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All Journal HAYATI Journal of Biosciences Pharmaciana: Jurnal Kefarmasian JPSCR : Journal of Pharmaceutical Science and Clinical Research Indonesian Journal of Community Services Jurnal Nuansa Akademik: Jurnal Pembangunan Masyarakat Medical Sains : Jurnal Ilmiah Kefarmasian Prosiding Seminar Nasional Pengabdian Kepada Masyarakat Media Farmasi Indonesia Jurnal Ilmiah Sultan Agung Medical Sains : Jurnal Ilmiah Kefarmasian
Putri, Chintiana Nindya
Universitas Islam Sultan Agung
Religion Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Earth & Planetary Sciences Economics, Econometrics & Finance Education Electrical & Electronics Engineering Energy Environmental Science Immunology & microbiology Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Nursing Public Health Social Sciences Other

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FORMULATION AND EVALUATION OF SACHA INCHI OIL LIP BALM PREPARATIONS WITH CONCENTRATION VARIATIONS OF CERA ALBA AND LANOLIN AS LIP BALM Putri, Chintiana Nindya; Latifah, Fadzil; Zahro, Honest Fatimatuz
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 9 No 3 (2024)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v9i3.1265

Abstract

Lip balm is used on lips that require protection, such as when humidity is low, to prevent the evaporation of water and epithelial cells on the lip mucosa. The active substance used in making this lip balm is Sancha inchi oil, which is a cold-pressed oil from the seeds of Plukenetia volubilista. This oil contains omega 3 (40–50%) and omega 6 (30–40%), as well as lower oleic acid (10%) than olive oil. Natural antioxidants, including tocopherols and polyphenols, have also been found in Sacha Inchi oil. Sacha inchi oil has a fatty acid ratio and phytochemical composition, it can be used as a cosmetic ingredient as an emollient and skin protector. An experimental laboratory method was used for this study. The research was carried out by preparing lip balm from various ingredients containing the active ingredient Sacha inchi oil (Plukenetia volubilis L) at a concentration of 15%, as well as varying concentrations of cera alba (range 5-25%) and lanolin (range 2-10%) as bases and additional ingredients for preparations, whose optimization had been determined using the simplex lattice design method. The aim of this study was to identify the lip balm formulation from Sacha inchi oil and identify the effect of changes in the concentration of cera alba and lanolin based on the results of the preparation evaluation. The results of this test show that sacha inchi oil can be used as an active lip-moisturizing agent in lip balm preparations ...
The Potential of Swiftlet Bird's Nest Extract (Aerodramus fucipaghus) as an Antioxidant and Serum Formulation Widyaningrum, Naniek; Putri, Chintiana Nindya; Arief, Thendi Abdul; Sofa, Nada Aini; Virdaus, Monica
Pharmaciana Vol. 14 No. 3 (2024): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/pharmaciana.v14i3.27001

Abstract

The white swiftlet bird's nest (Aerodramus fucipaghus) constitutes one of nature's treasures endowed with diverse health benefits. The swiftlet bird's nest is a potential source of antioxidants, capable of counteracting free radicals contributing to premature ageing. It can be harnessed as a serum formulation featuring small molecules, facilitating deeper skin penetration, efficient delivery of highly concentrated active agents, and expedited resolution of skin issues. This study aimed to ascertain the swiftlet bird's nest serum's physical properties, physical stability, and antioxidant activities. Serum formulations span a range of concentrations: 10%, 20%, 30%, and 40%. Physical attributes of the serum, including organoleptic properties, homogeneity, pH, spreadability, and viscosity, were observed. Serum stability was assessed over a 21-day storage period. The antioxidant activity of the serum was gauged via DPPH assay, determining the IC50 values. The serum, across varying concentrations, exhibited commendable physical characteristics, satisfying stipulated criteria. Antioxidant activity was detected in the serum across a spectrum of concentrations, revealing IC50 values of 250.00 µg/mL, signifying a range from weak to strong efficacy (90.137 µg/mL). The swiftlet bird's nest serum with its concentration variants demonstrated physical stability during the 21-day storage duration. Drawing from the research, it can be deduced that the swiftlet bird's nest holds promise for development into a serum formulation that fulfils both physical and stability criteria, endowed with robust antioxidant activity. Notably, the swiftlet bird's nest serum at a 40% concentration exhibited potent antioxidant activity, manifesting an IC50 value of 90.137 µg/mL
DETERMINASI TOTAL FLAVONOID, TOTAL FENOLIK, DAN AKTIVITAS ANTIBAKTERI EKSTRAK ETANOL DAUN INSULIN (Smallanthus Sonchifolius) DENGAN METODE PERKOLASI Ramonah, Dewi; Rahardhian, Muhammad Ryan Radix; Putri, Chintiana Nindya
Media Farmasi Indonesia Vol. 15 No. 1 (2020): Media Farmasi Indonesia
Publisher : SEKOLAH TINGGI ILMU FARMASI YAYASAN PHARMASI SEMARANG

