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All Journal HAYATI Journal of Biosciences Pharmaciana: Jurnal Kefarmasian Journal of Islamic Pharmacy JPSCR : Journal of Pharmaceutical Science and Clinical Research Jurnal Mandala Pharmacon Indonesia Indonesian Journal of Community Services Jurnal Nuansa Akademik: Jurnal Pembangunan Masyarakat INPHARNMED Journal (Indonesian Pharmacy and Natural Medicine Journal) Medical Sains : Jurnal Ilmiah Kefarmasian Prosiding Seminar Nasional Pengabdian Kepada Masyarakat Media Farmasi Indonesia Jurnal Ilmiah Sultan Agung Journal of Innovative and Creativity Medical Sains : Jurnal Ilmiah Kefarmasian
Putri, Chintiana Nindya
Universitas Islam Sultan Agung
Religion Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Earth & Planetary Sciences Economics, Econometrics & Finance Education Electrical & Electronics Engineering Energy Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Mathematics Medicine & Pharmacology Nursing Public Health Social Sciences Other

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FORMULATION AND EVALUATION OF SACHA INCHI OIL LIP BALM PREPARATIONS WITH CONCENTRATION VARIATIONS OF CERA ALBA AND LANOLIN AS LIP BALM Putri, Chintiana Nindya; Latifah, Fadzil; Zahro, Honest Fatimatuz
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 9 No 3 (2024)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v9i3.1265

Abstract

Lip balm is used on lips that require protection, such as when humidity is low, to prevent the evaporation of water and epithelial cells on the lip mucosa. The active substance used in making this lip balm is Sancha inchi oil, which is a cold-pressed oil from the seeds of Plukenetia volubilista. This oil contains omega 3 (40–50%) and omega 6 (30–40%), as well as lower oleic acid (10%) than olive oil. Natural antioxidants, including tocopherols and polyphenols, have also been found in Sacha Inchi oil. Sacha inchi oil has a fatty acid ratio and phytochemical composition, it can be used as a cosmetic ingredient as an emollient and skin protector. An experimental laboratory method was used for this study. The research was carried out by preparing lip balm from various ingredients containing the active ingredient Sacha inchi oil (Plukenetia volubilis L) at a concentration of 15%, as well as varying concentrations of cera alba (range 5-25%) and lanolin (range 2-10%) as bases and additional ingredients for preparations, whose optimization had been determined using the simplex lattice design method. The aim of this study was to identify the lip balm formulation from Sacha inchi oil and identify the effect of changes in the concentration of cera alba and lanolin based on the results of the preparation evaluation. The results of this test show that sacha inchi oil can be used as an active lip-moisturizing agent in lip balm preparations ...
The Potential of Swiftlet Bird's Nest Extract (Aerodramus fucipaghus) as an Antioxidant and Serum Formulation Widyaningrum, Naniek; Putri, Chintiana Nindya; Arief, Thendi Abdul; Sofa, Nada Aini; Virdaus, Monica
Pharmaciana Vol. 14 No. 3 (2024): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/pharmaciana.v14i3.27001

Abstract

The white swiftlet bird's nest (Aerodramus fucipaghus) constitutes one of nature's treasures endowed with diverse health benefits. The swiftlet bird's nest is a potential source of antioxidants, capable of counteracting free radicals contributing to premature ageing. It can be harnessed as a serum formulation featuring small molecules, facilitating deeper skin penetration, efficient delivery of highly concentrated active agents, and expedited resolution of skin issues. This study aimed to ascertain the swiftlet bird's nest serum's physical properties, physical stability, and antioxidant activities. Serum formulations span a range of concentrations: 10%, 20%, 30%, and 40%. Physical attributes of the serum, including organoleptic properties, homogeneity, pH, spreadability, and viscosity, were observed. Serum stability was assessed over a 21-day storage period. The antioxidant activity of the serum was gauged via DPPH assay, determining the IC50 values. The serum, across varying concentrations, exhibited commendable physical characteristics, satisfying stipulated criteria. Antioxidant activity was detected in the serum across a spectrum of concentrations, revealing IC50 values of 250.00 µg/mL, signifying a range from weak to strong efficacy (90.137 µg/mL). The swiftlet bird's nest serum with its concentration variants demonstrated physical stability during the 21-day storage duration. Drawing from the research, it can be deduced that the swiftlet bird's nest holds promise for development into a serum formulation that fulfils both physical and stability criteria, endowed with robust antioxidant activity. Notably, the swiftlet bird's nest serum at a 40% concentration exhibited potent antioxidant activity, manifesting an IC50 value of 90.137 µg/mL
DETERMINASI TOTAL FLAVONOID, TOTAL FENOLIK, DAN AKTIVITAS ANTIBAKTERI EKSTRAK ETANOL DAUN INSULIN (Smallanthus Sonchifolius) DENGAN METODE PERKOLASI Ramonah, Dewi; Rahardhian, Muhammad Ryan Radix; Putri, Chintiana Nindya
Media Farmasi Indonesia Vol. 15 No. 1 (2020): Media Farmasi Indonesia
Publisher : SEKOLAH TINGGI ILMU FARMASI YAYASAN PHARMASI SEMARANG

