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All Journal Journal of Pharmaceuticals and Natural Sciences Jurnal Abdita Naturafarm
M. Arifuddin
Mulawarman University
Religion Humanities Biochemistry, Genetics & Molecular Biology Decision Sciences, Operations Research & Management Health Professions Immunology & microbiology Medicine & Pharmacology Other

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Extension on Prevention and Early Treatment of Diarrhea to Children of Sekolah Dasar Negeri 006 Kota Samarinda: Penyuluhan Pencegahan dan Penatalaksanaan Awal Diare pada Anak Sekolah Dasar Negeri 006 Kota Samarinda M. Arifuddin; Fitri Nurul Choiriyah; Amalia Pratamasari Hartini Nurul Mahmudah
Jurnal Abdita Naturafarm Vol. 3 No. 2 (2026): J Abdita Naturafarm
Publisher : B-Creta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70392/jan.v3i2.39

Abstract

Diarrhea is a public health issue with a high incidence rate, especially among children. School-age children were a vulnerable group due to limited knowledge regarding the prevention and early management of diarrhea. This activity aimed to ensure that students at Sekolah Dasar Negeri 006 Kota Samarinda had adequate knowledge about diarrhea and were aware of the importance of prevention and early management of diarrhea. Counseling was conducted with 22 children of Sekolah Dasar Negeri 006 Kota Samarinda. The activity involved distributing leaflets, presenting materials, and demonstrating the preparation of oral rehydration salts (ORS) solution, accompanied by questionnaires. Based on the questionnaire results, 27.3% of respondents had good knowledge in the pre-test and 90.9% in the post-test with an Asymp. Sig. (2-tailed) value of 0.000 in the Wilcoxon test. Provided this education increased children's knowledge about the prevention and early management of diarrhea.
Antibacterial Activity of Lactic Acid Bacteria Isolates Mountain Rice Wash Water (Mayas Rice) Against Propionibacterium acnes M. Arifuddin; Rezti Amanda; Arfiani Arifin; Arfina Sukmawati Arifin; Iswahyudi Iswahyudi; Erwin Samsul; Riki Riki; Hifdzur Rashif Rija'i; Baso Didik Hikmawan; Arsyik Ibrahim; Laode Rijai
Journal of Pharmaceuticals and Natural Sciences Vol. 3 No. 1 (2026): J. Pharm. Nat. Sci.
Publisher : B-CRETA Publisher (CV. Borneo Citra Kreatama)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70392/jpns.v3i1.42

Abstract

This study aims to explore the antibacterial activity potential of fermented dragon fruit peel juice (Hylocereus polyrhizus) fermented using Lactic Acid Bacteria (LAB) isolated from rice washing water (Beras Mayas). The process begins with the preparation of dragon fruit peel samples, which are washed, peeled, and mashed to obtain the juice. The juice is pasteurized and inoculated with a 5% LAB starter, with the addition of a 10% sugar solution before being incubated for 3, 7, 12, and 17 days at 37ºC. pH measurements were taken during fermentation, showing a significant decrease in pH, reaching the lowest value of 3.76 on day 17. The antibacterial activity was measured using the well-diffusion method with the fermented juice at a concentration of 100%, showing a very strong inhibition zone (>20 mm) against Propionibacterium acnes on day 7. The results indicate that the pH changes during fermentation are closely related to the antibacterial activity
Alkaloid Profiling of Kadamba (Mitragyna speciosa Korth. Havil.) Leaves through Chromatographic Separation and UV-Vis Spectrophotometery Analysis M. Arifuddin; Fatur Rahman Azmi; Iswahyudi Iswahyudi; Mahfuzun Bone; Harra Ismi Farrah; Hanggara Arifian; Maria Almeida; Arman Rusman; Erwin Samsul; Riki Riki; Hifdzur Rashif Rija'i; Baso Didik Hikmawan; Junaidin Junaidin; Lizma Febrina; Rolan Rusli; Arsyik Ibrahim; Islamudin Ahmad; Herman Herman
Journal of Pharmaceuticals and Natural Sciences Vol. 2 No. 3 (2025): J. Pharm. Nat. Sci.
Publisher : B-CRETA Publisher (CV. Borneo Citra Kreatama)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70392/jpns.v2i3.44