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (656.674 KB) | DOI: 10.53359/mfi.v15i1.143

Abstract

Indonesia kaya akan keanekaragaman hayati yang berkhasiat sebagai pengobatan. Salah satunya adalah daun insulin yang mengandung senyawa fenolik golongan flavonoid, dimana senyawa tersebut memiliki potensi sebagai antibakteri. Penelitian ini bertujuan untuk mengetahui kandungan senyawa ekstrak etanol daun insulin (EDI) dengan metode perkolasi pada skrining fitokimia, kromatografi lapis tipis (KLT), determinasi total phenolic content (TPC), total flavonoid content (TFC), dan aktivitas antibakteri terhadap bakteri Sthapylococcus aureus. Hasil skrining fitokimia dan TLC membuktikan bahwa, EDI mengandung senyawa flavonoid, tanin, alkaloid, saponin dan steroid. Nilai TPC 6,7315±0,15 mg/g Gallat Acid Equivalent (GAE), Nilai TFC 66,1857±13,34 mg/g Quercetin Equivalent (QE), Aktivitas antibakteri terhadap bakteri Sthapylococcus aureus pada konsentrasi 5, 10 dan 15 % berturut-turut adalah 1,632±0,00; 1,957±0,00; dan 2,528±0,02 . Berdasarkan hasil tersebut membuktikan bahwa EDI memiliki potensi sebagai sumber fenolik golongan flavonoid dan memiliki aktivitas antibakteri terhadap bakteri Sthapylococcus aureus, potensi terbesar pada EDI konsentrasi 15 %. Penelitian selanjutnya perlu dilakukan pemurnian dan karakterisasi senyawa bioaktif untuk aplikasi industri makanan, nutraceutical dan farmasi.
Exploring the α-Amylase Inhibitory Potential of Peronema canescens Jack: An In Vitro and In Silico Study Rahardhian, Muhammad Ryan Radix; Aryanti, Ninda; Susilawati, Yasmiwar; Sumiwi, Sri Adi; Putri, Chintiana Nindya; Ramonah, Dewi; Suharsanti, Ririn
HAYATI Journal of Biosciences Vol. 32 No. 3 (2025): May 2025
Publisher : Bogor Agricultural University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.4308/hjb.32.3.712-726

Abstract

Hyperglycemia in individuals with type 2 diabetes mellitus is primarily driven by the rapid hydrolysis of starch by the enzyme α-amylase in the pancreas and the breakdown of oligosaccharides by α-glucosidase in the intestine. Peronema canescens Jack. (PC) has shown promise as a potential antidiabetic agent. This study aimed to evaluate the total flavonoid, phenolic, and α-amylase inhibitory activity of extracts and fractions derived from PC leaves using both in vitro and in silico approaches. The ethanol extract of PC leaves was fractionated through liquid-liquid extraction using n-hexane, ethyl acetate, and water as solvents. Preliminary phytochemical screening of the extracts and fractions identified the presence of alkaloids, flavonoids, saponins, tannins, and steroids/triterpenoids. The n-hexane fraction exhibited the highest total flavonoid content, averaging 203.37±4.38 mg QE/gram, while the ethyl acetate fraction demonstrated the highest total phenolic content, averaging 147.04±0.79 mg GAE/gram. Furthermore, the ethyl acetate fraction showed the strongest α-amylase inhibitory activity, with an average inhibition rate of 70.38±1.26%. In silico analysis, combined with GC-MS identification, suggested that three compounds, bis(2-ethylhexyl) phthalate, myristyl oleate, and 14 beta H-pregna may contribute to the observed α-amylase inhibitory activity. These findings highlight the potential of PC as a source of natural antidiabetic agents.
Co-Authors Arief, Thendi Abdul Aryanti, Ninda Bayu Tri Murti Dwi Endah Kusumawati Dyah Wigati Fadzil Latifah, Fadzil Ika Buana Januarti Lusiana, Aprie Muhammad Ryan Radix Rahardhian Naniek Widyaningrum Ningrum, Yuyun Darma Ayu Ramonah, Dewi Ririn Suharsanti Ririn Suharsanti, Ririn Sofa, Nada Aini Sri Adi Sumiwi Virdaus, Monica Yasmiwar Susilawati Yuyun Darma Ayu Ningrum Yuyun Darma Ayu Ningrum Zahro, Honest Fatimatuz