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All Journal HAYATI Journal of Biosciences VALENSI Journal of Tropical Life Science : International Journal of Theoretical, Experimental, and Applied Life Sciences JURNAL KIMIA SAINS DAN APLIKASI Jurnal Riset Kimia Agrokreatif Jurnal Ilmiah Pengabdian kepada Masyarakat EduChemia: Jurnal Kimia dan Pendidikan KOVALEN: Jurnal Riset Kimia JURNAL HAMA DAN PENYAKIT TUMBUHAN TROPIKA Indonesian Journal of Chemistry Jurnal Jamu Indonesia Jurnal Pusat Inovasi Masyarakat Makara Journal of Science Jurnal Tumbuhan Obat Indonesia Indonesian Journal of Jamu Biodiversitas Journal of Biological Diversity
Auliya Ilmiawati
Department Of Chemistry, Faculty Of Mathematics And Natural Sciences, IPB University, Bogor 16680, Indonesia. Tropical Biopharmaca Research Center-Institute Of Research And Community Services, IPB University, Bogor 16128, Indonesia
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Earth & Planetary Sciences Education Engineering Environmental Science Health Professions Materials Science & Nanotechnology Medicine & Pharmacology Public Health Social Sciences Other

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The Potency of Adenostemma platyphyllum as Antimelanogenic Agent: In-vitro and In-silico Studies Lutfia Mutmainnah; Irmanida Batubara; Auliya Ilmiawati
Jurnal Kimia Sains dan Aplikasi Vol 27, No 5 (2024): Volume 27 Issue 5 Year 2024
Publisher : Chemistry Department, Faculty of Sciences and Mathematics, Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jksa.27.5.232-242

Abstract

Melanin is a crucial amino acid in determining human skin and hair pigmentation. Excessive melanin production can lead to hyperpigmentation and darkening of the skin. This study aims to assess the capability of Adenostemma platyphyllum as a tyrosinase enzyme inhibitor. It predicts its anti-melanogenic activity through molecular docking with proteins involved in the melanogenesis process. The in-vitro approach was conducted by determining the tyrosinase enzyme inhibition capacity, while the in-silico approach involved ligand binding to target proteins from melanogenesis pathways. The highest tyrosinase inhibition capacity was observed in the ethanol extract, with values of 9.74 Kojic Acid Equivalent (KAE)/g extract (L-tyrosine) and 17.91 (KAE)/g extract (L-DOPA). Molecular docking analysis showed that the binding of eriodictyol 7-O-sophoroside (ΔG = -9.7 kcal/mol) has the best energy affinity for the PKC-β protein, genistein (ΔG = -7.5 kcal/mol) for the tyrosinase-related protein-1 (TYRP1) protein, eriodictyol 7-O-sophoroside (ΔG = -10.2 kcal/mol) for the cGMP protein, vincosamide (ΔG = -7.2 kcal/mol) for the microphthalmia-associated transcription factor (MITF) protein, and dicaffeoylquinic acid (ΔG = -7.4 kcal/mol) for the β-catenin protein. Based on a comparison of in-vitro and in-silico studies, melanogenesis inhibition is more potent in the PKC-β and cGMP pathways than direct tyrosinase inhibition because they exhibit lower binding energy.
Oleogels from Watermelon Rind Extract and Orange Peel Essential Oil for Hair Nutrition Erlina, Iis; Fadilah, Nisa Lelita; Yulianti, Dwi Indah; Adiba, Asfiah; Febriany, Retno Putri; Ilmiawati, Auliya
EduChemia: Jurnal Kimia dan Pendidikan Vol 9, No 1 (2024)
Publisher : Department of Chemical Education Faculty of Teacher Training and Education Universitas Su

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30870/educhemia.v9i1.24709

Abstract

Watermelon rind extract is rich in protein, citrulline, and lycopene, whereas orange peel essential oil contains vitamins A, C, and E. Both ingredients have demonstrated potential in preventing hair loss. This study aimed to develop an oleogel that combines these two components to address hair loss. The efficacy of the oleogel for promoting hair growth was evaluated in male DDY (Deutchland Denken Yonken) mice. The oleogel characteristics, including pH, viscosity, color, homogeneity, oil binding capacity, spreadability, and organoleptic evaluations, were assessed through physical quality tests. Organoleptic analysis was conducted with 30 respondents from IPB University to identify the most preferred oleogel formulation. The yield of watermelon rind extract was 28.88%, while the orange peel essential oil constituted 2% (v/w) of the formulation. The optimal oleogel contained 3% watermelon rind extract and 1% orange peel essential oil, resulting in 100% hair growth in the mice. All the formulations met the standard requirements for oleogels, with the most favored being Formula F3, which includes 1% watermelon rind extract and 3% orange peel essential oil. This research highlights the potential of watermelon rind extract and orange peel essential oils as effective nutrients for hair loss treatment.
Potensi Beberapa Ekstrak Tumbuhan Asteraceae sebagai Antioksidan dan Antiglikasi Budiarti, Eka; Batubara, Irmanida; Ilmiawati, Auliya
Jurnal Jamu Indonesia Vol. 4 No. 3 (2019): Jurnal Jamu Indonesia
Publisher : Tropical Biopharmaca Research Center, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/jji.v4i3.161

