Juni Kurniawaty Muhdar Abubakar Djayanti Sari
Departemen Anestesiologi Dan Terapi Intensif, Fakultas Kedokteran, Kesehatan Masyarakat Dan Keperawatan, Universitas Gadjah Mada, Yogyakarta|Universitas Gadjah Mada

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Perbandingan Efektivitas Kombinasi Gabapentin-Ondansetron dengan Dexamethasone-Ondansetron sebagai Profilaksis Postoperative Nausea-Vomiting (PONV) pada Operasi Laparoskopi Ridha, Ihsanur; Wisudarti, Calcarina Fitriani Retno; Kurniawaty, Juni
Jurnal Komplikasi Anestesi Vol 8 No 2 (2021): Volume 8 Number 2 (2021)
Publisher : This journal is published by the Department of Anesthesiology and Intensive Therapy of Faculty of Medicine, Public Health and Nursing, in collaboration with the Indonesian Society of Anesthesiology and Intensive Therapy , Yogyakarta Special Region Br

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jka.v8i2.8364

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Background: Post Operative Nausea and Vomiting (PONV) is a complication that most often occurs in patients undergoing surgery under general anesthesia, with an incidence rate of 40-90%. The existing combination drug guidelines to prevent PONV have not been effective in significantly reducing the incidence of PONV. There are several research results that suggest that the GabapentinOndansetron combination is effective in reducing the incidence of PONV. Objective: This study aims to compare the effectiveness of the combination of Gabapentin-Ondansetron with Dexamethasone-Ondansetron as a prophylactic of Post Operative Nausea and Vomiting (PONV) in laparoscopic surgery. Methods: This study is a double-blind Randomized Controlled Trial/RCT involving 78 patients who underwent a laparoscopic procedure. Subjects were divided into two groups A and B. Group A was given a combination of Gabapentin 600 mg and Ondansetron 0.1 mg/kgBW. Group B was given a combination of Dexamethasone 10 mg and Ondansetron 0.1 mg/kgBW. Both groups assessed the incidence of PONV using VNRS for nausea and assessed the presence or absence of vomiting. Results: At 15 and 30 minutes postoperatively, Gabapentin-Ondansetron was better than Dexamethasone-Ondansetron as a prophylactic of nausea (p <0.05) in laparoscopic surgery. At 60, 90, and 24 hours postoperatively, the drug combination of the two groups was as good as nausea prophylaxis (p >0.05) for laparoscopic surgery. Both of these drug combinations had the same effect as vomiting prophylaxis (p >0.05) after laparoscopic surgery. Conclusion: Gabapentin-Ondansetron combination is more effective thanDexamethasone-Ondansetron combination as a prophylactic of Post OperativeNausea and Vomiting (PONV) in laparoscopic surgery
Perbandingan Pengukuran Cardiac Output, Cardiac Index, dan Systemic Vascular Resistance Antara Menggunakan Non-Invasive Cardiometry (Icon®) dan Pressure-Recording Analytic Method (MOST- CARE®) pada Pasien Pascaoperasi Mayor di RSUP Dr. Sardjito Yogyakarta Daniswara; Wisudarti, Calcarina Fitriani Retno; Kurniawaty, Juni
Jurnal Komplikasi Anestesi Vol 8 No 3 (2021): Volume 8 Number 3 (2021)
Publisher : This journal is published by the Department of Anesthesiology and Intensive Therapy of Faculty of Medicine, Public Health and Nursing, in collaboration with the Indonesian Society of Anesthesiology and Intensive Therapy , Yogyakarta Special Region Br

