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Serum Albumin Levels of Oral Candidiasis Immunosuppressed Rats Treated With Hyperbaric Oxygen Pargaputri, Agni Febrina; Andriani, Dwi
International Journal of Integrated Health Sciences Vol 8, No 1 (2020)
Publisher : International Journal of Integrated Health Sciences

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15850/ijihs.v8n1.2086

Objective: To investigate serum albumin levels in oral candidiasis immunosuppressed rats treated with hyperbaric oxygen. One of the predisposing factors for oral candidiasis was the use of immunosuppressive drugs continuously. It can also affect the work of the liver because itâ€™s one of the organs responsible for drug metabolism. Hyperbaric oxygen therapy was used not only to suppressing fungal infections, but also to improve liver function by evaluating the serum albumin levels.Methods: This study used a post-test only control group design. Fifteen Wistar rats were divided into 3 groups(n=5/3): G1 (healthy group), G2 (oral candidiasis immunosuppressed rats group without hyperbaric oxygen therapy), and G3 (oral candidiasis immunosuppressed rats group with hyperbaric oxygen therapy). G2 and G3 groups were immunosuppressed by giving dexamethasone 0,5mg/day/rat orally for 14 days, added with tetracycline 1 mg/day/rat. Hyperbaric oxygen therapy was given to the G3 group in 5 days. Blood serum of rats in all groups was taken to calculate albumin levels.Results: The average value of albumin levels in G2 group showed a decrease compared to the G1 group, while G3 showed the highest level. One way Anova test showed a significant difference among groups (p<0,05). To compare the difference between each group we used LSD test and showed a significant difference (p<0,05) between G1 compared to G2, G1 compared to G3, and G2 compared to G3.Conclusion: Liver albumin levels of oral candidiasis immunosuppressed rats treated with hyperbaric oxygen therapy showed higher levels than those without therapy.

Potensi kitosan kepiting rajungan (Portunus pelagicus) dalam penghambatan pembentukan biofilm Porphyromonas gingivalis dan pertumbuhan Candida albicansPotential of flower crab (Portunus pelagicus) chitosan in the inhibition of Porphyromonas gingivalis and Candida albicans biofilm Yoifah Rizka Wedarti; Laurencia Isabella Loekito; Fani Pangabdian; Dwi Andriani
Padjadjaran Journal of Dental Researchers and Students Vol 4, No 2 (2020): Oktober 2020
Publisher : Fakultas Kedokteran Gigi Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/pjdrs.v4i2.26636