Abstract

Mitragyna speciosa Korth. berasal dari famili Rubiaceae yang banyak tumbuh di daratan negara-negara Asia Tenggara. Tumbuhan ini selain disebut Kratom, khususnya di daerah Kalimantan Timur dikenal juga dengan nama "Kadamba". Mitragyna speciosa Korth. belongs to the Rubiaceae family and is widely found in the mainland of Southeast Asian countries. This plant, known as Kratom, is also referred to as "Kadamba" in East Kalimantan. Kadamba has been used for generations as a traditional medicine and contains predominantly alkaloid compounds, which generally function as analgesics, antitussives, antidiarrheals, adrenergic agents, antimalarials, antibacterials, and antinociceptives. The aim of this research is to determine the isolation and identification methods for alkaloid compounds in Kadamba leaves. In this study, extraction was performed using methanol solvent, followed by fractionation using Vacuum Liquid Chromatography (VLC) and Column Chromatography (CC) with gradient eluents: 100% hexane, n-hexane : Ethyl Acetate (5:1, 1:1, 1:5), 100% Ethyl Acetate, Ethyl Acetate : Methanol (1:1, 1:5), and 100% Methanol. The compounds were then identified using Thin Layer Chromatography (TLC). The isolation process used preparative Thin Layer Chromatography (PTLC) with eluent n-hexane: ethyl acetate: 25% ammonia (6.5:3:0.5 v/v/v), and the spots were observed under UV light at 245 nm and 366 nm. The visible spots were sprayed with Dragendorff's reagent to identify the alkaloid compounds. The results showed that the UV-Vis spectrophotometric characterization of isolate B6-b had two peaks at wavelengths of 288 nm and 294 nm.
Toxicity of Extracts and Fractions of Bangkal Leaves (Nauclea subdita (Korth.) Steud.) and Genjer (Limnocharis flava (L.) Buch) on the Bioindicator Artemia salina Leach Arsyik Ibrahim; Sealti Puji Salea; Sri Windarti; M. Rahmad Ramadhan; Hidfdzur Rashif Rija'i; M. Arifuddin; Laode Rijai
Journal of Pharmaceuticals and Natural Sciences Vol. 3 No. 1 (2026): J. Pharm. Nat. Sci.
Publisher : B-CRETA Publisher (CV. Borneo Citra Kreatama)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70392/jpns.v3i1.47

Abstract

A study was conducted on the secondary metabolite content and toxicity testing of Artemia salina leach larvae using extracts from Bangkal leaves (Nauclea subdita (Korth.) Steud.) and Genjer plants (Limnocharis flava (L.) Buch). The objective of this study is twofold: firstly, to ascertain the compounds present in Bangkal leaf extract and Genjer plant extract, and secondly, to assess the toxicity levels of the extracts and fractions from Bangkal leaves and Genjer plants on Artemia salina Leach larvae. In this study, the extraction method employed was maceration with 96% ethanol as the solvent. The crude 96% ethanol extract was fractionated in stages using n-hexane, ethyl acetate, and n-butanol solvents based on polarity levels. The toxicity testing was conducted using the Brine Shrimp Lethality Test (BSLT) method, with Artemia salina Leach larvae serving as the bioindicator. A range of test concentrations were utilised, with each concentration having three replicates. The mortality of Artemia salina was observed after a 24-hour period and was analysed using the Reed and Muench method to determine the LC50 value. The results of the study demonstrated that the secondary metabolites present in the 96% ethanol extract of bangkal leaves com-prised the following groups of compounds: steroids, and triterpenoids, phenols, quinones, and saponins. The toxicity test results of the bangkal leaf extract and fractions yielded LC50 values of 418.79 ppm for the 96% ethanol extract; 716.14 ppm for the n-hexane fraction; 263.03 ppm for the ethyl acetate fraction; and 70,79 ppm for the extract n-buthanol fraction. Meanwhile, the toxicity test results of the genjer plant extract and fractions obtained an LC50 value of 490.23 ppm for the 96% ethanol extract; n-hexane fraction 551.31 ppm; ethyl acetate fraction 425.01 ppm; and n-butanol fraction extract 46.02 ppm. These results indicate that the n-butanol fraction of bangkal leaves and genjer plants have stronger cytotoxic activity than other fraction extracts.
Co-Authors Amalia Pratamasari Hartini Nurul Mahmudah Arfiani Arifin Arfina Sukmawati Arifin Arman Rusman Arsyik Ibrahim Baso Didik Hikmawan Erwin Samsul Fatur Rahman Azmi Fitri Nurul Choiriyah Hanggara Arifian Harra Ismi Farrah Herman Herman Hidfdzur Rashif Rija'i Hifdzur Rashif Rija'i Islamudin Ahmad Iswahyudi Iswahyudi Junaidin Junaidin Laode Rijai Lizma Febrina M. Rahmad Ramadhan Mahfuzun Bone Maria Almeida Rezti Amanda Riki Riki Rolan Rusli Sealti Puji Salea Sri Windarti