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jka.v8i3.8372

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Background: Pulmonary Artery Catheter (PAC) is the gold standard for examining cardiac output (CO), cardiac index (CI), and systemic vascular resistance (SVR), however, PAC insertion is very invasive, causing complications. A less invasive method is currently being developed in the form of Most-Care® (pressure recording analytical method (PRAM)) and non-invasive ICON® (electrical cardiometry (EC)). Methods: The study sample was adult patients who were treated in the ICU Dr. Sardjito with age ≥ 18 years,post major surgery with an arterial line and central venous catheter (CVC). CO, CI, and SVR values were measured at the first hour after the patient arrived at the ICU using ICON® and Most-Care®. Collected data were processed and analyzed to compare between two of them using paired ttest. Results: From a total population of 49 patients, 23 subjects met the inclusion criteria, and the remaining 26 subjects were eliminated due to CHF, obesity, atrial fibrillation, tachycardia, bradycardia, and thoracic surgery. CO and CI of ICON® and Most-Care® are not significantly different (p>0.05). High SVR of ICON® and Most-Care® are not significantly different (p=0.667), but showed a significant difference in normal SVRp=0.015. Conclusion: The measurement of CO and CI between ICON® and Most-Care® showed no significant difference (p>0.05), but showed a significant difference (p=0.015) in the normal SVR category
Panduan Pemeriksaan Analisis Gas Darah Menggunakan Bedside Poct (I‐STAT®) dan Laboratorium Sentral (NOVA PHOX®) dI RSUP Dr. Sardjito Nurdiansyah, Elba; Pratomo, Bhirowo Yudo; Kurniawaty, Juni
Jurnal Komplikasi Anestesi Vol 8 No 3 (2021): Volume 8 Number 3 (2021)
Publisher : This journal is published by the Department of Anesthesiology and Intensive Therapy of Faculty of Medicine, Public Health and Nursing, in collaboration with the Indonesian Society of Anesthesiology and Intensive Therapy , Yogyakarta Special Region Br

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jka.v8i3.8373

Abstract

Background: Proper postoperative ventilator weaning requires regular monitoring of the patient's blood gas analysis (BGA). Delays in getting the results of the BGA test will be an obstacle in guiding the weaning procedure and affect the length of use of the ventilator. The central laboratory examination (NOVA pHOx®) requires more blood samples, a longer examination time and process compared to POCT which uses fewer blood samples and processes faster results. Methods: This study used a prospective observational design, cohort study, and unpaired comparative analytics. The samples were divided into 2 groups for blood gas analysis i-STAT® and a central laboratory (Nova pHOx®). The inclusion criteria were patients aged 5-60 years who underwent post-open heart surgicaltreatment with a ventilator and a EURO Score <5, The exclusion criteria were patients with ventilator problems, acquired pneumonia, and adult patients with severe chest restriction spirometry. Results: The number of samples was 46 people (POCT: n = 23, Central Laboratory (Nova pHOx®): n = 23).The length of time using the ventilator in the i-STAT group was 1122.8 minutes while the central laboratory group (Nova pHOx®) was 1291.4 minutes with a mean difference of 168.8 minutes but both showed no significant difference with p = 0.303 (p> 0.05). Conclusion: The length of time of using the ventilator in post-cardiac surgery patients with the guidance of blood gas analysis in the i-STAT group and central laboratory (Nova pHOx®). showed no evidence of interaction and no significant effect on the two test modalities
Penggunaan Non-Invasive Ventilation pada Pasien COVID-19 Kurniawaty, Juni; Adiyanto, Bowo; Sadewo, Yuri
Jurnal Komplikasi Anestesi Vol 9 No 1 (2021)
Publisher : This journal is published by the Department of Anesthesiology and Intensive Therapy of Faculty of Medicine, Public Health and Nursing, in collaboration with the Indonesian Society of Anesthesiology and Intensive Therapy , Yogyakarta Special Region Br