Abstract

Tumbuhan Asteraceae dilaporkan mengandung metabolit sekunder tinggi yang aktif sebagai antioksidan. Senyawa antioksidan juga digunakan untuk mencegah penuaan/reaksi glikasi. Penelitian ini bertujuan menentukan aktivitas antioksidan dan antiglikasi 7 tumbuhan Asteraceae. Daun Adenostema lavenia, Ageratum conyzoides, Dichrocephala integrifolia, Galinsoga parvifolia, Synedrella nodiflora, Mikania micrantha, dan Sphagneticola trilobata masing-masing diekstraksi menggunakan air. Ekstrak kemudian ditentukan kandungan total fenol, flavonoid, dan aktivitas antioksidan menggunakan metode 1,1-difenil-2-pikrilhidrazil (DPPH) dan 2,2’-azino-bis(3 ethylbenzothiazoline-6-sulfonic acid (ABTS), serta aktivitas antiglikasi. Ekstrak dengan kadar total fenolik dan flavonoid tertinggi adalah ekstrak M. micrantha. Ekstrak A. lavenia memiliki aktivitas antioksidan terhadap DPPH tertinggi dengan nilai IC50 sebesar 121,82 μg/mL dan A. conyzoides tertinggi terhadap ABTS dengan kapasitas sebesar 4,51 mg trolox ekivalen (TE)/g ekstrak. Aktivitas antiglikasi tertinggi pada ekstrak G. parvifolia sebesar 90,67% yang tidak berbeda nyata dengan ekstrak A. lavenia (87,87%) dan S. trilobata (87,38%). Secara keseluruhan ekstrak A. lavenia dan S. trilobata baik dikembangkan sebagai antioksidan dan antiglikasi.
PELITA: Peningkatan Literasi Anak melalui Pendekatan Participatory Learning and Ecosystem Development di Desa Cimanggu II, Bogor Ilmiawati, Auliya; Nazhifah, Athiq; Wulandari, Desi; Sagraha, Ghiffari Kenang; Nasution, Lise Meitner Aribah; Rahmah, Lutfita Anisa; Fiqri, Muhammad; Asyari, R. Mugni Chairil Arbi; Larasati, Rizki Marsha; Kenang Sagraha, Ghiffari
Jurnal Pusat Inovasi Masyarakat Vol. 7 No. 2 (2025): Oktober 2025
Publisher : Direktorat Pengembangan Masyarakat Agromaritim, Institut Pertanian Bogor

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/jpim.7.2.407-421

Abstract

Cimanggu II Village, located in Cibungbulang Subdistrict, Bogor Regency, has several libraries. However, libraries and literacy interest in this village are still relatively low, as evidenced by poorly maintained facilities and low public understanding of literacy issues. The Pelita (Improving Children's Literacy through Participatory Learning and Ecosystem Development) program was implemented in Cimanggu II Village to address the low interest in reading due to the poor condition of the Lentera Community Reading Park (TBM) and the minimal community support. The objectives of this activity include improving children's literacy skills, revitalizing the Lentera Community Library, strengthening community and external stakeholder involvement, and creating an inclusive literacy environment. This program integrates Community Engagement, Enriched Learning Environment, and Fun Learning Method based on Maslow's Hierarchy of Needs theory. The Pelita Sehati subprogram focuses on revitalizing TBM facilities and digitizing data, while Pelita Cerdas emphasizes improving literacy through interactive activities such as storytelling, magic chemistry, reading aloud, book reviews, story writing, and reading-based creative projects. The results showed a significant increase in children's interest in reading, literacy skills, courage, creativity, and participation. Evaluation using the Logic Model confirms the relationship between inputs, activities, outputs, and outcomes, while the sustainability strategy using the Quadruple Helix Model strengthens multi-stakeholder collaboration. This program has succeeded in building an inclusive, sustainable, and impactful literacy ecosystem.
Isolation and Structural Characterization of Biflavonoids from Araucaria hunsteinii and Araucaria columnaris: Chemotaxonomic and Pharmacological Perspectives Sugita, Purwantiningsih; Ningtias, Widya Sekar Ayu; Priandanda, Rafi Chandra; Ilmiawati, Auliya; Kurniawanti, Kurniawanti; Agusta, Dhea Demitri; Dianhar, Hanhan; Rahayu, Dyah Utami Cahyaning
Jurnal Kimia Valensi Jurnal Kimia VALENSI, Volume 11, No. 2, November 2025
Publisher : Department of Chemistry, Faculty of Science and Technology Syarif Hidayatullah Jakarta State Islamic University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/jkv.v11i2.46173