Pendahuluan: Pembentukan biofilm sangat penting dalam patogenesis periodontitis. Porphyromonas gingivalis merupakan bakteri yang banyak ditemukan pada plak gigi dan memiliki kemampuan membentuk biofilm demikian juga Candida albicans memiliki faktor virulensi yang dapat membantu kolonisasi dan proliferasi bakteri di dalam poket periodontal. Ekstrak kitosan kepiting rajungan (Portunus pelagicus) mempunyai potensi antimikrobial yang dapat digunakan sebagai alternatif terapi. Tujuan penelitian ini adalah untuk menganalisis potensi kitosan kepiting rajungan (Portunus pelagicus) dalam penghambatan biofilm Porphyromonas gingivalis dan Candida albicans. Metode: Jenis penelitian adalah eksperimental murni. Penelitian ini menggunakan ekstrak kitosan kepiting rajungan (Portunus pelagicus) terhadap biofilm Porphyromonas gingivalis dan biofilm Candida albicans. Dibagi menjadi 4 kelompok, di mana tiap kelompok terdiri dari 4 sampel. Kelompok K+ (kelompok kontrol positif), P1(kitosan 0,25%), P2 (kitosan 0,5%), P3 (kitosan 1%). Penghambatan biofilm ditentukan dengan menggunakan metode microtiter plate yang menghasilkan nilai optical density kemudian dihitung dengan menggunakan rumus persen penghambatan. Analisis data menggunakan one-way ANOVA diikuti dengan uji LSD. Hasil: Terdapat perbedaan yang signifikan penghambatan biofilm dari kitosan Portunus pelagicus terhadap Porphyromonas gingivalis (p<0,05) antara kelompok, kecuali K + dengan P3. Sedangkan untuk penghambatan Candida albicans menunjukkan bahwa ada perbedaan yang signifikan dalam persentase penghambatan biofilm (p<0,05), antara kelompok K+ dengan P2 dan P3; kelompok P1 dengan P2 dan P3; kelompok P2 dengan P3. Simpulan: Kitosan Portunus pelagicus memiliki potensi dalam menghambat pembentukan biofilm Porphyromonas gingivalis dan pertumbuhan Candida albicans. Kitosan Portunus pelagicus 1% memiliki efek antimikrobial terbesar pada biofilm.Kata kunci: Biofilm, Porphyromonas gingivalis, Candida albicans, kitosan portunus pelagicus, periodontitis. ABSTRACTIntroduction: Biofilm formation is important in periodontitis pathogenesis. Porphyromonas gingivalis and Candida albicans, which are found in dental plaque and can form a biofilm, have virulence factor that facilitates the bacterial colonisation and proliferation in periodontal pockets. Chitosan extract of flower crab (Portunus pelagicus) has antimicrobial potential which can be used as an alternative therapy. The objective of this research was to analyse the potential of flower crab (Portunus pelagicus) chitosan in the inhibition of Porphyromonas gingivalis and Candida albicans biofilms. Methods: This research was a pure experimental laboratory. This study used flower crab (Portunus pelagicus) chitosan to inhibit the biofilm formation of Porphyromonas gingivalis and Candida albicans. The subjects were divided into four groups, where each group consisted of 4 samples. The K+ (positive control group), P1 (0.25% chitosan), P2 (0.5% chitosan), and P3 (1% chitosan). The biofilm inhibition was determined using the microtiter plate methods, which results in the value of optical density, then calculated using the inhibition formula percentage. Data analysis was conducted using the one-way ANOVA followed by the LSD test. Results: There were significant differences in the Porphyromonas gingivalis biofilm inhibition between groups (p < 0.05), except in group K+ with P3. Whereas for Candida albicans biofilm inhibition showed no significant difference (p < 0.05) between group K+ with P2 and P3; group P1 with P2 and P3; and group P2 with P3. Conclusion: The chitosan of flower crab (Portunus pelagicus) has the potential in inhibiting the biofilm formation of Porphyromonas gingivalis and Candida albicans. The highest antibacterial effect on the biofilm formation is shown in the concentration of 1%.Keywords: Biofilm, Porphyromonas gingivalis, Candida albicans, chitosan, Portunus pelagicus, periodontitis.

The effects of Acanthus ilicifolius chloroform extract on TLR-2 expression of macrophages in oral candidiasis Dwi Andriani; Agni Febrina Pargaputri
Dental Journal (Majalah Kedokteran Gigi) Vol. 51 No. 4 (2018): December 2018
Publisher : Faculty of Dental Medicine, Universitas Airlangga https://fkg.unair.ac.id/en

Background: Immunosuppressed conditions due to long-term corticosteroid and tetracycline consumption are susceptible to fungal invasion, especially by Candida albicans (C. albicans), that requires treatment of oral candidiasis. Toll like receptor-2 (TLR-2) plays a role in candida recognition. Nystatin is regularly employed for oral candidiasis, but produces certain side-effects. Chloroform extract of Acanthus ilicifolius (A. ilicifolius) leaves represents both a potent inhibitor of C. albicans growth and an antioxidant. Purpose: This study aimed to compare the effect of A. ilicifolius leaf chloroform extract and nystatin treatment on TLR-2 expression in oral candidiasis immunosupressed models. Methods: This study constitutes a true experimental investigation incorporating a post test-only control group design. 20 healthy male Rattus novergicus (Wistar), aged 12 weeks and with an average weight of 250g, were immunosuppressed through oral administration of dexamethasoneand tetracycline for a period of 21 days before being induced with C. albicans (ATCC-10231) 6 x 108 for two weeks. The subjects were divided into five groups (n=4/group): healthy (H), no-treatment(P), nystatin treatment(N), A. Ilicifollius (8%) treatment (AI-1) and A. ilicifollius (16%) treatment (AI-2). The subjects were treated for 14 days, with their tongue being subsequently biopsied. TLR-2 expression was subjected to immunohistochemical examination, observed under a microscope (400x magnification) and statistically analyzed (one-way Anova, LSD-test, p<0.05). Results: TLR-2 expression of P (6.25 ± 2.5), N (11.25 ± 0.96), AI-1 (13.00 ± 1.15), AI-2 (12.75 ± 1.7) was higher than H (1.75 ± 0.5). Significant differences existed between N to P, N, AI-1, AI-2; P to N, AI-1 and AI-2 (p<0.05). No significant differences were present between N, AI-1 and AI-2 (p < 0.05). Conclusion: A. ilicifolius extract can increase expression of TLR-2 in oral Candidiasis-immunosuppressed models. A. ilicifolius extract produces the same effect in increasing TLR-2 expression when compared to nystatin.

