunjukkan gambaran eritrosit normositik normokromik.
Co-Authors ., Pestariati A'yunin, Zahratin Nisa' Anggraini, Anita Dwi Arifin, Hidayat Ariyani, Ahna Fitri Edy Haryanto Endarini, Lully Hanni Entuy Kurniawan Entuy Kurniawan Kurniawan Evi Diah Woelansari Evy Diah Woelansari Farah Adilah Ambar Sari Handayati, Anik Istanto, Wisnu Kusnanto Kusnanto Marshanda Pratiwi Miftahurrahma Museyaroh, Museyaroh Musholli Himmatun Nabilah Nina Aulia Santi Noer Widy Astutik Reni Susanti Roni Yuliwar S.Pd. M Kes I Ketut Sudiana . Sasongkowati, Retno Sholihah, Irodatus Sindi Afrilia Dewi Suhariyadi Sulaeman Sulaeman Suliati Suliati Syamsul Arifin Syamsul Arifin Syamsul, Arifin Widya Kartika Sari Yulia Hermawati