Abstract

Biflavonoids are a distinctive class of dimeric flavonoids known for their diverse biological activities and chemotaxonomic significance. In this study, two biflavonoids were isolated from the acetone extracts of Araucaria hunsteinii twigs and Araucaria columnaris leaves collected from Bogor Botanical Garden, Indonesia. Chromatographic techniques, including Sephadex LH-20 column chromatography and preparative thin-layer chromatography, were employed for purification, followed by structural elucidation using LC-MS/MS and 1D/2D NMR spectroscopy. The compounds were identified as 4',4''',7,7''-tetra-O-methylcupressuflavone (1) and 7-O-methylcupressuflavone (2). Notably, this is the first report of 7-O-methylcupressuflavone isolated from A. columnaris leaves, providing new chemotaxonomic insights into the genus Araucaria. A literature-based pharmacological analysis revealed promising cytotoxic and α-glucosidase-inhibitory activities of the isolated compounds. These findings contribute to the phytochemical profiling and highlight the pharmaceutical potential of Araucaria-derived biflavonoids.
Toxicity and Antioxidant Activities of Indonesian Rambutan (Nephelium lappaceum L.) Peel Extracts: A Comparative Analysis Across Varieties Based on Phytochemical Content Adzkia Failasufa; Irmanida Batubara; Bambang Pontjo Priosoeryanto; Auliya Ilmiawati
Jurnal Kimia Sains dan Aplikasi Vol 28, No 8 (2025): Volume 28 Issue 8 Year 2025
Publisher : Chemistry Department, Faculty of Sciences and Mathematics, Diponegoro University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jksa.28.8.416-425

Abstract

Indonesia has long been known as a tropical country rich in various local cultivars of rambutan (Nephelium lappaceum L.), including Aceh Lebak (AL), Aceh Pelat (AP), Binjai (B), Gula Batu (GB), and Sikoneng (SK). Due to their phenolic and flavonoid compound, rambutan peel extracts have been reported to exhibit antioxidant and antiproliferative properties. Variation among cultivars suggests potential differences in bioactive compound content and biological activity. The objective of this study was to evaluate the antioxidant and toxicity profiles of five rambutan peel varieties and their correlation with total phenolic compound (TPC) and total flavonoid content (TFC). The antioxidant activity was evaluated using the 2,2-diphenyl-1-picrylhydrazyl (DPPH) method, and phenolic and flavonoid contents were measured by colorimetric assays. Toxicity was assessed using the Brine Shrimp Lethality Test (BSLT). Bioautography analysis using TLC-DPPH was conducted to identify antioxidant-active compounds. In this study, all rambutan peel extracts indicated the presence of flavonoids, phenolics, saponins, steroids, alkaloids, and triterpenoids. The highest extract yield was observed in Sikoneng, also with the highest TPC and TFC values. The Binjai variety exhibited strong antioxidant activity (IC50 = 4.73 ± 0.19 mg/L) and three active antioxidant spots; however, it also exhibited toxicity (LC50 = 136.27 ± 6.58 mg/L). The correlation between total phenolic or flavonoid content and the observed biological activity was not statistically significant, indicating that additional metabolites or synergistic interactions may also contribute. These findings underscore the significant impact of biodiversity on differences in compound levels and potential biological activities among rambutan peel varieties.
Sidik Jari KLT dan Evaluasi Aktivitas Inhibisi Xantin Oksidase Ekstrak Etanol Sidaguri (Sida rhombifolia) Berdasarkan Umur Tanam Berbeda Ade Heri Mulyati; Tamimah Shafwatul Ishlah; Dea Silviani; Taopik Ridwan; Auliya Ilmiawati; Alfi Hudatul Karomah; Mohamad Rafi
Jurnal Tumbuhan Obat Indonesia Vol. 18 No. 2 (2025): December 2025
Publisher : Universitas Tidar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31002/jtoi.v18i2.1366

