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All Journal Jurnal Penelitian Kesehatan Suara Forikes Jurnal Ilmu dan Teknologi Kesehatan INDONESIAN JOURNAL OF MEDICAL LABORATORY SCIENCE AND TECHNOLOGY Journal of Indonesian Medical Laboratory and Science (JoIMedLabS) CENDEKIA : Jurnal Ilmu Pengetahuan HEALTHY: Jurnal Inovasi Riset Ilmu Kesehatan Journal of Global Pharma Technology Termometer: Jurnal Ilmiah Ilmu Kesehatan Dan Kedokteran Analis Kesehatan Sains (e-Journal) Jurnal Sains Student Research Media Penelitian dan Pengembangan Kesehatan
Krihariyani, Dwi
Teknologi Laboratorium Medis, Poltekkes Kemenkes Surabaya, Surabaya
Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Education Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Social Sciences Other

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EFEKTIVITAS PEMBERIAN TABLET TAMBAH DARAH TERHADAP KADAR HEMOGLOBIN PADA SISWI Susanti, Reni; Krihariyani, Dwi; Endarini, Lully Hanni; Suliati, Suliati
HEALTHY : Jurnal Inovasi Riset Ilmu Kesehatan Vol. 4 No. 2 (2025)
Publisher : Pusat Pengembangan Pendidikan dan Penelitian Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51878/healthy.v4i2.6391

Abstract

ABSTRACT Iron deficiency anemia is a common nutritional problem among adolescent girls in developing countries such as Indonesia, affecting both health and academic performance. The government has implemented a school-based iron supplementation program to address this issue. This study aims to evaluate the effectiveness of iron tablet supplementation in increasing hemoglobin levels among 10th-grade female students at MAN 3 Magetan. The study used a quasi-experimental design with a one-group pre-test and post-test approach. A total of 122 students aged 15–18 years participated based on inclusion criteria and parental consent. The intervention involved weekly iron tablet supplementation for three months. Hemoglobin levels were measured before and after the intervention using a HemoCue device, and data were analyzed using the Wilcoxon Signed-Rank test. The results showed a significant increase in hemoglobin levels after the intervention (p < 0.05). Prior to supplementation, 39% of the students were anemic, which decreased to 8% after the intervention, with 92% having normal hemoglobin levels. These findings indicate that regular iron supplementation effectively improves hemoglobin levels and reduces anemia prevalence. The program should be continued with sustained nutrition education and monitoring of compliance to ensure long-term effectiveness. ABSTRAK Anemia defisiensi zat besi merupakan masalah gizi yang umum pada remaja putri di negara berkembang seperti Indonesia, berdampak pada kesehatan dan prestasi belajar. Pemerintah telah menjalankan program pemberian tablet tambah darah (TTD) di sekolah sebagai upaya pencegahan. Penelitian ini bertujuan mengevaluasi efektivitas pemberian TTD terhadap peningkatan kadar hemoglobin pada siswi kelas X di MAN 3 Magetan. Desain penelitian menggunakan kuasi eksperimen dengan pendekatan one group pre-test dan post-test. Sebanyak 122 siswi usia 15–18 tahun menjadi responden berdasarkan kriteria inklusi dan persetujuan orang tua. Intervensi berupa pemberian TTD dilakukan seminggu sekali selama tiga bulan. Kadar hemoglobin diukur sebelum dan sesudah intervensi menggunakan alat HemoCue, dan data dianalisis dengan uji Wilcoxon Signed-Rank. Hasil menunjukkan peningkatan signifikan kadar hemoglobin setelah intervensi (p < 0,05). Sebelum intervensi, 39% siswi mengalami anemia, sementara setelahnya hanya 8%, dengan 92% memiliki kadar hemoglobin normal. Temuan ini menunjukkan bahwa pemberian TTD secara rutin efektif meningkatkan kadar hemoglobin dan menurunkan prevalensi anemia. Program ini perlu dilanjutkan secara berkelanjutan dengan edukasi gizi dan pemantauan kepatuhan konsumsi untuk hasil jangka panjang.
In silico evaluation of brazilin (Caesalpinia sappan L.) as a Dpre1 Mycobacterium tuberculosis inhibitor Entuy Kurniawan; Sulaeman Sulaeman; Dwi Krihariyani; Evi Diah Woelansari
Media Penelitian dan Pengembangan Kesehatan Vol. 36 No. 2 (2026): MEDIA PENELITIAN DAN PENGEMBANGAN KESEHATAN
Publisher : Poltekkes Kemenkes Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34011/jmp2k.v36i2.4564

