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Respon Antibiotik Salmonella typhi pada Anak dengan Demam Tifoid Febilla Naili Alfalah; Intanri Kurniati; Dian Isti Angraini; Oktadoni Saputra
Jurnal Riset Ilmu Kesehatan Umum dan Farmasi (JRIKUF) Vol. 3 No. 3 (2025): Juli : Jurnal Riset Ilmu Kesehatan Umum dan Farmasi (JRIKUF)
Publisher : LPPM STIKES KESETIAKAWANAN SOSIAL INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.57213/jrikuf.v3i3.774

Abstract

Typhoid fever is a significant health issue worldwide, especially in developing countries. The highest incidence of typhoid fever occurs in the pediatric population, particularly among school-age children. Patients often resort to self-medication with antibiotics, where chloramphenicol is the primary choice for treating typhoid fever in Indonesia. However, reports of resistance to the chloramphenicol group have been documented in some locations. A total of 8 articles are included in this literature, revealing the existence of resistant isolates in the antibiotic susceptibility test for Salmonella thypi during the primary therapy. Several cases demonstrate resistance to various antibiotics such as ceftriaxone, cefuroxime, amoxicillin, ampicillin, ciprofloxacin, augmentin, fluoroquinolones, azithromycin, and nalidixic acid. However, some drugs have proven effective, including Cefixime, ceftriaxone, chloramphenicol, ofloxacin, cefepime, quinolones, and third-generation cephalosporins, which are considered sensitive to S. Typhi.
Asap Rokok dan Pneumonia Balita: Tinjauan Literatur Muhammad Hisyam Hibaturramadhan; Oktadoni Saputra; Laisa Azka; Novita Carolia
Journal of Language and Health Vol. 6 No. 4 (2025): Journal of Language and Health: December 2025
Publisher : CV. Global Health Science Group

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/jlh.v6i4.1060

Abstract

Pneumonia merupakan salah satu penyebab utama morbiditas dan mortalitas pada anak balita, dan paparan asap rokok (second-hand smoke/SHS) merupakan faktor risiko lingkungan yang dapat dimodifikasi serta meningkatkan kerentanan terhadap infeksi saluran napas. Tinjauan ini bertujuan untuk merangkum bukti ilmiah terbaru mengenai hubungan antara paparan SHS dengan kejadian serta derajat keparahan pneumonia pada anak balita. Pendekatan tinjauan naratif sistematis dilakukan dengan menggunakan Google Scholar untuk mengidentifikasi penelitian observasional yang dipublikasikan pada tahun 2020–2025 di Indonesia, dengan fokus pada SHS sebagai paparan utama dan pneumonia sebagai luaran. Hasil pencarian mendapatkan 26 artikel dan sebanyak enam studi memenuhi kriteria inklusi. Artikel dianalisis dengan membuat ringkasan dan hasil dari penelitian. Seluruh studi yang dianalisis secara konsisten menunjukkan bahwa paparan SHS meningkatkan risiko pneumonia secara signifikan, dengan besar efek mulai dari dua kali lipat hingga lebih dari tiga belas kali lipat pada kondisi paparan tinggi. Beberapa penelitian juga menunjukkan bahwa perilaku merokok orang tua berhubungan dengan derajat pneumonia yang lebih berat. Bukti mekanistik menggambarkan bahwa SHS mengganggu pembersihan mukosilier, merusak epitel saluran napas, dan melemahkan respons imun bawaan sehingga mempermudah invasi patogen. Paparan SHS merupakan determinan kuat dan dapat dicegah dalam upaya menurunkan kejadian pneumonia pada anak balita.
Peran Identitas Profesional dalam Adaptasi Mahasiswa Kedokteran di Kepaniteraan Klinik: Tinjauan Literatur Aina Wijdan Chairunisa; Rika Lisiswanti; Septia Eva Lusina; Oktadoni Saputra
JOURNAL SAINS STUDENT RESEARCH Vol. 4 No. 2 (2026): April: Jurnal Sains Student Research
Publisher : CV. KAMPUS AKADEMIK PUBLISING

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61722/jssr.v4i2.9855

Abstract

Pendidikan kedokteran tidak hanya berfokus pada penguasaan pengetahuan dan keterampilan klinis tetapi juga pada aspek profesionalisme, salah satunya adalah identitas profesional sebagai dasar dalam menjalankan peran sebagai dokter. Identitas profesional berperan penting dalam membantu mahasiswa kedokteran beradaptasi dengan lingkungan kepaniteraan klinik yang kompleks dan penuh tuntutan. Tinjauan literatur ini bertujuan untuk mengkaji peran identitas profesional dalam mendukung adaptasi mahasiswa kedokteran di lingkungan klinik. Metode yang digunakan adalah tinjauan literatur dengan menganalisis 20 artikel yang diperoleh melalui basis data Google Scholar dan PubMed dengan rentang publikasi tahun 2016–2025. Analisis dilakukan secara tematik untuk mengidentifikasi faktor-faktor yang memengaruhi pembentukan identitas profesional serta keterkaitannya dengan kemampuan adaptasi mahasiswa. Hasil kajian menunjukkan bahwa identitas profesional terbentuk melalui interaksi antara faktor individu, lingkungan pembelajaran klinik, pengalaman emosional, dan interaksi sosial. Identitas profesional yang berkembang secara optimal berkontribusi dalam meningkatkan kemampuan adaptasi mahasiswa, termasuk dalam hal pengelolaan tekanan, kepercayaan diri, dan kemampuan berinteraksi dalam praktik klinik. Dengan demikian, pembentukan identitas profesional menjadi aspek penting dalam pendidikan kedokteran untuk mendukung kesiapan mahasiswa dalam menghadapi lingkungan klinik.
Relationship between Frequency of Fast Food and Beverage Consumption and Tonsillitis in Children Mukhlis Imanto; Roro Rukmi Windi Perdani; Oktadoni Saputra; Diyan Ekawati; Dustin Delano Pranata Sembiring
Indonesian Journal of Global Health Research Vol. 8 No. 3 (2026): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v8i3.1171