The effects of shark liver oil on fibroblasts and collagen density in the periodontal ligaments of Wistar rats induced with Porphyromonas gingivalis Dian Mulawarmanti; Dwi Andriani; Dian Widya Damaiyanti; Farizia Putri Khoirunnisa; Alifati Nita Juliatin
Dental Journal (Majalah Kedokteran Gigi) Vol. 52 No. 4 (2019): December 2019
Publisher : Faculty of Dental Medicine, Universitas Airlangga https://fkg.unair.ac.id/en

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/j.djmkg.v52.i4.p209-214

Background: Periodontitis is an infection in tooth-supporting tissues caused by a specific microorganism, Porphyromonas Gingivalis (PG), which can trigger collagen destruction. Generally, periodontal therapy employs a combination of mechanical (scaling root planning/SRP) and chemical (antibiotics) remedies, the latter of which can cause bacterial resistance. On the other hand, shark liver oil contains active natural ingredients such as alkylglycerols, squalene, squalamine, and omega-3, which have antibacterial and antioxidant effects. Purpose: This study aims to determine the impact of shark liver oil on fibroblasts and collagen density in the periodontal ligament of Wistar rats induced with PG. Methods: This study represents a laboratory experiment with post-test only control group design. The research subjects consisted of 35 Wistar rats divided into five groups, namely; a negative control group (K-); a positive control group with PG induction (K+); and three treatment groups induced with PG and shark liver oil once a day for seven days at varying doses of 0.2 g/gBB (P1), 0.3 g/gBB (P2), and 0.4 g/gBB (P3). Following treatment, the subjects were euthanized. The number of fibroblasts was then histologically examined with Hematoxylin Eosin (HE). Meanwhile, the collagen density was histologically analyzed with Masson’s Tricrome. Fibroblast cells were observed through a microscope at 400x magnification. Data was statistically analyzed with a one-way ANOVA and post hoc LSD. Collagen Density scoring was then performed. The results were analyzed with a non-parametric Kruskal-Wallis test (p=0.05), and subsequently with a Mann-Whitney U test (p<0.05). Results: The number of fibroblasts in the periodontal ligament areas of each group were 18.6 ± 1.21 for K-; 12 ± 1.26 for K;16.8 ± 1.72 for P1; 17.1 ± 1.94 for P2; and 23.16 ± 2.78 for P3. The results also indicated that there were significant differences between K- with K+ and P3, K+ with P1, P2, and P3, as well as P3 with P1 and P2. However, there was no significant difference between K- and P1 and P2 or P1 and P2. The results showed that collagen density in the negative control group did not significantly decrease compared to that in the positive control group in which PG was induced. Meanwhile, collagen density in all three treatment groups following doses of 0.2 g/gBB, 0.3 g/gBB, and 0.4 g/gBB being administered significantly increased compared to that in the negative control group and the positive control group subjected to PG induction. Conclusion: Shark liver oil can significantly increase fibroblast cells and collagen density in the periodontal ligament of Wistar rats induced with PG.

Efektifitas Sabun Cair Ekstrak Kulit Nanas Sebagai Pembersih Basis Gigi Tiruan Resin Akrilik Heat Cured Terhadap Pertumbuhan Candida Albicans Tiffany Augusta Posuma; Meinar Nur Ashrin; Dwi Andriani
Denta Journal Kedokteran Gigi Vol 10 No 1 (2016): Februari
Publisher : Fakultas Kedokteran Gigi Universitas Hang Tuah