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (656.674 KB) | DOI: 10.53359/mfi.v15i1.143

Abstract

Indonesia kaya akan keanekaragaman hayati yang berkhasiat sebagai pengobatan. Salah satunya adalah daun insulin yang mengandung senyawa fenolik golongan flavonoid, dimana senyawa tersebut memiliki potensi sebagai antibakteri. Penelitian ini bertujuan untuk mengetahui kandungan senyawa ekstrak etanol daun insulin (EDI) dengan metode perkolasi pada skrining fitokimia, kromatografi lapis tipis (KLT), determinasi total phenolic content (TPC), total flavonoid content (TFC), dan aktivitas antibakteri terhadap bakteri Sthapylococcus aureus. Hasil skrining fitokimia dan TLC membuktikan bahwa, EDI mengandung senyawa flavonoid, tanin, alkaloid, saponin dan steroid. Nilai TPC 6,7315±0,15 mg/g Gallat Acid Equivalent (GAE), Nilai TFC 66,1857±13,34 mg/g Quercetin Equivalent (QE), Aktivitas antibakteri terhadap bakteri Sthapylococcus aureus pada konsentrasi 5, 10 dan 15 % berturut-turut adalah 1,632±0,00; 1,957±0,00; dan 2,528±0,02 . Berdasarkan hasil tersebut membuktikan bahwa EDI memiliki potensi sebagai sumber fenolik golongan flavonoid dan memiliki aktivitas antibakteri terhadap bakteri Sthapylococcus aureus, potensi terbesar pada EDI konsentrasi 15 %. Penelitian selanjutnya perlu dilakukan pemurnian dan karakterisasi senyawa bioaktif untuk aplikasi industri makanan, nutraceutical dan farmasi.
Exploring the α-Amylase Inhibitory Potential of Peronema canescens Jack: An In Vitro and In Silico Study Rahardhian, Muhammad Ryan Radix; Aryanti, Ninda; Susilawati, Yasmiwar; Sumiwi, Sri Adi; Putri, Chintiana Nindya; Ramonah, Dewi; Suharsanti, Ririn
HAYATI Journal of Biosciences Vol. 32 No. 3 (2025): May 2025
Publisher : Bogor Agricultural University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.4308/hjb.32.3.712-726

Abstract

Hyperglycemia in individuals with type 2 diabetes mellitus is primarily driven by the rapid hydrolysis of starch by the enzyme α-amylase in the pancreas and the breakdown of oligosaccharides by α-glucosidase in the intestine. Peronema canescens Jack. (PC) has shown promise as a potential antidiabetic agent. This study aimed to evaluate the total flavonoid, phenolic, and α-amylase inhibitory activity of extracts and fractions derived from PC leaves using both in vitro and in silico approaches. The ethanol extract of PC leaves was fractionated through liquid-liquid extraction using n-hexane, ethyl acetate, and water as solvents. Preliminary phytochemical screening of the extracts and fractions identified the presence of alkaloids, flavonoids, saponins, tannins, and steroids/triterpenoids. The n-hexane fraction exhibited the highest total flavonoid content, averaging 203.37±4.38 mg QE/gram, while the ethyl acetate fraction demonstrated the highest total phenolic content, averaging 147.04±0.79 mg GAE/gram. Furthermore, the ethyl acetate fraction showed the strongest α-amylase inhibitory activity, with an average inhibition rate of 70.38±1.26%. In silico analysis, combined with GC-MS identification, suggested that three compounds, bis(2-ethylhexyl) phthalate, myristyl oleate, and 14 beta H-pregna may contribute to the observed α-amylase inhibitory activity. These findings highlight the potential of PC as a source of natural antidiabetic agents.
Pengaruh Variasi Konsentrasi Carbomer sebagai Gelling Agent terhadap Sifat Fisik Gel Benzoil Peroksida Putri, Chintiana Nindya; Hijriah, Hovifatul; Lathifah, Fadzil
INPHARNMED Journal (Indonesian Pharmacy and Natural Medicine Journal) Vol. 8 No. 2 (2024)
Publisher : Alma Ata University Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21927/inpharnmed.v8i2.4409