Abstract

Tonsillitis is an inflammation of the palatine tonsils commonly affecting children aged 5–15 years. One of the contributing risk factors is the frequent consumption of fast food and fast beverages. This study aimed to analyse the association between fast food and fast beverage consumption and the incidence of tonsillitis among children aged 5–15 years. An observational analytic study with a case–control design was conducted involving 52 respondents, consisting of 26 cases and 26 controls, selected using consecutive sampling. Data were collected from children aged 5–15 years attending the Otorhinolaryngology outpatient clinic at Advent Hospital. Fast food and fast beverage consumption was assessed using a Semi-Quantitative Food Frequency Questionnaire (SQ-FFQ), followed by clinical diagnosis by a specialist. The Semi-Quantitative Food Frequency Questionnaire (SQ-FFQ) used to assess fast food and fast beverage consumption was tested for validity and reliability prior to data collection. Item validity was confirmed using correlation analysis with significance values < 0.05, while reliability testing demonstrated satisfactory internal consistency, with Cronbach’s alpha coefficients exceeding 0.70, indicating that the instrument was valid and reliable for measuring dietary consumption patterns. Consumption frequency was categorised as frequent (score ≥ median) and infrequent/never (score < median). Data analysis was performed using the Chi-square test. The study subjects consisted of 27 males (51.9%) and 25 females (48.1%). A total of 26 subjects (50.0%) were diagnosed with tonsillitis, while 26 subjects (50.0%) were non-tonsillitis. Frequent fast food consumption was reported in 25 subjects (48.1%), while frequent fast beverage consumption was reported in 23 subjects (44.2%). Fast food consumption more than twice daily showed a highly significant association with tonsillitis (p = 0.000). Similarly, fast beverage consumption was also significantly associated with tonsillitis (p = 0.000). A high frequency of fast food and fast beverage consumption (OR: 23.100 and 14.929, respectively) is significantly associated with the incidence of tonsillitis in children aged 5–15 years. Health education regarding healthy dietary patterns is essential to reduce the risk of tonsillitis in this age group.
PENGETAHUAN IBU BALITA DENGAN PEMANFAATAN BUKU KIA: a Literature Review Jihan Sayyidina Putri; Oktadoni Saputra; Tetra Arya Saputra; Prambudi Rukmono
Nusantara Hasana Journal Vol. 5 No. 8 (2026): Nusantara Hasana Journal, January 2026
Publisher : Yayasan Nusantara Hasana Berdikari

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Maternal knowledge plays a crucial role in monitoring growth and improving the health of under-five children. The Maternal and Child Health (MCH) handbook is an educational and recording tool designed to support optimal childcare practices. However, its utilization remains suboptimal despite high ownership rates. This study discusses the relationship between maternal knowledge and the utilization of the MCH handbook, as well as factors influencing its use. Findings indicate that mothers with higher levels of knowledge are more likely to actively use the handbook for child health monitoring. Therefore, continuous education and supportive interventions are essential to optimize the use of the MCH handbook in promoting child health and development. This study employed a literature review method by examining relevant scientific articles on mothers’ knowledge of toddlers and the utilization of the MCH handbook obtained from various national and international databases.
DUAL OREXIN RECEPTOR ANTAGONIST (DORA) SEBAGAI TERAPI INSOMNIA: SEBUAH TINJAUAN PUSTAKA Dianda Faradiba Wardani; Oktafany Oktafany; Anisa Nuraisa Jausal; Oktadoni Saputra
Nusantara Hasana Journal Vol. 5 No. 8 (2026): Nusantara Hasana Journal, January 2026
Publisher : Yayasan Nusantara Hasana Berdikari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59003/nhj.v5i8.1832

Abstract

Insomnia affects more than 852 million adults worldwide and 43.7% of individuals aged ≥19 years in Indonesia, highlighting the need for effective and safe therapy. Benzodiazepines and Z-drugs are commonly used but are associated with risks of tolerance and dependence. Dual orexin receptor antagonists (DORAs) have emerged as a more selective therapeutic alternative. A systematic literature review was conducted using PubMed and Google Scholar, focusing on meta-analyses of suvorexant, lemborexant, and daridorexant. Suvorexant improved subjective total sleep time (MD −19.10), subjective time to sleep onset (MD −8.23), and subjective wake after sleep onset (MD −6.45). Lemborexant at doses of 5–10 mg was effective in improving wake after sleep onset (MD −19.90; −22.24) and sleep onset latency (MD −9.23; −12.56). Daridorexant at doses of 25–50 mg reduced wake after sleep onset (MD −0.30; −0.53) and latent persistent sleep (MD −0.30; −0.53). Adverse effects of DORAs include somnolence, daytime sleepiness, fatigue, abnormal dreams, and nasopharyngitis. Overall, DORAs demonstrated significant effectiveness on subjective sleep parameters compared with control groups, with variations in effect size and safety profiles. DORAs may be considered effective and safe treatments for insomnia, with drug and dose selection tailored to clinical needs.