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jka.v9i1.8499

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COVID-19 patients with acute respiratory distress require hospitalization and require invasive and/or non-invasive mechanical ventilation support. NonInvasive Ventilation (NIV) is used in cases requiring escalation of standard oxygen therapy to a higher level. NIV can also reduce early intubation, but long-term use of NIV is not recommended. NIV also does not decrease intubation rates. We report a 52-year-old female patient with a confirmed diagnosis of severe COVID-19. Our patient was admitted to the ICU with the use of HFNC and NIV during treatment. The use of NIV at the right time could determine the patient's prognosis. Persistent weaning of NIV could maintain PO2 and reduce the patient's oxygen fraction requirements. This patient’s condition could improve and become a survivor of COVID-19.
Terapi Opioid pada Kasus COVID-19 Jufan, Akhmad Yun; Kurniawaty, Juni; Dewi, Baiq Dessy Resmana
Jurnal Komplikasi Anestesi Vol 9 No 1 (2021)
Publisher : This journal is published by the Department of Anesthesiology and Intensive Therapy of Faculty of Medicine, Public Health and Nursing, in collaboration with the Indonesian Society of Anesthesiology and Intensive Therapy , Yogyakarta Special Region Br

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jka.v9i1.8515

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One-third of COVID-19 patients experience a variety of neurological symptoms involving the central and peripheral nervous systems. These symptoms include headache, dizziness, loss of consciousness, impaired smell, neuralgia, and skeletal muscle damage. Myalgia is the most common symptom in cases of COVID-19. Therefore, adequate pain management isneeded, one of the choices is using opioids. Opioid receptor agonists are a group of drugs that stimulate opioid receptors and produce their effects by mimicking endogenous opioid peptides known as endorphins.
Anesthesia in Renal Transplant Kurniawaty, Juni; Ancilla, Cornelia; Arovah, Novita Intan
Jurnal Komplikasi Anestesi Vol 10 No 3 (2022)
Publisher : This journal is published by the Department of Anesthesiology and Intensive Therapy of Faculty of Medicine, Public Health and Nursing, in collaboration with the Indonesian Society of Anesthesiology and Intensive Therapy , Yogyakarta Special Region Br

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jka.v10i3.8769

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Background: Transplantation provides near-normal life and excellent rehabilitation compared to dialysis and is the preferred method of treating end-stage renal disease (ESRD) patients. Methods: We conducted a retrospective analysis of anesthesia management from 20 cases of live renal transplants carried out between August 2017 and April 2019 at Dr. Sardjito Central General Hospital, Yogyakarta. The subjects ' preoperative patient status, anesthesia management, and postoperative care were assessed. Results: Most patients had preoperative anemia, normal serum potassium, serum creatinine, and average ejection fraction. Anesthesia management began 24 hours before surgery, in which the patients were hospitalized, had peripheral IV access and fluid maintenance, and hemodialysis, followed by premedication 1 hour before surgery. Before surgery, anesthesia induction and intubation were done, followed by maintenance of anesthesia and intraoperative monitoring. Postoperative care consisted of the administration of analgesia and management of complications. Conclusion: Optimization of preoperative status, proper anesthesia management, and good postoperative care are keys to a successful renal transplant program.
Efikasi Profilaksis Granisetron 40 mcg/kgBB Dibandingkan Ondansetron 8 mg dan Meperidine 0,4 mg/kgBB dalam Mencegah Shivering Paska Anestesi Spinal di RSUP Dr. Sardjito Gentong, Metia Gledis Gilang; Kurniawaty, Juni; Sudadi, Sudadi
Jurnal Komplikasi Anestesi Vol 11 No 3 (2023)
Publisher : This journal is published by the Department of Anesthesiology and Intensive Therapy of Faculty of Medicine, Public Health and Nursing, in collaboration with the Indonesian Society of Anesthesiology and Intensive Therapy , Yogyakarta Special Region Br