Abstract

Jerawat adalah salah satu masalah kulit yang sering terjadi pada semua kalangan usia, jerawat dapat menyebabkan menurunkan tingkat percaya diri bagi penderita. Salah satu sediaan yang banyak diminati untuk obat jerawat adalah gel karena memilki tekstur yang ringan mudah menyerap dan tidak lengket pada kulit. Benzoil peroksida adalah salah satu bahan aktif yang dapat digunakan untuk jerawat ringan hingga sedang dengan konsentrasi 2,5%-10%. Pada penelitian ini bertujuan untuk merancang formulasi optimal sediaan gel dengan menggunakan carbomer dengan konsentrasi 1-2% sebagai gelling agent. Pada uji ini dihasilkan sediaan gel paling baik dengan konsentrasi carbomer 1,25% dengan dilakukan uji organoleptis, uji homogenitas, uji daya sebar, uji pH, uji viskositas dan uji stabilitas yang baik pada konsentrasi tersebut.
Formulation Optimization and Antibacterial Activity of Citronella (Cymbopogon nardus (L.) Rendle) Topical Gel Spray Against Staphylococcus aureus Using a Simplex Lattice Design Rajab, Muhammad Andy; Putri, Chintiana Nindya; Suryani, Arman; Salamah, Nina
Jurnal Mandala Pharmacon Indonesia Vol. 11 No. 2 (2025): Jurnal Mandala Pharmacon Indonesia 
Publisher : Program Studi Farmasi Universitas Mandala Waluya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35311/jmpi.v11i2.867

Abstract

Atopic dermatitis is skin inflammation in the form of dermatitis caused by Staphylococcus aureus bacterial infection. Citronella essential oil has the potential as an active ingredient in spray gel preparations to help overcome atopic dermatitis due to Staphylococcus aureus bacterial infection. The aim is to determine the optimal spray gel formula from citronella essential oil (Cymbopogon nardus (L.) Rendle) and antibacterial activity against Staphylococcus aureus bacteria. The methods material optimized are Na-CMC, Propylene glycol, and tween 20. Evaluation of the preparation in the form of organoleptic tests, homogeneity, pH, viscosity, drying time, spraying patterns, yeast mold numbers using the spread plate method, and antibacterial activity against Staphylococcus aureus bacteria using the good diffusion method. The results of the concentration of Na-CMC: Propylene glycol: Tween 20 (0.27: 4.72: 10) produced an optimal preparation formula. The spray gel is milky white, has a distinctive lemongrass odor, and is slightly thick. The spray gel is homogeneous with a pH of 4.94 ± 0.16, a viscosity of 76.73 ± 7.01 cPs, and a drying time of 3.60 ± 0.40 minutes. The mold/yeast count test showed that the spray gel was free from mold/yeast contamination and was stable at storage temperatures of 4?C and 40?C. The results of antibacterial activity were able to inhibit Staphylococcus aureus bacteria with an inhibition zone diameter of 6.85 mm ± 2.80. Conclusion: Na-CMC concentration of 0.27%, Propylene Glycol concentration of 4.72%, and Tween 20 concentration of 10% produced optimal spray gel and inhibited Staphylococcus aureus.
Analisis Hubungan Pelayanan Informasi Obat Berbasis Syariah Terhadap Kepuasan Pasien Hipertensi Di Puskesmas Kedungmundu Amey Putri Karini; Chintiana Nindya Putri
Journal of Innovative and Creativity Vol. 5 No. 3 (2025)
Publisher : Fakultas Ilmu Pendidikan Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/joecy.v5i3.5405