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Background: Candida albicans acts as a trigger to denture stomatitis. Prevention of denture stomatitis can be done by cleaning dentures with mechanic and chemical methods. Bromelin enzymes from pineapple can be use as a chemical substance to purify dentures for its ability to prevent the growth of Candida albicans with its proteolytic activity. Objectives: to determine the influence of soap from pineapple peel extract as acrylic resin heat cured denture cleanser in Candida albicans impure. Materials and Methods: The experiment is post test only group design. The subject is divided into 6 groups. Control group (aquadest), Positive control group (soap with lime extract brand X), and four treatment groups (soap from pineapple peel extract with 0%, 3,5%, 7%, and 14% concentration). Each group is brushed with an electric tooth brush for 5’. Then each sample is inserted into Saboraud Dextrose Broth and 0,1 ml is taken and is vortexed for 30’ then is incubated in Saboraud Dextrose Agar for 24 hours. The colony is counted with the colony counter in CFU/ml. The data will be tested with One Way ANOVA and continued with LSD test. Result: The mean of Candida albicans colony in K-, P1, P2, P3, P4, K+ is 44.00; 32.25; 2.25; 6.00; 11.50; 19.00. There is a difference between the control groups and all the treatment groups (p<0,05). Conclusions: Soap from pineapple peel extract with the concentration 3,5% is the most effective soap as an acrylic resin heat cured denture cleanser to influence the growth of Candida albicans

Perbedaan Efektivitas Ekstrak Daun Mangrove Acanthus ilicifolius Dengan Sodium Bikarbonat 5% Terhadap Penurunan Jumlah Koloni Candida albicans Pada Perendaman Nilon Termoplastik Aviyuda Prabowo; Paulus Budi Teguh; Dwi Andriani
Denta Journal Kedokteran Gigi Vol 9 No 2 (2015): Agustus
Publisher : Fakultas Kedokteran Gigi Universitas Hang Tuah

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Background: Nylon thermoplastic is denture base materials are often used. Dentures cleansing immersion can reduce calculus accumulation and Candida albicans (C.albicans) attachment. Sodium bicarbonate 5% is commonly used but has flaws. Acanthus ilicifolius leaves can be alternative herbal ingredients for denture cleanser because it has potency as antifungal and antibacterial. Purpose: To compare the difference in the effectiveness of antiC.albicans between Acanthus ilicifolius leaf extract and sodium bicarbonate 5% on nylon thermoplastic immersion. Materials and Methods: This study was true experimental laboratories with post test only control group design. The subjects in this study was a nylon thermoplastic soaked for 5 minutes and were divided into 5 groups: negative control group (DMSO 1%), positive control group (Sodium Bicarbonate 5%), and treatment groups (Acanthus ilicifolius leaf extract 1% , 0.5%, 0.25%). 0.1 ml of Sabouraud broth that has been contaminated with C.albicans in the immersion nylon thermoplastic then cultured in media SDA and incubated for 24 hours. Colony counted by colony counter in CFU/mL. The datawas processed by one way ANOVA and followed by LSD test. Result: There were differences in the number of colonies of C.albicans significantly between treatment groups with the negative control extract 1% and 0.5% (P <0,05) there is no significant difference between the negative control group with treatment group 3 (P3) (P>0,05). Conclusion: There were differences in the effectiveness of anti-C.albicans of Acanthus ilicifolius leaf extract concentration of 1% and 0,5% with sodium bicarbonate 5% on nylon thermoplasticimmersion

The effect of effervescent acanthus ilicifolius l. extract on antifungal properties and flexural strength acrylic Widyasri Prananingrum; Fitria Rahmitasari; Dwi Andriani; Arifzan Razak
Odonto : Dental Journal Vol 9, No 2 (2022): December 2022
Publisher : Faculty of Dentistry, Universitas Islam Sultan Agung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/odj.9.2.310-318

Background: Acanthus ilicifolius L. has antifungal potential and makes it possible to be a candidate for denture cleanser. This study aims to evaluate the effect of effervescent Acanthus ilicifolius L. extract on antifungal properties and flexural strength acrylic after immersion for three duration times.Method: Extracts were made by maceration method with ethanol. For the antifungal test, effervescent Acanthus ilicifolius L extract was prepared by combining the Acanthus ilicifolius L extract 4% and sodium perborate with two ratios, 1:7 and 1:14. The microdilution method was carried out. Effervescent Acanthus ilicifolius L extract 4% with ratio 1:7 was prepared for the flexural strength test. The fifty-four heat-cured acrylic resin (20x10x2.5mm) were fabricated and divided into 3 groups. Group 1 was immersed in aquadest (control); Group 2 was immersed in sodium perborate; Group 3 was immersed in effervescent Acanthous ilicifolius L. extract. Each group was immersed for 15 min, 8, and 56 hours (n=6). The flexural strength test was performed using Universal Testing Machine.Result: Effervescent Acanthus ilicifolius L. extract exhibited antifungal activity which increased in an effervescent Acanthus ilicifolius L extract-dependent manner significantly (0.57 to 0.50 OD). There were no significant differences between sodium perborate, effervescent_AI1 (1:7) and effervescent_AI2 (1:14). The flexural strength was found to be within the range of 66.1 - 68.3 MPa. There were no significant differences between groups (p < 0.05).Conclusion: Effervescent Acanthus ilicifolius L extract with the ratios 1:7 had a good antifungal effect and appropriate flexural strength after immersion for 15 min, 8, and 56 hours.