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jka.v11i3.13178

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Background. Spinal anesthesia induced hypothermia resulting in shivering and inducing adverse complications for the patient. Meperidine effectively prevent the incidence of shivering but has many side effects. Granisetron and ondasetron are known to prevent shivering with minimal side effects when working in thermoregulation. Aim. Efficacy of granisetron compared to ondansetron and meperidine in preventing shivering after spinal anesthesia. Method. The study was a double-blind randomized clinical trial of 97 male/female subjects, aged 18-65 years, physical status ASA I and II with emergency or elective surgery in RSUP Dr. Sardjito Yogyakarta. Subjects divided into three groups: Granisetron 40 mcg/kgbw (group G), Ondansetron 8 mg (Group O) and Meperidine 0.4 mg/kgbw (group M). Results. We found shivering in Group G showed 10 subjects (31.3%), group O showed 15 subjects (45.5%) and group M showed 10 subjects (31.3%) (p=0.386). Group G decreased the severity of shivering because grade 3 and 4 did not occur at 60 minutes, better than group O, which showed 5 subjects (15.2%) experiencing grade 3 and 1 subject (5%) experiencing grade 4. (p=0.044). Conclusion. Prophylactic granisetron 40 mcg/kgbw before spinal anesthesia reduces the severity of shivering compared to ondansetron 8 mg. Prophylactic granisetron 40 mcg/kgbw and ondansetron 8 mg reduced the incidence of shivering same as meperidine 0.4 mg/kgbw. Keywords. Shivering, Spinal Anesthesia, Granisetron, Ondansetron, Meperidine.
CORRELATION STUDY OF SERUM VITAMIN D LEVELS WITH IN-HOSPITAL MORTALITY IN SEPTIC SHOCK PATIENTS Kusumandaru , Novierta Prima; R W, Calcarina Fitriani; Kurniawaty, Juni
Jurnal Komplikasi Anestesi Vol 12 No 1 (2024)
Publisher : This journal is published by the Department of Anesthesiology and Intensive Therapy of Faculty of Medicine, Public Health and Nursing, in collaboration with the Indonesian Society of Anesthesiology and Intensive Therapy , Yogyakarta Special Region Br

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jka.v12i1.15898

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Latar Belakang: Sepsis adalah keadaan darurat medis yang melibatkan respons imunologis sistem tubuh terhadap infeksi, yang dapat menyebabkan disfungsi organ dan kematian. Syok sepsis, sebagai bentuk parah dari sepsis, memiliki tingkat mortalitas yang tinggi. Vitamin D diketahui memiliki peran penting dalam modulasi imun dan inflamasi, yang dapat mempengaruhi hasil klinis pada pasien sepsis. Tujuan: Penelitian ini bertujuan untuk mengevaluasi korelasi antara kadar serum vitamin D dengan mortalitas pada pasien syok sepsis di RSUP Dr. Sardjito. Metode: Penelitian ini merupakan studi kohort prospektif yang melibatkan 22 pasien syok sepsis. Kadar vitamin D serum diukur saat pasien masuk ICU, dan mortalitas dicatat selama 28 hari. Skor SAPS-3 digunakan untuk menilai keparahan penyakit. Analisis statistik dilakukan untuk menentukan hubungan antara kadar vitamin D, skor SAPS-3, dan mortalitas. Hasil: Dari 22 pasien, 15 pasien (68,18%) memiliki kadar vitamin D normal-insufisiensi, sementara 7 pasien (31,82%) mengalami defisiensi ringan-berat. Mortalitas tercatat sebesar 27,27% (6 pasien). Analisis menunjukkan bahwa pasien dengan defisiensi vitamin D memiliki odds ratio (OR) sebesar 8,6667 untuk mortalitas dibandingkan dengan pasien dengan kadar vitamin D normal-insufisiensi (p= 0.026; 95% CI: 1,0495 hingga 71,5719). Selain itu, terdapat korelasi negatif yang signifikan antara kadar vitamin D dan skor SAPS-3 (p= 0.0001; OR=7,1111; 95% CI: 1,0888 hingga 46,4425). Kesimpulan: Penelitian ini menunjukkan bahwa defisiensi vitamin D berkorelasi dengan peningkatan risiko mortalitas pada pasien syok sepsis.
ANESTHESIA FOR PATENT DUCTUS ARTERIOSUS LIGATION SURGERY IN ADULT Kurniaji, Kurniaji; Pratomo, Bhirowo Yudo; Kurniawaty, Juni
Jurnal Kesehatan Tambusai Vol. 5 No. 4 (2024): DESEMBER 2024
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jkt.v5i4.35551