Abstract

Latar Belakang: Hipertensi dijuluki the silent killer dan merupakan masalah kesehatan kronis dengan prevalensi yang meningkat di Indonesia, mencapai 34,1% pada tahun 2018. Peningkatan kualitas pelayanan kesehatan, khususnya Pelayanan Informasi Obat (PIO), sangat penting untuk meningkatkan pemahaman dan kepatuhan pasien. Penelitian ini berfokus pada pengembangan PIO berbasis syariah, yang mengintegrasikan nilai-nilai keislaman seperti kejujuran (sidiq), amanah, profesionalisme (fathonah), serta komunikasi yang ramah dan sopan (tabligh). Pendekatan ini diperkirakan dapat meningkatkan kepuasan pasien, terutama pada penyakit kronis seperti hipertensi yang memerlukan pengobatan jangka panjang. Tujuan dari penelitian ini adalah untuk menganalisis hubungan antara Pelayanan Informasi Obat berbasis Syariah dengan kepuasan pasien hipertensi di Puskesmas Kedungmundu. Metode: Penelitian ini menggunakan desain kuantitatif dengan rancangan potong lintang (cross sectional). Data dikumpulkan melalui penyebaran kuisioner kepada 96 responden pasien hipertensi di Puskesmas Kedungmundu selama periode Agustus–September 2025.  Variabel bebas adalah Pelayanan Informasi Obat Berbasis Syariah dan variabel terikat adalah Kepuasan Pasien Hipertensi. Data dianalisis secara bivariat menggunakan uji Chi-Square dengan tingkat kepercayaan 95% ($p < 0,05$). Hasil: Karakteristik sosiodemografi responden didominasi oleh perempuan (71,9%) dan kelompok usia 51–60 tahun (46,9%) Hasil uji statistik Chi-Square menunjukkan nilai $p$-value = 0,000. Nilai ini berada jauh di bawah ambang batas signifikansi ($p < 0,05$), yang mengindikasikan bahwa terdapat hubungan yang sangat signifikan. Mayoritas responden berada pada kategori sangat puas, menunjukkan bahwa kualitas pelayanan yang menerapkan prinsip syariah secara positif memengaruhi tingkat kepuasan pasien. Kesimpulan: Terdapat hubungan yang sangat signifikan dan positif antara Pelayanan Informasi Obat berbasis Syariah dengan kepuasan pasien hipertensi di Puskesmas Kedungmundu14. Temuan ini memperkuat pentingnya pengintegrasian nilai-nilai etis dan keagamaan dalam pelayanan kefarmasian untuk meningkatkan kualitas layanan dan rasa aman serta nyaman bagi pasien.
Hubungan Pelayanan Informasi Obat dengan Kepatuhan Pengobatan pada Pasien Diabetes Melitus di Puskesmas Bandarharjo Ditinjau dari Aspek Syariah Putri, Chintiana Nindya; Septiani, Isna Rizqi
Journal of Islamic Pharmacy Vol 10, No 2 (2025): J. Islamic Pharm.
Publisher : Universitas Islam Negeri Maulana Malik Ibrahim Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18860/jip.v10i2.32462

Abstract

Diabetes melitus membutuhkan pengobatan jangka panjang dan kepatuhan pengobatan untuk mengontrol kadar gula darah. Apoteker berperan penting dalam pengelolaan penyakit ini melalui pelayanan informasi obat yang komprehensif. Selain aspek klinis, pelayanan kefarmasian juga perlu memperhatikan aspek syariah seperti prinsip amanah, kejujuran, kemaslahatan, dan pemberian informasi yang transparan kepada pasien. Tujuan penelitian ini untuk mengetahui hubungan pelayanan informasi obat dengan kepatuhan pengobatan terhadap pasien diabetes melitus di Puskesmas Bandarharjo Kota Semarang. Pengukuran pelayanan informasi obat terhadap kepatuhan penggunaan obat dilakukan dengan penyebaran kuesioner Medication Adherence Rate Scale-10 (MARS-10) pada pasien diabetes melitus yang masih menjalani terapi obat serta penilaian secara objektif dari aspek syariah. Hasil penelitian persentase item pelayanan informasi obat tentang nama obat, jumlah obat, bentuk sediaan, indikasi obat, dan dosis yang telah mencapai 100%, menunjukkan bahwa terdapat 27 responden yang mengikuti Prolanis di Puskesmas Bandarharjo dan telah mendapatkan pelayanan informasi obat. Namun informasi obat mengenai efek samping hanya disampaikan 14,8%; cara penyimpanan hanya 11,1%; serta pentingnya kepatuhan pengobatan hanya 33,3%. Berdasarkan tingkat pencapaian responden (TCR) didapatkan 100% tentang informasi nama obat, jumlah obat, bentuk sediaan, indikasi obat, dan dosis. Berdasarkan hubungan menunjukkan bahwa angka korelasi pada hasil bernilai positif, yaitu 0,989. Berdasarkan nilai signifikansi didapatkan nilai sig. 0,000 0,05 yang artinya terdapat hubungan signifikan antara variabel pelayanan informasi obat dengan kepatuhan pengobatan.
Co-Authors Amey Putri Karini Arief, Thendi Abdul Aryanti, Ninda Bayu Tri Murti Dwi Endah Kusumawati Dyah Wigati Fadzil Latifah, Fadzil Hijriah, Hovifatul Ika Buana Januarti Lathifah, Fadzil Lusiana, Aprie Muhammad Ryan Radix Rahardhian Naniek Widyaningrum Nina Salamah Ningrum, Yuyun Darma Ayu Rajab, Muhammad Andy Ramonah, Dewi Ririn Suharsanti Ririn Suharsanti, Ririn Septiani, Isna Rizqi Sofa, Nada Aini Sri Adi Sumiwi Suryani, Arman Virdaus, Monica Yasmiwar Susilawati Yuyun Darma Ayu Ningrum Yuyun Darma Ayu Ningrum Zahro, Honest Fatimatuz