Effect of hyperbaric oxygen treatment on liver hepatocyte damage in oral candidiasis immunosuppressed rats Agni Febrina Pargaputri; Dwi Andriani; Mardiyanto Riski Hartono; Kharinna Widowati
Odonto : Dental Journal Vol 9, No 2 (2022): December 2022
Publisher : Faculty of Dentistry, Universitas Islam Sultan Agung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/odj.9.2.319-326

Background: Liver is an organ that performs a role in metabolism and detoxification of chemical substances. The use of immunosuppressive drugs excessively not only become predisposing factor for oral candidiasis, but also can cause damage and affect liver’s function. Hyperbaric oxygen treatment was known to preserve hepatocytes and prevent liver damage. This study was aimed to investigate the effect of hyperbaric oxygen treatment on liver hepatocyte damage in oral candidiasis immunosuppressed rats.Method: We divided fifteen Wistar rats randomly into three groups: G1 (healthy rats), G2 (immunosuppressed rats with oral candidiasis), and G3 (immunosuppressed rats with oral candidiasis given hyperbaric oxygen). The immunosuppressed condition was made by giving dexamethasone and tetracycline orally for 14 days. Induction of Candida albicans 0.1 cc was conducted on the fourth day. Hyperbaric oxygen treatment was given for five days continuously. The histopathological changes in the liver were measured by counting the amount of normal hepatocytes, pycnotic, karyolysis, karyorrhexis, and score of necrosis area using light microscope with 400x magnification.Result: The amount of pycnotic, karyolysis, and karyorrhexis hepatocytes increased in G2 and decreased significantly in G3, likewise the score of necrosis area. The statistical test using oneway Anova and LSD test showed significant differences (p<0,05) in pycnotic, karyolysis, and karyorrhexis hepatocytes between G1, G2, and G3.Conclusion: The hyperbaric oxygen treatment effect on liver hepatocyte damage in oral candidiasis immunosuppressed rats.

Efek pemberian astaxanthin (Haematococcus pluvialis) terhadap ukuran diameter pada model ulkus traumatikusThe effect of astaxanthin (Haematococcus pluvialis) on diameter measurement in traumatic ulcer model Anastasia Natasa Aripin; Dwi Andriani; Meinar Nur Ashrin
Jurnal Kedokteran Gigi Universitas Padjadjaran Vol 34, No 3 (2022): Desember 2022
Publisher : Fakultas Kedokteran Gigi Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/jkg.v34i3.38504

