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Erwin Samsul
Mulawarman University
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology

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Antibacterial Activity of Lactic Acid Bacteria Isolates Mountain Rice Wash Water (Mayas Rice) Against Propionibacterium acnes M. Arifuddin; Rezti Amanda; Arfiani Arifin; Arfina Sukmawati Arifin; Iswahyudi Iswahyudi; Erwin Samsul; Riki Riki; Hifdzur Rashif Rija'i; Baso Didik Hikmawan; Arsyik Ibrahim; Laode Rijai
Journal of Pharmaceuticals and Natural Sciences Vol. 3 No. 1 (2026): J. Pharm. Nat. Sci.
Publisher : B-CRETA Publisher (CV. Borneo Citra Kreatama)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70392/jpns.v3i1.42

Abstract

This study aims to explore the antibacterial activity potential of fermented dragon fruit peel juice (Hylocereus polyrhizus) fermented using Lactic Acid Bacteria (LAB) isolated from rice washing water (Beras Mayas). The process begins with the preparation of dragon fruit peel samples, which are washed, peeled, and mashed to obtain the juice. The juice is pasteurized and inoculated with a 5% LAB starter, with the addition of a 10% sugar solution before being incubated for 3, 7, 12, and 17 days at 37ºC. pH measurements were taken during fermentation, showing a significant decrease in pH, reaching the lowest value of 3.76 on day 17. The antibacterial activity was measured using the well-diffusion method with the fermented juice at a concentration of 100%, showing a very strong inhibition zone (>20 mm) against Propionibacterium acnes on day 7. The results indicate that the pH changes during fermentation are closely related to the antibacterial activity
Alkaloid Profiling of Kadamba (Mitragyna speciosa Korth. Havil.) Leaves through Chromatographic Separation and UV-Vis Spectrophotometery Analysis M. Arifuddin; Fatur Rahman Azmi; Iswahyudi Iswahyudi; Mahfuzun Bone; Harra Ismi Farrah; Hanggara Arifian; Maria Almeida; Arman Rusman; Erwin Samsul; Riki Riki; Hifdzur Rashif Rija'i; Baso Didik Hikmawan; Junaidin Junaidin; Lizma Febrina; Rolan Rusli; Arsyik Ibrahim; Islamudin Ahmad; Herman Herman
Journal of Pharmaceuticals and Natural Sciences Vol. 2 No. 3 (2025): J. Pharm. Nat. Sci.
Publisher : B-CRETA Publisher (CV. Borneo Citra Kreatama)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70392/jpns.v2i3.44

Abstract

Mitragyna speciosa Korth. berasal dari famili Rubiaceae yang banyak tumbuh di daratan negara-negara Asia Tenggara. Tumbuhan ini selain disebut Kratom, khususnya di daerah Kalimantan Timur dikenal juga dengan nama "Kadamba". Mitragyna speciosa Korth. belongs to the Rubiaceae family and is widely found in the mainland of Southeast Asian countries. This plant, known as Kratom, is also referred to as "Kadamba" in East Kalimantan. Kadamba has been used for generations as a traditional medicine and contains predominantly alkaloid compounds, which generally function as analgesics, antitussives, antidiarrheals, adrenergic agents, antimalarials, antibacterials, and antinociceptives. The aim of this research is to determine the isolation and identification methods for alkaloid compounds in Kadamba leaves. In this study, extraction was performed using methanol solvent, followed by fractionation using Vacuum Liquid Chromatography (VLC) and Column Chromatography (CC) with gradient eluents: 100% hexane, n-hexane : Ethyl Acetate (5:1, 1:1, 1:5), 100% Ethyl Acetate, Ethyl Acetate : Methanol (1:1, 1:5), and 100% Methanol. The compounds were then identified using Thin Layer Chromatography (TLC). The isolation process used preparative Thin Layer Chromatography (PTLC) with eluent n-hexane: ethyl acetate: 25% ammonia (6.5:3:0.5 v/v/v), and the spots were observed under UV light at 245 nm and 366 nm. The visible spots were sprayed with Dragendorff's reagent to identify the alkaloid compounds. The results showed that the UV-Vis spectrophotometric characterization of isolate B6-b had two peaks at wavelengths of 288 nm and 294 nm.
Evaluation of the Analgesic Potential of Bangle Rhizome (Zingiber cassumunar Roxb.) Extract in Mice (Mus musculus) Yunanda Pratiwi Sakkung; Erwin Samsul; Maria Almeida; Lizma Febrina; Junaidin Junaidin; Herman Herman
Journal of Pharmaceuticals and Natural Sciences Vol. 3 No. 2 (2026): J Pharm Nat Sci
Publisher : B-CRETA Publisher (CV. Borneo Citra Kreatama)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70392/jpns.v3i2.55

Abstract

Bangle (Zingiber cassumunar Roxb.) is a medicinal plant traditionally used by local communities for various health conditions, including fever, stomach discomfort, constipation, and common cold symptoms. This study was conducted to evaluate the analgesic activity of bangle rhizome extract in mice, determine the most effective dose for producing an analgesic response, and compare its analgesic efficacy with aspirin. The experimental animals were randomly allocated into six groups consisting of a normal control group, a negative control group receiving 0.5% NaCMC, a positive control group administered aspirin, and three treatment groups receiving bangle rhizome extract at doses of 150, 200, and 300 mg/kg body weight, respectively. Analgesic activity was assessed using a chemical pain induction model in which 1% acetic acid was administered intraperitoneally 30 minutes after oral administration of the respective treatments. The number of writhing responses was recorded at 10-minute intervals over a 60-minute observation period. The findings demonstrated that the bangle rhizome extract exhibited analgesic activity by reducing the frequency of writhing responses in mice. Among the tested doses, 200 mg/kg body weight produced the most favorable analgesic effect. Furthermore, the analgesic activity observed at this dose was comparable to that produced by aspirin, suggesting that bangle rhizome extract has promising potential as a natural analgesic agent.
Co-Authors Almeida, Maria Arfiani Arifin Arfina Sukmawati Arifin Arman Rusman Arsyik Ibrahim Baso Didik Hikmawan Fatur Rahman Azmi Hanggara Arifian Harra Ismi Farrah Herman Herman Hifdzur Rashif Rija’i Islamudin Ahmad Iswahyudi Iswahyudi Junaidin Junaidin Laode Rijai Lizma Febrina M. Arifuddin Mahfuzun Bone Rezti Amanda Riki Riki Rolan Rusli Yunanda Pratiwi Sakkung