Abstract

Sidaguri (Sida rhombifolia) belongs to the family Malvaceae and is used in traditional medicine to treat skindiseases, diarrhea, malaria, fever, and gout. These activities are caused by the presence of bioactivemetabolites, such as alkaloids, flavonoids, steroids, tannins, and saponins. Several factors, including harvestage, could affect the metabolite composition and concentration in a plant. In this study, the TLC fingerprint ofS. rhombifolia at planting ages of 3, 4, and 5 months was determined and in vitro xanthine oxidase inhibitoryactivity was evaluated. The TLC fingerprints obtained from the three planting ages had similar patterns. Thereare 11 compound bands with different color intensities at each planting age. Principal component analysis candifferentiate S. rhombifolia by planting age using TLC fingerprint analysis, with a total PC of 99%. The resultsof xanthine oxidase inhibition showed that the S. rhombifolia ethanol extract at 3, 4, and 5 months of plantingage inhibited the enzyme activity, with percent inhibitions of 45.37%, 44.72%, and 6.87%, respectively, at aconcentration of 100 ppm. Different planting ages of sidaguri are thought to contain varying concentrationsof compounds, as indicated by TLC fingerprints, and to result in different levels of xanthine oxidase inhibition. Kata kunci: sidaguri, TLC fingerprints, PCA, xanthine oxidase
Peningkatan Nilai Tambah Tanaman Obat pada Pekarangan Rumah Ibu-ibu PKK (Pemberdayaan Kesejahteraan Keluarga) Kecamatan Pasirwangi, Kabupaten Garut Siti Sadiah; Sandra Arifin Aziz; Auliya Ilmiawati; Taopik Ridwan
Agrokreatif: Jurnal Ilmiah Pengabdian kepada Masyarakat Vol. 9 No. 2 (2023): Agrokreatif Jurnal Ilmiah Pengabdian Kepada Masyarakat
Publisher : Institut Pertanian Bogor

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/agrokreatif.9.2.199-205

Abstract

Polyscias scutellaria can be planted as hedge plants at home. This plant has many advantages, one of which is a hair tonic that already has a patent number. To be used on an industrial scale, it is necessary to provide raw materials on a large scale, which can be done by planting in certain regions. The objective is that the empowerment of the PKK in Pasirwangi District, Garut will make the Pasirwangi sub-district one of the centers for producing P. scutellaria leaf raw materials. The activities carried out include educating on the use of medicinal plants, especially P. scutellaria and ginger, practicing training on planting techniques, cultivating them, and giving P. scutellaria cuttings and post-harvest processing techniques. This activity is an activity of the IPB Lecturer Homecoming Program in 2022 which is carried out in several stages. Evaluation and monitoring of cultivation executed two months after training. The evaluation results showed that there was an increase in knowledge related to the cultivation of P. scutellaria and participants cultivated P. scutellaria in their garden after the training was more than 90%. All of the participant’s responses to the training carried out stated that it was very useful and hoped that the activities would be sustainable.
Variation of morphological characteristics, total phenolic, and total flavonoid in Adenostemma lavenia, A. madurense, and A. platyphyllum NURLELA NURLELA; RIFAN NURFALAH; FIRA ANANDA; TAOPIK RIDWAN; AULIYA ILMIAWATI; WARAS NURCHOLIS; HIROSHI TAKEMORI; IRMANIDA BATUBARA
Biodiversitas Journal of Biological Diversity Vol. 23 No. 8 (2022)
Publisher : Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13057/biodiv/d230818

Abstract

Abstract. Nurlela, Nurfalah R, Ananda F, Ridwan T, Ilmiawati A, Nurcholis W, Takemori H, Batubara I. 2022. Variation of morphological characteristics, total phenolic, and total flavonoid in Adenostemma lavenia, A. madurense, and A. platyphyllum. Biodiversitas 23: 3999-4005. Adenostemma has long been used as a herbal medication. Despite some studies regarding the morphology and potency of Adenostemma carried out, the variation of morphological traits, total phenolic content (TPC), and total flavonoid content (TFC) on different species of Adenostemma has been poorly investigated. This study was designed to observe the morphological characteristics, TPC, and TFC of Adenostemma lavenia, A. madurense, and A. platyphyllum. Morphological characteristics were observed using qualitative and quantitative parameters. The colorimetric method determined TPC and TFC in plant leaf ethanol extracts. The plants were morphologically diverse, which significant variation among the three species in plant height, length and width of leaf, and internodes distance. Morphological traits such as leaf length and width, plant height, and internodes distance significantly correlate with phenolic and flavonoid content in Adenostemma. These may be used as important selection criteria in Adenostemma for obtaining high phenolic and flavonoid content. The study revealed that different species of these plants with varying morphological traits substantially impact the content of their chemical compounds. The highest TPC and TFC were found in A. lavenia, suggesting that it is potentially an alternative source of bioactive compounds as herbal medicine.
The effect of Cerbera odollam leaf and fruit peel extract on subterranean termite Coptotermes curvignathus Ummahatul Mujahidah; Auliya Ilmiawati; Arinana Arinana; Gustini Syahbirin; Irmanida Batubara
Jurnal Hama dan Penyakit Tumbuhan Tropika Vol. 26 No. 1 (2026): MARCH, JURNAL HAMA DAN PENYAKIT TUMBUHAN TROPIKA: JOURNAL OF TROPICAL PLANT PE
Publisher : Universitas Lampung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23960/jhptt.126100-111