Abstract

Background: The increasing incidence of drug-resistant Mycobacterium tuberculosis (Mtb) necessitates the identification of novel molecular targets and therapeutic candidates. Decaprenylphosphoryl-β-D-ribose 2′-epimerase subunit 1 (DprE1) is a key enzyme in Mtb cell wall biosynthesis and represents a promising therapeutic target. Brazilin, a natural compound derived from Caesalpinia sappan L., has been reported to exhibit diverse biological activities; however, its interaction with DprE1 remains insufficiently explored, highlighting a gap for computational-based investigation. Objective: To evaluate the binding affinity and molecular interaction profile of brazilin against DprE1 through an in silico approach. Methods: Molecular docking was performed using the crystal structure of DprE1 (PDB ID: 5OEP) with Molegro Virtual Docker. Key parameters included an active-site grid radius of 15 Å, grid resolution of 0.30 Å, and 10 independent docking runs per ligand to ensure reproducibility. Method validation was performed via redocking of the native ligand, yielding an RMSD <2.0 Å. Binding affinity and interaction patterns of brazilin were compared with rifampicin, isoniazid, and the native ligand. Results: Brazilin exhibited a rerank score of −71.287, indicating moderate binding affinity, stronger than isoniazid but lower than rifampicin and the native ligand. Notably, brazilin consistently occupied the catalytic binding pocket and established hydrogen bonding and hydrophobic interactions with key residues, suggesting a stable and functionally relevant binding orientation. This represents the first target-specific computational evidence linking brazilin to DprE1 inhibition. Conclusion: Brazilin from Caesalpinia sappan L. shows potential as a natural DprE1 of Mycobacterium tuberculosis inhibitor, although further experimental validation is required to confirm its biological efficacy.
In Silico Analysis of Antiviral Activity and Pharmacokinetic Prediction of Brazilein Sappan Wood (Caesalpinia sappan L.) Against SARS-CoV-2 Spike Glycoproteins Dwi Krihariyani; Edy Haryanto; Retno Sasongkowati
JURNAL INDONESIA DARI ILMU LABORATORIUM MEDIS DAN TEKNOLOGI Vol 3 No 1 (2021): Laboratory innovation : The challenge for medical laboratory
Publisher : Universitas Nahdlatul Ulama Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33086/ijmlst.v3i1.1854

Abstract

Brazilein is one of the secondary sappan wood metabolites which can be used empirically as an antivirus. The SARS-CoV-2 spike (S) glycoproteins play significant roles in attaching and entering the virus into the host cell. This study aims to predict the antiviral activity and pharmacokinetic properties of brazilein of the sappan wood against the in-silico SARS-CoV-2 S glycoproteins with vitamin C as the reference compound. Molegro Virtual Docker 5.5 was used to predict antiviral activity by docking process. SARS-CoV-2 S glycoprotein with NAG ligand available in Protein Data Bank (PDB) (PDB ID: 7C01) was the receptor used. The pkCSM online tool was used to predict the pharmacokinetic properties and toxicity of brazilein. Data were analyzed on the target receptors by comparing the docking bond energies between NAG, brazilein, and vitamin C. The smaller the ligands’ bond energy to the target receptor, the more stable the bonds are. The bond energy of NAG, brazilein, and vitamin C was -59.2864 kcal/mol, -65.8911 kcal/mol, and -53.9093 kcal/mol, respectively. These results suggested that brazilein has a greater capacity as an antivirus compared to NAG and vitamin C. In silico test using the pkCSM online tool demonstrated that brazilein had strong pharmacokinetic properties and relatively low toxicity.
GAMBARAN PEMERIKSAAN RHEUMATOID FACTOR PADA LANSIA DI WILAYAH KERJA PUSKESMAS PUCANG SEWU SURABAYA Widya Kartika Sari; Evy Diah Woelansari; Museyaroh Museyaroh; Dwi Krihariyani
CENDEKIA: Jurnal Ilmu Pengetahuan Vol. 6 No. 4 (2026)
Publisher : Pusat Pengembangan Pendidikan dan Penelitian Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51878/cendekia.v6i4.14049