ABSTRAKPendahuluan: Prevalensi ulser rongga mulut di Indonesia tinggi (96,6%). Astaxanthin yang berasal dari mikroalga hijau Haematococcus pluvialis merupakan salah satu alternatif pengobatan ulser karena adanya sifat antioksidan yang tinggi dan efek anti inflamasinya. Tujuan penelitian menganalisis pengaruh efektivitas pemberian astaxanthin terhadap selisih ukuran diameter ulser hari ke-1 dan hari ke-3 pada model ulkus traumatikus. Metode: Sampel 30 ekor tikus putih Wistar dibagi secara acak menjadi 5 kelompok penelitian yang diberi perlakuan ulkus traumatikus kemudian di terapi selama 3 hari sesuai dengan kelompok masing-masing: K- (kelompok kontrol yang diberi basis gel); K+ (kelompok kontrol yang diberi asam hialuronat); P1 (pemberian astaxanthin 0,1%); P2 (pemberian astaxanthin 0,5%); P3 (pemberian astaxanthin 1%). Data hasil penelitian selanjutnya dilakukan uji one way ANOVA dan dilanjutkan dengan uji Post Hoc LSD dengan p=0,05. Hasil: Hasil analisis uji parametrik One Way ANOVA menunjukkan terdapat perbedaan bermakna (p<0,05) diameter ulser pada hari ke-1 dan hari ke-3. Uji Post Hoc LSD menunjukkan terdapat perbedaan bermakna (p<0,05) antara K- (5,300 ± 2,832) dibandingkan dengan K+ (2,297 ± 1,045), P1(1,740 ± 1,168), P2(1,993 ± 0,738), dan P3 (2,448 ± 1,320). Simpulan: Terdapat pengaruh pemberian astaxanthin gel dalam menurunkan selisih diameter ulser pada hari ke-1 dan hari ke-3 terhadap proses penyembuhan ulkus traumatikus.Kata kunci: antiinflamasi; astaxanthin; haematococcus pluvialis; ulkus traumatikusABSTRACTIntroduction: The prevalence of traumatic ulcers in Indonesia is high (96,6%). Astaxanthin, derived from the green microalgae Haematococcus Pluvialis, is one of the alternative treatments for ulcer healing due to its potent antioxidant and anti-inflammatory effect. This study aimed to analyze astaxanthin’s effectiveness on the difference in the diameter of the ulcer on day 1 and day 3 in a traumatic ulcer model. Methods: Samples of 30 Wistar rats were randomly divided into 5 groups which were treated with traumatic ulcers and then treated for 3 days according to their respective groups: K- (control group given gel base); K+ (control group given hyaluronic acid); P1 (application of 0.1% astaxanthin); P2 (application of 0.5% astaxanthin); P3 (application of 1% astaxanthin). The data results were then carried out with one way ANOVA test, and the Post Hoc LSD test proceeded with p=0,05. Results: The statistical parametric test using One Way ANOVA showed a significant difference (p<0,05) in the diameter ulcer on day 1 and day 3. Post Hoc LSD test showed a significant difference (p<0,05) between K- (5,300 ± 2,832) compare to K+ (2,297 ± 1,045), P1(1,740 ± 1,168), P2(1,993 ± 0,738), and P3 (2,448 ± 1,320). Conclusions: There is an effect of giving astaxanthin gel in reducing the difference in the diameter of the ulcer on day 1 and day 3 on the healing process of traumatic ulcer.Keywords: anti-inflammatory; astaxanthin; haematococcus pluvialis; traumatic ulcer

Effect of hyperbaric oxygen treatment on liver hepatocyte damage in oral candidiasis immunosuppressed rats Agni Febrina Pargaputri; Dwi Andriani; Mardiyanto Riski Hartono; Kharinna Widowati
Odonto : Dental Journal Vol 9, No 2 (2022): December 2022
Publisher : Faculty of Dentistry, Universitas Islam Sultan Agung

Background: Liver is an organ that performs a role in metabolism and detoxification of chemical substances. The use of immunosuppressive drugs excessively not only become predisposing factor for oral candidiasis, but also can cause damage and affect liver’s function. Hyperbaric oxygen treatment was known to preserve hepatocytes and prevent liver damage. This study was aimed to investigate the effect of hyperbaric oxygen treatment on liver hepatocyte damage in oral candidiasis immunosuppressed rats.Method: We divided fifteen Wistar rats randomly into three groups: G1 (healthy rats), G2 (immunosuppressed rats with oral candidiasis), and G3 (immunosuppressed rats with oral candidiasis given hyperbaric oxygen). The immunosuppressed condition was made by giving dexamethasone and tetracycline orally for 14 days. Induction of Candida albicans 0.1 cc was conducted on the fourth day. Hyperbaric oxygen treatment was given for five days continuously. The histopathological changes in the liver were measured by counting the amount of normal hepatocytes, pycnotic, karyolysis, karyorrhexis, and score of necrosis area using light microscope with 400x magnification.Result: The amount of pycnotic, karyolysis, and karyorrhexis hepatocytes increased in G2 and decreased significantly in G3, likewise the score of necrosis area. The statistical test using oneway Anova and LSD test showed significant differences (p<0,05) in pycnotic, karyolysis, and karyorrhexis hepatocytes between G1, G2, and G3.Conclusion: The hyperbaric oxygen treatment effect on liver hepatocyte damage in oral candidiasis immunosuppressed rats.

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