Abstract

Coptotermes curvignathus is a termite pest that attacks buildings, plantations, and forests. Controlling this pest requires environmentally friendly natural materials. The bintaro plant (Cerbera odollam) are known in Indonesia as natural insecticides and traditional medicines because of their strong toxic properties, so they have the potential to be used in termite control. This study evaluated the efficacy of C. odollam leaf and fruit peel extracts as natural termiticides and their effectiveness against subterranean termite C. curvignathus. The extraction process used three solvents with different polarities: n-hexane, acetone, and ethanol. Anti-termite bioactivity tests were conducted following the Japanese Industrial Standard (JIS) 1571-2010 method. Ethanol extract from C. odollam leaves produced the highest yield (9.52%). Phytochemical analysis showed the presence of alkaloids, flavonoids, phenolics, steroids, and saponins in both leaf and fruit peel extracts. The anti-termite bioactivity test showed that the leaf extract with acetone solvent caused 97.33% mortality, while the fruit peel extract with ethanol solvent caused 100% mortality at a 5% concentration. This study demonstrates that C. odollam leaf and fruit peel extracts have strong potential as natural termiticides.
Co-Authors Abdul Rohman Ade Heri Mulyati Adiba, Asfiah Adzkia Failasufa Agusta, Dhea Demitri Akhiruddin Maddu Alfi Hudatul Karomah Alfi Hudatul Karomah Andi Thaariq Muhammad Arinana Arinana Arini Septianti Asep Hidayat Asep Hidayat Asyari, R. Mugni Chairil Arbi Auliatifani, Reza Ayu Rahmania Lestari Bambang Pontjo Priosoeryanto Budi Arifin Budiarti, Eka Dea Silviani Desi Wulandari, Desi Eka Budiarti Erlina, Iis Fadia Fahira Fadilah, Nisa Lelita Febriany, Retno Putri Fiqri, Muhammad FIRA ANANDA Gustini Syahbirin Gustini Syahbirin Gustini Syahbirin Hafizah Fatunisa Hanhan Dianhar HIROSHI TAKEMORI Ika Resmeiliana Irma Herawati Suparto Irmanida Batubara Ishika Jauza Nasywa Kenang Sagraha, Ghiffari Khaydanur Khaydanur Khaydanur, Khaydanur Kurniawanti, Kurniawanti Laela Wulansari Larasati, Rizki Marsha Lutfia Mutmainnah Luthfan Irfana M. Raffi Rayandhika Melinia Falestin Moch Ikkbal Aditya Kasmaran Mohamad Rafi Muhamad Insanu Nafisa Muthia Wafa Nanik Siti Aminah Nasution, Lise Meitner Aribah Nazhifah, Athiq Nengsih, Nunuk Kurniati Ningtias, Widya Sekar Ayu Nunuk Kurniati Nengsih NURLELA NURLELA Priandanda, Rafi Chandra Pujiyati Pujiyati Pujiyati, Purnomo, Tsania Firqin Purwantinigsih Sugita Purwantiningsih Sugita Purwantiningsih Sugita Rahayu, Dyah Utami Cahyaning Rahmah, Lutfita Anisa Rahmani, Nabiila Reza Auliatifani RIFAN NURFALAH Risda Fardilya Nihayah Sagraha, Ghiffari Kenang Sandra Arifin Aziz Septaningsih, Dewi Anggraini Setyanto Tri Wahyudi Siti Sadiah Tamimah Shafwatul Ishlah TAOPIK RIDWAN Taopik Ridwan Taopik Ridwan Tsania Firqin Purnomo Ummahatul Mujahidah Utami Dyah Syafitri Waras Nurcholis Wina Yulianti Wisnu Ananta Kusuma Wulansari, Laela Yulianti, Dwi Indah