Abstract

Patent Ductus Arteriosus (PDA) adalah suatu kondisi jantung bawaan yang terjadi ketika pembuluh darah normal janin yang disebut ductus arteriosus, yang menghubungkan arteri pulmonalis dan aorta di dalam rahim, gagal menutup setelah bayi lahir. Laporan kasus ini berfokus pada manajemen anestesi pada pasien PDA dewasa yang menjalani operasi ligasi PDA, kemudian dilakukan teknik deep hypothermic circulatory arrest  (DHCA) yang tidak terencana karena terjadi ruptur aorta. Seorang wanita berusia 33 tahun, mengalami gejala kelelahan, sesak napas, dan intoleransi latihan yang memburuk sejak pertama kali didiagnosis 12 tahun lalu. Setelah pemeriksaan menyeluruh, pasien didiagnosis dengan PDA bidirectional shunt, hipertensi pulmonal dengan high flow high resistance, dan tes oksigen reaktif. Prosedur pembedahan pasien meliputi penutupan PDA melalui median sternotomi dengan mesin cardiopulmonary bypass (CPB). Anestesi yang digunakan yaitu anestesi berbasis opioid dengan DHCA selama 9 menit.  Beberapa faktor yang perlu diperhatikan dalam DHCA yang tidak terencana antara lain: (1) respon, keterampilan, dan kemampuan adaptasi terhadap situasi dari ahli bedah; (2) pembagian waktu yang baik; (3) pemberian es blok di area sekitar kepala pasien; dan (4) pemberian agen-agen farmakologis seperti midazolam, steroid dan manitol untuk menekan laju konsumsi oksigen serebral serta memberikan proteksi serebral pada kondisi ini. CPB dan DGCA yang disertai dengan tindakan neuroprotektif dan pemantauan yang tepat, dapat menjadi metode anestesi yang aman untuk pasien dewasa penderita PDA dan hipertensi pulmonal yang menjalani operasi ligasi PDA.
DEVELOPING A PREDICTIVE MODEL OF SOCIAL COGNITIVE INFLUENCES ON PHYSICAL ACTIVITY IN MIDDLE-AGED AND OLDER ADULTS: A CROSS-SECTIONAL STUDY Arovah, Novita Intan; Kurniawaty, Juni; Haroen, Hartiah
The Indonesian Journal of Public Health Vol. 20 No. 1 (2025): THE INDONESIAN JOURNAL OF PUBLIC HEALTH
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/ijph.v20i1.2025.133-146

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Introduction: Increasing physical activity levels in middle-aged and older adults is a critical public health agenda, as regular physical activity reduces morbidity, healthcare costs, and chronic disease risks by up to 90%. Developing effective physical activity programs, however, requires comprehension of factors influencing physical activity behavior. Aims: This research aimed to develop a predictive model of social cognitive influences on moderate and vigorous physical activity (MVPA) in this demographic. Method: A cross-sectional study was conducted in 118 participants, 76% of whom were female. Social cognitive factors, which included self-efficacy, outcome expectations (physical, social, and self-evaluation), self-regulation (goal setting and planning), and social support (from family and friends) regarding physical activity, were assessed using validated self-reported questionnaires. A 7-day Physical Activity Recall interview was conducted to measure MVPA. Data were analyzed using bivariate correlations and stepwise multiple linear regressions, adjusted for sex and age. Results: All social cognitive measures showed moderate to strong correlations with MVPA (r = 0.43-0.79). The regression model, which included self-efficacy, physical outcome expectations, planning, and social support, explained 77% of the variance in MVPA. Conclusion: These results highlight the importance of strengthening these social cognitive factors to encourage more physically activity among middle-aged and older adults in Indonesia.