Abstract

Rheumatoid Factor (RF) is an autoantibody commonly used as a supporting laboratory test for the identification of Rheumatoid Arthritis (RA). Rheumatoid Arthritis is an autoimmune disease characterized by chronic inflammation of the joints and may occur among older adults. This study aimed to describe the results of Rheumatoid Factor examination among elderly individuals in the working area of Pucang Sewu Public Health Center, Surabaya. This study employed a descriptive design involving 34 elderly respondents selected using purposive sampling based on predetermined inclusion and exclusion criteria. Rheumatoid Factor examination was performed using the latex agglutination method. Samples with reactive results were subsequently examined using a semi-quantitative method to determine the Rheumatoid Factor titer. Data were analyzed descriptively and presented in frequency distribution tables based on Rheumatoid Factor results, sex, and age group. The results showed that 31 respondents (91.2%) had negative Rheumatoid Factor results, while 3 respondents (8.8%) had positive results. All respondents with positive results had a Rheumatoid Factor titer of 16 IU/mL. Based on sex, all positive results were found among male respondents. Based on age group, positive results were found among respondents aged 60–69 years and 80–89 years. It can be concluded that most elderly individuals in the working area of Pucang Sewu Public Health Center, Surabaya, had negative Rheumatoid Factor results, while a small proportion had positive results with low titers. ABSTRAK Rheumatoid Factor (RF) merupakan salah satu autoantibodi yang digunakan sebagai pemeriksaan penunjang dalam identifikasi Rheumatoid Arthritis (RA). Rheumatoid Arthritis merupakan penyakit autoimun yang ditandai dengan peradangan kronis pada sendi dan dapat ditemukan pada kelompok lanjut usia. Penelitian ini bertujuan untuk mengetahui gambaran hasil pemeriksaan Rheumatoid Factor pada lansia di wilayah kerja Puskesmas Pucang Sewu Surabaya. Penelitian ini menggunakan desain deskriptif dengan melibatkan 34 responden lansia yang dipilih menggunakan teknik purposive sampling berdasarkan kriteria inklusi dan eksklusi. Pemeriksaan Rheumatoid Factor dilakukan menggunakan metode aglutinasi lateks. Sampel dengan hasil reaktif selanjutnya diperiksa secara semikuantitatif untuk menentukan titer Rheumatoid Factor. Data dianalisis secara deskriptif dan disajikan dalam bentuk tabel distribusi frekuensi berdasarkan hasil pemeriksaan Rheumatoid Factor, jenis kelamin, dan kelompok usia. Hasil penelitian menunjukkan bahwa 31 responden (91,2%) memiliki hasil Rheumatoid Factor negatif, sedangkan 3 responden (8,8%) menunjukkan hasil positif. Seluruh responden dengan hasil positif memiliki titer Rheumatoid Factor sebesar 16 IU/mL. Berdasarkan jenis kelamin, seluruh hasil positif ditemukan pada responden laki-laki. Berdasarkan kelompok usia, hasil positif ditemukan pada kelompok usia 60–69 tahun dan 80–89 tahun. Dapat disimpulkan bahwa sebagian besar lansia di wilayah kerja Puskesmas Pucang Sewu Surabaya memiliki hasil Rheumatoid Factor negatif, sedangkan sebagian kecil menunjukkan hasil positif dengan titer rendah.
Co-Authors ., Pestariati A'yunin, Zahratin Nisa' Arifin, Hidayat Ariyani, Ahna Fitri Edy Haryanto Endarini, Lully Hanni Entuy Kurniawan Entuy Kurniawan Kurniawan Evi Diah Woelansari Evy Diah Woelansari Farah Adilah Ambar Sari Istanto, Wisnu Kusnanto Kusnanto Museyaroh, Museyaroh Reni Susanti Roni Yuliwar S.Pd. M Kes I Ketut Sudiana . Sasongkowati, Retno Sholihah, Irodatus Suhariyadi Suhariyadi Sulaeman Sulaeman Suliati Suliati Syamsul Arifin Syamsul Arifin Widya Kartika Sari Wisnu Istanto Yulia Hermawati